{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:40:40Z","timestamp":1770986440963,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T00:00:00Z","timestamp":1593302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["#SAF 2014-59701"],"award-info":[{"award-number":["#SAF 2014-59701"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastly, an in vitro model of myotube atrophy with Tumor Necrosis Factor-\u03b1 (TNF\u03b1). In all these models, we observed that NeuroHeal reduced muscle atrophy and that SIRT1 activation seems to be required for that. The treatment downregulated some critical markers of protein degradation: Muscle Ring Finger 1 (MuRF1), K48 poly-Ub chains, and p62\/SQSTM1. Moreover, it seems to restore the autophagy flux associated with denervation. Hence, we envisage a prospective use of NeuroHeal at clinics for different myopathies.<\/jats:p>","DOI":"10.3390\/cells9071575","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T09:36:04Z","timestamp":1593509764000},"page":"1575","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-2123","authenticated-orcid":false,"given":"Sara","family":"Marmolejo-Mart\u00ednez-Artesero","sequence":"first","affiliation":[{"name":"Institut de Neuroci\u00e8ncies (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-9302","authenticated-orcid":false,"given":"David","family":"Romeo-Guitart","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Ma\u00f1as-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2273-6321","authenticated-orcid":false,"given":"Caty","family":"Casas","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies (INc) and Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,28]]},"reference":[{"key":"ref_1","first-page":"1434","article-title":"Advances in Experimental Medicine and Biology","volume":"1088","author":"Cohen","year":"2018","journal-title":"Springer Singapore"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/jgs.12840","article-title":"Muscle Strength and Physical Performance as Predictors of Mortality, Hospitalization, and Disability in the Oldest Old","volume":"62","author":"Legrand","year":"2014","journal-title":"J. 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