{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T23:08:53Z","timestamp":1774134533557,"version":"3.50.1"},"reference-count":235,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/21783-4, 2018\/25410-0, 2019\/02405-4, 2016\/01743-5"],"award-info":[{"award-number":["2017\/21783-4, 2018\/25410-0, 2019\/02405-4, 2016\/01743-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["Programme grant and personal Chair awards (RG\/15\/5\/31446, CH\/15\/1\/31199)"],"award-info":[{"award-number":["Programme grant and personal Chair awards (RG\/15\/5\/31446, CH\/15\/1\/31199)"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409902\/2018-7"],"award-info":[{"award-number":["409902\/2018-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BHF Centre of Vascular Regeneration","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"BHF Centre of Regenerative Medicine","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Research England Global Challenges Research Fund","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Gestational diabetes Mellitus (GDM) is a complex clinical condition that promotes pelvic floor myopathy, thus predisposing sufferers to urinary incontinence (UI). GDM usually regresses after birth. Nonetheless, a GDM history is associated with higher risk of subsequently developing type 2 diabetes, cardiovascular diseases (CVD) and UI. Some aspects of the pathophysiology of GDM remain unclear and the associated pathologies (outcomes) are poorly addressed, simultaneously raising public health costs and diminishing women\u2019s quality of life. Exosomes are small extracellular vesicles produced and actively secreted by cells as part of their intercellular communication system. Exosomes are heterogenous in their cargo and depending on the cell sources and environment, they can mediate both pathogenetic and therapeutic functions. With the advancement in knowledge of exosomes, new perspectives have emerged to support the mechanistic understanding, prediction\/diagnosis and ultimately, treatment of the post-GMD outcomes. Here, we will review recent advances in knowledge of the role of exosomes in GDM and related areas and discuss the possibilities for translating exosomes as therapeutic agents in the GDM clinical setting.<\/jats:p>","DOI":"10.3390\/cells9030675","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T12:22:51Z","timestamp":1584015771000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus"],"prefix":"10.3390","volume":"9","author":[{"given":"Juliana Ferreira","family":"Floriano","sequence":"first","affiliation":[{"name":"Botucatu Medical School, Sao Paulo State University, 18618687 Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gareth","family":"Willis","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine\/Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Catapano","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Rodrigues","family":"de Lima","sequence":"additional","affiliation":[{"name":"Botucatu Medical School, Sao Paulo State University, 18618687 Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Vieira Duarte Souza","family":"Reis","sequence":"additional","affiliation":[{"name":"Botucatu Medical School, Sao Paulo State University, 18618687 Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-9511","authenticated-orcid":false,"given":"Ang\u00e9lica Mercia Pascon","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Botucatu Medical School, Sao Paulo State University, 18618687 Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-832X","authenticated-orcid":false,"given":"Marilza Vieira Cunha","family":"Rudge","sequence":"additional","affiliation":[{"name":"Botucatu Medical School, Sao Paulo State University, 18618687 Botucatu, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Emanueli","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Whiting, D.R., Guariguata, L., Weil, C., and Shaw, J. (2011). IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract.","DOI":"10.1016\/j.diabres.2011.10.029"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/HYPERTENSIONAHA.110.156810","article-title":"Breathing life into the lifecourse approach: Pregnancy history and cardiovascular disease in women","volume":"56","author":"McElrath","year":"2010","journal-title":"Hypertension"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.2337\/diacare.25.10.1862","article-title":"Gestational Diabetes and the Incidence of Type 2 Diabetes","volume":"25","author":"Kim","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60731-5","article-title":"Type 2 diabetes mellitus after gestational diabetes: A systematic review and meta-analysis","volume":"373","author":"Bellamy","year":"2009","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11892-011-0238-3","article-title":"Gestational diabetes: Implications for cardiovascular health","volume":"12","author":"Sullivan","year":"2012","journal-title":"Curr. Diab. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.diabres.2018.04.008","article-title":"Hyperglycemia in pregnancy and its implications for a woman\u2019s future risk of cardiovascular disease","volume":"145","author":"Retnakaran","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/1753-0407.12524","article-title":"American Diabetes Association Standards of Medical Care in Diabetes 2017","volume":"9","author":"Marathe","year":"2017","journal-title":"J. Diabetes."},{"key":"ref_8","first-page":"1341","article-title":"Urinary incontinence and vaginal squeeze pressure two years post-cesarean delivery in primiparous women with previous gestational diabetes mellitus","volume":"66","author":"Barbosa","year":"2011","journal-title":"Clinics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1111\/j.1471-0528.2012.03468.x","article-title":"The impact of gestational diabetes mellitus on postpartum urinary incontinence: A longitudinal cohort study on singleton pregnancies","volume":"119","author":"Chuang","year":"2012","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/jwh.2007.0616","article-title":"Stress urinary incontinence in women with a history of gestational diabetes mellitus","volume":"7","author":"Kim","year":"2008","journal-title":"J. Women\u2019s Heal."},{"key":"ref_11","first-page":"398","article-title":"Annual direct cost of urinary incontinence","volume":"98","author":"Wilson","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"ref_12","first-page":"1189","article-title":"Urinary Incontinence: An Analysis in the Perspective of Aging Policies","volume":"11","author":"Pinto","year":"2017","journal-title":"J. Nurs. UFPE \/ Rev. Enferm. UFPE"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0022-5347(06)00588-X","article-title":"Increasing Costs of Urinary Incontinence Among Female Medicare Beneficiaries","volume":"176","author":"Anger","year":"2006","journal-title":"J. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2298\/VSP1111940M","article-title":"Quality of life in women with pelvic floor dysfunction","volume":"68","author":"Segedi","year":"2011","journal-title":"Vojnosanit. Pregl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.2741\/3038","article-title":"Muscular response and adaptation to diabetes mellitus","volume":"13","author":"Sun","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1557-0843(09)80003-1","article-title":"Metabolic consequences of hyperglycemia and insulin resistance","volume":"4","author":"Jellinger","year":"2009","journal-title":"Insulin"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2015.05.012","article-title":"Pregnancy-induced adaptations in the intrinsic structure of rat pelvic floor muscles","volume":"213","author":"Alperin","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2016.02.018","article-title":"Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles","volume":"215","author":"Alperin","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00192-013-2218-4","article-title":"Urethral striated muscle and extracellular matrix morphological characteristics among mildly diabetic pregnant rats: Translational approach","volume":"25","author":"Piculo","year":"2014","journal-title":"Int. Urogynecol. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/nau.22974","article-title":"Effects of short-term severe and long-term mild STZ-induced diabetes in urethral tissue of female rats","volume":"36","author":"Marini","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"R837","DOI":"10.1152\/ajpregu.00917.2005","article-title":"Temporal diabetes- and diuresis-induced remodeling of the urinary bladder in the rat","volume":"291","author":"Liu","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejogrb.2017.12.032","article-title":"The influence of hyperglycemia on the remodeling of urethral connective tissue in pregnant rats","volume":"221","author":"Marini","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_23","first-page":"1","article-title":"Diabetic myopathy: Impact of diabetes mellitus on skeletal muscle progenitor cells","volume":"4","author":"Hawke","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1007\/s00125-014-3293-x","article-title":"Effects of calcium-vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: A randomised placebo-controlled trial","volume":"57","author":"Asemi","year":"2014","journal-title":"Diabetologia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1017\/S1368980015000609","article-title":"Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: Randomized, double-blind, placebo-controlled trial","volume":"19","author":"Karamali","year":"2016","journal-title":"Public Health Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1042\/CS20180487","article-title":"Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity","volume":"132","author":"Nair","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2337\/db11-1790","article-title":"Altered response of skeletal muscle to IL-6 in type 2 diabetic patients","volume":"62","author":"Jiang","year":"2013","journal-title":"Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ejim.2009.08.001","article-title":"Upper limb musculoskeletal abnormalities and poor metabolic control in diabetes","volume":"20","author":"Ramchurn","year":"2009","journal-title":"Eur. J. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00586-012-2162-x","article-title":"Pregnancy-related pelvic girdle pain and its relationship with relaxin levels during pregnancy: A systematic review","volume":"21","author":"Aldabe","year":"2012","journal-title":"Eur. Spine J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1083\/jcb.201212113","article-title":"Exosomes: Looking back three decades and into the future","volume":"200","author":"Harding","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","article-title":"Exosomes--vesicular carriers for intercellular communication","volume":"21","author":"Simons","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: Composition, biogenesis and function","volume":"2","author":"Zitvogel","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.97.2.329","article-title":"Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes","volume":"97","author":"Harding","year":"1983","journal-title":"J. Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00441-012-1428-2","article-title":"Exosomes: Vesicular carriers for intercellular communication in neurodegenerative disorders","volume":"352","author":"Schneider","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Skog","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ncb1725","article-title":"Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells","volume":"10","author":"Meehan","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.bcp.2011.12.037","article-title":"The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function and frontiers for pharmacological and biomarker opportunities","volume":"83","author":"Pant","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/ijo.2014.2712","article-title":"The fusion of two worlds: Non-coding RNAs and extracellular vesicles - Diagnostic and therapeutic implications (Review)","volume":"46","author":"Melo","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/sj.leu.2404132","article-title":"Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery","volume":"20","author":"Ratajczak","year":"2006","journal-title":"Leukemia"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3892\/br.2016.725","article-title":"Extracellular vesicle microRNAs mediate skeletal muscle myogenesis and disease (Review)","volume":"5","author":"Wang","year":"2016","journal-title":"Biomed. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","article-title":"B lymphocytes secrete antigen-presenting vesicles","volume":"183","author":"Raposo","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1182\/blood-2004-03-1095","article-title":"Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation","volume":"106","author":"Shrimpton","year":"2005","journal-title":"Blood"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: Biology and emerging therapeutic opportunities","volume":"12","author":"Breakefield","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/bies.201100169","article-title":"Extracellular vesicles - vehicles that spread cancer genes","volume":"34","author":"Rak","year":"2012","journal-title":"BioEssays"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI81135","article-title":"The biology and function of exosomes in cancer","volume":"126","author":"Kalluri","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/77498","article-title":"Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection","volume":"6","author":"Mack","year":"2000","journal-title":"Nat. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/path.2145","article-title":"Packaging of prions into exosomes is associated with a novel pathway of PrP processing","volume":"211","author":"Vella","year":"2007","journal-title":"J. Pathol."},{"key":"ref_50","first-page":"151","article-title":"Multicolor flow cytometry and nanoparticle tracking analysis of extracellular vesicles in the plasma of normal pregnant and pre-eclamptic women","volume":"89","author":"Jia","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"E1280","DOI":"10.1210\/jc.2015-2270","article-title":"The effect of glucose on the release and bioactivity of exosomes from first trimester trophoblast cells","volume":"100","author":"Rice","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.ajog.2015.07.001","article-title":"Placental exosomes in normal and complicated pregnancy","volume":"213","author":"Mitchell","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fphys.2016.00098","article-title":"Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies","volume":"7","author":"Escudero","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_54","first-page":"176","article-title":"The possible involvement of microRNAs in preeclampsia and gestational diabetes mellitus. Best Pract","volume":"29","author":"Pillar","year":"2015","journal-title":"Res. Clin. Obstet. Gynaecol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: Extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J. Proteomics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ncb2574","article-title":"Active Wnt proteins are secreted on exosomes","volume":"14","author":"Gross","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/bjc.2015.201","article-title":"Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer","volume":"113","author":"Matsumura","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, Secretion and Intercellular Interactions of Exosomes and Other Extracellular Vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Schorey, J.S., and Bhatnagar, S. (2008). Exosome function: From tumor immunology to pathogen biology. Traffic.","DOI":"10.1111\/j.1600-0854.2008.00734.x"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2217\/bmm.13.63","article-title":"Exosomes: The future of biomarkers in medicine","volume":"7","author":"Properzi","year":"2013","journal-title":"Biomark. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Emanueli, C., Shearn, A.I.U., Laftah, A., Fiorentino, F., Reeves, B.C., Beltrami, C., Mumford, A., Clayton, A., Gurney, M., and Shantikumar, S. (2016). Coronary artery-bypass-graft surgery increases the plasma concentration of exosomes carrying a cargo of cardiac microRNAs: An example of exosome trafficking out of the human heart with potential for cardiac biomarker discovery. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154274"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Hill, A.F., Pegtel, D.M., Lambertz, U., Leonardi, T., O\u2019Driscoll, L., Pluchino, S., Ter-Ovanesyan, D., and Nolte-\u2018t Hoen, E.N.M. (2013). ISEV position paper: Extracellular vesicle RNA analysis and bioinformatics. J. Extracell. Vesicles, 2.","DOI":"10.3402\/jev.v2i0.22859"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Witwer","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1089\/ten.tea.2017.0302","article-title":"Extracellular Vesicles and Their Versatile Roles in Tissue Engineering","volume":"23","author":"Jay","year":"2017","journal-title":"Tissue Eng."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"L\u00f6tvall, J., Hill, A.F., Hochberg, F., Buz\u00e1s, E.I., Di Vizio, D., Gardiner, C., Gho, Y.S., Kurochkin, I.V., Mathivanan, S., and Quesenberry, P. (2014). Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles. J. Extracell. Vesicles, 3.","DOI":"10.3402\/jev.v3.26913"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1582-4934.2006.tb00406.x","article-title":"Prospects for exosomes in immunotherapy of cancer","volume":"10","author":"Mignot","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"ref_67","first-page":"2","article-title":"Exosomes-structure, biogenesis and biological role in non-small-cell lung cancer. Scand","volume":"81","author":"Frydrychowicz","year":"2015","journal-title":"J. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"14240","DOI":"10.3390\/ijms140714240","article-title":"Intercellular communication by exosome-derived microRNAs in cancer","volume":"14","author":"Hannafon","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_69","first-page":"270","article-title":"ExoCarta 2012: Database of exosomal proteins, RNA and lipids","volume":"66","author":"Mathivanan","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Treiber, T., Treiber, N., Plessmann, U., Harlander, S., Dai\u00df, J.L., Eichner, N., Lehmann, G., Schall, K., Urlaub, H., and Meister, G. (2017). A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol. Cell.","DOI":"10.1016\/j.molcel.2017.03.014"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and exosomal microRNA: Trafficking, sorting and function","volume":"1","author":"Zhang","year":"2015","journal-title":"Genom. Proteom. Bioinf."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Simpson, R.J., Kalra, H., and Mathivanan, S. (2012). Exocarta as a resource for exosomal research. J. Extracell. Vesicles, 1.","DOI":"10.3402\/jev.v1i0.18374"},{"key":"ref_73","first-page":"7309","article-title":"The Development of Stem Cell-Derived Exosomes as a Cell-Free Regenerative Medicine","volume":"166","author":"Vishnubhatla","year":"2014","journal-title":"J. Circ. Biomarkers"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Th\u00e9ry, C., Boussac, M., V\u00e9ron, P., Ricciardi-Castagnoli, P., Raposo, G., Garin, J., and Amigorena, S. (2001). Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles. J. Immunol.","DOI":"10.4049\/jimmunol.166.12.7309"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Gould, S.J., and Raposo, G. (2013). As we wait: Coping with an imperfect nomenclature for extracellular vesicles. J. Extracell. Vesicles, 2.","DOI":"10.3402\/jev.v2i0.20389"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.placenta.2016.12.020","article-title":"Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation","volume":"50","author":"Elfeky","year":"2017","journal-title":"Placenta"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Salomon, C., Kobayashi, M., Ashman, K., Sobrevia, L., Mitchell, M.D., and Rice, G.E. (2013). Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079636"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: Emerging role of extracellular vesicles","volume":"68","author":"Aradi","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/sctm.17-0055","article-title":"Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles","volume":"6","author":"Reiner","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"30087","DOI":"10.3402\/jev.v4.30087","article-title":"Applying extracellular vesicles based therapeutics in clinical trials - An ISEV position paper","volume":"4","author":"Lener","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"ref_81","first-page":"3","article-title":"Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids","volume":"30","author":"Amigorena","year":"2006","journal-title":"Curr. Protoc. Cell Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1515\/hsz-2013-0141","article-title":"Current methods for the isolation of extracellular vesicles","volume":"394","author":"Balaj","year":"2013","journal-title":"Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Witwer, K.W., Buz\u00e1s, E.I., Bemis, L.T., Bora, A., L\u00e4sser, C., L\u00f6tvall, J., Nolte-\u2019t Hoen, E.N., Piper, M.G., Sivaraman, S., and Skog, J. (2013). Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J. Extracell. Vesicles, 2.","DOI":"10.3402\/jev.v2i0.20360"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fcvm.2017.00063","article-title":"Toward Exosome-Based Therapeutics: Isolation, Heterogeneity and Fit-for-Purpose Potency","volume":"4","author":"Willis","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, P., Kaslan, M., Lee, S.H., Yao, J., and Gao, Z. (2017). Progress in exosome isolation techniques. Theranostics.","DOI":"10.7150\/thno.18133"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/jth.13190","article-title":"Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles","volume":"14","author":"Gool","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1093\/nar\/gks658","article-title":"Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions","volume":"40","author":"Buermans","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcancer.2014.04.009","article-title":"Sorting it out: Regulation of exosome loading. Semin","volume":"28","author":"Baixauli","year":"2014","journal-title":"Cancer Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, Biogenesis, Mechanism and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.omtn.2019.05.002","article-title":"miR-15a\/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a\/16 Decoy System in Limb Ischemia","volume":"17","author":"Besnier","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature10661","article-title":"A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells","volume":"481","author":"Png","year":"2012","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1038\/nature07362","article-title":"MicroRNA-10b and breast cancer metastasis","volume":"455","author":"Gee","year":"2008","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nature07299","article-title":"MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation","volume":"455","author":"Tay","year":"2008","journal-title":"Nature"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature06174","article-title":"Tumour invasion and metastasis initiated by microRNA-10b in breast cancer","volume":"449","author":"Ma","year":"2007","journal-title":"Nature"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/ncomms4292","article-title":"HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells","volume":"5","author":"Tabet","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/ATVBAHA.112.300139","article-title":"Intercellular transport of MicroRNAs","volume":"33","author":"Boon","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Gallo, A., Tandon, M., Alevizos, I., and Illei, G.G. (2012). The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030679"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1601-0825.2009.01604.x","article-title":"Exosomes from human saliva as a source of microRNA biomarkers","volume":"16","author":"Michael","year":"2010","journal-title":"Oral Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.7150\/ijbs.6100","article-title":"Isolation and quantification of MicroRNAs from urinary exosomes\/microvesicles for biomarker discovery","volume":"9","author":"Lv","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"118","DOI":"10.7150\/ijbs.8.118","article-title":"Immune-related microRNAs are abundant in breast milk exosomes","volume":"8","author":"Zhou","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1200\/JCO.2009.24.9342","article-title":"Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer","volume":"28","author":"Hu","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.4049\/jimmunol.163.4.2168","article-title":"CD40 ligand-activated human monocytes amplify glomerular inflammatory responses through soluble and cell-to-cell contact-dependent mechanisms","volume":"163","author":"Kuroiwa","year":"1999","journal-title":"J. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.addr.2015.05.014","article-title":"MicroRNA delivery for regenerative medicine","volume":"88","author":"Peng","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_106","unstructured":"Sen, C.K. (2014). MicroRNA in Regenerative Medicine, Elsevier."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.0914843107","article-title":"Functional delivery of viral miRNAs via exosomes","volume":"107","author":"Pegtel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"20370","DOI":"10.1073\/pnas.1014194107","article-title":"Human tumor virus utilizes exosomes for intercellular communication","volume":"107","author":"Meckes","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_109","first-page":"329","article-title":"Nanovesicular vaccines: Exosomes","volume":"53","author":"Li","year":"2005","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"A28","DOI":"10.1016\/S0264-410X(02)00384-5","article-title":"Tumor-derived exosomes: A new source of tumor rejection antigens","volume":"20","author":"Schartz","year":"2002","journal-title":"Vaccine"},{"key":"ref_111","first-page":"2165","article-title":"Exosomes and anti-tumour immunotherapy","volume":"8","author":"Chaput","year":"2003","journal-title":"Bull. Cancer"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-3-9","article-title":"A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer","volume":"3","author":"Morse","year":"2005","journal-title":"J. Transl. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/mt.2008.1","article-title":"Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer","volume":"16","author":"Dai","year":"2008","journal-title":"Mol. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/CJI.0b013e3181fe535b","article-title":"Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: A critical role of interferon-\u03b3","volume":"34","author":"Viaud","year":"2011","journal-title":"J. Immunother."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-3-10","article-title":"Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of the first phase 1 clinical trial","volume":"3","author":"Escudier","year":"2005","journal-title":"J. Transl. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e1071008","DOI":"10.1080\/2162402X.2015.1071008","article-title":"Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC","volume":"5","author":"Besse","year":"2016","journal-title":"Oncoimmunology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/cmi.2017.161","article-title":"Functions of NKG2D in CD8+ T cells: An opportunity for immunotherapy","volume":"15","author":"Prajapati","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Viaud, S., Terme, M., Flament, C., Taieb, J., Andr\u00e9, F., Novault, S., Escudier, B., Robert, C., Caillat-Zucman, S., and Tursz, T. (2009). Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: A role for NKG2D ligands and IL-15R\u03b1. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004942"},{"key":"ref_119","unstructured":"(2019, December 29). Search of: MSC exosome - List Results - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/results?cond=&term=MSC+exosome&cntry=&state=&city=&dist=&Search=Search."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41409-019-0616-z","article-title":"Mesenchymal stem cell-derived exosomes for clinical use","volume":"54","author":"Mendt","year":"2019","journal-title":"Bone Marrow Transplant."},{"key":"ref_121","unstructured":"(2020, January 02). A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients with Duchenne Muscular Dystrophy - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03406780?term=exosomes&cond=treatment&draw=4&rank=29."},{"key":"ref_122","unstructured":"(2020, January 02). Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01294072?term=exosomes%2CTherapy%2C+Treatment&draw=3&rank=19."},{"key":"ref_123","unstructured":"(2020, January 02). Plant Exosomes and Patients Diagnosed with Polycystic Ovary Syndrome (PCOS) 17 - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03493984?term=exosomes%2CTherapy%2C+Treatment&draw=7&rank=54."},{"key":"ref_124","unstructured":"(2020, January 02). Trial of a Vaccination With Tumor Antigen-loaded Dendritic Cell-derived Exosomes - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01159288?term=exosomes%2CTherapy%2C+Treatment&draw=4&rank=29."},{"key":"ref_125","unstructured":"(2019, December 29). iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation - Full Text View - ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03608631?term=exosomes%2C+MSC%2C+Stromal%2C+Therapy%2C+Treatment&draw=2&rank=1."},{"key":"ref_126","unstructured":"(2020, January 02). MSC-Exos Promote Healing of MHs - Full Text View - ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03437759?term=exosomes%2CTherapy%2C+Treatment&cond=macular&draw=2&rank=1."},{"key":"ref_127","unstructured":"(2020, January 02). Effect of Microvesicles and Exosomes Therapy on \u03b2-cell Mass in Type I Diabetes Mellitus (T1DM) - Full Text View - ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02138331?term=exosomes%2CTherapy%2C+Treatment&cond=Type+I+Diabetes&draw=2&rank=1."},{"key":"ref_128","unstructured":"(2020, January 02). Effect of UMSCs Derived Exosomes on Dry Eye in Patients with cGVHD - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04213248?term=exosomes%2CTherapy%2C+Treatment&draw=4&rank=21."},{"key":"ref_129","unstructured":"(2020, January 02). Focused Ultrasound and Exosomes to Treat Depression, Anxiety and Dementias - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04202770?term=exosomes&cond=treatment&draw=2&rank=1."},{"key":"ref_130","unstructured":"(2020, January 02). The Use of Exosomes in Craniofacial Neuralgia - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04202783?term=exosomes%2CTherapy%2C+Treatment&draw=2&rank=9."},{"key":"ref_131","unstructured":"(2020, January 02). Allogenic Mesenchymal Stem Cell Derived Exosome in Patients With Acute Ischemic Stroke - Full Text View - ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03384433?term=exosomes%2CTherapy%2C+Treatment&cond=Stroke&draw=2&rank=1."},{"key":"ref_132","unstructured":"(2020, January 02). Therapeutic Potential of Stem Cell Conditioned Medium on Chronic Ulcer Wounds - Full Text View - ClinicalTrials.gov, Available online: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04134676?term=exosomes&cond=treatment&draw=3&rank=13."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.gt.3302356","article-title":"siRNA therapeutics: Big potential from small RNAs","volume":"12","author":"Ryther","year":"2005","journal-title":"Gene Ther."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Koutsilieri, E., Rethwilm, A., and Scheller, C. (2007). The therapeutic potential of siRNA in gene therapy of neurodegenerative disorders. J. Neural Transm. Suppl., 43\u201349.","DOI":"10.1007\/978-3-211-73574-9_7"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1093\/nar\/gks463","article-title":"Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes","volume":"40","author":"Wahlgren","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1038\/ncomms8321","article-title":"Exosome-delivered microRNAs modulate the inflammatory response to endotoxin","volume":"6","author":"Alexander","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41467-017-01146-7","article-title":"Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice","volume":"8","author":"Voit","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/eurheartj\/ehw019","article-title":"Gene therapy for the treatment of heart failure: Promise postponed","volume":"37","author":"Hulot","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1016\/j.biomaterials.2014.05.032","article-title":"Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo","volume":"35","author":"Fitzpatrick","year":"2014","journal-title":"Biomaterials"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/mt.2011.303","article-title":"Microvesicle-associated AAV vector as a novel gene delivery system","volume":"20","author":"Maguire","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_141","first-page":"1525","article-title":"Exosome mimetics: A novel class of drug delivery systems","volume":"7","author":"Kooijmans","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.biotechadv.2012.08.008","article-title":"Exosomes for drug delivery\u2014A novel application for the mesenchymal stem cell","volume":"31","author":"Lai","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/mt.2011.164","article-title":"Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain","volume":"19","author":"Zhuang","year":"2011","journal-title":"Mol. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jconrel.2015.07.030","article-title":"Using exosomes, naturally-equipped nanocarriers, for drug delivery","volume":"219","author":"Batrakova","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2014.04.018","article-title":"Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia","volume":"107","author":"Kalani","year":"2014","journal-title":"Life Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/mt.2010.105","article-title":"A novel nanoparticle drug delivery system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes","volume":"18","author":"Sun","year":"2010","journal-title":"Mol. Ther."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood or Adipose Tissue","volume":"24","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.21704","article-title":"Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes","volume":"46","author":"Banas","year":"2007","journal-title":"Hepatology"},{"key":"ref_149","first-page":"845","article-title":"Mesenchymal stem cells in human second-trimester bone marrow, liver, lung and spleen exhibit a similar immunophenotype but a heterogeneous multilineage differentiation potential","volume":"88","author":"Noort","year":"2003","journal-title":"Haematologica"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ar.1128","article-title":"Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult and geriatric donors","volume":"264","author":"Young","year":"2001","journal-title":"Anat. Rec."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1089\/scd.2007.0036","article-title":"Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: Comparison to bone marrow mesenchymal stem cells","volume":"16","author":"Roubelakis","year":"2007","journal-title":"Stem Cells Dev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1634\/stemcells.22-5-649","article-title":"Human Placenta-Derived Cells Have Mesenchymal Stem\/Progenitor Cell Potential","volume":"22","author":"Fukuchi","year":"2004","journal-title":"Stem Cells"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cellbi.2006.03.009","article-title":"Isolation of mesenchymal stem cells from human placenta: Comparison with human bone marrow mesenchymal stem cells","volume":"30","author":"Miao","year":"2006","journal-title":"Cell Biol. Int."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.semcdb.2007.09.012","article-title":"Therapeutic applications of mesenchymal stromal cells","volume":"18","author":"Brooke","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_155","unstructured":"(2019, December 28). Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. - PubMed \u2013 NCBI, Available online: https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19767575."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1634\/stemcells.2006-0420","article-title":"Derivation of Clinically Compliant MSCs from CD105+, CD24\u2212 Differentiated Human ESCs","volume":"25","author":"Lian","year":"2007","journal-title":"Stem Cells"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.addr.2012.07.001","article-title":"Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery","volume":"65","author":"Yeo","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2015.10.020","article-title":"Bovine milk-derived exosomes for drug delivery","volume":"371","author":"Munagala","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1479-5876-12-204","article-title":"Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy","volume":"12","author":"Sarker","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Salomon, C., Torres, M.J., Kobayashi, M., Scholz-Romero, K., Sobrevia, L., Dobierzewska, A., Illanes, S.E., Mitchell, M.D., and Rice, G.E. (2014). A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098667"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2337\/db15-0966","article-title":"Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation","volume":"65","author":"Salomon","year":"2016","journal-title":"Diabetes"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/01.AOG.0000558864.31601.aa","article-title":"Exosome Profiles for Normal and Complicated Pregnancies\u2014A Longitudinal Study [3O]","volume":"133","author":"Nakahara","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Sobrevia, L. (2013). The Role of Placental Exosomes in Gestational Diabetes Mellitus. Gestational Diabetes-Causes, Diagnosis and Treatment, InTech.","DOI":"10.5772\/46133"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e1800164","DOI":"10.1002\/pmic.201800164","article-title":"Quantitative Proteomics by SWATH-MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus","volume":"19","author":"Jayabalan","year":"2019","journal-title":"Proteomics"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Jayabalan, N., Ormazabal, V., Lai, A., Lappas, M., and Salomon, C. (2018). Proteomic Profile of Adipose Tissue-Derived Exosomes and Their Potential Role on Placental Glucose Metabolism in Gestational Diabetes Mellitus. Diabetes.","DOI":"10.2337\/db18-165-LB"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fendo.2017.00239","article-title":"Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes","volume":"8","author":"Jayabalan","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.placenta.2017.11.007","article-title":"Is there a role for exosomes in foetoplacental endothelial dysfunction in gestational diabetes mellitus?","volume":"61","author":"Sobrevia","year":"2018","journal-title":"Placenta"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Arrial, R.T., Togawa, R.C., and Marcelo, M.M. (2009). Screening non-coding RNAs in transcriptomes from neglected species using PORTRAIT: Case study of the pathogenic fungus Paracoccidioides brasiliensis. BMC Bioinform., 10.","DOI":"10.1186\/1471-2105-10-239"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (2010). Current Protocols in Molecular Biology: Preface. Curr. Protoc. Mol. Biol.","DOI":"10.1002\/0471142727.mbprefs90"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.stem.2012.01.017","article-title":"Alternative polyadenylation mediates microRNA regulation of muscle stem cell function","volume":"10","author":"Boutet","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/MCB.01394-14","article-title":"Novel Long Noncoding RNAs (lncRNAs) in Myogenesis: A miR-31 Overlapping lncRNA Transcript Controls Myoblast Differentiation","volume":"35","author":"Ballarino","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ceb.2013.08.005","article-title":"Long non-coding RNAs: Modulators of nuclear structure and function","volume":"26","author":"Bergmann","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1146\/annurev.cellbio.23.090506.123438","article-title":"The Role of Pax Genes in the Development of Tissues and Organs: Pax3 and Pax7 Regulate Muscle Progenitor Cell Functions. Annu","volume":"23","author":"Buckingham","year":"2007","journal-title":"Rev. Cell Dev. Biol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.devcel.2013.12.020","article-title":"Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis","volume":"28","author":"Buckingham","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1113\/jphysiol.2010.194175","article-title":"MicroRNAs in skeletal muscle: Their role and regulation in development, disease and function","volume":"588","author":"Russell","year":"2010","journal-title":"J. Physiol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2217\/epi-2018-0022","article-title":"Downregulation of miRNA-29, -23 and -21 in urine of Duchenne muscular dystrophy patients","volume":"10","author":"Catapano","year":"2018","journal-title":"Epigenomics"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/embor.2010.208","article-title":"MiR-31 modulates dystrophin expression: New implications for Duchenne muscular dystrophy therapy","volume":"12","author":"Cacchiarelli","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/09513590.2014.969700","article-title":"Upregulation of microRNA processing enzymes drosha and dicer in gestational diabetes mellitus","volume":"31","author":"Rahimi","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2017.07.024","article-title":"Circulating early- and mid-pregnancy microRNAs and risk of gestational diabetes","volume":"132","author":"Wander","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/jog.13317","article-title":"Plasma microRNA-16-5p, -17-5p and -20a-5p: Novel diagnostic biomarkers for gestational diabetes mellitus","volume":"43","author":"Cao","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000430349","article-title":"A MicroRNA signature in gestational diabetes mellitus associated with risk of macrosomia","volume":"37","author":"Li","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3892\/mmr.2014.2058","article-title":"MicroRNA-518d regulates PPAR\u03b1 protein expression in the placentas of females with gestational diabetes mellitus","volume":"9","author":"Zhao","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1210\/en.2013-2046","article-title":"Differential expression of micrornas in omental adipose tissue from gestational diabetes mellitus subjects reveals mir-222 as a regulator of er\u03b1 expression in estrogen-induced insulin resistance","volume":"155","author":"Shi","year":"2014","journal-title":"Endocrinology"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Hunter, M.P., Ismail, N., Zhang, X., Aguda, B.D., Lee, E.J., Yu, L., Xiao, T., Schafer, J., Lee, M.L.T., and Schmittgen, T.D. (2008). Detection of microRNA expression in human peripheral blood microvesicles. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003694"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/molehr\/gas013","article-title":"The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes","volume":"18","author":"Donker","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow-derived myogenic progenitors","volume":"5356","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.biocel.2003.11.001","article-title":"Mesenchymal stem cells: Clinical applications and biological characterization","volume":"4","author":"Barry","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1634\/stemcells.22-4-617","article-title":"Skeletal Myogenic Differentiation of Mesenchymal Stem Cells Isolated from Human Umbilical","volume":"22","author":"Gang","year":"2004","journal-title":"Cord Blood Stem Cells"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e00191","DOI":"10.1042\/BSR20150025","article-title":"Human Mesenchymal Stem Cells\u2014Current trends and future prospective","volume":"35","author":"Ullah","year":"2015","journal-title":"Biosci. Rep."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Xin, H., Li, Y., and Chopp, M. (2014). Exosomes\/miRNAs as mediating cell-based therapy of stroke. Front. Cell. Neurosci., 8.","DOI":"10.3389\/fncel.2014.00377"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-019-1802-2","article-title":"An acute immune response underlies the benefit of cardiac stem-cell therapy","volume":"577","author":"Vagnozzi","year":"2019","journal-title":"Nature"},{"key":"ref_193","first-page":"12","article-title":"Isolation and expansion of mesenchymal stem\/stromal cells derived from human placenta tissue","volume":"2016","author":"Pelekanos","year":"2016","journal-title":"J. Vis. Exp."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.116.310557","article-title":"Angiogenic Mechanisms of Human CD34 + Stem Cell Exosomes in the Repair of Ischemic Hindlimb","volume":"120","author":"Mathiyalagan","year":"2017","journal-title":"Circ. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.3389\/fimmu.2018.03053","article-title":"Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes","volume":"9","author":"Khare","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fcell.2016.00083","article-title":"Stem Cell-Derived Extracellular Vesicles and Immune-Modulation","volume":"4","author":"Burrello","year":"2016","journal-title":"Front. cell Dev. Biol."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Willis, G.R., Fernandez-Gonzalez, A., Reis, M., Mitsialis, S.A., and Kourembanas, S. (2018). Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension?. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092534"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1164\/rccm.201705-0925OC","article-title":"Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation","volume":"197","author":"Willis","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ymthe.2016.12.022","article-title":"Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis","volume":"3","author":"Beltrami","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.jacc.2015.02.026","article-title":"Plasma exosomes protect the myocardium from ischemia-reperfusion injury","volume":"65","author":"Vicencio","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jcmm.13302","article-title":"Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro","volume":"22","author":"Davidson","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.2337\/dbi16-0041","article-title":"Exosomes in diabetic cardiomyopathy: The next-generation therapeutic targets?","volume":"65","author":"Sahoo","year":"2016","journal-title":"Diabetes"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2174\/1574888X14666190228103230","article-title":"Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine","volume":"14","author":"Zhao","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.scr.2013.01.002","article-title":"Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K\/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia\/reperfusion injury","volume":"10","author":"Arslan","year":"2013","journal-title":"Stem Cell Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.4049\/jimmunol.1700562","article-title":"Mesenchymal Stem Cells Recruit CCR2+ Monocytes to Suppress Allergic Airway Inflammation","volume":"200","author":"Takeda","year":"2018","journal-title":"J. Immunol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1111\/j.1582-4934.2012.01597.x","article-title":"Intrapleural delivery of MSCs attenuates acute lung injury by paracrine\/endocrine mechanism","volume":"16","author":"Qin","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s13287-015-0232-9","article-title":"Acellular approaches for regenerative medicine: On the verge of clinical trials with extracellular membrane vesicles? Extracellular vesicles and regenerative medicine","volume":"6","author":"Gessler","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1089\/scd.2011.0621","article-title":"Stem Cell Therapy for Stress Urinary Incontinence: A Critical Review","volume":"21","author":"Lin","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_209","first-page":"311","article-title":"Development of stem cell therapy for stress urinary incontinence","volume":"24","author":"Ho","year":"2012","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Marquez-Curtis, L.A., and Janowska-Wieczorek, A. (2013). Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF-1\/CXCR4 axis. Biomed Res. Int., 561098.","DOI":"10.1155\/2013\/561098"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/mt.2015.44","article-title":"Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications","volume":"23","author":"Rani","year":"2015","journal-title":"Mol. Ther."},{"key":"ref_212","first-page":"608","article-title":"Extracellular vesicles: Potential roles in regenerative medicine","volume":"5","author":"Schiffelers","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1159\/000492298","article-title":"Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry Original Paper Therapeutic Potential of Human Adipose-Derived Stem Cell Exosomes in Stress Urinary Incontinence-An in Vitro and in Vivo Study Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry","volume":"48","author":"Ni","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13287-018-0899-9","article-title":"Exosomes secreted by adipose-derived mesenchymal stem cells regulate type i collagen metabolism in fibroblasts from women with stress urinary incontinence","volume":"9","author":"Liu","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_215","first-page":"510","article-title":"Regulatory effect of exosomes secreted by vaginal wall fibroblasts on angiogenesis in patients with stress urinary incontinence","volume":"99","author":"Liu","year":"2019","journal-title":"Natl. Med. J. China"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13287-019-1182-4","article-title":"Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats","volume":"10","author":"Wu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"854","DOI":"10.4103\/ijem.IJEM_66_17","article-title":"Maternal and neonatal outcome in mothers with gestational diabetes mellitus","volume":"21","author":"Das","year":"2017","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_218","first-page":"419","article-title":"Maternal complications in women with chronic hypertension: A population-based cohort study","volume":"84","author":"Lindeberg","year":"2005","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1055\/s-0036-1571318","article-title":"Rate of Gestational Diabetes Mellitus and Pregnancy Outcomes in Patients with Chronic Hypertension","volume":"33","author":"Leon","year":"2016","journal-title":"Am. J. Perinat."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/ten.teb.2014.0300","article-title":"Emerging Roles for Extracellular Vesicles in Tissue Engineering and Regenerative Medicine","volume":"21","author":"Lamichhane","year":"2014","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"513","DOI":"10.5966\/sctm.2014-0267","article-title":"Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4\/\u03b2-Catenin Pathway","volume":"4","author":"Zhang","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2014-05-576116","article-title":"Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1","volume":"124","author":"Umezu","year":"2014","journal-title":"Blood"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1089\/scd.2014.0316","article-title":"Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts and Enhance Angiogenesis in Vitro","volume":"24","author":"Shabbir","year":"2015","journal-title":"Stem Cells Dev."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.111.253286","article-title":"Exosomes from human CD34+ stem cells mediate their proangiogenic paracrine activity","volume":"109","author":"Sahoo","year":"2011","journal-title":"Circ. Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1242\/jcs.170373","article-title":"Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a","volume":"129","author":"Liang","year":"2016","journal-title":"J. Cell Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3389\/fimmu.2014.00556","article-title":"Immunomodulatory potential of human adipose mesenchymal stem cells derived exosomes on in vitro stimulated T cells","volume":"5","author":"Blazquez","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.placenta.2012.10.005","article-title":"Immunomodulatory molecules are released from the first trimester and term placenta via exosomes","volume":"33","author":"Kshirsagar","year":"2012","journal-title":"Placenta"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s12026-016-8798-6","article-title":"Immunomodulatory effects of mesenchymal stromal cells-derived exosome","volume":"64","author":"Chen","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.semcancer.2014.04.008","article-title":"Novel insights into exosome-induced, tumor-associated inflammation and immunomodulation","volume":"28","author":"Altevogt","year":"2014","journal-title":"Semin. Cancer Biol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1089\/scd.2013.0479","article-title":"Mesenchymal stem cells secrete immunologically active exosomes","volume":"23","author":"Zhang","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1681\/ASN.2012101031","article-title":"TGF-\u03b21-Containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis","volume":"24","author":"Borges","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.joca.2016.06.022","article-title":"Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration","volume":"24","author":"Zhang","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.febslet.2015.03.031","article-title":"Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration","volume":"589","author":"Nakamura","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biomaterials.2016.09.029","article-title":"Exosomes as biomimetic tools for stem cell differentiation: Applications in dental pulp tissue regeneration","volume":"111","author":"Huang","year":"2016","journal-title":"Biomaterials"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/675\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:05:50Z","timestamp":1760173550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":235,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["cells9030675"],"URL":"https:\/\/doi.org\/10.3390\/cells9030675","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,10]]}}}