{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:53:42Z","timestamp":1771030422232,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["No. 2019R1A2C1005440"],"award-info":[{"award-number":["No. 2019R1A2C1005440"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Pyridoxine, one of the vitamin B6 vitamers, plays a crucial role in amino acid metabolism and synthesis of monoamines as a cofactor. In the present study, we observed the effects of pyridoxine deficiency on novel object recognition memory. In addition, we examined the levels of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), 3,4-dihydroxyphenethylamine (DA), 3,4-dihydroxyphenylacetic acid, and homovanillic acid and the number of proliferating cells and neuroblasts in the hippocampus. We also examined the effects of pyridoxine deficiency on protein profiles applying a proteomic study. Five-week-old mice fed pyridoxine-deficient diets for 8 weeks and showed a significant decrease in the serum and brain (cerebral cortex, hippocampus, and thalamus) levels of pyridoxal 5\u2032-phosphate, a catalytically active form of vitamin-B6, and decline in 5-HT and DA levels in the hippocampus compared to controls fed a normal chow. In addition, pyridoxine deficiency significantly decreased Ki67-positive proliferating cells and differentiated neuroblasts in the dentate gyrus compared to controls. A proteomic study demonstrated that a total of 41 spots were increased or decreased more than two-fold. Among the detected proteins, V-type proton ATPase subunit B2 (ATP6V1B2) and heat shock cognate protein 70 (HSC70) showed coverage and matching peptide scores. Validation by Western blot analysis showed that ATP6V1B2 and HSC70 levels were significantly decreased and increased, respectively, in pyridoxine-deficient mice compared to controls. These results suggest that pyridoxine is an important element of novel object recognition memory, monoamine levels, and hippocampal neurogenesis. Pyridoxine deficiency causes cognitive impairments and reduction in 5-HT and DA levels, which may be associated with a reduction of ATP6V1B2 and elevation of HSC70 levels in the hippocampus.<\/jats:p>","DOI":"10.3390\/cells9051067","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T01:29:15Z","timestamp":1588123755000},"page":"1067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70"],"prefix":"10.3390","volume":"9","author":[{"given":"Hyo Young","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woosuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Ri","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Min","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05030, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo Sung","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-2291","authenticated-orcid":false,"given":"Dae Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan 31151, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-4638","authenticated-orcid":false,"given":"In Koo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1007\/s12035-016-0072-3","article-title":"GABAergic regulation of adult hippocampal neurogenesis","volume":"54","author":"Sibbe","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1523\/JNEUROSCI.4280-07.2008","article-title":"Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal output","volume":"28","author":"Hodge","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"717958","DOI":"10.1155\/2015\/717958","article-title":"Involvement of adult hippocampal neurogenesis in learning and forgetting","volume":"2015","author":"Yau","year":"2015","journal-title":"Neural Plast."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I","article-title":"Interneurons of the hippocampus","volume":"6","author":"Freund","year":"1996","journal-title":"Hippocampus"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1101\/lm.1172609","article-title":"Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats","volume":"16","author":"Jessberger","year":"2009","journal-title":"Learn. Mem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1570-9639(03)00065-7","article-title":"Pyridoxine 5\u2032-phosphate synthase: De novo synthesis of vitamin B6 and beyond","volume":"1647","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00063110-200504000-00007","article-title":"Pyridoxine in clinical toxicology: A review","volume":"12","author":"Lheureux","year":"2005","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/molecules14010329","article-title":"Vitamin B6: A long known compound of surprising complexity","volume":"14","author":"Mooney","year":"2009","journal-title":"Molecules"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00006842-199805000-00016","article-title":"Plasma pyridoxine deficiency is related to increased psychological distress in recently bereaved homosexual men","volume":"60","author":"Baldewicz","year":"1998","journal-title":"Psychosom. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.bbagen.2017.09.006","article-title":"Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway","volume":"1861","author":"Jung","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1054\/mehy.1999.0955","article-title":"High-dose pyridoxine as an \u2018anti-stress\u2019 strategy","volume":"54","author":"McCarty","year":"2000","journal-title":"Med. Hypotheses"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s11064-010-0385-y","article-title":"Pyridoxine enhances cell proliferation and neuroblast differentiation by upregulating the GABAergic system in the mouse dentate gyrus","volume":"36","author":"Yoo","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Preedy, V., and Patel, V. (2017). Vitamin B6: Effects of deficiency, and metabolic and therapeutic functions. Handbook of Famine, Starvation, and Nutrient Deprivation, Springer.","DOI":"10.1007\/978-3-319-40007-5"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1111\/j.1471-4159.1971.tb00196.x","article-title":"Pyridoxine deficiency and development of the central nervous system in the rat","volume":"18","author":"Stephens","year":"1971","journal-title":"J. Neurochem."},{"key":"ref_15","first-page":"262","article-title":"Brain lipids in pyridoxine-deficient young rats","volume":"5","author":"Stephens","year":"1975","journal-title":"Neurobiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1471-4159.1971.tb00565.x","article-title":"The effects of pyridoxine deficiency and of caloric restriction on lipids in the developing rat brain","volume":"18","author":"Williamson","year":"1971","journal-title":"J. Neurochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8679506","DOI":"10.1155\/2016\/8679506","article-title":"Neuroprotection of grape seed extract and pyridoxine against triton-induced neurotoxicity","volume":"2016","author":"Abdou","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1139\/cjpp-2015-0098","article-title":"Antihypertensive and neuroprotective actions of pyridoxine and its derivatives","volume":"93","author":"Dakshinamurti","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.expneurol.2007.04.005","article-title":"Time course of changes in pyridoxal 5\u2032-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage","volume":"206","author":"Hwang","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1089\/neu.2010.1327","article-title":"Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat","volume":"27","author":"Kuypers","year":"2010","journal-title":"J. Neurotrauma"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/s41467-020-14788-x","article-title":"Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection","volume":"11","author":"Wei","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbadis.2018.08.018","article-title":"Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice","volume":"1865","author":"Jeanclos","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/j.1471-4159.1972.tb01477.x","article-title":"Some effects of dietary vitamin B6 deficiency on \u03b3-aminobutyric acid metabolism in developing rat brain","volume":"19","author":"Bayoumi","year":"1972","journal-title":"J. Neurochem."},{"key":"ref_24","first-page":"304","article-title":"Effect of pyridoxine deficiency on the structural and functional development of hippocampus","volume":"48","author":"Krishna","year":"2004","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_25","unstructured":"Brown, M.J., and Beier, K. (2019). Vitamin B6 deficiency (pyridoxine). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3177\/jnsv.58.446","article-title":"Comparative study on the responses of concentrations of B6-vitamers in several tissues of mice to the dietary level of pyridoxine","volume":"58","author":"Masisi","year":"2012","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0031-9384(95)00105-R","article-title":"Effect of dexfenfluramine on metabolic and neurochemical measures in restraint-stressed ob\/ob mice","volume":"58","author":"Rowland","year":"1995","journal-title":"Physiol. Behav."},{"key":"ref_28","unstructured":"Franklin, K.B.J., and Paxinos, G. (1997). The Mouse Brain in Stereotaxic Coordinates, Academic Press."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e3075","DOI":"10.1038\/cddis.2017.473","article-title":"Tat-protein disulfide-isomerase A3: A possible candidate for preventing ischemic damage in the spinal cord","volume":"8","author":"Yoo","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.semcdb.2011.05.003","article-title":"Pyridoxine supply in human development","volume":"22","author":"Bowling","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S0954579415000061","article-title":"Early life nutrition and neural plasticity","volume":"27","author":"Georgieff","year":"2015","journal-title":"Dev. Psychopathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0361-9230(91)90249-J","article-title":"Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats","volume":"26","author":"Guilarte","year":"1991","journal-title":"Brain Res. Bull."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00234219","article-title":"Nonparallel changes in brain monoamines of pyridoxine-deficient growing rats","volume":"26","author":"Dakshinamurti","year":"1976","journal-title":"Exp. Brain Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1471-4159.1987.tb04111.x","article-title":"Effects of perinatal vitamin B6 deficiency on dopaminergic neurochemistry","volume":"48","author":"Guilarte","year":"1987","journal-title":"J. Neurochem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/BF00964920","article-title":"Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum","volume":"14","author":"Guilarte","year":"1989","journal-title":"Neurochem. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/mnfr.201500950","article-title":"Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic, or glutamatergic pathways in hippocampus of rat dams and their offspring","volume":"60","author":"Almeida","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/mnfr.201200636","article-title":"Methyl nutrients, DNA methylation, and cardiovascular disease","volume":"58","author":"Glier","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_38","unstructured":"Gilarte, T.R. (1995). The role of vitamin B6 in central nervous system development: Neurochemistry and behavior. Vitamin B6 Metabolism in Pregnancy, Lactation, and Infancy, CRC Press."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2197975","DOI":"10.1155\/2017\/2197975","article-title":"Effects of vitamin B6 deficiency on the composition and functional potential of T cell populations","volume":"2017","author":"Qian","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2014.08.002","article-title":"Assessing rodent hippocampal involvement in the novel object recognition task. A review","volume":"285","author":"Cohen","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/ajcn\/37.4.540","article-title":"Brain cell alterations suggesting premature aging induced by dietary deficiency of vitamin B6 and\/or copper","volume":"37","author":"Root","year":"1983","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.exger.2009.12.005","article-title":"Acceleration of brain amyloidosis in an Alzheimer\u2019s disease mouse model by a folate, vitamin B6 and B12-deficient diet","volume":"45","author":"Zhuo","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/10641963.2017.1356844","article-title":"Vitamin B6 prevents isocarbophos-induced vascular dementia in rats through N-methyl-D-aspartate receptor signaling","volume":"40","author":"Li","year":"2018","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/npp.2016.134","article-title":"Constitutive and acquired serotonin deficiency alters memory and hippocampal synaptic plasticity","volume":"42","author":"Fernandez","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuron.2018.04.030","article-title":"Hippocampal 5-HT input regulates memory formation and Schaffer collateral excitation","volume":"98","author":"Teixeira","year":"2018","journal-title":"Neuron"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1073\/pnas.1616515114","article-title":"Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory","volume":"113","author":"Kempadoo","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","first-page":"171","article-title":"Cognitive effects of dopamine depletion in the context of diminished acetylcholine signaling capacity in mice","volume":"6","author":"Zurkovsky","year":"2013","journal-title":"Dis. Model Mech."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1749-6632.1990.tb28054.x","article-title":"Neuronal development in vitamin B6 deficiency","volume":"585","author":"Kirksey","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1152\/physrev.00045.2003","article-title":"Renal vacuolar H+-ATPase","volume":"84","author":"Wagner","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3233\/JAD-160307","article-title":"Human ApoE \u03b52 promotes regulatory mechanisms of bioenergetic and synaptic function in female brain: A focus on V-type H+-ATPase","volume":"53","author":"Woody","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ebiom.2019.06.035","article-title":"A subunit of V-ATPases, ATP6V1B2, underlies the pathology of intellectual disability","volume":"45","author":"Zhao","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e945","DOI":"10.1038\/tp.2016.221","article-title":"Association of ATP6V1B2 rs1106634 with lifetime risk of depression and hippocampal neurocognitive deficits: Possible novel mechanisms in the etiopathology of depression","volume":"6","author":"Gonda","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3389\/fncel.2015.00498","article-title":"\u03b2-Secretase 1\u2019s targeting reduces hyperphosphorilated Tau, implying autophagy actors in 3xTg-AD mice","volume":"9","author":"Piedrahita","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fphar.2018.00048","article-title":"Heat shock cognate 70 inhibitor, VER-155008, reduces memory deficits and axonal degeneration in a mouse model of Alzheimer\u2019s disease","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.biopsych.2013.02.027","article-title":"Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau","volume":"74","author":"Abisambra","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1093\/hmg\/ddv135","article-title":"The active Hsc70\/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics","volume":"24","author":"Fontaine","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1096\/fj.12-220889","article-title":"Imbalance of Hsp70 family variants fosters tau accumulation","volume":"27","author":"Jinwal","year":"2013","journal-title":"FASEB J."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/5\/1067\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:23:44Z","timestamp":1760361824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/5\/1067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,25]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["cells9051067"],"URL":"https:\/\/doi.org\/10.3390\/cells9051067","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,25]]}}}