{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:20:31Z","timestamp":1782400831515,"version":"3.54.5"},"reference-count":61,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["10048038"],"award-info":[{"award-number":["10048038"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["KOITA-139"],"award-info":[{"award-number":["KOITA-139"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Conventional therapeutic applications of mesenchymal stromal cells (MSCs) focus on cell replacement and differentiation; however, increasing evidence suggests that most of their therapeutic effects are carried out by their various secretions. This study investigated the application of conditioned medium (CM) from human umbilical cord blood-derived MSCs (hUCB-MSCs) to improve hair growth and developed a method to reliably produce this optimized CM. Primed MSC-derived CM (P-CM) with combinations of TGF-\u03b21 and LiCl was optimized by comparing its effects on the cell viability of dermal papilla cells (DPCs). P-CM significantly increased the viability of DPCs compared to CM. The secretion of vascular endothelial growth factor (VEGF) in DPCs was regulated by the macrophage migration inhibitory factor (MIF) in the P-CM secreted by MSCs. These findings suggest that P-CM can improve the efficacy in hair growth via a paracrine mechanism and that MIF in P-CM exerts hair growth-promoting effects via a VEGF-related \u03b2-catenin and p-GSK-3\u03b2 [SER9] signaling pathway. Furthermore, clinical trials have shown that 5% P-CM improved androgenetic alopecia through producing an increased hair density, thickness, and growth rate, suggesting that this topical agent may be a novel and effective treatment option for patients with androgenetic alopecia.<\/jats:p>","DOI":"10.3390\/cells9061344","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:44:02Z","timestamp":1590713042000},"page":"1344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth"],"prefix":"10.3390","volume":"9","author":[{"given":"Hyun Ah","family":"Oh","sequence":"first","affiliation":[{"name":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Kwak","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Jin","family":"Jin","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Aesthetic Research Team, Amore Pacific Corporation Research and Development Center, Yongin 17074, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonil","family":"Oh","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0034-114X","authenticated-orcid":false,"given":"Soyoun","family":"Um","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, MEDIPOST Co., Ltd., Seongnam 13494, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7861\/clinmedicine.16-1-74","article-title":"Alopecia in general medicine","volume":"16","author":"Nalluri","year":"2016","journal-title":"Clin. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.mcna.2015.07.003","article-title":"Selected Disorders of Skin Appendages\u2014Acne, Alopecia, Hyperhidrosis","volume":"99","author":"Vary","year":"2015","journal-title":"Med. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1056\/NEJM199909233411307","article-title":"Treatment of hair loss","volume":"341","author":"Price","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/14764172.2018.1525743","article-title":"The rise of transcutaneous drug delivery for the management of alopecia: A review of existing literature and an eye towards the future","volume":"21","author":"Wipf","year":"2019","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alsalhi, W., Alalola, A., Randolph, M., Gwillim, E., and Tosti, A. (2020). Novel drug delivery approaches for the management of hair loss. Expert Opin. Drug Deliv., 1\u20139.","DOI":"10.1080\/17425247.2020.1723543"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/0974-2077.85020","article-title":"A review of surgical methods (excluding hair transplantation) and their role in hair loss management today","volume":"4","author":"Sattur","year":"2011","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/187221312800166859","article-title":"Minoxidil use in dermatology, side effects and recent patents","volume":"6","author":"Rossi","year":"2012","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/j.1743-6109.2011.02255.x","article-title":"Persistent sexual side effects of finasteride for male pattern hair loss","volume":"8","author":"Irwig","year":"2011","journal-title":"J. Sex. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM199908123410706","article-title":"The biology of hair follicles","volume":"341","author":"Paus","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jdermsci.2009.11.005","article-title":"Review of hair follicle dermal cells","volume":"57","author":"Yang","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.devcel.2014.10.022","article-title":"Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type","volume":"31","author":"Rahmani","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1523-1747.2003.12171.x","article-title":"Molecular control of epithelial-mesenchymal interactions during hair follicle cycling","volume":"8","author":"Botchkarev","year":"2003","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.semcdb.2012.08.011","article-title":"Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling","volume":"23","author":"Sennett","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nrm3675","article-title":"Regenerating the skin: A task for the heterogeneous stem cell pool and surrounding niche","volume":"14","author":"Solanas","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2478\/v10136-012-0019-6","article-title":"Regulatory effect of \u03b2-catenin on proliferation of hair follicle stem cells involves PI3K\/Akt pathway","volume":"11","author":"Zhang","year":"2013","journal-title":"J. Appl. Biomed."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMra1103442","article-title":"Alopecia areata","volume":"366","author":"Gilhar","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/cdd.2013.158","article-title":"Immunobiology of mesenchymal stem cells","volume":"21","author":"Ma","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Allan, D.S. (2020). Using umbilical cord blood for regenerative therapy: Proof or promise?. Stem Cells.","DOI":"10.1002\/stem.3150"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/14712598.2017.1316713","article-title":"Advances in umbilical cord blood cell therapy: The present and the future","volume":"17","author":"Berglund","year":"2017","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4196\/kjpp.2018.22.5.555","article-title":"Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth","volume":"22","author":"Bak","year":"2018","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"965849","DOI":"10.1155\/2014\/965849","article-title":"Prospect of stem cell conditioned medium in regenerative medicine","volume":"2014","author":"Pawitan","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_22","first-page":"e10","article-title":"Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms","volume":"15","author":"Fukuoka","year":"2015","journal-title":"Eplasty"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.1038\/srep05432","article-title":"Treatment of MSCs with Wnt1a-conditioned medium activates DP cells and promotes hair follicle regrowth","volume":"4","author":"Dong","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2220\/biomedres.31.27","article-title":"Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: Evidence of increased growth factor secretion","volume":"31","author":"Park","year":"2010","journal-title":"Biomed. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jdermsci.2009.10.013","article-title":"Hair growth promoting effects of adipose tissue-derived stem cells","volume":"57","author":"Won","year":"2010","journal-title":"J. Dermatol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1089\/scd.2011.0289","article-title":"Hypoxic preconditioning enhances survival of human adipose-derived stem cells and conditions endothelial cells in vitro","volume":"21","author":"Stubbs","year":"2012","journal-title":"Stem Cells Dev."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Di Santo, S., Yang, Z., Wyler von Ballmoos, M., Voelzmann, J., Diehm, N., Baumgartner, I., and Kalka, C. (2009). Novel cell-free strategy for therapeutic angiogenesis: In vitro generated conditioned medium can replace progenitor cell transplantation. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005643"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Song, L.L., Cui, Y., Yu, S.J., Liu, P.G., and He, J.F. (2019). TGF-beta and HSP70 profiles during transformation of yak hair follicles from the anagen to catagen stage. J. Cell. Physiol.","DOI":"10.1002\/jcp.28212"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1523-1747.2003.12173.x","article-title":"A potential suppressor of TGF-beta delays catagen progression in hair follicles","volume":"8","author":"Tsuji","year":"2003","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lee, S.H., Yoon, J., Shin, S.H., Zahoor, M., Kim, H.J., Park, P.J., Park, W.S., Min do, S., Kim, H.Y., and Choi, K.Y. (2012). Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034152"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1074\/jbc.M309325200","article-title":"Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway","volume":"279","author":"Rao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.2000.0721327.x","article-title":"The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3","volume":"72","author":"Chen","year":"1999","journal-title":"J. Neurochem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kwon, J.H., Kim, M., Bae, Y.K., Kim, G.H., Choi, S.J., Oh, W., Um, S., and Jin, H.J. (2019). Decorin Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Induces Macrophage Polarization via CD44 to Repair Hyperoxic Lung Injury. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194815"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0974-7753.130390","article-title":"Evaluation of utility of phenol in alopecia areata","volume":"5","author":"Chikhalkar","year":"2013","journal-title":"Int. J. Trichology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"119881","DOI":"10.1016\/j.biomaterials.2020.119881","article-title":"Label-free separation of mesenchymal stem cell subpopulations with distinct differentiation potencies and paracrine effects","volume":"240","author":"Yin","year":"2020","journal-title":"Biomaterials"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1089\/ten.tea.2014.0102","article-title":"Freeze-dried rat bone marrow mesenchymal stem cell paracrine factors: A simplified novel material for skin wound therapy","volume":"21","author":"Peng","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1600-0625.2010.01104.x","article-title":"Skin-derived mesenchymal stem cells (S-MSCs) induce endothelial cell activation by paracrine mechanisms","volume":"19","author":"Salvolini","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/1574888X13666180913123424","article-title":"The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review","volume":"14","author":"Golchin","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_39","first-page":"1308","article-title":"Hair regrowth following a Wnt- and follistatin containing treatment: Safety and efficacy in a first-in-man phase 1 clinical trial","volume":"10","author":"Zimber","year":"2011","journal-title":"J. Drugs Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jdermsci.2011.08.010","article-title":"Androgen receptor transactivity is potentiated by TGF-beta1 through Smad3 but checked by its coactivator Hic-5\/ARA55 in balding dermal papilla cells","volume":"64","author":"Inui","year":"2011","journal-title":"J. Dermatol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2164\/jandrol.110.011999","article-title":"Negative androgen-response elements mediate androgen-dependent transcriptional inhibition of TGF-beta1 and CDK2 promoters in the prostate gland","volume":"33","author":"Qi","year":"2012","journal-title":"J. Androl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1096\/fj.02-0043fje","article-title":"Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: A clue to understand paradoxical effects of androgen on human hair growth","volume":"16","author":"Inui","year":"2002","journal-title":"FASEB J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Choi, Y.M., Choi, S.Y., Kim, H., Kim, J., Ki, M.S., An, I.-S., and Jung, J. (2018). TGF\u03b2 family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL\/6 mice. Biomed. Dermatol., 2.","DOI":"10.1186\/s41702-018-0033-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/2211-5463.12220","article-title":"Activation of Wnt\/beta-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging","volume":"7","author":"Xia","year":"2017","journal-title":"FEBS Open Bio"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/cbin.10340","article-title":"Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt\/beta-catenin signaling","volume":"39","author":"Shan","year":"2015","journal-title":"Cell Biol. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.stem.2011.11.005","article-title":"Paracrine TGF-beta signaling counterbalances BMP-mediated repression in hair follicle stem cell activation","volume":"10","author":"Oshimori","year":"2012","journal-title":"Cell Stem Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ydbio.2012.10.021","article-title":"Differential response of epithelial stem cell populations in hair follicles to TGF-beta signaling","volume":"373","author":"Lin","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2015.03.055","article-title":"Effects of dihydrotestosterone on rat dermal papilla cells in vitro","volume":"757","author":"Kang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1365-2133.2012.10856.x","article-title":"Hair follicle stem cell differentiation is inhibited through cross-talk between Wnt\/beta-catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia","volume":"166","author":"Leiros","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3892\/ijmm.2015.2316","article-title":"Human placental extract exerts hair growth-promoting effects through the GSK-3beta signaling pathway in human dermal papilla cells","volume":"36","author":"Kwon","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1101\/gad.1324905","article-title":"Defining the impact of beta-catenin\/Tcf transactivation on epithelial stem cells","volume":"19","author":"Lowry","year":"2005","journal-title":"Genes Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jdermsci.2014.01.011","article-title":"A role of placental growth factor in hair growth","volume":"74","author":"Yoon","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI11317","article-title":"Control of hair growth and follicle size by VEGF-mediated angiogenesis","volume":"107","author":"Yano","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/exd.12906","article-title":"Effects of the biomimetic peptide Sh-Polypeptide 9 (CG-VEGF) on cocultures of human hair follicle dermal papilla cells and microvascular endothelial cells","volume":"25","author":"Bassino","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.yexcr.2012.05.003","article-title":"VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK","volume":"318","author":"Li","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nm0603-669","article-title":"The biology of VEGF and its receptors","volume":"9","author":"Ferrara","year":"2003","journal-title":"Nat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1476-4598-13-209","article-title":"Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K\/Akt enhanced beta-catenin\/Tcf-Lef dependent transcription","volume":"13","author":"Fernandez","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_58","first-page":"3145","article-title":"beta-Catenin regulates vascular endothelial growth factor expression in colon cancer","volume":"63","author":"Easwaran","year":"2003","journal-title":"Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/ijd.13344","article-title":"Evaluation of macrophage migration inhibitory factor (MIF) levels in serum and lesional skin of patients with alopecia areata","volume":"55","author":"Salem","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/jcla.21731","article-title":"Serum level of macrophage migration inhibitory factor (MIF) in Egyptians with alopecia areata and its relation to the clinical severity of the disease","volume":"29","author":"Younan","year":"2015","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8104","DOI":"10.1021\/acs.jmedchem.8b00589","article-title":"Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor","volume":"61","author":"Jorgensen","year":"2018","journal-title":"J. Med. Chem."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/6\/1344\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:33:23Z","timestamp":1760175203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/6\/1344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,28]]},"references-count":61,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["cells9061344"],"URL":"https:\/\/doi.org\/10.3390\/cells9061344","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,28]]}}}