{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:53:40Z","timestamp":1766516020348,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>We analyzed the influence of the neutrophil\/lymphocyte ratio (NLR) and platelet\/lymphocyte ratio (PLR) on the biochemical recurrence (BCR) in low-intermediate risk prostate cancer (PCa). A total of 604 patients treated with exclusive brachytherapy for low- and intermediate-risk cancers were included in this study. No patient received either androgen deprivation or brachytherapy as a boost. BCR was defined according to the Phoenix definition (nadir prostatic specific antigen (PSA) +2). The median follow-up was 60 months (IQR 44\u201348 months). An NLR &gt; 3 was more frequent in statin users (p = 0.025), but not in diabetics (p = 0.079). In univariate analysis (UVA) and multivariate analysis (MVA), a NLR &gt; 3 (MVA p = 0.03), as well as Cancer of the Prostate Risk Assessment (CAPRA) low- vs. intermediate-risk (MVA p = 0.04), were predictive of BCR. When combining the NLR score with the CAPRA risk group, CAPRA intermediate risk patients with an NLR \u2264 3 (n = 157) had the worst (p = 0.0276) BCR rates, with a 5-year recurrence-free survival (p = 0.004, Bonferroni correction for six comparisons p = 0.024). We were able to identify a subgroup of PCa patients with CAPRA intermediate-risk and an NLR \u2264 3 who had worse BCR. This is in contrast to most other cancers, which have a worse prognosis when the NLR is high.<\/jats:p>","DOI":"10.3390\/cells9102153","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T02:56:43Z","timestamp":1600916203000},"page":"2153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic Inflammatory Markers Are Predictive of the Response to Brachytherapy in the Prostate"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-3213","authenticated-orcid":false,"given":"Daniel","family":"Taussky","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC H2X 0C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Soulieres","sequence":"additional","affiliation":[{"name":"D\u00e9partement H\u00e9matologie-oncologie, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, QC H2X 0C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Chagnon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Math\u00e9matiques et de Statistique, Universit\u00e9 de Montr\u00e9al, Montreal, QC H2X 0C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guila","family":"Delouya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC H2X 0C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Bahig","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM), Montreal, QC H2X 0C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrc2090","article-title":"Inflammation in prostate carcinogenesis","volume":"7","author":"Platz","year":"2007","journal-title":"Nat. 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