{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:18:30Z","timestamp":1793834310333,"version":"4.6.1"},"reference-count":193,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00020, GINOP-2.3.2-15-2016-00034, FK-124114"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00020, GINOP-2.3.2-15-2016-00034, FK-124114"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["EMMI:11136-2\/2019\/FIRFIN"],"award-info":[{"award-number":["EMMI:11136-2\/2019\/FIRFIN"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-TE-2016-1352"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2016-1352"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1\u03b2, IL-18), inflammation is initiated, resulting in tissue injury in various organs, the brain and the spinal cord included. Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position. In this review, we discuss the inflammatory changes in normal aging and summarize the current knowledge on the role of inflammasomes and contributing mechanisms in common CNS diseases, namely Alzheimer\u2019s disease, Parkinson\u2019s disease, amyotrophic lateral sclerosis and stroke, all of which occur more frequently with aging.<\/jats:p>","DOI":"10.3390\/cells9071614","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:49:11Z","timestamp":1594028951000},"page":"1614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Neurovascular Inflammaging in Health and Disease"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-1128","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"M\u00e9sz\u00e1ros","sequence":"first","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Doctoral School of Biology, University of Szeged, 6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0596-2191","authenticated-orcid":false,"given":"Kinga","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Theoretical Medicine Doctoral School, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8643-0367","authenticated-orcid":false,"given":"Bern\u00e1t","family":"N\u00f3gr\u00e1di","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Foundation for the Future of Biomedical Sciences in Szeged, Szeged Scientists Academy, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Hern\u00e1di","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Foundation for the Future of Biomedical Sciences in Szeged, Szeged Scientists Academy, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Ny\u00fal-T\u00f3th","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging\/Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imola","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Institute of Life Sciences, Vasile Goldi\u015f Western University of Arad, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n A.","family":"Krizbai","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary"},{"name":"Institute of Life Sciences, Vasile Goldi\u015f Western University of Arad, 310414 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ympev.2016.11.007","article-title":"Complete mitochondrial genome and evolutionary analysis of Turritopsis dohrnii, the \u201cimmortal\u201d jellyfish with a reversible life-cycle","volume":"107","author":"Lisenkova","year":"2017","journal-title":"Mol. 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