{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:52:41Z","timestamp":1792036361269,"version":"4.4.0"},"reference-count":99,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mildred Scheel School of Oncology Cologne-Bonn","award":["MSSO 2020 Postgraduate Program to P.J.B."],"award-info":[{"award-number":["MSSO 2020 Postgraduate Program to P.J.B."]}]},{"name":"Bas Mulder grant of Alpe d\u2019HuZes\/Dutch Cancer Society","award":["RUG 2014-6727 to M.R.W.d.J"],"award-info":[{"award-number":["RUG 2014-6727 to M.R.W.d.J"]}]},{"name":"Else Kro\u0308ner-Fresenius Stiftung","award":["2016_Kolleg.19 to R.D.J."],"award-info":[{"award-number":["2016_Kolleg.19 to R.D.J."]}]},{"name":"Exzellenz Initiieren \u2013 Stiftung K\u00f6lner Krebsforschung","award":["to R. D. J."],"award-info":[{"award-number":["to R. D. J."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>The DNA double-strand break (DSB) is the most cytotoxic lesion and compromises genome stability. In an attempt to efficiently repair DSBs, cells activate ATM kinase, which orchestrates the DNA damage response (DDR) by activating cell cycle checkpoints and initiating DSB repair pathways. In physiological B cell development, however, programmed DSBs are generated as intermediates for effective immune responses and the maintenance of genomic integrity. Disturbances of these pathways are at the heart of B cell lymphomagenesis. Here, we review the role of DNA repair and cell cycle control on B cell development and lymphomagenesis. In addition, we highlight the intricate relationship between the DDR and the tumor microenvironment (TME). Lastly, we provide a clinical perspective by highlighting treatment possibilities of defective DDR signaling and the TME in mantle cell lymphoma, which serves as a blueprint for B cell lymphomas.<\/jats:p>","DOI":"10.3390\/cells9102287","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T21:42:21Z","timestamp":1602798141000},"page":"2287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Targeting DNA Repair, Cell Cycle, and Tumor Microenvironment in B Cell Lymphoma"],"prefix":"10.3390","volume":"9","author":[{"given":"Paul J.","family":"Br\u00f6ckelmann","sequence":"first","affiliation":[{"name":"Max Planck Research Group Mechanisms of DNA Repair, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), University of Cologne, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0427-6384","authenticated-orcid":false,"given":"Mathilde R. W.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"},{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron D.","family":"Jachimowicz","sequence":"additional","affiliation":[{"name":"Max Planck Research Group Mechanisms of DNA Repair, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany"},{"name":"Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), University of Cologne, 50937 Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrm3640","article-title":"Phospho-Ser\/Thr-binding domains: Navigating the cell cycle and DNA damage response","volume":"14","author":"Reinhardt","year":"2013","journal-title":"Nat. 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