{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:02:19Z","timestamp":1792231339793,"version":"4.4.0"},"reference-count":151,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nicolaus Copernicus University in Toru\u0144, Faculty of Medicine, Collegium Medicum in Bydgoszcz.","award":["The framework of statutory activities no. 163"],"award-info":[{"award-number":["The framework of statutory activities no. 163"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The actin cytoskeleton plays a crucial role in many cellular processes while its reorganization is important in maintaining cell homeostasis. However, in the case of cancer cells, actin and ABPs (actin-binding proteins) are involved in all stages of carcinogenesis. Literature has reported that ABPs such as SATB1 (special AT-rich binding protein 1), WASP (Wiskott-Aldrich syndrome protein), nesprin, and villin take part in the initial step of carcinogenesis by regulating oncogene expression. Additionally, changes in actin localization promote cell proliferation by inhibiting apoptosis (SATB1). In turn, migration and invasion of cancer cells are based on the formation of actin-rich protrusions (Arp2\/3 complex, filamin A, fascin, \u03b1-actinin, and cofilin). Importantly, more and more scientists suggest that microfilaments together with the associated proteins mediate tumor vascularization. Hence, the presented article aims to summarize literature reports in the context of the potential role of actin and ABPs in all steps of carcinogenesis.<\/jats:p>","DOI":"10.3390\/cells9102245","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T09:12:58Z","timestamp":1602061978000},"page":"2245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Involvement of Actin and Actin-Binding Proteins in Carcinogenesis"],"prefix":"10.3390","volume":"9","author":[{"given":"Magdalena","family":"Izdebska","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3065-0931","authenticated-orcid":false,"given":"Wioletta","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-0481","authenticated-orcid":false,"given":"Marta","family":"Ha\u0142as-Wi\u015bniewska","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Grzanka","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","article-title":"Actin, a central player in cell shape and movement","volume":"326","author":"Pollard","year":"2009","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ito, T., Taniguchi, H., Fukagai, K., Okamuro, S., and Kobayashi, A. (2015). Inhibitory Mechanism of FAT4 Gene Expression in Response to Actin Dynamics during Src-Induced Carcinogenesis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118336"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4578373","article-title":"The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets","volume":"2018","author":"Izdebska","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1152\/physrev.00026.2002","article-title":"Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments","volume":"83","author":"Chhabra","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1242\/jcs.01670","article-title":"Actin-binding proteins","volume":"118","author":"Winder","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/01913123.2010.548113","article-title":"Actin Cytoskeleton Reorganization Correlates with Cofilin Nuclear Expression and Ultrastructural Changes in CHO AA8 Cell Line after Apoptosis and Mitotic Catastrophe Induction by Doxorubicin","volume":"35","author":"Grzanka","year":"2011","journal-title":"Ultrastruct. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"a018267","DOI":"10.1101\/cshperspect.a018267","article-title":"The Actin Cytoskeleton and Actin-Based Motility","volume":"10","author":"Svitkina","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1083\/jcb.131.2.385","article-title":"Sequences, structural models, and cellular localization of the actin-related proteins Arp2 and Arp3 from Acanthamoeba","volume":"131","author":"Kelleher","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.biochem.70.1.649","article-title":"Regulation of actin filament network formation through ARP2\/3 complex: Activation by a diverse array of proteins","volume":"70","author":"Higgs","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.95.11.6181","article-title":"The interaction of Arp2\/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments","volume":"95","author":"Mullins","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E472","DOI":"10.1073\/pnas.1100236108","article-title":"Arp2\/3 complex is bound and activated by two WASP proteins","volume":"108","author":"Padrick","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0960-9822(01)00098-7","article-title":"Cortactin promotes and stabilizes Arp2\/3-induced actin filament network formation","volume":"11","author":"Weaver","year":"2001","journal-title":"Curr. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jtbi.2006.02.017","article-title":"Actin filament branching and protrusion velocity in a simple 1D model of a motile cell","volume":"242","author":"Dawes","year":"2006","journal-title":"J. Theor. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1083\/jcb.201112113","article-title":"The Arp2\/3 complex is required for lamellipodia extension and directional fibroblast cell migration","volume":"197","author":"Suraneni","year":"2012","journal-title":"J. Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nrm.2016.106","article-title":"Internetwork competition for monomers governs actin cytoskeleton organization","volume":"17","author":"Suarez","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.devcel.2015.12.024","article-title":"Profilin Interaction with Actin Filament Barbed End Controls Dynamic Instability, Capping, Branching, and Motility","volume":"36","author":"Pernier","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"E4596","DOI":"10.1073\/pnas.1412271111","article-title":"Structural basis of thymosin- 4\/profilin exchange leading to actin filament polymerization","volume":"111","author":"Xue","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e34176","DOI":"10.7554\/eLife.34176","article-title":"Modulation of formin processivity by profilin and mechanical tension","volume":"7","author":"Cao","year":"2018","journal-title":"eLife"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tibs.2016.03.004","article-title":"The WH2 Domain and Actin Nucleation: Necessary but Insufficient","volume":"41","author":"Dominguez","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.1021\/bi901354z","article-title":"Isoform-Selective Chemical Inhibition of mDia-Mediated Actin Assembly","volume":"48","author":"Gauvin","year":"2009","journal-title":"Biochemistry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1091\/mbc.e07-10-1086","article-title":"mDia2 Induces the Actin Scaffold for the Contractile Ring and Stabilizes Its Position during Cytokinesis in NIH 3T3 Cells","volume":"19","author":"Watanabe","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.devcel.2011.01.008","article-title":"Aurora B Regulates Formin mDia3 in Achieving Metaphase Chromosome Alignment","volume":"20","author":"Cheng","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4161\/cib.20214","article-title":"mDia1-3 in mammalian filopodia","volume":"5","author":"Goh","year":"2012","journal-title":"Commun. Integr. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1242\/jcs.083725","article-title":"Dynamic remodeling of the actin cytoskeleton by FMNL1\u03b3 is required for structural maintenance of the Golgi complex","volume":"124","author":"Gomez","year":"2011","journal-title":"J. Cell Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gardberg, M., Kaipio, K., Lehtinen, L., Mikkonen, P., Heuser, V.D., Talvinen, K., Iljin, K., Kampf, C., Uhlen, M., and Grenman, R. (2013). FHOD1, a Formin Upregulated in Epithelial-Mesenchymal Transition, Participates in Cancer Cell Migration and Invasion. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074923"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"a018226","DOI":"10.1101\/cshperspect.a018226","article-title":"Actin and Actin-Binding Proteins","volume":"8","author":"Pollard","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"E544","DOI":"10.1073\/pnas.1118880109","article-title":"Active maintenance of nuclear actin by importin 9 supports transcription","volume":"109","author":"Dopie","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1021\/acs.biochem.8b01001","article-title":"Quantitative Variations with pH of Actin Depolymerizing Factor\/Cofilin\u2019s Multiple Actions on Actin Filaments","volume":"58","author":"Wioland","year":"2018","journal-title":"Biochemistry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.molonc.2016.03.006","article-title":"Improving fascin inhibitors to block tumor cell migration and metastasis","volume":"10","author":"Han","year":"2016","journal-title":"Mol. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4161\/cam.5.5.17644","article-title":"The role of actin bundling proteins in the assembly of filopodia in epithelial cells","volume":"5","author":"Khurana","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1091\/mbc.e17-01-0059","article-title":"ADP-ribosylation factor\u2013like 4C binding to filamin-A modulates filopodium formation and cell migration","volume":"28","author":"Chiang","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1016\/j.cub.2016.07.080","article-title":"Fascin- and \u03b1-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting","volume":"26","author":"Winkelman","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1038\/ncomms8465","article-title":"Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization","volume":"6","author":"Huang","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhang, J.J., and Huang, X.-Y. (2020). Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers. Cancers, 12.","DOI":"10.3390\/cancers12082287"},{"key":"ref_35","unstructured":"US National Library of Medicine (2020, September 17). ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03199586."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1074\/jbc.M308878200","article-title":"Association of Villin with Phosphatidylinositol 4,5-Bisphosphate Regulates the Actin Cytoskeleton","volume":"279","author":"Kumar","year":"2003","journal-title":"J. Boil. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"35491","DOI":"10.1038\/srep35491","article-title":"Both the anti- and pro-apoptotic functions of villin regulate cell turnover and intestinal homeostasis","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.201003014","article-title":"VASP is a processive actin polymerase that requires monomeric actin for barbed end association","volume":"191","author":"Hansen","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-58591-3_1","article-title":"Rho family proteins and regulation of the actin cytoskeleton","volume":"22","author":"Ridley","year":"1999","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.biochem.77.060407.135452","article-title":"Physical mechanisms of signal integration by WASP family proteins","volume":"79","author":"Padrick","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"ref_41","first-page":"533","article-title":"Structure and control of the actin regulatory WAVE complex","volume":"468","author":"Chen","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.devcel.2007.08.011","article-title":"Cofilin Activity Downstream of Pak1 Regulates Cell Protrusion Efficiency by Organizing Lamellipodium and Lamella Actin Networks","volume":"13","author":"Delorme","year":"2007","journal-title":"Dev. Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4196\/kjpp.2012.16.3.159","article-title":"Pak1\/LIMK1\/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines","volume":"16","author":"Jang","year":"2012","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1365-2443.2007.01078.x","article-title":"Actin filaments-stabilizing and -bundling activities of cofilin-phosphatase Slingshot-1","volume":"12","author":"Kurita","year":"2007","journal-title":"Genes Cells"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4176","DOI":"10.1038\/sj.emboj.7600879","article-title":"The regulation of mDia1 by autoinhibition and its release by Rho\u2022GTP","volume":"24","author":"Lammers","year":"2005","journal-title":"EMBO J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1091\/mbc.12.4.780","article-title":"A Millennial Myosin Census","volume":"12","author":"Berg","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cub.2011.12.053","article-title":"Myosin IIIB Uses an Actin-Binding Motif in Its Espin-1 Cargo to Reach the Tips of Actin Protrusions","volume":"22","author":"Merritt","year":"2012","journal-title":"Curr. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-10964-w","article-title":"Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion","volume":"10","author":"Alieva","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1182\/blood-2016-04-711630","article-title":"Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes","volume":"128","author":"Roy","year":"2016","journal-title":"Blood"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1242\/jcs.099754","article-title":"Nuclear actin and myosins at a glance","volume":"125","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/cdd.2012.28","article-title":"Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells","volume":"19","author":"Wang","year":"2012","journal-title":"Cell Death Differ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/15548627.2018.1564417","article-title":"Regulation of JMY\u2019s actin nucleation activity by TTC5\/STRAP and LC3 during autophagy","volume":"15","author":"Liu","year":"2019","journal-title":"Autophagy"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e02786","DOI":"10.7554\/eLife.02786","article-title":"G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion","volume":"3","author":"Purvanov","year":"2014","journal-title":"eLife"},{"key":"ref_54","first-page":"1","article-title":"TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis","volume":"39","author":"Wang","year":"2019","journal-title":"Cancer Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.canlet.2019.01.042","article-title":"Hypoxia induces actin cytoskeleton remodeling by regulating the binding of CAPZA1 to F-actin via PIP2 to drive EMT in hepatocellular carcinoma","volume":"448","author":"Huang","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7314\/APJCP.2012.13.1.247","article-title":"Expression of CDX2 and villin in gastric cardiac intestinal metaplasia and the relation with gastric cardiac carcinogenesis","volume":"13","author":"Xiao","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.3892\/or.2013.2669","article-title":"Expression of the Arp2\/3 complex in human gliomas and its role in the migration and invasion of glioma cells","volume":"30","author":"Liu","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/carcin\/bgz168","article-title":"\u03b1-Actinin-4 regulates cancer stem cell properties and chemoresistance in cervical cancer","volume":"41","author":"Jung","year":"2019","journal-title":"Carcinog."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.3748\/wjg.v21.i7.2199","article-title":"New cancer suppressor gene for colorectal adenocarcinoma: Filamin A","volume":"21","author":"Tian","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s12282-019-00981-4","article-title":"Transgelin-2 expression in breast cancer and its relationships with clinicopathological features and patient outcome","volume":"26","author":"Hao","year":"2019","journal-title":"Breast Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/ijc.21559","article-title":"siRNA gelsolin knockdown induces epithelial-mesenchymal transition with a cadherin switch in human mammary epithelial cells","volume":"118","author":"Tanaka","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"dev181636","DOI":"10.1242\/dev.181636","article-title":"Parallels between wound healing, epimorphic regeneration and solid tumors","volume":"147","author":"Wong","year":"2020","journal-title":"Development"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/nyas.12811","article-title":"Resveratrol nanoformulation for cancer prevention and therapy","volume":"1348","author":"Siddiqui","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e07735","DOI":"10.7554\/eLife.07735","article-title":"DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-\u00bd that promotes efficient DNA repair","volume":"4","author":"Belin","year":"2015","journal-title":"Elife"},{"key":"ref_65","first-page":"2743","article-title":"Functions of nuclear actin-binding proteins in human cancer","volume":"15","author":"Yang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_66","first-page":"765","article-title":"Fluorescence and ultrastructural localization of actin distribution patterns in the nucleus of HL-60 and K-562 cell lines treated with cytostatic drugs","volume":"11","author":"Grzanka","year":"2004","journal-title":"Oncol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.acthis.2012.11.005","article-title":"Ultrastructural localization of F-actin using phalloidin and quantum dots in HL-60 promyelocytic leukemia cell line after cell death induction by arsenic trioxide","volume":"115","author":"Izdebska","year":"2013","journal-title":"Acta Histochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1093\/emboj\/cdg565","article-title":"Exportin 6: A novel nuclear export receptor that is specific for profilin\u00b7actin complexes","volume":"22","author":"Hartmann","year":"2003","journal-title":"EMBO J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1073\/pnas.032662899","article-title":"Phosphatidylinositol-dependent actin filament binding by the SWI\/SNF-like BAF chromatin remodeling complex","volume":"99","author":"Rando","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.sbi.2019.09.002","article-title":"INO80 and SWR1 complexes: The non-identical twins of chromatin remodelling","volume":"61","author":"Willhoft","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1101\/gad.1250804","article-title":"A role for -actin in RNA polymerase III transcription","volume":"18","author":"Hu","year":"2004","journal-title":"Genes Dev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7616","DOI":"10.1074\/jbc.M607596200","article-title":"A Novel Role of the Actin-nucleating Arp2\/3 Complex in the Regulation of RNA Polymerase II-dependent Transcription","volume":"282","author":"Yoo","year":"2007","journal-title":"J. Boil. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/ncb3641","article-title":"A transient pool of nuclear F-actin at mitotic exit controls chromatin organization","volume":"19","author":"Baarlink","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/nucl.14508","article-title":"The F-actin severing protein cofilin-1 is required for RNA polymerase II transcription elongation","volume":"2","author":"Obrdlik","year":"2011","journal-title":"Nucleus"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/bies.20200","article-title":"Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators","volume":"27","author":"Archer","year":"2005","journal-title":"BioEssays"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/cm.21182","article-title":"Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration","volume":"71","author":"King","year":"2014","journal-title":"Cytoskeleton"},{"key":"ref_77","first-page":"921","article-title":"Nesprin-1 impact on tumorigenic cell phenotypes","volume":"47","author":"Hussain","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/ijc.32256","article-title":"Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer","volume":"145","author":"Elgendy","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_79","first-page":"28","article-title":"Genetic alterations and PIK3CA gene mutations and amplifications analysis in cervical cancer by racial groups in the United States","volume":"12","author":"Femi","year":"2018","journal-title":"Int. J. Health Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10325","DOI":"10.3748\/wjg.v22.i47.10325","article-title":"Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma","volume":"22","author":"Galamb","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/cam4.495","article-title":"Global loss of a nuclear lamina component, lamin A\/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer","volume":"4","author":"Matsumoto","year":"2015","journal-title":"Cancer Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/19491034.2015.1128608","article-title":"Nesprin-2 mediated nuclear trafficking and its clinical implications","volume":"6","author":"Kelkar","year":"2015","journal-title":"Nucleus"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1091\/mbc.e15-06-0453","article-title":"By moonlighting in the nucleus, villin regulates epithelial plasticity","volume":"27","author":"Patnaik","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.29271\/jcpsp.2019.11.1057","article-title":"Prognostic Value of CDX2 and Villin Expression in Advanced Stage Colorectal Carcinoma","volume":"29","author":"Altintas","year":"2019","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/1878-0261.12347","article-title":"Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer","volume":"12","author":"Bruun","year":"2018","journal-title":"Mol. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"354","DOI":"10.18632\/oncoscience.487","article-title":"Senescence regulation by nuclear N-WASP: A role in cancer?","volume":"6","author":"Li","year":"2019","journal-title":"Oncoscience"},{"key":"ref_87","first-page":"61","article-title":"Nuclear ARP2\/3 drives DNA break clustering for homology-directed repair","volume":"559","author":"Schrank","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13073-017-0481-6","article-title":"Nuclear Wiskott\u2013Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells","volume":"9","author":"Kuznetsov","year":"2017","journal-title":"Genome Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1158\/0008-5472.CAN-18-1253","article-title":"Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA\/TPA-Induced Skin Tumor Formation","volume":"79","author":"Li","year":"2019","journal-title":"Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ebiom.2016.12.013","article-title":"Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions","volume":"15","author":"Alexandrow","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1038\/onc.2016.117","article-title":"\u03b1-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and \u03b2-catenin stabilization in cervical cancer","volume":"35","author":"An","year":"2016","journal-title":"Oncogene"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5603\/FHC.a2015.0008","article-title":"The alterations in SATB1 and nuclear F-actin expression affect apoptotic response of the MCF-7 cells to geldanamycin","volume":"53","author":"Grzanka","year":"2015","journal-title":"Folia Histochem. et Cytobiol."},{"key":"ref_93","first-page":"3189","article-title":"ARPC2 promotes breast cancer proliferation and metastasis","volume":"41","author":"Cheng","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12253-015-9980-1","article-title":"Filamin A: Insights into its Exact Role in Cancers","volume":"22","author":"Shao","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1073\/pnas.1107879109","article-title":"Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription","volume":"109","author":"Deng","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.18632\/oncotarget.9472","article-title":"Signaling regulation and role of filamin A cleavage in Ca2+-stimulated migration of androgen receptor-deficient prostate cancer cells","volume":"8","author":"Huang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_97","first-page":"6261","article-title":"Filamin A inhibits tumor progression through regulating BRCA1 expression in human breast cancer","volume":"16","author":"Guo","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s11033-014-3804-3","article-title":"Towards a systemic paradigm in carcinogenesis: Linking epigenetics and genetics","volume":"42","author":"Burgio","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3892\/br.2015.494","article-title":"Role of cellular cytoskeleton in epithelial-mesenchymal transition process during cancer progression","volume":"3","author":"Sun","year":"2015","journal-title":"Biomed. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"19161","DOI":"10.1074\/jbc.RA118.002779","article-title":"Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation","volume":"293","author":"Argenzio","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Shankar, J., and Nabi, I.R. (2015). Actin Cytoskeleton Regulation of Epithelial Mesenchymal Transition in Metastatic Cancer Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132759"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3892\/ijo_00000761","article-title":"Involvement of the Wnt-\u03b2-catenin pathway in invasion and migration of oral squamous carcinoma cells","volume":"37","author":"Iwai","year":"2010","journal-title":"Int. J. Oncol."},{"key":"ref_103","first-page":"4572","article-title":"Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation","volume":"126","author":"Steffen","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1111\/cas.14205","article-title":"Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2\/3 complex","volume":"110","author":"Choi","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.3892\/ol.2017.5765","article-title":"SATB1 promotes epithelial-mesenchymal transition and metastasis in prostate cancer","volume":"13","author":"Qi","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1475-2867-13-8","article-title":"Silencing SATB1 with siRNA inhibits the proliferation and invasion of small cell lung cancer cells","volume":"13","author":"Huang","year":"2013","journal-title":"Cancer Cell Int."},{"key":"ref_107","first-page":"187","article-title":"SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis","volume":"452","author":"Han","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1757-2215-5-24","article-title":"Expression of the global regulator SATB1 is an independent factor of poor prognosis in high grade epithelial ovarian cancer","volume":"5","author":"Nodin","year":"2012","journal-title":"J. Ovarian Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1002\/ijc.28895","article-title":"Multiple effects of the special AT-rich binding protein 1 (SATB1) in colon carcinoma","volume":"135","author":"Rabe","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1478-3231.2012.02815.x","article-title":"Upregulation of SATB1 promotes tumor growth and metastasis in liver cancer","volume":"32","author":"Tu","year":"2012","journal-title":"Liver Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s12272-019-01153-w","article-title":"Targeting ROCK\/LIMK\/cofilin signaling pathway in cancer","volume":"42","author":"Lee","year":"2019","journal-title":"Arch. Pharmacal Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1158\/0008-5472.CAN-13-3058","article-title":"Cofilin drives cell-invasive and metastatic responses to TGF-\u03b2 in prostate cancer","volume":"74","author":"Collazo","year":"2014","journal-title":"Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"24097","DOI":"10.18632\/oncotarget.25303","article-title":"Cofilin-1 levels and intracellular localization are associated with melanoma prognosis in a cohort of patients","volume":"9","author":"Bracalente","year":"2018","journal-title":"Oncotarget"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"39131","DOI":"10.18632\/oncotarget.16608","article-title":"Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.humpath.2016.06.020","article-title":"Association of epithelial-mesenchymal transition and nuclear cofilin with advanced urothelial cancer","volume":"57","author":"Hensley","year":"2016","journal-title":"Hum. Pathol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1007\/s13277-013-1504-6","article-title":"Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion","volume":"35","author":"Sun","year":"2014","journal-title":"Tumor Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00432-014-1722-3","article-title":"Filamin A expression correlates with proliferation and invasive properties of human metastatic melanoma tumors: Implications for survival in patients","volume":"140","author":"Zhang","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_118","first-page":"783","article-title":"Sperm-associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma","volume":"40","author":"Ji","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Kovac, B., M\u00e4kel\u00e4, T.P., and Vallenius, T. (2018). Increased \u03b1-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196986"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.12659\/MSM.912404","article-title":"Actinin-4 as a Diagnostic Biomarker in Serum of Breast Cancer Patients","volume":"25","author":"Fang","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/labinvest.2017.28","article-title":"\u03b1-Actinin-4 promotes metastasis in gastric cancer","volume":"97","author":"Liu","year":"2017","journal-title":"Lab. Investig."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"E1380","DOI":"10.1073\/pnas.1218446110","article-title":"Enterocyte loss of polarity and gut wound healing rely upon the F-actin\u2013severing function of villin","volume":"110","author":"Ubelmann","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.18632\/oncotarget.23275","article-title":"Elevated transgelin\/TNS1 expression is a potential biomarker in human colorectal cancer","volume":"9","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.tcb.2019.02.010","article-title":"Nuclear Actin and Actin-Binding Proteins in DNA Repair","volume":"29","author":"Hurst","year":"2019","journal-title":"Trends Cell Boil."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1002\/cam4.2474","article-title":"Are 90% of deaths from cancer caused by metastases?","volume":"8","author":"Rogers","year":"2019","journal-title":"Cancer Med."},{"key":"ref_126","first-page":"66","article-title":"Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium","volume":"376","author":"Fong","year":"1995","journal-title":"Nat. Cell Biol."},{"key":"ref_127","first-page":"62","article-title":"Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice","volume":"376","author":"Shalaby","year":"1995","journal-title":"Nat. Cell Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/ncomms1977","article-title":"The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis","volume":"3","author":"Cudmore","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.yexcr.2004.01.008","article-title":"Nck and Crk mediate distinct VEGF induced signaling pathways that serve overlapping functions in endothelial cell migration","volume":"295","author":"Stoletov","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10456-004-7960-2","article-title":"VEGF treatment induces signaling pathways that regulate both actin polymerization and depolymerization","volume":"7","author":"Gong","year":"2004","journal-title":"Angiogenesis"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.150.6.1299","article-title":"Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate","volume":"150","author":"Rohatgi","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_132","first-page":"3058","article-title":"Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice","volume":"142","author":"Barry","year":"2015","journal-title":"Development"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.onc.1207034","article-title":"Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2\/p38","volume":"23","author":"Lamalice","year":"2004","journal-title":"Oncogene"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"jcs239947","DOI":"10.1242\/jcs.239947","article-title":"DLC1 is a direct target of activated YAP\/TAZ that drives collective migration and sprouting angiogenesis","volume":"133","author":"Schimmel","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"eaau1165","DOI":"10.1126\/scisignal.aau1165","article-title":"Convergence of VEGF and YAP\/TAZ signaling: Implications for angiogenesis and cancer biology","volume":"11","author":"Elaimy","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1172\/JCI93825","article-title":"YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation","volume":"127","author":"Kim","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13256-018-1619-x","article-title":"Bevacizumab-induced intestinal perforation in a patient with inoperable breast cancer: A case report and review of the literature","volume":"12","author":"Fujii","year":"2018","journal-title":"J. Med. Case Rep."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1074\/jbc.M109.062984","article-title":"Filamin B Plays a Key Role in Vascular Endothelial Growth Factor-induced Endothelial Cell Motility through Its Interaction with Rac-1 and Vav-2","volume":"285","author":"Figueras","year":"2010","journal-title":"J. Boil. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3892\/ijmm.2013.1357","article-title":"Effect of L-homocysteine on endothelial cell-cell junctions following F-actin stabilization through tropomyosin-1 overexpression","volume":"32","author":"Gagat","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.acthis.2013.11.013","article-title":"Tropomyosin-1 protects endothelial cell\u2013cell junctions against cigarette smoke extract through F-actin stabilization in EA.hy926 cell line","volume":"116","author":"Gagat","year":"2014","journal-title":"Acta Histochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3389\/fonc.2019.00803","article-title":"Vasculogenic Mimicry: Become an Endothelial Cell \u201cBut Not So Much\u201d","volume":"9","author":"Oliver","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3389\/fonc.2019.00680","article-title":"Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry?","volume":"9","author":"Valdivia","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10456-016-9500-2","article-title":"Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: A meta-analysis","volume":"19","author":"Yang","year":"2016","journal-title":"Angiogenesis"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1159\/000493227","article-title":"ALDH1 Expression and Vasculogenic Mimicry Are Positively Associated with Poor Prognosis in Patients with Breast Cancer","volume":"49","author":"Xing","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/jcmm.14039","article-title":"LOXL2 promotes vasculogenic mimicry and tumour aggressiveness in hepatocellular carcinoma","volume":"23","author":"Shao","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-019-1167-3","article-title":"Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer","volume":"21","author":"Hori","year":"2019","journal-title":"Breast Cancer Res."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Fu, D., He, X., Yang, S., Xu, W., Lin, T., and Feng, X. (2011). Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-146"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e1127","DOI":"10.1038\/cddis.2014.94","article-title":"BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton","volume":"5","author":"Maes","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/1535370216685435","article-title":"Featured Article: Downregulation of transgelin blocks interleukin-8 utilization and suppresses vasculogenic mimicry in breast cancer cells","volume":"242","author":"Aikins","year":"2017","journal-title":"Exp. Boil. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.cub.2020.04.085","article-title":"Arp2\/3 and Mena\/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge","volume":"30","author":"Skruber","year":"2020","journal-title":"Curr. Biol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: Causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2019","journal-title":"Cell. Mol. Life Sci."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/10\/2245\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:16:59Z","timestamp":1760177819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/10\/2245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":151,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["cells9102245"],"URL":"https:\/\/doi.org\/10.3390\/cells9102245","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,6]]}}}