{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:20:11Z","timestamp":1791584411671,"version":"4.3.4"},"reference-count":201,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A2C1086858"],"award-info":[{"award-number":["NRF-2019R1A2C1086858"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Ca2+ itself or Ca2+-dependent signaling pathways play fundamental roles in various cellular processes from cell growth to death. The most representative example can be found in skeletal muscle cells where a well-timed and adequate supply of Ca2+ is required for coordinated Ca2+-dependent skeletal muscle functions, such as the interactions of contractile proteins during contraction. Intracellular Ca2+ movements between the cytosol and sarcoplasmic reticulum (SR) are strictly regulated to maintain the appropriate Ca2+ supply in skeletal muscle cells. Added to intracellular Ca2+ movements, the contribution of extracellular Ca2+ entry to skeletal muscle functions and its significance have been continuously studied since the early 1990s. Here, studies on the roles of channel proteins that mediate extracellular Ca2+ entry into skeletal muscle cells using skeletal myoblasts, myotubes, fibers, tissue, or skeletal muscle-originated cell lines are reviewed with special attention to the proposed functions of transient receptor potential canonical proteins (TRPCs) as store-operated Ca2+ entry (SOCE) channels under normal conditions and the potential abnormal properties of TRPCs in muscle diseases such as Duchenne muscular dystrophy (DMD).<\/jats:p>","DOI":"10.3390\/cells9040850","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T11:57:14Z","timestamp":1585828634000},"page":"850","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["TRPCs: Influential Mediators in Skeletal Muscle"],"prefix":"10.3390","volume":"9","author":[{"given":"Jun Hee","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yeon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ri","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Allen","sequence":"additional","affiliation":[{"name":"Leeds Institute of Biomedical &amp; Clinical Sciences, St. James\u2019s University Hospital, University of Leeds, Leeds LS97TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hui","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"},{"name":"Department of Biomedicine &amp; Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"The sarcoplasmic reticulum Ca2+ channel\/ryanodine receptor: Modulation by endogenous effectors, drugs and disease states","volume":"49","author":"Zucchi","year":"1997","journal-title":"Pharmacol. 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