{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:29:23Z","timestamp":1787318963107,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T00:00:00Z","timestamp":1601596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Departments of Excellence 2017 - legge 232\/2016 - art.1, commi 314\u2013337 awarded to Dept. of Science - University Roma Tre - Rome - Italy for 2018-2022"],"award-info":[{"award-number":["Departments of Excellence 2017 - legge 232\/2016 - art.1, commi 314\u2013337 awarded to Dept. of Science - University Roma Tre - Rome - Italy for 2018-2022"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs. In this study, we aimed at assessing the expression and the putative involvement of NGF signaling in skeletal muscle physiology. To reach this objective, we employed satellite cell-derived myoblasts as an in vitro culture model. In vivo experiments were performed on Tibialis anterior from wild-type mice and an mdx mouse model of Duchenne muscular dystrophy. Targets of interest were mainly assessed by means of morphological, Western blot and qRT-PCR analysis. The results show that proNGF is involved in myogenic differentiation. Importantly, the proNGF\/p75NTR pathway orchestrates a slow-to-fast fiber type transition by counteracting the expression of slow myosin heavy chain and that of oxidative markers. Concurrently, proNGF\/p75NTR activation facilitates the induction of fast myosin heavy chain and of fast\/glycolytic markers. Furthermore, we also provided evidence that the oxidative metabolism is impaired in mdx mice, and that these alterations are paralleled by a prominent buildup of proNGF and p75NTR. These findings underline that the proNGF\/p75NTR pathway may play a crucial role in fiber type determination and suggest its prospective modulation as an innovative therapeutic approach to counteract muscle disorders.<\/jats:p>","DOI":"10.3390\/cells9102232","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T09:39:25Z","timestamp":1601631565000},"page":"2232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["ProNGF\/p75NTR Axis Drives Fiber Type Specification by Inducing the Fast-Glycolytic Phenotype in Mouse Skeletal Muscle Cells"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-6168","authenticated-orcid":false,"given":"Valentina","family":"Pallottini","sequence":"first","affiliation":[{"name":"Department of Science, University of Rome \u201cRoma Tre\u201d, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Colardo","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise, 86090 Pesche (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9979-1142","authenticated-orcid":false,"given":"Claudia","family":"Tonini","sequence":"additional","affiliation":[{"name":"Department of Science, University of Rome \u201cRoma Tre\u201d, 00146 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-1494","authenticated-orcid":false,"given":"Noemi","family":"Martella","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise, 86090 Pesche (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6021-9704","authenticated-orcid":false,"given":"Georgios","family":"Strimpakos","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, National Research Council (CNR), 00015 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Colella","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise, 86090 Pesche (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-4424","authenticated-orcid":false,"given":"Paola","family":"Tirassa","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Cell Biology, National Research Council (CNR), 00015 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5748-1541","authenticated-orcid":false,"given":"Sabrina Di","family":"Bartolomeo","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise, 86090 Pesche (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-9470","authenticated-orcid":false,"given":"Marco","family":"Segatto","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Territory, University of Molise, 86090 Pesche (IS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201696","DOI":"10.1155\/2011\/201696","article-title":"The recent understanding of the neurotrophin\u2018s role in skeletal muscle adaptation","volume":"2011","author":"Sakuma","year":"2011","journal-title":"J. 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