{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:41:17Z","timestamp":1792179677849,"version":"4.4.0"},"reference-count":114,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A6A1A03044512"],"award-info":[{"award-number":["2020R1A6A1A03044512"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1A2B6001020"],"award-info":[{"award-number":["NRF-2018R1A2B6001020"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass entity, strength development, and degeneration and increases the proliferative capacity of muscle satellite cells (MSCs). IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K\/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance. IGF-1 synthesis is elevated in MSCs of injured muscles and stimulates MSCs proliferation and myogenic differentiation. Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance. IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease conditions.<\/jats:p>","DOI":"10.3390\/cells9081773","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T09:06:09Z","timestamp":1595581569000},"page":"1773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":189,"title":["Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases"],"prefix":"10.3390","volume":"9","author":[{"given":"Syed Sayeed","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea"},{"name":"Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-8445","authenticated-orcid":false,"given":"Khurshid","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea"},{"name":"Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea"},{"name":"Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Daegu Catholic University, Gyeongsan 38430, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea"},{"name":"Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal muscle: A brief review of structure and function","volume":"96","author":"Frontera","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kim, T., Ahmad, K., Shaikh, S., Jan, A.T., Seo, M.G., Lee, E.J., and Choi, I. (2019). Dermatopontin in skeletal muscle extracellular matrix regulates myogenesis. Cells, 8.","DOI":"10.3390\/cells8040332"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/5584_2016_53","article-title":"Regulation of skeletal muscle myoblast differentiation and proliferation by pannexins","volume":"925","author":"Langlois","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Lee, E.J., Pokharel, S., Jan, A.T., Huh, S., Galope, R., Lim, J.H., Lee, D.M., Choi, S.W., Nahm, S.S., and Kim, Y.W. (2017). Transthyretin: A transporter protein essential for proliferation of myoblast in the myogenic program. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010115"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/0300985809352981","article-title":"Growth factors as active participants in carcinogenesis: A perspective","volume":"47","author":"Halper","year":"2010","journal-title":"Vet. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cytogfr.2016.11.004","article-title":"Post-transcriptional regulation of cytokine and growth factor signaling in cancer","volume":"33","author":"Bohjanen","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1016\/j.biomaterials.2010.04.053","article-title":"Toward delivery of multiple growth factors in tissue engineering","volume":"31","author":"Chen","year":"2010","journal-title":"Biomaterials"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000178867","article-title":"Tissue engineering for cutaneous wounds: Selecting the proper time and space for growth factors, cells and the extracellular matrix","volume":"22","author":"Macri","year":"2009","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: A review of current management and treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1096\/fj.201500133R","article-title":"Fibromodulin: A master regulator of myostatin controlling progression of satellite cells through a myogenic program","volume":"30","author":"Lee","year":"2016","journal-title":"FASEB J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2018.06.041","article-title":"Fibromodulin modulates myoblast differentiation by controlling calcium channel","volume":"503","author":"Lee","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1096\/fj.201700665R","article-title":"Fibromodulin and regulation of the intricate balance between myoblast differentiation to myocytes or adipocyte-like cells","volume":"32","author":"Lee","year":"2018","journal-title":"FASEB J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.lfs.2016.12.011","article-title":"Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program","volume":"172","author":"Ahmad","year":"2017","journal-title":"Life Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.jaad.2009.10.048","article-title":"Wound healing in the 21st century","volume":"63","author":"Schreml","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.12968\/jowc.2009.18.4.41607","article-title":"The resource impact of wounds on health-care providers in Europe","volume":"18","author":"Posnett","year":"2009","journal-title":"J. Wound Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clindermatol.2006.12.005","article-title":"Impaired wound healing","volume":"25","author":"Menke","year":"2007","journal-title":"Clin. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1016\/S0002-9610(98)00186-X","article-title":"The future of recombinant growth factors in wound healing","volume":"176","author":"Robson","year":"1998","journal-title":"Am. J. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Park, J.W., Hwang, S.R., and Yoon, I.S. (2017). Advanced growth factor delivery systems in wound management and skin regeneration. Molecules, 22.","DOI":"10.3390\/molecules22081259"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.peptides.2007.08.010","article-title":"Heparin-mimetic sulfated peptides with modulated affinities for heparin-binding peptides and growth factors","volume":"28","author":"Kim","year":"2007","journal-title":"Peptides"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0142-9612(97)00050-1","article-title":"Polypeptide growth factors: Targeted delivery systems","volume":"18","author":"Nimni","year":"1997","journal-title":"Biomaterials"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1359-6446(03)02623-0","article-title":"Peptide and protein drug delivery to and into tumors: Challenges and solutions","volume":"8","author":"Torchilin","year":"2003","journal-title":"Drug Discov. Today"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1172\/JCI115607","article-title":"Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries","volume":"89","author":"Edelman","year":"1992","journal-title":"J. Clin. Invest."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jcp.1041280317","article-title":"Heparin protects basic and acidic FGF from inactivation","volume":"128","author":"Gospodarowicz","year":"1986","journal-title":"J. Cell. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1016\/S0021-9258(17)41730-3","article-title":"Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding","volume":"269","author":"Roghani","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jconrel.2005.02.013","article-title":"Controlled release from fibers of polyelectrolyte complexes","volume":"104","author":"Liao","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-4886(03)00258-9","article-title":"Controlled release of nerve growth factor enhances sciatic nerve regeneration","volume":"184","author":"Lee","year":"2003","journal-title":"Exp. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-981-13-1435-3_9","article-title":"Hormones and muscle atrophy","volume":"1088","author":"Martin","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJM199702273360907","article-title":"Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors","volume":"336","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/bcr50","article-title":"Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer","volume":"2","author":"Zhang","year":"2000","journal-title":"Breast Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/edrv-10-1-68","article-title":"Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations","volume":"10","author":"Daughaday","year":"1989","journal-title":"Endocr. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","article-title":"Role of insulin-like growth factors in embryonic and postnatal growth","volume":"75","author":"Baker","year":"1993","journal-title":"Cell"},{"key":"ref_33","first-page":"3604","article-title":"Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts","volume":"14","author":"Sell","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fendo.2019.00027","article-title":"ROLE of IGF-1 system in the modulation of longevity: Controversies and new insights from a centenarians\u2019 perspective","volume":"10","author":"Vitale","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tem.2013.03.004","article-title":"The therapeutic potential of IGF-I in skeletal muscle repair","volume":"24","author":"Song","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1002\/stem.2045","article-title":"Pro-insulin-like growth factor-ii ameliorates age-related inefficient regenerative response by orchestrating self-reinforcement mechanism of muscle regeneration","volume":"33","author":"Uezumi","year":"2015","journal-title":"Stem Cells"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.bbagrm.2016.03.014","article-title":"MIR retroposon exonization promotes evolutionary variability and generates species-specific expression of IGF-1 splice variants","volume":"1859","author":"Annibalini","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1210\/en.2010-1279","article-title":"Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation","volume":"152","author":"Matheny","year":"2011","journal-title":"Endocrinology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jcp.20107","article-title":"Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle","volume":"202","author":"Cheema","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Sandona, D., Desaphy, J.F., Camerino, G.M., Bianchini, E., Ciciliot, S., Danieli-Betto, D., Dobrowolny, G., Furlan, S., Germinario, E., and Goto, K. (2012). Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033232"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"T187","DOI":"10.1530\/JME-18-0076","article-title":"40 YEARS of IGF1: Understanding the tissue-specific roles of IGF1\/IGF1R in regulating metabolism using the Cre\/loxP system","volume":"61","author":"Kineman","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13402-015-0263-3","article-title":"Human IGF1 pro-forms induce breast cancer cell proliferation via the IGF1 receptor","volume":"39","author":"Annibalini","year":"2016","journal-title":"Cell. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1210\/er.2009-0010","article-title":"The role of liver-derived insulin-like growth factor-I","volume":"30","author":"Ohlsson","year":"2009","journal-title":"Endocr. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wan, X., Wang, S., Xu, J., Zhuang, L., Xing, K., Zhang, M., Zhu, X., Wang, L., Gao, P., and Xi, Q. (2017). Dietary protein-induced hepatic IGF-1 secretion mediated by PPARgamma activation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173174"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000342577","article-title":"Insulin-like growth factors, nutrition and growth","volume":"106","author":"Savage","year":"2013","journal-title":"World Rev. Nutr. Diet."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1096\/fj.201700442R","article-title":"AMPK in skeletal muscle function and metabolism","volume":"32","author":"Kjobsted","year":"2018","journal-title":"FASEB J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e12954","DOI":"10.1111\/acel.12954","article-title":"Effects of IGF-1 isoforms on muscle growth and sarcopenia","volume":"18","author":"Ascenzi","year":"2019","journal-title":"Aging Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/er.2001-0033","article-title":"Cellular actions of the insulin-like growth factor binding proteins","volume":"23","author":"Firth","year":"2002","journal-title":"Endocr. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/17425255.4.3.311","article-title":"Mecasermin rinfabate: rhIGF-I\/rhIGFBP-3 complex: iPLEX","volume":"4","author":"Williams","year":"2008","journal-title":"Expert Opin. Drug. Metab. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/cbin.10466","article-title":"Insulin-like growth factor-1 (IGF-1) promotes myoblast proliferation and skeletal muscle growth of embryonic chickens via the PI3K\/Akt signalling pathway","volume":"39","author":"Yu","year":"2015","journal-title":"Cell Biol. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tem.2009.04.002","article-title":"Role of IGF-I in skeletal muscle mass maintenance","volume":"20","author":"Clemmons","year":"2009","journal-title":"Trends Endocrino.l Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ghir.2011.03.001","article-title":"Circulating IGF-I is associated with fitness and health outcomes in a population of 846 young healthy men","volume":"21","author":"Nindl","year":"2011","journal-title":"Growth Horm. IGF Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"38969","DOI":"10.1074\/jbc.M110.160986","article-title":"Long range interactions regulate Igf2 gene transcription during skeletal muscle differentiation","volume":"285","author":"Alzhanov","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1210\/me.2010-0292","article-title":"TGF-beta inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II","volume":"25","author":"Gardner","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/mp.54.5.311","article-title":"Insulin-like growth factor 1 (IGF-1): A growth hormone","volume":"54","author":"Laron","year":"2001","journal-title":"Mol. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Hamilton, D.L., Philp, A., MacKenzie, M.G., and Baar, K. (2010). A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011624"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Fu, S., Yin, L., Lin, X., Lu, J., and Wang, X. (2018). Effects of cyclic mechanical stretch on the proliferation of L6 myoblasts and its mechanisms: PI3K\/Akt and MAPK signal pathways regulated by IGF-1 receptor. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061649"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10522-013-9432-9","article-title":"Signalling pathways regulating muscle mass in ageing skeletal muscle: The role of the IGF1-Akt-mTOR-FoxO pathway","volume":"14","author":"Sandri","year":"2013","journal-title":"Biogerontology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mce.2011.06.004","article-title":"Amphioxus IGF-like peptide induces mouse muscle cell development via binding to IGF receptors and activating MAPK and PI3K\/Akt signaling pathways","volume":"343","author":"Liu","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gad.1089403","article-title":"Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2","volume":"17","author":"Peng","year":"2003","journal-title":"Genes Dev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1073\/pnas.0903875106","article-title":"Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors","volume":"107","author":"Borselli","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-201x.1999.00618.x","article-title":"Contribution of satellite cells to IGF-I induced hypertrophy of skeletal muscle","volume":"167","author":"Shoturma","year":"1999","journal-title":"Acta Physiol. Scand."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1210\/endo-124-2-820","article-title":"Induction of insulin-like growth factor I messenger ribonucleic acid during regeneration of rat skeletal muscle","volume":"124","author":"Edwall","year":"1989","journal-title":"Endocrinology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF00123364","article-title":"Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch","volume":"17","author":"Yang","year":"1996","journal-title":"J. Muscle Res. Cell Motil."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1530\/JOE-17-0032","article-title":"IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice","volume":"234","author":"Hennebry","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"E1036","DOI":"10.1152\/ajpendo.00001.2019","article-title":"Myostatin regulates pituitary development and hepatic IGF1","volume":"316","author":"Czaja","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"E557","DOI":"10.1152\/ajpendo.00098.2015","article-title":"Role of IGF-I in follistatin-induced skeletal muscle hypertrophy","volume":"309","author":"Barbe","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_68","first-page":"59","article-title":"Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)","volume":"75","author":"Liu","year":"1993","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.febslet.2010.04.039","article-title":"Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice","volume":"584","author":"Lipina","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"C1124","DOI":"10.1152\/ajpcell.00043.2009","article-title":"Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt","volume":"297","author":"Morissette","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways","volume":"3","author":"Rommel","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12098-017-2397-y","article-title":"Duchenne muscular dystrophy: A practice update","volume":"85","author":"Suthar","year":"2018","journal-title":"Indian J. Pediatr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fphar.2020.00142","article-title":"Cross-talk between extracellular matrix and skeletal muscle: Implications for myopathies","volume":"11","author":"Ahmad","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_74","first-page":"115","article-title":"The biological function of insulin-like growth factor-I in myogenesis and its therapeutic effect on muscular dystrophy","volume":"24","author":"Noguchi","year":"2005","journal-title":"Acta Myol."},{"key":"ref_75","first-page":"230","article-title":"Molecular mechanisms involving IGF-1 and myostatin to induce muscle hypertrophy as a therapeutic strategy for Duchenne muscular dystrophy","volume":"24","author":"Patel","year":"2005","journal-title":"Acta Myol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00207454.2020.1730367","article-title":"Synergistic effect of glucocorticoids and IGF-1 on myogenic differentiation through the Akt\/GSK-3beta pathway in C2C12 myoblasts","volume":"130","author":"Fang","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0960-8966(00)00192-9","article-title":"IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice","volume":"11","author":"Lynch","year":"2001","journal-title":"Neuromuscul. Disord."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/978-981-13-1435-3_29","article-title":"Muscle Atrophy: Present and Future","volume":"1088","author":"Cao","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/00913847.2018.1406778","article-title":"The role of hormones in muscle hypertrophy","volume":"46","author":"Fink","year":"2018","journal-title":"Phys. Sportsmed."},{"key":"ref_80","first-page":"4624","article-title":"IGF-1\/GH axis enhances losartan treatment in Lama2-related muscular dystrophy","volume":"25","author":"Accorsi","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1536012117736648","article-title":"Molecular Imaging of IGF-1R in Cancer","volume":"16","author":"Sun","year":"2017","journal-title":"Mol. Imaging"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2015.00025","article-title":"IGF-Binding Protein 2\u2014Oncogene or Tumor Suppressor?","volume":"6","author":"Pickard","year":"2015","journal-title":"Front. Endocrinol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s13277-015-4561-1","article-title":"IGF-binding protein 2 is a candidate target of therapeutic potential in cancer","volume":"37","author":"Yao","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_84","first-page":"695","article-title":"Cancer invasion and angiogenesis by IGF-1-induced MMP-2 and VEGF in human Breast cancer cells","volume":"46","author":"Thant","year":"2005","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2017.12.003","article-title":"Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy","volume":"56","author":"Baig","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mrrev.2016.09.005","article-title":"Clinical studies in humans targeting the various components of the IGF system show lack of efficacy in the treatment of cancer","volume":"772","author":"Philippou","year":"2017","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1210\/jc.2009-1378","article-title":"Insulin-like growth factor-I and cancer mortality in older men","volume":"95","author":"Major","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Ahmad, S.S., Khan, H., Danish Rizvi, S.M., Ansari, S.A., Ullah, R., Rastrelli, L., Mahmood, H.M., and Siddiqui, M.H. (2019). Computational study of natural compounds for the clearance of amyloid-betaeta: A potential therapeutic management strategy for alzheimer\u2019s disease. Molecules, 24.","DOI":"10.3390\/molecules24183233"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2174\/0929866526666190405125334","article-title":"Current updates on the regulation of beta-secretase movement as a potential restorative focus for management of alzheimer\u2019s disease","volume":"26","author":"Ahmad","year":"2019","journal-title":"Protein Pept. Lett."},{"key":"ref_90","first-page":"445","article-title":"Update on diagnostics and therapy of idiopathic Parkinson\u2019s disease","volume":"87","author":"Waldthaler","year":"2019","journal-title":"Fortschr. Neurol. Psychiatr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2174\/1389200221666200103092719","article-title":"Therapeutic study of phytochemicals against cancer and alzheimer\u2019s disease management","volume":"20","author":"Ahmad","year":"2019","journal-title":"Curr. Drug Metab."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev-neuro-071714-033828","article-title":"Neurodegenerative diseases: Expanding the prion concept","volume":"38","author":"Walker","year":"2015","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e1259709","DOI":"10.1080\/23262133.2016.1259709","article-title":"Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging","volume":"4","author":"Morel","year":"2017","journal-title":"Neurogenesis"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1210\/jc.2009-2450","article-title":"Off-label use of recombinant igf-I to promote growth: Is it appropriate?","volume":"95","author":"Rosenbloom","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Bianchi, V.E., Locatelli, V., and Rizzi, L. (2017). Neurotrophic and neuroregenerative effects of GH\/IGF1. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112441"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"119591","DOI":"10.1016\/j.biomaterials.2019.119591","article-title":"Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing","volume":"233","author":"Park","year":"2020","journal-title":"Biomaterials"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1161\/ATVBAHA.118.311134","article-title":"SM22alpha (Smooth Muscle protein 22-alpha) promoter-driven IGF1R (Insulin-like Growth Factor 1 Receptor) deficiency promotes atherosclerosis","volume":"38","author":"Sukhanov","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"045015","DOI":"10.1088\/1748-605X\/ab229d","article-title":"In vitro evaluation of functionalized decellularized muscle scaffold for in situ skeletal muscle regeneration","volume":"14","author":"Shapiro","year":"2019","journal-title":"Biomed. Mater."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Manzella, L., Massimino, M., Stella, S., Tirro, E., Pennisi, M.S., Martorana, F., Motta, G., Vitale, S.R., Puma, A., and Romano, C. (2019). Activation of the IGF axis in thyroid cancer: Implications for tumorigenesis and treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133258"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.23736\/S0391-1977.17.02733-X","article-title":"Acromegaly and bone","volume":"43","author":"Maffezzoni","year":"2018","journal-title":"Minerva Endocrinol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/EJE-18-0076","article-title":"The relationship between serum IGF-1, handgrip strength, physical performance and falls in elderly men and women","volume":"179","author":"Vlot","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.metabol.2016.05.018","article-title":"Role of metabolism in neurodegenerative disorders","volume":"65","author":"Procaccini","year":"2016","journal-title":"Metabolism"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.euroneuro.2014.12.013","article-title":"IGF-I in major depression and antidepressant treatment response","volume":"25","author":"Kopczak","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_104","first-page":"D504","article-title":"SIGNOR 2.0, the SIGnaling network open resource 2.0: 2019 update","volume":"48","author":"Licata","year":"2020","journal-title":"Nucleic Acid. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acid. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"a008342","DOI":"10.1101\/cshperspect.a008342","article-title":"Building muscle: Molecular regulation of myogenesis","volume":"4","author":"Bentzinger","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.semcdb.2015.09.017","article-title":"PAX3 and PAX7 as upstream regulators of myogenesis","volume":"44","author":"Buckingham","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Forcina, L., Miano, C., Scicchitano, B.M., and Musaro, A. (2019). Signals from the niche: Insights into the role of IGF-1 and IL-6 in modulating skeletal muscle fibrosis. Cells, 8.","DOI":"10.3390\/cells8030232"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fendo.2018.00499","article-title":"Insulin-like growth factor binding proteins in autoimmune diseases","volume":"9","author":"Ding","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1677\/joe.0.1700063","article-title":"The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: An important but forgotten component of the circulating IGF system","volume":"170","author":"Boisclair","year":"2001","journal-title":"J. Endocrinol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1002\/jcp.22672","article-title":"CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway","volume":"226","author":"Tzeng","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-540-79088-4_8","article-title":"Growth hormone","volume":"195","author":"Bidlingmaier","year":"2010","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jsams.2018.02.011","article-title":"Musculoskeletal training injury prevention in the U.S. Army: Evolution of the science and the public health approach","volume":"21","author":"Jones","year":"2018","journal-title":"J. Sci. Med. Sport"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ghir.2013.03.002","article-title":"Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury","volume":"23","author":"Martins","year":"2013","journal-title":"Growth Horm. IGF Res."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/8\/1773\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:51:30Z","timestamp":1760176290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/8\/1773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":114,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["cells9081773"],"URL":"https:\/\/doi.org\/10.3390\/cells9081773","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]}}}