{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:38:38Z","timestamp":1790361518232,"version":"4.1.0"},"reference-count":103,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The growing incidence of cardiovascular disease (CVD) has promoted investigations of natural molecules that could prevent and treat CVD. Among these, hydroxytyrosol, a polyphenolic compound of olive oil, is well known for its antioxidant, anti-inflammatory, and anti-atherogenic effects. Its strong antioxidant properties are due to the scavenging of radicals and the stimulation of synthesis and activity of antioxidant enzymes (SOD, CAT, HO-1, NOS, COX-2, GSH), which also limit the lipid peroxidation of low-density lipoprotein (LDL) cholesterol, a hallmark of atherosclerosis. Lowered inflammation and oxidative stress and an improved lipid profile were also demonstrated in healthy subjects as well as in metabolic syndrome patients after hydroxytyrosol (HT) supplementation. These results might open a new therapeutic scenario through personalized supplementation of HT in CVDs. This review is the first attempt to collect together scientific literature on HT in both in vitro and in vivo models, as well as in human clinical studies, describing its potential biological effects for cardiovascular health.<\/jats:p>","DOI":"10.3390\/cells9091932","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T09:21:51Z","timestamp":1598001711000},"page":"1932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-0706","authenticated-orcid":false,"given":"Chiara","family":"D\u2019Angelo","sequence":"first","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti- Pescara, Via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-6520","authenticated-orcid":false,"given":"Sara","family":"Franceschelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti- Pescara, Via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-9086","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Quiles","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d Biomedical Research Center, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Speranza","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti- Pescara, Via dei Vestini 31, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.nut.2011.11.028","article-title":"Novel phytonutrient contributors to antioxidant protection against cardiovascular disease","volume":"28","author":"Riccioni","year":"2012","journal-title":"Nutrition"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24412","DOI":"10.3390\/ijms141224412","article-title":"Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease","volume":"14","author":"Franceschelli","year":"2013","journal-title":"Int. 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