{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:09:23Z","timestamp":1768342163665,"version":"3.49.0"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antibodies has been useful in the transplantation field; however, its contribution to autoimmune diseases as RA has not been fully studied. We aimed to determine the presence of anti-HLA antibodies in RA patients with and without ILD and its possible association with clinical and biochemical markers. One-hundred and forty-seven RA patients, of which 65 had ILD (RA-ILD group), were included. Sera samples for Anti-HLA Class II LABScreen panel-reactive antibodies (PRA) were analyzed. In both groups, women predominated, and lung function was worse in patients with ILD. The anti-CCP+ (UI\/mL) was higher in the RA group in comparison to RA-ILD (p &lt; 0.001). Expositional risk factors (tobacco smoking and biomass-burning smoke) were higher in RA-ILD patients. PRA+ was identified in ~25% RA-ILD patients, while ~29% in the RA group. The CRP levels have a positive correlation with the percentage of reactivity (%PRA, p = 0.02, r2 = 0.60) in the RA-ILD group. In conclusion, anti-HLA antibodies correlate with C-reactive protein levels in RA patients with ILD.<\/jats:p>","DOI":"10.3390\/cells9030691","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T12:22:51Z","timestamp":1584015771000},"page":"691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti-HLA Class II Antibodies Correlate with C-Reactive Protein Levels in Patients with Rheumatoid Arthritis Associated with Interstitial Lung Disease"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-4396","authenticated-orcid":false,"given":"Alma D.","family":"Del Angel-Pablo","sequence":"first","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Mexico City, Mexico"},{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, 11340 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-506X","authenticated-orcid":false,"given":"Ivette","family":"Buend\u00eda-Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Mej\u00eda","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-1012","authenticated-orcid":false,"given":"Gloria","family":"P\u00e9rez-Rubio","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-2646","authenticated-orcid":false,"given":"Karol J.","family":"Nava-Quiroz","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rojas-Serrano","sequence":"additional","affiliation":[{"name":"Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6877-8124","authenticated-orcid":false,"given":"Ramc\u00e9s","family":"Falf\u00e1n-Valencia","sequence":"additional","affiliation":[{"name":"HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cos\u00edo Villegas, 14080 Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0140-6736(09)60008-8","article-title":"Rheumatoid arthritis","volume":"373","author":"Klareskog","year":"2009","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2669","article-title":"Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases","volume":"11","author":"Gabriel","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.chest.2017.05.015","article-title":"Lung Manifestations in the Rheumatic Diseases","volume":"152","author":"Doyle","year":"2017","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/MD.0b013e318289ce01","article-title":"Extraarticular Manifestations of Rheumatoid Arthritis in a Multiethnic Cohort of Predominantly Hispanic and Asian Patients","volume":"92","author":"Richman","year":"2013","journal-title":"Medicine (Baltimore)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1136\/annrheumdis-2017-211138","article-title":"A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: Comorbidity and mortality","volume":"76","author":"Hyldgaard","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00296-017-3781-7","article-title":"Impact of interstitial lung disease on mortality of patients with rheumatoid arthritis","volume":"37","author":"Kim","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41584-019-0219-5","article-title":"HLA associations in inflammatory arthritis: Emerging mechanisms and clinical implications","volume":"6","author":"Busch","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrg1489","article-title":"Gene map of the extended human MHC","volume":"5","author":"Horton","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jbspin.2005.09.001","article-title":"Genetic basis of rheumatoid arthritis","volume":"72","author":"Dieude","year":"2005","journal-title":"Jt. Bone Spine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/138920207783591690","article-title":"The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action","volume":"8","author":"Gough","year":"2007","journal-title":"Curr. Genom."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/eji.200526000","article-title":"Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis","volume":"35","author":"Burkhardt","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.transproceed.2017.02.004","article-title":"Association Between HLA Antibodies and Different Sensitization Events in Renal Transplant Candidates","volume":"49","author":"Akgul","year":"2017","journal-title":"Transplant. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/j.1537-2995.2009.02206.x","article-title":"The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: Implications for a transfusion-related acute lung injury risk reduction strategy","volume":"49","author":"Triulzi","year":"2009","journal-title":"Transfus."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0198-8859(03)00058-2","article-title":"Differential immunogenicity of paternal HLA Class I antigens in pregnant women","volume":"64","author":"Roelen","year":"2003","journal-title":"Hum. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3389\/fimmu.2016.00571","article-title":"A Previous Miscarriage and a Previous Successful Pregnancy Have a Different Impact on HLA Antibody Formation during a Subsequent Successful Pregnancy","volume":"7","author":"Geneugelijk","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1387\/ijdb.082767hg","article-title":"Naturally acquired microchimerism","volume":"54","author":"Gammill","year":"2010","journal-title":"Int. J. Dev. Boil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/clim.2002.5222","article-title":"Increased Microchimeric CD4+ T Lymphocytes in Peripheral Blood from Women with Systemic Sclerosis","volume":"103","author":"Artlett","year":"2002","journal-title":"Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.autrev.2004.06.004","article-title":"Possible roles and determinants of microchimerism in autoimmune and other disorders","volume":"3","author":"Sarkar","year":"2004","journal-title":"Autoimmun. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/art.30155","article-title":"The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases","volume":"63","author":"Crowson","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/art.24224","article-title":"Transfer of the shared epitope through microchimerism in women with rheumatoid arthritis","volume":"60","author":"Rak","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-12163-z","article-title":"HIF1\u03b1 inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis","volume":"10","author":"Liang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/1529-0131(200007)43:7<1473::AID-ANR9>3.0.CO;2-N","article-title":"Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis","volume":"43","author":"Plant","year":"2000","journal-title":"Arthritis Rheum."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/art.39228","article-title":"Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis","volume":"67","author":"Kim","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/acr.21649","article-title":"Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice","volume":"64","author":"Anderson","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_26","first-page":"304","article-title":"American Thoracic Society\/ European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society","volume":"165","author":"International","year":"2002","journal-title":"Am. Thorac Soc."},{"key":"ref_27","first-page":"S100","article-title":"The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): A review of their usefulness and validity in rheumatoid arthritis","volume":"23","author":"Aletaha","year":"2005","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/cyto.b.20353","article-title":"Luminex technology for anti-HLA antibody screening: Evaluation of performance and of impact on laboratory routine","volume":"72","author":"Colombo","year":"2007","journal-title":"Cytom. Part. B Clin. Cytom."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.1537-2995.2009.02523.x","article-title":"Impact of using different laboratory assays to detect human leukocyte antigen antibodies in female blood donors","volume":"50","author":"Lopes","year":"2010","journal-title":"Transfusion"},{"key":"ref_30","unstructured":"One Lambda, I. (2020, March 11). HLA FusionTM Software 4.x.x User Manual. Available online: https:\/\/manualzz.com\/doc\/6750498\/hla-fusiontm-ivd-and-research-software-v4.xx."},{"key":"ref_31","unstructured":"(2019, December 27). RStudio. Available online: https:\/\/rstudio.com\/."},{"key":"ref_32","unstructured":"(2019, December 27). Centers for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/epiinfo\/index.html."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/rheumatology\/keq035","article-title":"Interstitial lung disease has a poor prognosis in rheumatoid arthritis: Results from an inception cohort","volume":"49","author":"Koduri","year":"2010","journal-title":"Rheumatology"},{"key":"ref_34","first-page":"344","article-title":"Patterns of interstitial lung disease and mortality in rheumatoid arthritis","volume":"56","author":"Krause","year":"2016","journal-title":"Rheumatology"},{"key":"ref_35","first-page":"1","article-title":"Asymptomatic Preclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease","volume":"2013","author":"Chen","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/art.27272","article-title":"Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of RF and ACPA","volume":"62","author":"Bang","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.rmed.2012.07.006","article-title":"Different risk factors between interstitial lung disease and airway disease in rheumatoid arthritis","volume":"106","author":"Mori","year":"2012","journal-title":"Respir. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1136\/ard.2007.075192","article-title":"Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells","volume":"67","author":"Makrygiannakis","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.rmed.2013.05.002","article-title":"Fibrosing interstitial pneumonia predicts survival in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD)","volume":"107","author":"Solomon","year":"2013","journal-title":"Respir. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s10067-017-3561-5","article-title":"Retrospective study of the clinical characteristics and risk factors of rheumatoid arthritis-associated interstitial lung disease","volume":"36","author":"Zhang","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","article-title":"The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide","volume":"43","author":"Schellekens","year":"2000","journal-title":"Arthritis Rheum."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3899\/jrheum.101261","article-title":"High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis","volume":"38","author":"Aubart","year":"2011","journal-title":"J. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Yin, Y., Liang, D., Zhao, L., Li, Y., Liu, W., Ren, Y., Li, Y., Zeng, X., Zhang, F., and Tang, F. (2014). Anti-Cyclic Citrullinated Peptide Antibody Is Associated with Interstitial Lung Disease in Patients with Rheumatoid Arthritis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0092449"},{"key":"ref_44","first-page":"1","article-title":"Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis","volume":"2015","author":"Mejia","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1136\/ard.2003.014647","article-title":"Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNF\u03b1 therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement","volume":"63","author":"Alessandri","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/ard.2005.038851","article-title":"The effect of etanercept on anti-cyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis","volume":"65","author":"Chen","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1002\/art.30596","article-title":"Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment","volume":"63","author":"Lal","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3899\/jrheum.111488","article-title":"Longterm Effects of Rituximab on B Cell Counts and Autoantibody Production in Rheumatoid Arthritis: Use of High-sensitivity Flow Cytometry for More Sensitive Assessment of B Cell Depletion","volume":"40","author":"Szamosi","year":"2013","journal-title":"J. Rheumatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/rheumatology\/41.12.1367","article-title":"The rheumatoid arthritis patient in the clinic: Comparing more than 1300 consecutive DMARD courses","volume":"41","author":"Aletaha","year":"2002","journal-title":"Rheumatology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF02031616","article-title":"C-Reactive protein levels in patients with rheumatoid arthritis: The impact of therapy","volume":"4","author":"Tishler","year":"1985","journal-title":"Clin. Rheumatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/art.1780340805","article-title":"Methotrexate versus azathioprine in the treatment of rheumatoid arthritis. A forty-eight\u2013week randomized, double-blind trial","volume":"34","author":"Jeurissen","year":"1991","journal-title":"Arthritis Rheum."},{"key":"ref_52","first-page":"238","article-title":"Platelet Alloimmunization after Transfusion. A Prospective Study in 117 Heart Surgery Patients","volume":"72","author":"Taaning","year":"1997","journal-title":"Vox Sang."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/01.CIR.98.8.786","article-title":"Preformed IgG antibodies against major histocompatibility complex class II antigens are major risk factors for high-grade cellular rejection in recipients of heart transplantation","volume":"98","author":"Itescu","year":"1998","journal-title":"Circulation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/TP.0b013e31827afb0f","article-title":"Lung Transplantation in Patients with Pretransplantation Donor-Specific Antibodies Detected by Luminex Assay","volume":"95","author":"Suberbielle","year":"2013","journal-title":"Transplantation"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.transproceed.2016.02.029","article-title":"Significance of HLA Antibody Detected by PRA-Bead Method in Kidney Transplant Outcomes","volume":"48","author":"Wiwattanathum","year":"2016","journal-title":"Transplant. Proc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1182\/asheducation-2018.1.585","article-title":"TACO and TRALI: Biology, risk factors, and prevention strategies","volume":"2018","author":"Roubinian","year":"2018","journal-title":"Am. Soc. Hematol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4137\/BMI.S28209","article-title":"Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD","volume":"10","author":"Furukawa","year":"2015","journal-title":"Biomark. Insights"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e000278","DOI":"10.1136\/lupus-2018-000278","article-title":"Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis","volume":"5","author":"Jackman","year":"2018","journal-title":"Lupus Sci. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Bay-Jensen, A.-C., Platt, A., Jenkins, M.A., Weinblatt, M.E., Byrjalsen, I., Musa, K., Genovese, M.C., and Karsdal, M.A. (2019). Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis. BMC Rheumatol., 3.","DOI":"10.1186\/s41927-019-0052-0"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e14296","DOI":"10.1097\/MD.0000000000014296","article-title":"High preoperative C-reactive protein level is a risk factor for acute exacerbation of interstitial lung disease after non-pulmonary surgery","volume":"98","author":"Takao","year":"2019","journal-title":"Medicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.autrev.2018.10.005","article-title":"Innate immune-responses and their role in driving autoimmunity","volume":"18","author":"Elias","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1385\/IR:30:3:261","article-title":"C-reactive Protein: An Activator of Innate Immunity and a Modulator of Adaptive Immunity","volume":"30","author":"Mold","year":"2004","journal-title":"Immunol Res."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/691\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:06:05Z","timestamp":1760173565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/3\/691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,11]]},"references-count":64,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["cells9030691"],"URL":"https:\/\/doi.org\/10.3390\/cells9030691","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,11]]}}}