{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:37:37Z","timestamp":1790411857807,"version":"4.1.0"},"reference-count":145,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Aggregation and deposition of \u03b2-amyloid and\/or tau protein are the key neuropathological features in neurodegenerative disorders such as Alzheimer\u2019s disease (AD) and other tauopathies including frontotemporal dementia (FTD). The interaction between oxidative stress, mitochondrial dysfunction and the impairment of calcium ions (Ca2+) homeostasis induced by misfolded tau and \u03b2-amyloid plays an important role in the progressive neuronal loss occurring in specific areas of the brain. In addition to the control of bioenergetics and ROS production, mitochondria are fine regulators of the cytosolic Ca2+ homeostasis that induce vital signalling mechanisms in excitable cells such as neurons. Impairment in the mitochondrial Ca2+ uptake through the mitochondrial Ca2+ uniporter (MCU) or release through the Na+\/Ca2+ exchanger may lead to mitochondrial Ca2+ overload and opening of the permeability transition pore inducing neuronal death. Recent evidence suggests an important role for these mechanisms as the underlying causes for neuronal death in \u03b2-amyloid and tau pathology. The present review will focus on the mechanisms that lead to cytosolic and especially mitochondrial Ca2+ disturbances occurring in AD and tau-induced FTD, and propose possible therapeutic interventions for these disorders.<\/jats:p>","DOI":"10.3390\/cells9092135","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T21:01:21Z","timestamp":1600722081000},"page":"2135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology"],"prefix":"10.3390","volume":"9","author":[{"given":"Noemi","family":"Esteras","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7646-7235","authenticated-orcid":false,"given":"Andrey Y.","family":"Abramov","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(13)70090-5","article-title":"Tau pathology and neurodegeneration","volume":"12","author":"Spillantini","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/jb\/mvz012","article-title":"Calcium signalling: A key regulator of neuronal migration","volume":"165","author":"Horigane","year":"2019","journal-title":"J. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/iub.91","article-title":"Calcium ions in neuronal degeneration","volume":"60","author":"Wojda","year":"2008","journal-title":"Iubmb Life"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association Calcium Hypothesis Workgroup, and Khachaturian, Z.S. (2017). Calcium Hypothesis of Alzheimer\u2019s disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis. Alzheimer\u2019s Dement., 13, 178\u2013182.","DOI":"10.1016\/j.jalz.2016.12.006"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"NS20180061","DOI":"10.1042\/NS20180061","article-title":"Mitochondrial calcium signalling and neurodegenerative diseases","volume":"2","author":"Britti","year":"2018","journal-title":"Neuronal Signal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.phrs.2015.05.007","article-title":"Mitochondrial Ca2+ in neurodegenerative disorders","volume":"99","author":"Abeti","year":"2015","journal-title":"Pharm. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neulet.2017.08.044","article-title":"Mitochondrial calcium imbalance in Parkinson\u2019s disease","volume":"663","author":"Ludtmann","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ceca.2018.12.007","article-title":"Spatiotemporal pattern of calcium activity in astrocytic network","volume":"78","author":"Semyanov","year":"2019","journal-title":"Cell Calcium"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","article-title":"Natural Oligomers of the Alzheimer Amyloid- Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway","volume":"27","author":"Shankar","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2015.01.137","article-title":"Calcium and mitochondria in the regulation of cell death","volume":"460","author":"Orrenius","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/s41418-020-0542-z","article-title":"Alpha synuclein aggregation drives ferroptosis: An interplay of iron, calcium and lipid peroxidation","volume":"27","author":"Angelova","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuron.2014.03.016","article-title":"Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction","volume":"82","author":"Simms","year":"2014","journal-title":"Neuron"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuron.2018.05.018","article-title":"Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert","volume":"98","author":"Reiner","year":"2018","journal-title":"Neuron"},{"key":"ref_14","first-page":"693","article-title":"Endoplasmic reticulum calcium signaling in nerve cells","volume":"37","author":"Verkhratsky","year":"2004","journal-title":"Boil. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Karagas, N.E., and Venkatachalam, K. (2019). Roles for the Endoplasmic Reticulum in Regulation of Neuronal Calcium Homeostasis. Cells, 8.","DOI":"10.3390\/cells8101232"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature05122","article-title":"Orai1 is an essential pore subunit of the CRAC channel","volume":"443","author":"Prakriya","year":"2006","journal-title":"Nat."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"L\u00f3pez, J.J., Jardin, I., S\u00e1nchez-Collado, J., Salido, G.M., Smani, T., and Rosado, J.A. (2020). TRPC Channels in the SOCE Scenario. Cells, 9.","DOI":"10.3390\/cells9010126"},{"key":"ref_18","first-page":"a004168","article-title":"The Plasma Membrane Ca2+ ATPase and the Plasma Membrane Sodium Calcium Exchanger Cooperate in the Regulation of Cell Calcium","volume":"3","author":"Brini","year":"2010","journal-title":"Cold Spring Harb. Perspect. Boil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1152\/jn.00854.2012","article-title":"Transient reversal of the sodium\/calcium exchanger boosts presynaptic calcium and synaptic transmission at a cerebellar synapse","volume":"109","author":"Roome","year":"2013","journal-title":"J. Neurophysiol."},{"key":"ref_20","first-page":"a004051","article-title":"Cytosolic Ca2+ Buffers","volume":"2","author":"Schwaller","year":"2010","journal-title":"Cold Spring Harb. Perspect. Boil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2093","article-title":"Neuronal calcium sensor proteins: Generating diversity in neuronal Ca2+ signalling","volume":"8","author":"Burgoyne","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ceca.2018.09.002","article-title":"Calmodulin-binding proteins: A journey of 40 years","volume":"75","author":"Sharma","year":"2018","journal-title":"Cell Calcium"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Boil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1042\/BST20191042","article-title":"Cellular mechanisms of complex I-associated pathology","volume":"47","author":"Abramov","year":"2019","journal-title":"Biochem. Soc. Trans."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1042\/bst0210793","article-title":"The role of intramitochondrial Ca2+ in the regulation of oxidative phosphorylation in mammalian tissues","volume":"21","author":"McCormack","year":"1993","journal-title":"Biochem. Soc. Trans."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrm4039","article-title":"The molecular era of the mitochondrial calcium uniporter","volume":"16","author":"Kamer","year":"2015","journal-title":"Nat. Rev. Mol. Cell Boil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41418-018-0113-8","article-title":"MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake","volume":"26","author":"Patron","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41586-020-2309-6","article-title":"Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex","volume":"582","author":"Fan","year":"2020","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wu, W., Shen, Q., Zhang, R., Qiu, Z., Wang, Y., Zheng, J., and Jia, Z. (2020). The structure of the MICU 1- MICU 2 complex unveils the regulation of the mitochondrial calcium uniporter. Embo J., 10.","DOI":"10.15252\/embj.2019104285"},{"key":"ref_30","first-page":"1464","article-title":"The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter","volume":"15","author":"Pan","year":"2013","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yjmcc.2015.05.022","article-title":"Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter","volume":"85","author":"Holmstrom","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbrc.2014.04.144","article-title":"Unresolved questions from the analysis of mice lacking MCU expression","volume":"449","author":"Murphy","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1038\/ncomms10955","article-title":"MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration","volume":"7","author":"Antony","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1016\/j.celrep.2016.08.017","article-title":"Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila","volume":"16","author":"Drago","year":"2016","journal-title":"Cell Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15652","DOI":"10.1074\/jbc.RA118.002926","article-title":"Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria","volume":"293","author":"Hamilton","year":"2018","journal-title":"J. Boil. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10863-016-9676-6","article-title":"Mitochondrial Ca2+ uptake pathways","volume":"49","author":"Elustondo","year":"2016","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1016\/j.bbamcr.2015.04.008","article-title":"Structure and function of the mitochondrial calcium uniporter complex","volume":"1853","author":"Patron","year":"2015","journal-title":"Biochim. Et Biophys. Acta (Bba)"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0022-2828(74)90077-7","article-title":"The release of calcium from heart mitochondria by sodium","volume":"6","author":"Carafoli","year":"1974","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1073\/pnas.0908099107","article-title":"NCLX is an essential component of mitochondrial Na+\/Ca2+ exchange","volume":"107","author":"Palty","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12986","DOI":"10.1073\/pnas.1210718109","article-title":"Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes","volume":"109","author":"Drago","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature22082","article-title":"The mitochondrial Na+\/Ca2+ exchanger is essential for Ca2+ homeostasis and viability","volume":"545","author":"Luongo","year":"2017","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molcel.2009.02.013","article-title":"PINK1-Associated Parkinson\u2019s Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death","volume":"33","author":"Gandhi","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.celrep.2015.08.079","article-title":"PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons","volume":"13","author":"Ludtmann","year":"2015","journal-title":"Cell Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2019.01.009","article-title":"Functional properties and mode of regulation of the mitochondrial Na+\/Ca2+ exchanger, NCLX","volume":"94","author":"Kostic","year":"2019","journal-title":"Semin. Cell Dev. Boil."},{"key":"ref_45","first-page":"241","article-title":"The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson\u2019s Disease","volume":"961","author":"Deas","year":"2012","journal-title":"Neurotransm. Interact. Cogn. Funct."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.phrs.2007.10.005","article-title":"Mitochondrial localization of Na+\/Ca2+ exchangers NCX1\u20133 in neurons and astrocytes of adult rat brain in situ","volume":"56","author":"Gobbi","year":"2007","journal-title":"Pharm. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/cdd.2014.32","article-title":"Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection","volume":"21","author":"Sisalli","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1021\/bi2018909","article-title":"Role of Mitochondrial Ca2+in the Regulation of Cellular Energetics","volume":"51","author":"Glancy","year":"2012","journal-title":"Biochemistry"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"13957","DOI":"10.1523\/JNEUROSCI.0929-13.2013","article-title":"Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR\/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons","volume":"33","author":"Rueda","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tips.2018.11.004","article-title":"Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets","volume":"40","author":"Briston","year":"2019","journal-title":"Trends Pharm. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of mitochondrial ROS in the brain: From physiology to neurodegeneration","volume":"592","author":"Angelova","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Abramov, A.Y., Potapova, E., Dremin, V., and Dunaev, A.V. (2020). Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration. Life, 10.","DOI":"10.3390\/life10070101"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Angelova, P.R., Esteras, N., and Abramov, A.Y. (2020). Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention. Med. Res. Rev.","DOI":"10.1002\/med.21712"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer\u2019s disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2016.09.053","article-title":"Dysregulation of neuronal calcium homeostasis in Alzheimer\u2019s disease - A therapeutic opportunity?","volume":"483","author":"Popugaeva","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.bbrc.2016.07.103","article-title":"Alpha-synuclein and beta-amyloid \u2013 different targets, same players: Calcium, free radicals and mitochondria in the mechanism of neurodegeneration","volume":"483","author":"Angelova","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(96)01030-2","article-title":"Amyloid, the presenilins and Alzheimer\u2019s disease","volume":"20","author":"Hardy","year":"1997","journal-title":"Trends Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"101644","DOI":"10.1016\/j.pneurobio.2019.101644","article-title":"Four-repeat tauopathies","volume":"180","author":"Marvian","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/jnc.13588","article-title":"Molecular neuropathology of frontotemporal dementia: Insights into disease mechanisms from postmortem studies","volume":"138","author":"MacKenzie","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1994.tb44398.x","article-title":"Calcium Hypothesis of Alzheimer\u2019s Disease and Brain Aginga","volume":"747","author":"Khachaturian","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"10573","DOI":"10.1073\/pnas.90.22.10573","article-title":"Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes","volume":"90","author":"Arispe","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1523\/JNEUROSCI.23-12-05088.2003","article-title":"Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity","volume":"23","author":"Abramov","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbamcr.2004.09.006","article-title":"Calcium signals induced by amyloid \u03b2 peptide and their consequences in neurons and astrocytes in culture","volume":"1742","author":"Abramov","year":"2004","journal-title":"Biochim. Biophys. Acta (BBA)"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1021\/acs.biochem.5b00988","article-title":"Ion Channel Formation by Tau Protein: Implications for Alzheimer\u2019s Disease and Tauopathies","volume":"54","author":"Patel","year":"2015","journal-title":"Biochemistry"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Esteras, N., Kundel, F., Amodeo, G.F., Pavlov, E.V., Klenerman, D., and Abramov, A.Y. (2020). Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase. FEBS J.","DOI":"10.1111\/febs.15340"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/387500a0","article-title":"Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein","volume":"387","author":"Nalbantoglu","year":"1997","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nn1503","article-title":"Regulation of NMDA receptor trafficking by amyloid-\u03b2","volume":"8","author":"Snyder","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_72","first-page":"469","article-title":"Chronic Glutamate Toxicity in Neurodegenerative Diseases\u2014What is the Evidence?","volume":"9","author":"Lewerenz","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ceca.2011.02.001","article-title":"Amyloid \u03b2 peptide oligomers directly activate NMDA receptors","volume":"49","author":"Alberdi","year":"2011","journal-title":"Cell Calcium"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ceca.2011.11.008","article-title":"Amyloid beta peptide 1\u201342 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures","volume":"51","author":"Ferreira","year":"2012","journal-title":"Cell Calcium"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuropharm.2018.07.021","article-title":"The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (A\u03b2) species on long-term potentiation (LTP)","volume":"140","author":"Rammes","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo","volume":"27","author":"Liu","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3233\/JAD-161186","article-title":"Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-\u03b2-Induced Neurotoxicity","volume":"57","author":"Huang","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13024-017-0176-x","article-title":"Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture","volume":"12","author":"Miyamoto","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Monteiro-Fernandes, D., Silva, J., Soares-Cunha, C., Dalla, C., Kokras, N., Arnaud, F., Billiras, R., Zhuravleva, V., Waites, C., and Bretin, S. (2020). Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and A\u03b2-evoked hippocampal pathology. Mol. Psychiatry, 1\u201313.","DOI":"10.1038\/s41380-020-0794-5"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic Function of Tau Mediates Amyloid-\u03b2 Toxicity in Alzheimer\u2019s Disease Mouse Models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"552","DOI":"10.15252\/embr.201541439","article-title":"The Tau\/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR 2B receptor-mediated excitotoxicity","volume":"17","author":"Decker","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3233\/JAD-160763","article-title":"Role of Glutamate and NMDA Receptors in Alzheimer\u2019s Disease","volume":"57","author":"Wang","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fneur.2013.00074","article-title":"The Involvement of Cholinergic Neurons in the Spreading of Tau Pathology","volume":"4","author":"Simon","year":"2013","journal-title":"Front. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.biocel.2013.01.011","article-title":"Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity","volume":"45","author":"Kamynina","year":"2013","journal-title":"Int. J. Biochem. Cell Boil."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1523\/JNEUROSCI.0617-19.2019","article-title":"Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction","volume":"39","author":"Ishii","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1471-4159.2003.02020.x","article-title":"Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation","volume":"87","author":"Furukawa","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Lawlor, B., Segurado, R., Kennelly, S., Rikkert, M.O., Howard, R.J., Pasquier, F., B\u00f6rjesson-Hanson, A., Tsolaki, M., Lucca, U., and Molloy, D.W. (2018). Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial. PLoS Med., 15.","DOI":"10.1371\/journal.pmed.1002660"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fneur.2020.00149","article-title":"The Influence of Baseline Alzheimer\u2019s Disease Severity on Cognitive Decline and CSF Biomarkers in the NILVAD Trial","volume":"11","author":"Abdullah","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1253\/circj.CJ-16-0692","article-title":"Calcium-Channel Blockers and Dementia Risk in Older Adults \u2013 National Health Insurance Service \u2013 Senior Cohort (2002\u20132013)","volume":"80","author":"Hwang","year":"2016","journal-title":"Circ. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3109\/10641963.2016.1174249","article-title":"Amlodipine treatment of hypertension associates with a decreased dementia risk","volume":"38","author":"Feldman","year":"2016","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3233\/JAD-190362","article-title":"The Relationship Between the Use of Antihypertensive Drugs and the Incidence of Dementia in General Practices in Germany","volume":"70","author":"Bohlken","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1196\/annals.1379.025","article-title":"Enhanced Ryanodine-Mediated Calcium Release in Mutant PS1-Expressing Alzheimer\u2019s Mouse Models","volume":"1097","author":"Stutzmann","year":"2007","journal-title":"Ann. New York Acad. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1089\/ars.2010.3287","article-title":"Amyloid \u03b2-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF","volume":"14","author":"Adasme","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1523\/JNEUROSCI.4367-12.2013","article-title":"Cytotoxicity of intracellular a\u03b242 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate","volume":"33","author":"DeMuro","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2008.04.015","article-title":"Mechanism of Ca2+ Disruption in Alzheimer\u2019s Disease by Presenilin Regulation of InsP3 Receptor Channel Gating","volume":"58","author":"Cheung","year":"2008","journal-title":"Neuron"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.bbamcr.2008.11.008","article-title":"Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer\u2019s disease","volume":"1793","author":"Bojarski","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"ra89","DOI":"10.1126\/scisignal.aaf1371","article-title":"Familial Alzheimer\u2019s disease\u2013associated presenilin 1 mutants promote \u03b3-secretase cleavage of STIM1 to impair store-operated Ca2+entry","volume":"9","author":"Tong","year":"2016","journal-title":"Sci. Signal."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ye, J., Yin, Y., Yin, Y., Zhang, H., Wan, H., Wang, L., Zuo, Y., Gao, D., Li, M., and Li, J. (2020). Tau-induced upregulation of C\/EBP\u03b2-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging Cell, e13209.","DOI":"10.1111\/acel.13209"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neulet.2017.08.004","article-title":"Functional interplay between plasma membrane Ca 2+ -ATPase, amyloid \u03b2-peptide and tau","volume":"663","author":"Mata","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.bbadis.2012.02.013","article-title":"Calmodulin antagonizes amyloid-\u03b2 peptides-mediated inhibition of brain plasma membrane Ca2+-ATPase","volume":"1822","author":"Berrocal","year":"2012","journal-title":"Biochim. Et Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0306-4522(97)00053-5","article-title":"Alzheimer\u2019s amyloid-beta peptide inhibits sodium\/calcium exchange measured in rat and human brain plasma membrane vesicles","volume":"80","author":"Wu","year":"1997","journal-title":"Neuroscience"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"102190","DOI":"10.1016\/j.ceca.2020.102190","article-title":"The Na+\/Ca2+exchanger in Alzheimer\u2019s disease","volume":"87","author":"Pannaccione","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/acel.12148","article-title":"Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of A\u03b2 in Alzheimer\u2019s disease","volume":"13","author":"Atherton","year":"2013","journal-title":"Aging Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1196\/annals.1387.005","article-title":"Rapid downregulation of NCX and PMCA in hippocampal neurons following H2O2 oxidative stress","volume":"1099","author":"Kip","year":"2007","journal-title":"Ann. New York Acad. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2119\/molmed.2010.00220","article-title":"Calpain-Mediated Tau Cleavage: A Mechanism Leading to Neurodegeneration Shared by Multiple Tauopathies","volume":"17","author":"Ferreira","year":"2011","journal-title":"Mol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"27737","DOI":"10.1074\/jbc.M110.117960","article-title":"Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease","volume":"285","author":"Liang","year":"2010","journal-title":"J. Boil. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9222","DOI":"10.1523\/JNEUROSCI.1132-14.2014","article-title":"Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice","volume":"34","author":"Rao","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Reinecke, J.B., Devos, S.L., McGrath, J.P., Shepard, A.M., Goncharoff, D.K., Tait, D.N., Fleming, S.R., Vincent, M., and Steinhilb, M.L. (2011). Implicating Calpain in Tau-Mediated Toxicity In Vivo. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023865"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-142772","article-title":"Calmodulin Binding Proteins and Alzheimer\u2019s Disease","volume":"46","author":"Eshak","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/alzrt219","article-title":"Calmodulin levels in blood cells as a potential biomarker of Alzheimer\u2019s disease","volume":"5","author":"Esteras","year":"2013","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/hsz-2015-0295","article-title":"Nrf2 activation in the treatment of neurodegenerative diseases: A focus on its role in mitochondrial bioenergetics and function","volume":"397","author":"Esteras","year":"2016","journal-title":"Boil. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"13145","DOI":"10.1073\/pnas.0806192105","article-title":"The amyloid -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae","volume":"105","author":"Petersen","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1096\/fj.10-157230","article-title":"Mitochondrial \u03b3-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein","volume":"25","author":"Pavlov","year":"2010","journal-title":"FASEB J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1016\/j.bbadis.2018.07.011","article-title":"Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling","volume":"1864","author":"Cieri","year":"2018","journal-title":"Biochim. Et Biophys. Acta (Bba)"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3233\/JAD-2010-100120","article-title":"A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration","volume":"21","author":"Amadoro","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.bbabio.2008.04.017","article-title":"Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity","volume":"1777","author":"Abramov","year":"2008","journal-title":"Biochim. Biophys. Acta (BBA)"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1054\/ceca.2000.0170","article-title":"Mitochondria and Ca2+in cell physiology and pathophysiology","volume":"28","author":"Duchen","year":"2000","journal-title":"Cell Calcium"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1523\/JNEUROSCI.4042-03.2004","article-title":"\u03b2-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase","volume":"24","author":"Abramov","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/1577","article-title":"Glutamate-induced neuron death requires mitochondrial calcium uptake","volume":"1","author":"Stout","year":"1998","journal-title":"Nat. Neurosci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1523\/JNEUROSCI.0531-04.2004","article-title":"Excitotoxic Calcium Overload in a Subpopulation of Mitochondria Triggers Delayed Death in Hippocampal Neurons","volume":"24","author":"Pivovarova","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ncomms3034","article-title":"Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals","volume":"4","author":"Qiu","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1007\/s12035-018-1204-8","article-title":"Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity","volume":"56","author":"Angelova","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Sanz-Blasco, S., Valero, R.A., Rodr\u00edguez-Crespo, I., Villalobos, C., and Nu\u00f1ez, L. (2008). Mitochondrial Ca2+ Overload Underlies A\u03b2 Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002718"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2174\/1567205015666171227154016","article-title":"Is it All Said for NSAIDs in Alzheimer\u2019s Disease? Role of Mitochondrial Calcium Uptake","volume":"15","author":"Caballero","year":"2018","journal-title":"Curr. Alzheimer Res."},{"key":"ref_126","first-page":"1","article-title":"Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Hou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1038\/s41467-019-11813-6","article-title":"Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer\u2019s disease","volume":"10","author":"Jadiya","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molcel.2010.06.029","article-title":"Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface","volume":"39","author":"Roy","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3233\/JAD-160953","article-title":"Localization and Processing of the Amyloid-\u03b2 Protein Precursor in Mitochondria-Associated Membranes","volume":"55","author":"Suski","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1096\/fj.201601309","article-title":"On the Pathogenesis of Alzheimer\u2019s Disease: The MAM Hypothesis","volume":"31","author":"Schon","year":"2017","journal-title":"FASEB J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"7916","DOI":"10.1073\/pnas.1300677110","article-title":"Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer\u2019s disease and related models","volume":"110","author":"Hedskog","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1073\/pnas.1100735108","article-title":"Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk","volume":"108","author":"Zampese","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1474-9726.2012.00858.x","article-title":"Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin","volume":"11","author":"Kipanyula","year":"2012","journal-title":"Aging Cell"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cell.2006.06.059","article-title":"Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer\u2019s Disease-Linked Mutations","volume":"126","author":"Tu","year":"2006","journal-title":"Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1074\/jbc.M111.300491","article-title":"Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels","volume":"287","author":"Shilling","year":"2012","journal-title":"J. Boil. Chem."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1046\/j.1471-4159.2001.00112.x","article-title":"Neurotoxic A\u03b2 peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro","volume":"76","author":"Parks","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"18091","DOI":"10.1073\/pnas.0708959104","article-title":"Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death","volume":"104","author":"Abramov","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"102150","DOI":"10.1016\/j.ceca.2019.102150","article-title":"Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death","volume":"86","author":"Britti","year":"2020","journal-title":"Cell Calcium"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer\u2019s disease","volume":"14","author":"Du","year":"2008","journal-title":"Nat. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"jcs241687","DOI":"10.1242\/jcs.241687","article-title":"Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia","volume":"133","author":"Kopach","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.redox.2017.03.008","article-title":"Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration","volume":"12","author":"Esteras","year":"2017","journal-title":"Redox Boil."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/s41598-017-01678-4","article-title":"Pathogenic p62\/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates","volume":"7","author":"Bartolome","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_143","first-page":"120","article-title":"Deficiency of Parkinson\u2019s disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation","volume":"24","author":"Esteras","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0143-4160(02)00203-8","article-title":"Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells","volume":"33","author":"Abramov","year":"2003","journal-title":"Cell Calcium"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0143-4160(97)90062-2","article-title":"Ionophoretic properties of ferutinin","volume":"22","author":"Zamaraeva","year":"1997","journal-title":"Cell Calcium"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/9\/2135\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:12:08Z","timestamp":1760177528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/9\/2135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":145,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["cells9092135"],"URL":"https:\/\/doi.org\/10.3390\/cells9092135","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]}}}