{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:35:47Z","timestamp":1792348547820,"version":"4.4.0"},"reference-count":160,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008725","name":"Instytut Farmakologii, Polskiej Akademii Nauk","doi-asserted-by":"publisher","award":["statutory funds"],"award-info":[{"award-number":["statutory funds"]}],"id":[{"id":"10.13039\/501100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Several psychoactive drugs can evoke substance use disorders (SUD) in humans and animals, and these include psychostimulants, opioids, cannabinoids (CB), nicotine, and alcohol. The etiology, mechanistic processes, and the therapeutic options to deal with SUD are not well understood. The common feature of all abused drugs is that they increase dopamine (DA) neurotransmission within the mesocorticolimbic circuitry of the brain followed by the activation of DA receptors. D2 receptors were proposed as important molecular targets for SUD. The findings showed that D2 receptors formed heteromeric complexes with other GPCRs, which forced the addiction research area in new directions. In this review, we updated the view on the brain D2 receptor complexes with adenosine (A)2A receptors (A2AR) and discussed the role of A2AR in different aspects of addiction phenotypes in laboratory animal procedures that permit the highly complex syndrome of human drug addiction. We presented the current knowledge on the neurochemical in vivo and ex vivo mechanisms related to cocaine use disorder (CUD) and discussed future research directions for A2AR heteromeric complexes in SUD.<\/jats:p>","DOI":"10.3390\/cells9061372","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T09:19:27Z","timestamp":1591089567000},"page":"1372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adenosine A2AReceptors in Substance Use Disorders: A Focus on Cocaine"],"prefix":"10.3390","volume":"9","author":[{"given":"Karolina","family":"Wydra","sequence":"first","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-0564","authenticated-orcid":false,"given":"Dawid","family":"Gawli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-154X","authenticated-orcid":false,"given":"Kinga","family":"Gawli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Frankowska","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5736-373X","authenticated-orcid":false,"given":"Dasiel O.","family":"Borroto-Escuela","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Section of Physiology, Department of Biomolecular Science, University of Urbino, Campus Scientifico Enrico Mattei, Via Ca\u2019 Le Suore 2, 61029 Urbino, Italy"},{"name":"Observatorio Cubano de Neurociencias, Grupo Boh\u00edo-Estudio, Zayas 50, Yaguajay 62100, Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-4288","authenticated-orcid":false,"given":"Kjell","family":"Fuxe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"ref_1","first-page":"112","article-title":"Substance Misuse and Substance use Disorders: Why do they Matter in Healthcare?","volume":"128","author":"McLellan","year":"2017","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/00377317.2014.923629","article-title":"The Neurobiology of Substance Use Disorders: Information for Assessment and Clinical Treatment","volume":"84","author":"Bennett","year":"2014","journal-title":"Smith Coll. Stud. Soc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1176\/appi.ajp.2013.12060782","article-title":"DSM-5 Criteria for Substance Use Disorders: Recommendations and Rationale","volume":"170","author":"Hasin","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0006-8993(94)91066-9","article-title":"Evidence for functionally important adenosine A2a receptors in the rat hippocampus","volume":"649","author":"Cunha","year":"1994","journal-title":"Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1476-5381.1996.tb15561.x","article-title":"Tissue distribution of adenosine receptor mRNAs in the rat","volume":"118","author":"Dixon","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-2999(89)90571-2","article-title":"Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680","volume":"168","author":"Jarvis","year":"1989","journal-title":"Eur. J. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuroscience.2005.01.014","article-title":"Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat","volume":"132","author":"Rebola","year":"2005","journal-title":"Neuroscience"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/(SICI)1096-9861(19981116)401:2<163::AID-CNE2>3.0.CO;2-D","article-title":"Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system","volume":"401","author":"Rosin","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1212\/01.WNL.0000095205.33940.99","article-title":"Anatomy of adenosine A2A receptors in brain: Morphological substrates for integration of striatal function","volume":"61","author":"Rosin","year":"2003","journal-title":"Neurology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1096-9861(19980921)399:2<229::AID-CNE6>3.0.CO;2-2","article-title":"Cellular distribution of adenosine A2A receptor mRNA in the primate striatum","volume":"399","author":"Svenningsson","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(99)00011-8","article-title":"Distribution, biochemistry and function of striatal adenosine A2A receptors","volume":"59","author":"Svenningsson","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1046\/j.1471-4159.1996.66010362.x","article-title":"Characterization and expression of the human A2a adenosine receptor gene","volume":"66","author":"Peterfreund","year":"1996","journal-title":"J. Neurochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1471-4159.1991.tb08257.x","article-title":"Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study","volume":"57","author":"Schiffmann","year":"1991","journal-title":"J. Neurochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pneurobio.2007.05.001","article-title":"Adenosine A2A receptors and basal ganglia physiology","volume":"83","author":"Schiffmann","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/syn.20539","article-title":"Positron emission tomography analysis of [11C]KW-6002 binding to human and rat adenosine A2A receptors in the brain","volume":"62","author":"Brooks","year":"2008","journal-title":"Synapse"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1046\/j.1460-9568.2003.02907.x","article-title":"Characterization of the rat A2A adenosine receptor gene: a 4.8-kb promoter-proximal DNA fragment confers selective expression in the central nervous system","volume":"18","author":"Lee","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/glia.10100","article-title":"A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors","volume":"39","author":"Nishizaki","year":"2002","journal-title":"Glia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/157015909789152128","article-title":"Tuning and fine-tuning of synapses with adenosine","volume":"7","author":"Ribeiro","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1100\/tsw.2009.143","article-title":"Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway","volume":"9","author":"Quiroz","year":"2009","journal-title":"ScientificWorldJournal"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.physbeh.2007.05.031","article-title":"Modulation of glial cell functions by adenosine receptors","volume":"92","author":"Schulte","year":"2007","journal-title":"Physiol. Behav."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/1096-9861(20010312)431:3<331::AID-CNE1074>3.0.CO;2-W","article-title":"Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum","volume":"431","author":"Hettinger","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/glia.22290","article-title":"Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes","volume":"60","author":"Matos","year":"2012","journal-title":"Glia"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18492","DOI":"10.1523\/JNEUROSCI.1828-13.2013","article-title":"Antagonistic interaction between adenosine A2A receptors and Na+\/K+-ATPase-\u03b12 controlling glutamate uptake in astrocytes","volume":"33","author":"Matos","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0169-328X(94)90048-5","article-title":"Adenosine A2a receptor mRNA is expressed by enkephalin cells but not by somatostatin cells in rat striatum: a co-expression study","volume":"22","author":"Augood","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0169-328X(92)90173-9","article-title":"Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum","volume":"14","author":"Fink","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1471-4159.2004.02887.x","article-title":"Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum","volume":"92","author":"Rodrigues","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1471-4159.1990.tb08817.x","article-title":"Both A1 and A2a purine receptors regulate striatal acetylcholine release","volume":"55","author":"Brown","year":"1990","journal-title":"J. Neurochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1476-5381.1994.tb16171.x","article-title":"Inhibition by KF17837 of adenosine A2A receptor-mediated modulation of striatal GABA and ACh release","volume":"113","author":"Kurokawa","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1046\/j.1471-4159.1996.66051882.x","article-title":"Adenosine A2a receptor-mediated modulation of striatal acetylcholine release in vivo","volume":"66","author":"Kurokawa","year":"1996","journal-title":"J. Neurochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46741","DOI":"10.1074\/jbc.M306451200","article-title":"Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer","volume":"278","author":"Canals","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1046\/j.1471-4159.2003.02200.x","article-title":"Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer","volume":"88","author":"Canals","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.3390\/ijms15058570","article-title":"The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components","volume":"15","author":"Brito","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lujan, R., and Ciruela, F. (2016). In Situ Proximity Ligation Assay to Study and Understand the Distribution and Balance of GPCR Homo- and Heteroreceptor Complexes in the Brain. Receptor and Ion Channel Detection in the Brain, Humana Press.","DOI":"10.1007\/978-1-4939-3064-7"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.15379\/2409-3564.2015.02.01.5","article-title":"On the Role of the Balance of GPCR Homo\/ Heteroreceptor Complexes in the Brain","volume":"2","author":"Brito","year":"2015","journal-title":"J. Adv. Neurosci. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fnins.2018.00043","article-title":"Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation","volume":"12","author":"Hinz","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1523\/JNEUROSCI.3574-05.2006","article-title":"Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers","volume":"26","author":"Ciruela","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11940","DOI":"10.1073\/pnas.172393799","article-title":"Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function","volume":"99","author":"Ferre","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0028-3908(98)00154-3","article-title":"Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum","volume":"38","author":"Ferre","year":"1999","journal-title":"Neuropharmacology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1073\/pnas.0237126100","article-title":"Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling","volume":"100","author":"Nishi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1038\/sj.npp.1301375","article-title":"Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids","volume":"32","author":"Carriba","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1476-5381.2010.00723.x","article-title":"Adenosine-cannabinoid receptor interactions. Implications for striatal function","volume":"160","author":"Justinova","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1471-4159.2009.06078.x","article-title":"Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells","volume":"109","author":"Cabello","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nmeth.1229","article-title":"Detection of heteromerization of more than two proteins by sequential BRET-FRET","volume":"5","author":"Carriba","year":"2008","journal-title":"Nat. Methods"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1212\/01.WNL.0000095206.44418.5C","article-title":"Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson\u2019s disease","volume":"61","author":"Fuxe","year":"2003","journal-title":"Neurology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pneurobio.2009.10.012","article-title":"The discovery of central monoamine neurons gave volume transmission to the wired brain","volume":"90","author":"Fuxe","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2174\/1389203715666140901103205","article-title":"Adenosine A2A-D2 receptor-receptor interactions in putative heteromers in the regulation of the striato\u2013pallidal gaba pathway: possible relevance for parkinson\u2019s disease and its treatment","volume":"15","author":"Beggiato","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuropharm.2007.08.006","article-title":"Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission","volume":"53","author":"Tozzi","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/nn.2216","article-title":"FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity","volume":"11","author":"Flajolet","year":"2008","journal-title":"Nat. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbrc.2013.04.058","article-title":"Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers","volume":"435","author":"Ravani","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2174\/138920371507140916122738","article-title":"Understanding the role of heteroreceptor complexes in the central nervous system","volume":"15","author":"Fuxe","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1385\/JMN:26:2-3:209","article-title":"Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function","volume":"26","author":"Fuxe","year":"2005","journal-title":"J. Mol. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/mol.104.003376","article-title":"Adenosine A2A receptor and dopamine D3 receptor interactions: Evidence of functional A2A\/D3 heteromeric complexes","volume":"67","author":"Torvinen","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-3042.2001.00702.x","article-title":"Dopamine D4 receptors are heterogeneously distributed in the striosomes\/matrix compartments of the striatum","volume":"80","author":"Rivera","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2174\/138161208784480108","article-title":"An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors","volume":"14","author":"Ferre","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fnana.2011.00036","article-title":"Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function","volume":"5","author":"Ferre","year":"2011","journal-title":"Front. Neuroanat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1111\/j.1755-5949.2009.00126.x","article-title":"Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders","volume":"16","author":"Fuxe","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1523\/JNEUROSCI.4082-10.2011","article-title":"The Distinct Role of Medium Spiny Neurons and Cholinergic Interneurons in the D2\/A2AReceptor Interaction in the Striatum: Implications for Parkinson\u2019s Disease","volume":"31","author":"Tozzi","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jnc.13885","article-title":"A2A-D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes","volume":"140","author":"Cervetto","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s12031-018-1120-4","article-title":"Homocysteine and A2A-D2 Receptor-Receptor Interaction at Striatal Astrocyte Processes","volume":"65","author":"Cervetto","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2144\/000113719","article-title":"Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum","volume":"51","author":"Trifilieff","year":"2011","journal-title":"Biotechniques"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-12-391862-8.00015-6","article-title":"G protein-coupled receptor heterodimerization in the brain","volume":"521","author":"Garriga","year":"2013","journal-title":"Methods Enzymol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12031-009-9313-5","article-title":"Triplet puzzle: Homologies of receptor heteromers","volume":"41","author":"Tarakanov","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"P37","DOI":"10.1186\/2193-1801-4-S1-P37","article-title":"Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor-receptor interaction in the rat brain: Role in brain plasticity and cocaine action","volume":"4","author":"Pinton","year":"2015","journal-title":"SpringerPlus"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0006-8993(95)01223-0","article-title":"Effects of selective adenosine A1 and A2a agonists on amphetamine-induced locomotion and c-Fos in striatum and nucleus accumbens","volume":"707","author":"Turgeon","year":"1996","journal-title":"Brain Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0893-133X(97)00033-X","article-title":"Adenosine A2A agonists: A potential new type of atypical antipsychotic","volume":"17","author":"Rimondini","year":"1997","journal-title":"Neuropsychopharmacology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.neuropharm.2014.09.030","article-title":"Role of adenosine receptor subtypes in methamphetamine reward and reinforcement","volume":"89","author":"Kavanagh","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_67","first-page":"359","article-title":"Cocaine-induced hyperactivity is more influenced by adenosine receptor agonists than amphetamine-induced hyperactivity","volume":"54","author":"Poleszak","year":"2002","journal-title":"Pol. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2006.01.038","article-title":"Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine","volume":"1077","author":"Filip","year":"2006","journal-title":"Brain Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Czyzyk, J., Zaniewska, M., Bader, M., Fuxe, K., and Filip, M. Attenuated behavioral responses to acute and chronic cocaine in adenosine A2A overexpressed transgenic rats. European Neuropsychopharmacology. Proceedings of the The 24th ECNP Congress, Paris, France, 3\u20137 September 2011, ECNP.","DOI":"10.1016\/S0924-977X(11)70978-6"},{"key":"ref_70","first-page":"119","article-title":"Adenosine receptor ligands and cocaine in conditioned place preference (CPP) test in rats","volume":"54","author":"Poleszak","year":"2002","journal-title":"Pol. J. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00213-018-5097-z","article-title":"Effects of adenosine A2A receptor antagonists on cocaine-induced locomotion and cocaine seeking","volume":"236","author":"Haynes","year":"2019","journal-title":"Psychopharmacology (Berl)."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0306-4522(99)00604-1","article-title":"Selective attenuation of psychostimulant-induced behavioral responses in mice lacking A(2A) adenosine receptors","volume":"97","author":"Chen","year":"2000","journal-title":"Neuroscience"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/adb.12259","article-title":"A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine","volume":"21","author":"Wright","year":"2016","journal-title":"Addict. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1523\/JNEUROSCI.5255-07.2008","article-title":"A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs","volume":"28","author":"Shen","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-2999(99)00899-7","article-title":"Roles of adenosine A(1) and A(2A) receptors in the expression and development of methamphetamine-induced sensitization","volume":"388","author":"Shimazoe","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.npp.1300630","article-title":"A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization","volume":"30","author":"Bastia","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/sj.npp.1300152","article-title":"Inactivation of adenosine A2A receptors selectively attenuates amphetamine-induced behavioral sensitization","volume":"28","author":"Chen","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/sj.npp.1300876","article-title":"The lack of A2A adenosine receptors diminishes the reinforcing efficacy of cocaine","volume":"31","author":"Soria","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref_79","first-page":"679","article-title":"Involvement of adenosine receptor agonists on the development of hypersensitivity to acute dose of morphine during morphine withdrawal period","volume":"60","author":"Listos","year":"2008","journal-title":"Pharmacol. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pbb.2011.01.019","article-title":"Attenuating effect of adenosine receptor agonists on the development of behavioral sensitization induced by sporadic treatment with morphine","volume":"98","author":"Listos","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/bjp.2008.299","article-title":"Behavioural and biochemical responses to morphine associated with its motivational properties are altered in adenosine A(2A) receptor knockout mice","volume":"155","author":"Castane","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1111\/j.1460-9568.2004.03682.x","article-title":"Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC","volume":"20","author":"Soria","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pbb.2015.05.016","article-title":"2nd. Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL\/6J mice","volume":"135","author":"Fritz","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1601-183X.2008.00427.x","article-title":"Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice","volume":"7","author":"Houchi","year":"2008","journal-title":"Genes Brain Behav."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuropharm.2014.03.002","article-title":"Adenosine (A)(2A)receptor modulation of nicotine-induced locomotor sensitization. A pharmacological and transgenic approach","volume":"81","author":"Nowak","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuropharm.2006.05.005","article-title":"Attenuation of nicotine-induced rewarding effects in A2A knockout mice","volume":"51","author":"Castane","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1124\/jpet.103.056762","article-title":"Involvement of adenosine A1 and A2A receptors in the adenosinergic modulation of the discriminative-stimulus effects of cocaine and methamphetamine in rats","volume":"307","author":"Justinova","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00213-008-1270-0","article-title":"Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats","volume":"203","author":"Justinova","year":"2009","journal-title":"Psychopharmacology (Berl)."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00213-002-1075-5","article-title":"Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats","volume":"161","author":"Munzar","year":"2002","journal-title":"Psychopharmacol. Berl."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0091-3057(01)00486-5","article-title":"Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration","volume":"68","author":"Knapp","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-014-3675-2","article-title":"On the role of adenosine (A)(2)A receptors in cocaine-induced reward: A pharmacological and neurochemical analysis in rats","volume":"232","author":"Wydra","year":"2015","journal-title":"Psychopharmacology (Berl)."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1007\/s00213-018-5072-8","article-title":"Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats","volume":"235","author":"Wydra","year":"2018","journal-title":"Psychopharmacology (Berl)."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Borroto-Escuela, D.O., Wydra, K., Romero-Fernandez, W., Zhou, Z., Frankowska, M., Filip, M., and Fuxe, K. (2019). A2AR Transmembrane 2 Peptide Administration Disrupts the A2AR-A2AR Homoreceptor but Not the A2AR-D2R Heteroreceptor Complex: Lack of Actions on Rodent Cocaine Self-Administration. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236100"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1007\/s12035-018-0887-1","article-title":"Disruption of A2AR-D2R Heteroreceptor Complexes After A2AR Transmembrane 5 Peptide Administration Enhances Cocaine Self-Administration in Rats","volume":"55","author":"Wydra","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_95","first-page":"319","article-title":"Effects of adenosine receptor agonists and antagonists in amphetamine-induced conditioned place preference test in rats","volume":"55","author":"Poleszak","year":"2003","journal-title":"Pol. J. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1369-1600.2010.00258.x","article-title":"Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist","volume":"16","author":"Justinova","year":"2011","journal-title":"Addict. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1177\/0269881110389210","article-title":"The A2a adenosine receptor modulates the reinforcement efficacy and neurotoxicity of MDMA","volume":"25","author":"Ledent","year":"2011","journal-title":"J. Psychopharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/0269881119885917","article-title":"Effects of an adenosine A2A agonist on the rewarding associative properties of nicotine and neural plasticity in a rodent model of schizophrenia","volume":"34","author":"Gill","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-2999(99)00613-5","article-title":"Adenosine A(2) receptors inhibit morphine self-administration in rats","volume":"383","author":"Sahraei","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00210-015-1190-6","article-title":"Effects of the adenosinergic system on the expression and acquisition of sensitization to conditioned place preference in morphine-conditioned rats","volume":"389","author":"Listos","year":"2016","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/npp.2008.72","article-title":"A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior","volume":"34","author":"Brown","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/adb.12032","article-title":"The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals","volume":"18","author":"Houchi","year":"2013","journal-title":"Addict. Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuroscience.2019.08.030","article-title":"Increased Ethanol Consumption and Locomotion Develop upon Ethanol Deprivation in Rats Overexpressing the Adenosine (A)2A Receptor","volume":"418","author":"Zaniewska","year":"2019","journal-title":"Neuroscience"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1097\/01.ALC.0000139821.38167.20","article-title":"Ethanol operant self-administration in rats is regulated by adenosine A2 receptors","volume":"28","author":"Arolfo","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1111\/j.1530-0277.2007.00425.x","article-title":"Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats","volume":"31","author":"Thorsell","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S1461145707007845","article-title":"Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats","volume":"11","author":"Adams","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1523\/JNEUROSCI.3094-12.2013","article-title":"Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum","volume":"33","author":"Nam","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.1523\/JNEUROSCI.22-23-10487.2002","article-title":"Low ethanol sensitivity and increased ethanol consumption in mice lacking adenosine A2A receptors","volume":"22","author":"Naassila","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3389\/fnbeh.2018.00309","article-title":"Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators","volume":"12","author":"Mukhara","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00213-009-1624-2","article-title":"Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats","volume":"206","author":"Bachtell","year":"2009","journal-title":"Psychopharmacol. Berl."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00213-014-3818-5","article-title":"On the role of A(2)A and D(2) receptors in control of cocaine and food-seeking behaviors in rats","volume":"232","author":"Wydra","year":"2015","journal-title":"Psychopharmacol. Berl."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/npp.2011.312","article-title":"Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats","volume":"37","author":"LeTendre","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00213-018-5126-y","article-title":"Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking","volume":"236","author":"Larson","year":"2019","journal-title":"Psychopharmacol. Berl."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-003-1410-5","article-title":"The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons","volume":"168","author":"Weerts","year":"2003","journal-title":"Psychopharmacol. Berl."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s00213-014-3489-2","article-title":"Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats","volume":"231","author":"Hobson","year":"2014","journal-title":"Psychopharmacol. Berl."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1073\/pnas.0602661103","article-title":"Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats","volume":"103","author":"Yao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1523\/JNEUROSCI.19-24-11017.1999","article-title":"Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats","volume":"19","author":"Baldo","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0091-3057(92)90516-I","article-title":"Effect of adenosine analogues on the expression of opiate withdrawal in rats","volume":"42","author":"Dionyssopoulos","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF02246282","article-title":"Adenosine receptor agonists attenuate and adenosine receptor antagonists exacerbate opiate withdrawal signs","volume":"123","author":"Kaplan","year":"1996","journal-title":"Psychopharmacol. Berl."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0091-3057(96)00393-0","article-title":"Effect of adenosine receptor agonists and antagonists on the expression of opiate withdrawal in rats","volume":"57","author":"Salem","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1471-4159.2003.02214.x","article-title":"Enhanced morphine withdrawal and micro -opioid receptor G-protein coupling in A2A adenosine receptor knockout mice","volume":"88","author":"Bailey","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00213-005-0284-0","article-title":"Absence of quasi-morphine withdrawal syndrome in adenosine A2A receptor knockout mice","volume":"185","author":"Bilbao","year":"2006","journal-title":"Psychopharmacol. Berl."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.1460-9568.2003.02439.x","article-title":"Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1\/A2a double knockout mice","volume":"17","author":"Berrendero","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0741-8329(99)00033-6","article-title":"Role of adenosine A1 and A2A receptors in the alcohol withdrawal syndrome","volume":"19","author":"Kaplan","year":"1999","journal-title":"Alcohol"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1038\/sj.npp.1301001","article-title":"Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice","volume":"31","author":"Prediger","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0028-3908(00)00173-8","article-title":"Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice","volume":"40","author":"Ledent","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/syn.20168","article-title":"Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose \"binge\" cocaine-treated rats","volume":"57","author":"Bailey","year":"2005","journal-title":"Synapse"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.brainres.2007.01.079","article-title":"Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal","volume":"1143","author":"Marcellino","year":"2007","journal-title":"Brain Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1369-1600.2012.00452.x","article-title":"Effects of cocaine self-administration and extinction on D2 -like and A2A receptor recognition and D2 -like\/Gi protein coupling in rat striatum","volume":"18","author":"Frankowska","year":"2013","journal-title":"Addict. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12272-011-0214-0","article-title":"Increased non-rapid eye movement sleep by cocaine withdrawal: possible involvement of A2A receptors","volume":"34","author":"Yang","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1007\/s12035-018-1456-3","article-title":"Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts \u03949-Tetrahydrocannabinol-Induced Cognitive Impairment","volume":"56","author":"Aso","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/glia.23694","article-title":"Potentiation of cannabinoid signaling in microglia by adenosine A(2A) receptor antagonists","volume":"67","author":"Franco","year":"2019","journal-title":"Glia"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(94)90990-3","article-title":"Alterations of adenosine A1 receptors in morphine dependence","volume":"657","author":"Kaplan","year":"1994","journal-title":"Brain Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/1043-6618(92)90378-O","article-title":"Deacresed adenosine A2A receptor function in morphine dependent rats","volume":"25","author":"Devoto","year":"1992","journal-title":"Pharmacol. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/0024-3205(83)90819-6","article-title":"Possible role of adenosine in the CNS effects of ethanol","volume":"33","author":"Dar","year":"1983","journal-title":"Life Sci."},{"key":"ref_136","first-page":"203","article-title":"In vitro autoradiographic evidence for adenosine modulation of ethanol-induced motor disturbances in rats","volume":"1","author":"Clark","year":"1991","journal-title":"Alcohol Alcohol. Suppl."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(94)90219-4","article-title":"Chronic effects of ethanol on central adenosine function of mice","volume":"650","author":"Daly","year":"1994","journal-title":"Brain Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0006-8993(97)01413-3","article-title":"Single and repeated episodes of ethanol withdrawal increase adenosine A1, but not A2A, receptor density in mouse brain","volume":"786","author":"Jarvis","year":"1998","journal-title":"Brain Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0773.1996.tb00254.x","article-title":"Effects of ethanol and acetate on adenosine production in rat hippocampal slices","volume":"79","author":"Fredholm","year":"1996","journal-title":"Pharmacol. Toxicol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"5950818","DOI":"10.1155\/2019\/5950818","article-title":"Sequential Changes in Brain Glutamate and Adenosine A1 Receptors May Explain Severity of Adolescent Alcohol Withdrawal after Consumption of High Levels of Alcohol","volume":"2019","author":"Bolewska","year":"2019","journal-title":"Neurosci. J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/acer.13568","article-title":"Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats","volume":"42","author":"Feltmann","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/npp.2014.278","article-title":"Effects of adolescent caffeine consumption on cocaine sensitivity","volume":"40","author":"Levis","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0165-0173(97)00049-0","article-title":"Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A\/dopamine D2 and adenosine A1\/dopamine D1 receptor interactions in the basal ganglia","volume":"26","author":"Fuxe","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbrc.2010.02.168","article-title":"A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R","volume":"394","author":"Marcellino","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1007\/s12035-019-1580-8","article-title":"Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes","volume":"56","author":"Narvaez","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00702-010-0389-4","article-title":"Nanomolar concentrations of cocaine enhance D2-like agonist-induced inhibition of the K+-evoked [3H]-dopamine efflux from rat striatal synaptosomes: a novel action of cocaine","volume":"117","author":"Ferraro","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1038\/npp.2012.33","article-title":"A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study","volume":"37","author":"Ferraro","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s43440-020-00069-3","article-title":"Acute cocaine treatment enhances the antagonistic allosteric adenosine A2A-dopamine D2 receptor-receptor interactions in rat dorsal striatum without increasing significantly extracellular dopamine levels","volume":"72","author":"Zhou","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/adb.12031","article-title":"Accumbal and pallidal dopamine, glutamate and GABA overflow during cocaine self-administration and its extinction in rats","volume":"18","author":"Wydra","year":"2013","journal-title":"Addict. Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2016.03.004","article-title":"Cocaine self-administration differentially affects allosteric A2A-D2 receptor-receptor interactions in the striatum. Relevance for cocaine use disorder","volume":"144","author":"Pintsuk","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_151","first-page":"4827268","article-title":"Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes","volume":"2016","author":"Wydra","year":"2016","journal-title":"Neural Plast."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pbb.2017.03.003","article-title":"Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder","volume":"155","author":"Narvaez","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00213-004-1814-x","article-title":"The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming","volume":"175","author":"Romieu","year":"2004","journal-title":"Psychopharmacol. Berl."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.tins.2012.09.007","article-title":"The sigma-1 receptor: roles in neuronal plasticity and disease","volume":"35","author":"Kourrich","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Navarro, G., Moreno, E., Bonaventura, J., Brugarolas, M., Farre, D., Aguinaga, D., Mallol, J., Cortes, A., Casado, V., and Lluis, C. (2013). Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061245"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/mp.2012.3","article-title":"The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor","volume":"18","author":"Sahlholm","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s12640-019-00134-7","article-title":"OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes","volume":"37","author":"Wydra","year":"2020","journal-title":"Neurotox. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.tips.2018.10.007","article-title":"A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction","volume":"39","author":"Wydra","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3389\/fphar.2018.00829","article-title":"Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer","volume":"9","author":"Rodriguez","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.nlm.2006.05.004","article-title":"Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain","volume":"87","author":"Schiffmann","year":"2007","journal-title":"Neurobiol. Learn Mem."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/6\/1372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:34:44Z","timestamp":1760175284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/6\/1372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":160,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["cells9061372"],"URL":"https:\/\/doi.org\/10.3390\/cells9061372","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]}}}