{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:00:56Z","timestamp":1792692056584,"version":"4.5.0"},"reference-count":239,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with potent neurotoxins called ciguatoxins (CTXs). Ciguatera is a complex clinical syndrome in which peripheral neurological signs predominate in the acute phase of the intoxication but also persist or reoccur long afterward. Their recognition is of particular importance in establishing the diagnosis, which is clinically-based and can be a challenge for physicians unfamiliar with CFP. To date, no specific treatment exists. Physiopathologically, the primary targets of CTXs are well identified, as are the secondary events that may contribute to CFP symptomatology. This review describes the clinical features, focusing on the sensory disturbances, and then reports on the neuronal targets and effects of CTXs, as well as the neurophysiological and histological studies that have contributed to existing knowledge of CFP neuropathophysiology at the molecular, neurocellular and nerve levels.<\/jats:p>","DOI":"10.3390\/cells9102291","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T21:42:21Z","timestamp":1602798141000},"page":"2291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis"],"prefix":"10.3390","volume":"9","author":[{"given":"Killian","family":"L\u2019Herondelle","sequence":"first","affiliation":[{"name":"University of Brest, School of Medicine, Laboratoire Interactions Epith\u00e9liums-Neurones (Univ Brest, LIEN), F-29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-3364","authenticated-orcid":false,"given":"Matthieu","family":"Talagas","sequence":"additional","affiliation":[{"name":"University of Brest, School of Medicine, Laboratoire Interactions Epith\u00e9liums-Neurones (Univ Brest, LIEN), F-29200 Brest, France"},{"name":"Department of Dermatology, University Hospital of Brest, F-29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Mignen","sequence":"additional","affiliation":[{"name":"University of Brest, School of Medicine, INSERM U1227, Lymphocytes B et auto-immunit\u00e9, F-29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-7059","authenticated-orcid":false,"given":"Laurent","family":"Misery","sequence":"additional","affiliation":[{"name":"University of Brest, School of Medicine, Laboratoire Interactions Epith\u00e9liums-Neurones (Univ Brest, LIEN), F-29200 Brest, France"},{"name":"Department of Dermatology, University Hospital of Brest, F-29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-9076","authenticated-orcid":false,"given":"Raphaele","family":"Le Garrec","sequence":"additional","affiliation":[{"name":"University of Brest, School of Medicine, Laboratoire Interactions Epith\u00e9liums-Neurones (Univ Brest, LIEN), F-29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s002270050623","article-title":"Seasonal abundance and toxicity of the dinoflagellate Gambierdiscus spp. (Dinophyceae), the causative agent of ciguatera in Tahiti, French Polynesia","volume":"135","author":"Chinain","year":"1999","journal-title":"Mar. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.toxicon.2010.05.017","article-title":"Global distribution of ciguatera causing dinoflagellates in the genus Gambierdiscus","volume":"56","author":"Litaker","year":"2010","journal-title":"Toxicon"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.hal.2018.03.003","article-title":"Phylogeny, morphology and toxicity of benthic dinoflagellates of the genus Fukuyoa (Goniodomataceae, Dinophyceae) from a subtropical reef ecosystem in the South China Sea","volume":"74","author":"Leung","year":"2018","journal-title":"Harmful Algae"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1271\/bbb.60.2103","article-title":"Isolation and structure of ciguatoxin-4A, a new ciguatoxin precursor, from cultures of dinoflagellate Gambierdiscus toxicus and Parrotfish Scarus gibbus","volume":"60","author":"Satake","year":"1997","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.5740\/jaoacint.SGEYogi","article-title":"Determination of toxins involved in ciguatera fish poisoning in the Pacific by LC\/MS","volume":"97","author":"Yogi","year":"2014","journal-title":"J. AOAC Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1021\/ja00167a040","article-title":"Structures and configurations of ciguatoxin from the Moray Eel Gymnothorax javanicus and its likely precursor from the dinoglagellate Gambierdiscus toxicus","volume":"112","author":"Murata","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/S0040-4039(00)91978-6","article-title":"The structure of CTX3C, a ciguatoxin congener isolated from cultured Gambierdiscus toxicus","volume":"34","author":"Satake","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8886","DOI":"10.1021\/ac200799j","article-title":"Detailed LC-MS\/MS analysis of ciguatoxins revealing distinct regional and species characteristics in fish and causative alga from the Pacific","volume":"83","author":"Yogi","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109111","DOI":"10.1016\/j.envres.2020.109111","article-title":"Global impact of ciguatoxins and ciguatera fish poisoning on fish, fisheries and consumers","volume":"182","author":"Costa","year":"2020","journal-title":"Environ. Res."},{"key":"ref_10","first-page":"615","article-title":"Origin and transfer of toxins involved in ciguatera","volume":"106","author":"Lewis","year":"1993","journal-title":"Comp. Biochem. Physiol. Part C Comp. Pharmacol. Toxicol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/0041-0101(91)90209-A","article-title":"Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae)","volume":"29","author":"Lewis","year":"1991","journal-title":"Toxicon"},{"key":"ref_12","first-page":"461","article-title":"Gambiertoxin-induced modifications of the membrane potential of myelinated nerve fibres","volume":"34","author":"Benoit","year":"1994","journal-title":"Mem. Qld. Mus."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/19440049.2012.755644","article-title":"Evaluation of seafood toxicity in the Australes archipelago (French Polynesia) using the neuroblastoma cell-based assay","volume":"30","author":"Pawlowiez","year":"2013","journal-title":"Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.hal.2016.05.007","article-title":"Evidence of the bioaccumulation of ciguatoxins in giant clams (Tridacna maxima) exposed to Gambierdiscus spp. cells","volume":"57","author":"Roue","year":"2016","journal-title":"Harmful Algae"},{"key":"ref_15","unstructured":"FAO, and WHO (2020). Report of the Expert Meeting on Ciguatera Poisoning: Rome, 19\u201323 November 2018, FAO and WHO."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0168-1605(00)00382-2","article-title":"Ciguatera: Recent advances but the risk remains","volume":"61","author":"Lehane","year":"2000","journal-title":"Int. J. Food Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.envres.2015.09.014","article-title":"Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies)","volume":"143","author":"Hossen","year":"2015","journal-title":"Environ. Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aca.2015.06.018","article-title":"Ultrasensitive and accelerated detection of ciguatoxin by capillary electrophoresis via on-line sandwich immunoassay with rotating magnetic field and nanoparticles signal enhancement","volume":"888","author":"Zhang","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1021\/acs.analchem.8b00519","article-title":"Highly Sensitive and Practical Fluorescent Sandwich ELISA for Ciguatoxins","volume":"90","author":"Tsumuraya","year":"2018","journal-title":"Anal. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tsumuraya, T., and Hirama, M. (2019). Rationally Designed Synthetic Haptens to Generate Anti-Ciguatoxin Monoclonal Antibodies, and Development of a Practical Sandwich ELISA to Detect Ciguatoxins. Toxins, 11.","DOI":"10.3390\/toxins11090533"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Pasinszki, T., Lako, J., and Dennis, T.E. (2020). Advances in Detecting Ciguatoxins in Fish. Toxins, 12.","DOI":"10.3390\/toxins12080494"},{"key":"ref_22","first-page":"61","article-title":"Centers for Disease Control and Prevention (CDC) Ciguatera fish poisoning\u2014New York City, 2010\u20132011","volume":"62","author":"Graber","year":"2013","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.toxicon.2009.06.007","article-title":"Human fatality associated with Pacific ciguatoxin contaminated fish","volume":"56","author":"Hamilton","year":"2010","journal-title":"Toxicon"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1080\/02652030210155378","article-title":"Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies","volume":"19","author":"Pottier","year":"2002","journal-title":"Food Addit. Contam."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.toxicon.2014.05.006","article-title":"Ciguatera fish poisoning in Hong Kong\u2014A 10-year perspective on the class of ciguatoxins","volume":"86","author":"Wong","year":"2014","journal-title":"Toxicon"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hardison, D.R., Holland, W.C., McCall, J.R., Bourdelais, A.J., Baden, D.G., Darius, H.T., Chinain, M., Tester, P.A., Shea, D., and Flores Quintana, H.A. (2016). Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153348"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Estevez, P., Sibat, M., Le\u00e3o-Martins, J.M., Reis Costa, P., Gago-Mart\u00ednez, A., and Hess, P. (2020). Liquid Chromatography Coupled to High-Resolution Mass Spectrometry for the Confirmation of Caribbean Ciguatoxin-1 as the Main Toxin Responsible for Ciguatera Poisoning Caused by Fish from European Atlantic Coasts. Toxins, 12.","DOI":"10.3390\/toxins12040267"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.toxicon.2005.03.014","article-title":"Biomonitoring of ciguatoxin exposure in mice using blood collection cards","volume":"46","author":"Wang","year":"2005","journal-title":"Toxicon"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2011.02.005","article-title":"Toxicokinetics of the ciguatoxin P-CTX-1 in rats after intraperitoneal or oral administration","volume":"284","author":"Wang","year":"2011","journal-title":"Toxicology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1081\/CLT-120002885","article-title":"A pilot study for the detection of acute ciguatera intoxication in human blood","volume":"40","author":"Matta","year":"2002","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0041-0101(96)00191-2","article-title":"Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus)","volume":"35","author":"Vernoux","year":"1997","journal-title":"Toxicon Off. J. Int. Soc. Toxinol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.4269\/ajtmh.1979.28.1067","article-title":"Clinical observations on 3009 cases of ciguatera (fish poisoning) in the South Pacific","volume":"28","author":"Bagnis","year":"1979","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.toxicon.2009.05.036","article-title":"Ciguatera incidence and fish toxicity in Okinawa, Japan","volume":"56","author":"Oshiro","year":"2010","journal-title":"Toxicon"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0895-3988(09)60012-X","article-title":"Features of ciguatera fish poisoning cases in Hong Kong 2004\u20132007","volume":"21","author":"Wong","year":"2008","journal-title":"Biomed. Environ. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ware, G.W., and Nigg, H.N. (2001). Ciguatera fish poisoning in the Caribbean islands and Western Atlantic. Reviews of Environmental Contamination and Toxicology, Springer.","DOI":"10.1007\/978-1-4613-0161-5"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0041-0101(95)00164-6","article-title":"Ciguatera in R\u00e9union Island (SW Indian Ocean): Epidemiology and clinical patterns","volume":"34","author":"Quod","year":"1996","journal-title":"Toxicon"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0041-0101(96)00132-8","article-title":"Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography\/mass spectrometry","volume":"35","author":"Lewis","year":"1997","journal-title":"Toxicon"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.toxicon.2003.09.004","article-title":"Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC\/MS and radiolabelled ligand binding","volume":"42","author":"Pottier","year":"2003","journal-title":"Toxicon"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0041-0101(02)00088-0","article-title":"Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography\/mass spectrometry","volume":"40","author":"Pottier","year":"2002","journal-title":"Toxicon"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0041-0101(01)00259-8","article-title":"Isolation and characterisation of Indian Ocean ciguatoxin","volume":"40","author":"Hamilton","year":"2002","journal-title":"Toxicon"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0041-0101(02)00146-0","article-title":"Multiple ciguatoxins present in Indian Ocean reef fish","volume":"40","author":"Hamilton","year":"2002","journal-title":"Toxicon"},{"key":"ref_42","unstructured":"Fleming, L.E., Baden, D.G., Bean, J.A., Weisman, R., and Blythe, D.G. (1998). Marine Seafood Toxin Diseases: Issues in Epidemiology and Community Outreach. Harmful Algae, Proceedings of the VIII International Conference on Harmful Algae, Vigo, Spain, 25\u201329 June 1997, Xunta de Galicia and Intergovernmental Oceanographic Commission of UNESCO."},{"key":"ref_43","unstructured":"Ansdell, V.E. (2017). Food Poisoning from Marine Toxins. CDC Yellow Book 2018: Health Information for International Travel, Oxford University Press."},{"key":"ref_44","first-page":"25","article-title":"Clinical aspects of ciguatera (fish poisoning) in French Polynesia","volume":"28","author":"Bagnis","year":"1968","journal-title":"Hawaii Med. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.hal.2010.11.005","article-title":"Ciguatera poisoning in Rarotonga, southern Cook Islands","volume":"10","author":"Rongo","year":"2011","journal-title":"Harmful Algae"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Skinner, M.P., Brewer, T.D., Johnstone, R., Fleming, L.E., and Lewis, R.J. (2011). Ciguatera fish poisoning in the Pacific Islands (1998 to 2008). PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001416"},{"key":"ref_47","unstructured":"Hallegraeff, G.M., Blackburn, S.I., Bolch, C.J., and Lewis, R.J. (2001). Physician diagnosis and reporting of ciguatera fish poisoning in an endemic area. Harmful Algal Blooms 2000, Intergovernmental Oceanographic Commission of UNESCO."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1001\/archinte.1992.00400220075013","article-title":"Travel and Ciguatera Fish Poisoning","volume":"152","author":"Lange","year":"1992","journal-title":"Arch. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1081\/CLT-120026512","article-title":"Emergence of imported ciguatera in Europe: Report of 18 cases at the Poison Control Centre of Marseille","volume":"41","author":"Pommier","year":"2003","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"767","DOI":"10.3109\/15563650.2011.607461","article-title":"Ciguatera contracted by French tourists in Mauritius recurs in Senegal","volume":"49","author":"Glaizal","year":"2011","journal-title":"Clin. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.toxicon.2014.10.016","article-title":"Ciguatera fish poisoning: A first epidemic in Germany highlights an increasing risk for European countries","volume":"91","author":"Mattei","year":"2014","journal-title":"Toxicon"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.toxicon.2010.02.026","article-title":"Ciguatera fish poisoning and sea surface temperatures in the Caribbean Sea and the West Indies","volume":"56","author":"Tester","year":"2010","journal-title":"Toxicon"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1289\/ehp.1307196","article-title":"Ciguatera fish poisoning and climate change: Analysis of National Poison Center Data in the United States, 2001\u20132011","volume":"122","author":"Gingold","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Rhodes, L.L., Smith, K.F., Murray, J.S., Nishimura, T., and Finch, S.C. (2020). Ciguatera Fish Poisoning: The Risk from an Aotearoa\/New Zealand Perspective. Toxins, 12.","DOI":"10.3390\/toxins12010050"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.hal.2017.06.009","article-title":"Canary Islands (NE Atlantic) as a biodiversity \u201chotspot\u201d of Gambierdiscus: Implications for future trends of ciguatera in the area","volume":"67","author":"Rodriguez","year":"2017","journal-title":"Harmful Algae"},{"key":"ref_56","first-page":"609","article-title":"Clinical aspects of ciguatera: An overview","volume":"34","author":"Ruff","year":"1994","journal-title":"Mem. Qld. Mus."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0041-0101(75)90202-0","article-title":"Ciguatera poisoning: A report of 35 cases","volume":"13","author":"Russell","year":"1975","journal-title":"Toxicon"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archinte.1982.00340190046008","article-title":"Clinical features of ciguatera fish poisoning: A study of the disease in the US Virgin Islands","volume":"142","author":"Morris","year":"1982","journal-title":"Arch. Intern. Med."},{"key":"ref_59","first-page":"590","article-title":"Neurologic manifestations of ciguatera. 3 cases with a neurophysiologic study and examination of one nerve biopsy","volume":"142","author":"Allsop","year":"1986","journal-title":"Rev. Neurol."},{"key":"ref_60","unstructured":"Gopalakrishnakone, P., and Tan, C.K. (1987). Clinical features on 12,890 cases of ciguatera (fish poisoning) in French Polynesia. Progress in Venom and Toxin Research, Proceedings of the First Asia-Pacific Congress on Animal, Plant and Microbial Toxins, Singapore, 24\u201327 June 1987, Faculty of Medicine, National University of Singapore."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0041-0101(89)90121-9","article-title":"Variations in symptomatology of ciguatera poisoning","volume":"27","author":"Kodama","year":"1989","journal-title":"Toxicon"},{"key":"ref_62","first-page":"639","article-title":"Ciguatera fish poisoning in San Francisco, California, caused by imported barracuda","volume":"155","author":"Geller","year":"1991","journal-title":"West. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1055\/s-0040-100439","article-title":"Vergiftung durch Tropenfisch: Ciguatera-Epidemie in Deutschland","volume":"140","author":"Zimmermann","year":"2015","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"584","DOI":"10.5694\/j.1326-5377.1986.tb139504.x","article-title":"Ciguatera in Australia. Occurrence, clinical features, pathophysiology and management","volume":"145","author":"Gillespie","year":"1986","journal-title":"Med. J. Aust."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.3390\/toxins6072041","article-title":"Large Outbreaks of Ciguatera after Consumption of Brown Marbled Grouper","volume":"6","author":"Chan","year":"2014","journal-title":"Toxins"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0035-9203(98)90803-3","article-title":"Lengthy persistence of ciguatoxin in the body","volume":"92","author":"Chan","year":"1998","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4269\/ajtmh.1993.49.448","article-title":"Ciguatera on Kauai: Investigation of factors associated with severity of illness","volume":"49","author":"Katz","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Friedman, M.A., Fernandez, M., Backer, L.C., Dickey, R.W., Bernstein, J., Schrank, K., Kibler, S., Stephan, W., Gribble, M.O., and Bienfang, P. (2017). An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management. Mar. Drugs, 15.","DOI":"10.3390\/md15030072"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3109\/15563659309025762","article-title":"The basis of the paradoxical disturbance of temperature perception in ciguatera poisoning","volume":"31","author":"Cameron","year":"1993","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jns.2019.06.023","article-title":"A case of Ciguatera poisoning with paradoxical dysaesthesia and degenerative features at skin biopsy","volume":"403","author":"Ruiz","year":"2019","journal-title":"J. Neurol. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3959(02)00043-X","article-title":"Noxious cold evokes multiple sensations with distinct time courses","volume":"98","author":"Davis","year":"2002","journal-title":"Pain"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.pain.2013.06.015","article-title":"Analgesic treatment of ciguatoxin-induced cold allodynia","volume":"154","author":"Zimmermann","year":"2013","journal-title":"Pain"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ana.24841","article-title":"Brain mechanisms of abnormal temperature perception in cold allodynia induced by ciguatoxin","volume":"81","author":"Eisenblatter","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_74","first-page":"37","article-title":"La ciguatera dans l\u2019\u00eele de Saint-Barth\u00e9l\u00e9my: Aspects \u00e9pid\u00e9miologiques, toxicologiques et pr\u00e9ventifs","volume":"11","author":"Vernoux","year":"1988","journal-title":"Oceanol. Acta"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Banner, A.H., Shaw, S.W., Alender, C.B., and Helfrich, P. (1963). Fish Intoxication; Notes on Ciguatera, Its Mode of Action and a Suggested Therapy, South Pacific Commission. Technical Paper.","DOI":"10.21236\/AD0600446"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0196-0644(86)80873-3","article-title":"Ciguatera poisoning: A report of three cases","volume":"15","author":"Ho","year":"1986","journal-title":"Ann. Emerg. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1001\/jama.1980.03310030030021","article-title":"Ciguatera fish poisoning in Miami","volume":"244","author":"Lawrence","year":"1980","journal-title":"JAMA"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Ware, G.W. (1991). Foodborne Toxins of Marine Origin: Ciguatera. Reviews of Environmental Contamination and Toxicology: Continuation of Residue Reviews, Springer. Reviews of Environmental Contamination and Toxicology.","DOI":"10.1007\/978-1-4612-3078-6"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00063110-200112000-00009","article-title":"Ciguatera Poisoning: A Global Issue with Common Management Problems","volume":"8","author":"Ting","year":"2001","journal-title":"Eur. J. Emerg. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/jnnp.2007.129049","article-title":"Ciguatera poisoning","volume":"7","author":"Achaibar","year":"2007","journal-title":"Pract. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3109\/15563657008990130","article-title":"Concerning a fatal case of ciguatera poisoning in the Tuamotu Islands","volume":"3","author":"Bagnis","year":"1970","journal-title":"Clin. Toxicol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0002-9343(93)90268-T","article-title":"Coma due to ciguatera poisoning in Rhode Island","volume":"95","author":"Defusco","year":"1993","journal-title":"Am. J. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.toxicon.2007.11.025","article-title":"Severe seafood poisoning in French Polynesia: A retrospective analysis of 129 medical files","volume":"51","author":"Gatti","year":"2008","journal-title":"Toxicon"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jemermed.2011.09.030","article-title":"Reversible cerebellar dysfunction associated with ciguatera fish poisoning","volume":"43","author":"Oh","year":"2012","journal-title":"J. Emerg. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"704","DOI":"10.4269\/ajtmh.15-0686","article-title":"Characteristic Features and Contributory Factors in Fatal Ciguatera Fish Poisoning\u2014Implications for Prevention and Public Education","volume":"94","author":"Chan","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_86","first-page":"225","article-title":"A study of the distribution of ciguatoxin in individual Caribbean fish","volume":"42","author":"Vernoux","year":"1985","journal-title":"Acta Trop."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/infdis\/158.5.1128","article-title":"A large common-source outbreak of ciguatera fish poisoning","volume":"158","author":"Frenette","year":"1988","journal-title":"J. Infect. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1300\/J092v02n02_03","article-title":"Chronic Ciguatera: One Organic Cause of the Chronic Fatigue Syndrome","volume":"2","author":"Pearn","year":"1996","journal-title":"J. Chronic Fatigue Syndr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/jnnp.70.1.4","article-title":"Neurology of ciguatera","volume":"70","author":"Pearn","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.toxicon.2009.10.015","article-title":"Prevalence, symptoms and chronicity of ciguatera in New Caledonia: Results from an adult population survey conducted in Noumea during 2005","volume":"56","author":"Baumann","year":"2010","journal-title":"Toxicon"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/mus.20906","article-title":"Normal axonal ion channel function in large peripheral nerve fibers following chronic ciguatera sensitization","volume":"37","author":"Vucic","year":"2008","journal-title":"Muscle Nerve"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1001\/archneur.1991.00530200116031","article-title":"Polymyositis after ciguatera toxin exposure","volume":"48","author":"Stommel","year":"1991","journal-title":"Arch. Neurol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archneur.1993.00540060013009","article-title":"Another case of polymyositis after ciguatera toxin exposure","volume":"50","author":"Stommel","year":"1993","journal-title":"Arch. Neurol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2185\/jrm.2921","article-title":"Rheumatoid arthritis following ciguatera poisoning: A case report","volume":"12","author":"Ohta","year":"2017","journal-title":"J. Rural Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ntt.2010.05.007","article-title":"Defining the neurotoxin derived illness chronic ciguatera using markers of chronic systemic inflammatory disturbances: A case\/control study","volume":"32","author":"Shoemaker","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ryan, J.C., Wu, Q., and Shoemaker, R.C. (2015). Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin. BMC Med. Genom., 8.","DOI":"10.1186\/s12920-015-0089-x"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.toxicon.2018.01.002","article-title":"Immune effects of the neurotoxins ciguatoxins and brevetoxins","volume":"149","author":"Pierre","year":"2018","journal-title":"Toxicon"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/archpsyc.1989.01810040090018","article-title":"Ciguatera Poisoning Presenting as Psychiatric Disorder","volume":"46","author":"Lipkin","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.hal.2003.08.006","article-title":"A pilot study of the cognitive and psychological correlates of chronic ciguatera poisoning","volume":"3","author":"Arena","year":"2004","journal-title":"Harmful Algae"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.acn.2007.03.003","article-title":"Neuropsychological study of ciguatera fish poisoning: A longitudinal case-control study","volume":"22","author":"Friedman","year":"2007","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1039\/C5TX00475F","article-title":"Chronic ciguatoxin poisoning causes emotional and cognitive dysfunctions in rats","volume":"6","author":"Wang","year":"2017","journal-title":"Toxicol. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"8353","DOI":"10.1016\/S0021-9258(17)39735-1","article-title":"Ciguatoxin is a novel type of Na+ channel toxin","volume":"259","author":"Bidard","year":"1984","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0041-0101(86)90195-9","article-title":"Effects of ciguatoxin on current and voltage clamped frog myelinated nerve fibre","volume":"24","author":"Benoit","year":"1986","journal-title":"Toxicon"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0306-4522(95)00506-4","article-title":"Nodal swelling produced by ciguatoxin-induced selective activation of sodium channels in myelinated nerve fibers","volume":"71","author":"Benoit","year":"1996","journal-title":"Neuroscience"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00508787","article-title":"Direct and indirect effects of ciguatoxin on guinea-pig atria and papillary muscles","volume":"334","author":"Lewis","year":"1986","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1476-5381.1990.tb12991.x","article-title":"Ciguatoxin enhances quantal transmitter release from frog motor nerve terminals","volume":"99","author":"Molgo","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF00176780","article-title":"Sub-nanomolar concentrations of ciguatoxin-1 excite preganglionic terminals in guinea pig sympathetic ganglia","volume":"352","author":"Hamblin","year":"1995","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1460-9568.2002.02071.x","article-title":"Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons","volume":"16","author":"Hogg","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3940(98)00575-8","article-title":"Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones","volume":"252","author":"Hogg","year":"1998","journal-title":"Neurosci. Lett."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/sj.bjp.0704980","article-title":"Pacific ciguatoxin-1b effect over Na+ and K+ currents, inositol 1,4,5-triphosphate content and intracellular Ca2+ signals in cultured rat myotubes","volume":"137","author":"Hidalgo","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1038\/emboj.2012.207","article-title":"Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling","volume":"31","author":"Vetter","year":"2012","journal-title":"EMBO J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"42810","DOI":"10.1038\/srep42810","article-title":"Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1","volume":"7","author":"Inserra","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.taap.2004.08.020","article-title":"Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons","volume":"204","author":"Gunning","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1021\/tx500506q","article-title":"Chronic ciguatoxin treatment induces synaptic scaling through voltage gated sodium channels in cortical neurons","volume":"28","author":"Martin","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3940(97)00665-4","article-title":"Gambiertoxin (CTX-4B), purified from wild Gambierdiscus toxicus dinoflagellates, induces Na(+)-dependent swelling of single frog myelinated axons and motor nerve terminals in situ","volume":"234","author":"Mattei","year":"1997","journal-title":"Neurosci. Lett."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0006-8993(99)02032-6","article-title":"Hyperosmolar D-mannitol reverses the increased membrane excitability and the nodal swelling caused by Caribbean ciguatoxin-1 in single frog myelinated axons","volume":"847","author":"Mattei","year":"1999","journal-title":"Brain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neuropharm.2014.06.001","article-title":"Involvement of both sodium influx and potassium efflux in ciguatoxin-induced nodal swelling of frog myelinated axons","volume":"85","author":"Mattei","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.neuropharm.2005.04.024","article-title":"Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers","volume":"49","author":"Davies","year":"2005","journal-title":"Neuropharmacology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1749-6632.1991.tb36535.x","article-title":"Tetrodotoxin-sensitive ciguatoxin effects on quantal release, synaptic vesicle depletion, and calcium mobilization","volume":"635","author":"Molgo","year":"1991","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.toxicon.2009.07.026","article-title":"Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction","volume":"56","author":"Mattei","year":"2010","journal-title":"Toxicon"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF02337168","article-title":"Polyneuropathy secondary to ciguatoxin poisoning","volume":"9","author":"Sozzi","year":"1988","journal-title":"Ital. J. Neuro. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/jnnp.2008.161786","article-title":"Reversible corpus callosum lesion in ciguatera poisoning","volume":"80","author":"Liang","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1212\/WNL.0000000000006789","article-title":"Cytotoxic edema affecting distinct fiber tracts in ciguatera fish poisoning","volume":"92","author":"Yalachkov","year":"2019","journal-title":"Neurology"},{"key":"ref_124","unstructured":"Botana, L.M. (2000). Ciguatera Toxins: Toxinology. Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Marcel Dekker. Food Science and Technology."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0041-0101(91)90056-W","article-title":"Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning","volume":"29","author":"Terao","year":"1991","journal-title":"Toxicon"},{"key":"ref_126","unstructured":"Bon, C., Goudey-Perri\u00e8re, F., Poulain, B., and Puiseux-Dao, S. (2001). Un test biologique destin\u00e9 \u00e0 identifier les principes actifs des plantes utilis\u00e9es comme rem\u00e8des traditionnels contre l\u2019intoxication ciguat\u00e9rique en Nouvelle-Cal\u00e9donie. Explorer, Exploiter les Toxines et Ma\u00eetriser les Organismes Producteurs (Collection Rencontres en Toxinologie), Elsevier."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcmd.2005.10.007","article-title":"Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins","volume":"36","author":"Sauviat","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/nt.2620010106","article-title":"Light and electron microscopic studies of the murine heart after repeated administrations of ciguatoxin or ciguatoxin-4c","volume":"1","author":"Terao","year":"1992","journal-title":"Nat. Toxins"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0041-0101(82)90233-1","article-title":"Studies on the mode of action of ciguateric toxins","volume":"20","author":"Legrand","year":"1982","journal-title":"Toxicon"},{"key":"ref_130","first-page":"756","article-title":"Mode of action of ciguatoxin from the Spanish Mackerel, Scomberomorus commersoni, on the guinea-pig ileum and vas deferens","volume":"228","author":"Lewis","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_131","first-page":"783","article-title":"Potent excitatory effect of scaritoxin on the guinea-pig vas deferens, taenia caeci and ileum","volume":"235","author":"Tatsumi","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0041-0101(93)90179-M","article-title":"Comparative action of three major ciguatoxins on guinea-pig atria and ilea","volume":"31","author":"Lewis","year":"1993","journal-title":"Toxicon"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0041-0101(02)00117-4","article-title":"Muscarinic effects of the Caribbean ciguatoxin C-CTX-1 on frog atrial heart muscle","volume":"40","author":"Sauviat","year":"2002","journal-title":"Toxicon"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-3940(93)9000-4","article-title":"Ciguatoxin extracted from poisonous moray eels Gymnothorax javanicus triggers acetylcholine release from Torpedo cholinergic synaptosomes via reversed Na+-Ca2+ exchange","volume":"160","author":"Legrand","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_135","first-page":"467","article-title":"Mechanism of norepinephrine release by ciguatoxin","volume":"Volume 4","author":"Gabrie","year":"1985","journal-title":"Proceedings of the Fifth International Coral Reef Congress: Symposia and Seminars"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0041-0101(88)90246-2","article-title":"Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles","volume":"26","author":"Lewis","year":"1988","journal-title":"Toxicon"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0041-0101(92)90389-M","article-title":"Action of ciguatoxin on human atrial trabeculae","volume":"30","author":"Lewis","year":"1992","journal-title":"Toxicon"},{"key":"ref_138","first-page":"475","article-title":"Mode of the excitatory and inhibitory actions of ciguatoxin in the guinea-pig vas deferens","volume":"217","author":"Ohizumi","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1111\/j.1476-5381.1995.tb15056.x","article-title":"Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1","volume":"116","author":"Brock","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1038\/sj.bjp.0701055","article-title":"Contribution of alpha-adrenoceptors to depolarization and contraction evoked by continuous asynchronous sympathetic nerve activity in rat tail artery","volume":"120","author":"Brock","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Mattei, C., Wen, P.J., Nguyen-Huu, T.D., Alvarez, M., Benoit, E., Bourdelais, A.J., Lewis, R.J., Baden, D.G., Molg\u00f3, J., and Meunier, F.A. (2008). Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003448"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.toxicon.2009.08.002","article-title":"Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal","volume":"56","author":"Mattei","year":"2010","journal-title":"Toxicon"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1021\/tx500503d","article-title":"Synthetic ciguatoxin CTX 3C induces a rapid imbalance in neuronal excitability","volume":"28","author":"Martin","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Touska, F., Sattler, S., Malsch, P., Lewis, R.J., Reeh, P.W., and Zimmermann, K. (2017). Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1. Mar. Drugs, 15.","DOI":"10.3390\/md15090269"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.toxicon.2015.11.004","article-title":"Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins","volume":"116","author":"Lebonvallet","year":"2016","journal-title":"Toxicon"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"L\u2019Herondelle, K., Pierre, O., Fouyet, S., Leschiera, R., Le Gall-Ianotto, C., Philippe, R., Buscaglia, P., Mignen, O., Talagas, M., and Lewis, R.J. (2020). PAR2, keratinocytes and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning. J. Investig. Dermatol.","DOI":"10.1016\/j.jid.2020.07.020"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1749-6632.1996.tb44814.x","article-title":"Reversed mode Na(+)-Ca2+ exchange activated by ciguatoxin (CTX-1b) enhances acetylcholine release from Torpedo cholinergic synaptosomes","volume":"779","author":"Molgo","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3940(93)90250-O","article-title":"Ciguatoxin, extracted from poisonous morays eels, causes sodium-dependent calcium mobilization in NG108-15 neuroblastoma \u00d7 glioma hybrid cells","volume":"158","author":"Shimahara","year":"1993","journal-title":"Neurosci. Lett."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.niox.2008.03.001","article-title":"Modulation of inducible nitric oxide synthase gene expression in RAW 264.7 murine macrophages by Pacific ciguatoxin","volume":"19","author":"Matsui","year":"2008","journal-title":"Nitric Oxide"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.toxicon.2009.05.039","article-title":"Pacific ciguatoxin 1B-induced modulation of inflammatory mediators in a murine macrophage cell line","volume":"56","author":"Matsui","year":"2010","journal-title":"Toxicon"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Rubiolo, J.A., Vale, C., Boente-Juncal, A., Hirama, M., Yamashita, S., Camina, M., Vieytes, M.R., and Botana, L.M. (2018). Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons. Toxins, 10.","DOI":"10.3390\/toxins10050192"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.neuro.2007.05.013","article-title":"Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1","volume":"28","author":"Ryan","year":"2007","journal-title":"Neurotoxicology"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Ryan, J.C., Morey, J.S., Bottein, M.-Y.D., Ramsdell, J.S., and Van Dolah, F.M. (2010). Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response. BMC Neurosci., 11.","DOI":"10.1186\/1471-2202-11-107"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/toxsci\/kfn055","article-title":"Liver genomic responses to ciguatoxin: Evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice","volume":"103","author":"Morey","year":"2008","journal-title":"Toxicol. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1126\/science.147.3665.1580","article-title":"Ciguatera Fish Poison: A Cholinesterase Inhibitor","volume":"147","author":"Li","year":"1965","journal-title":"Science"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/path.1710970111","article-title":"The mechanism of respiratory failure in ciguatera poisoning","volume":"97","author":"Kew","year":"1969","journal-title":"J. Pathol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0041-008X(71)80022-4","article-title":"Effect of Ciguatoxin on sodium transport across the frog skin","volume":"18","author":"Setliff","year":"1971","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0014-5793(87)80252-1","article-title":"Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel","volume":"219","author":"Lombet","year":"1987","journal-title":"FEBS Lett."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0041-0101(98)00169-X","article-title":"Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels","volume":"37","author":"Dechraoui","year":"1999","journal-title":"Toxicon"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Catterall","year":"2000","journal-title":"Biochimie"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1476-5381.1988.tb11717.x","article-title":"The mode of inotropic action of ciguatoxin on guinea-pig cardiac muscle","volume":"95","author":"Seino","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"ref_162","first-page":"379","article-title":"Differential actions of pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons","volume":"288","author":"Strachan","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pain.2007.07.026","article-title":"The roles of sodium channels in nociception: Implications for mechanisms of pain","volume":"131","author":"Cummins","year":"2007","journal-title":"Pain"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1111\/ejn.13098","article-title":"Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera","volume":"42","author":"Patel","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","article-title":"Sodium channels in normal and pathological pain","volume":"33","author":"Cummins","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nature05880","article-title":"Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures","volume":"447","author":"Zimmermann","year":"2007","journal-title":"Nature"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2014.03.064","article-title":"A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.pain.2014.05.006","article-title":"Paroxysmal itch caused by gain-of-function Nav1.7 mutation","volume":"155","author":"Devigili","year":"2014","journal-title":"Pain"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Salvatierra, J., Diaz-Bustamante, M., Meixiong, J., Tierney, E., Dong, X., and Bosmans, F. (2018). A disease mutation reveals a role for NaV1.9 in acute itch. J. Clin. Investig.","DOI":"10.1172\/JCI122481"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.1523\/JNEUROSCI.1049-18.2018","article-title":"Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors","volume":"38","author":"Shields","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41598-020-59092-2","article-title":"Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling","volume":"10","author":"Kappes","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ncomms1795","article-title":"Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons","volume":"3","author":"Minett","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nrn3977","article-title":"NaV1.9: A sodium channel linked to human pain","volume":"16","author":"Black","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/mcne.1999.0828","article-title":"Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2","volume":"15","author":"Amaya","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.toxicon.2009.06.035","article-title":"Dual action of a dinoflagellate-derived precursor of Pacific ciguatoxins (P-CTX-4B) on voltage-dependent K+ and Na+ channels of single myelinated axons","volume":"56","author":"Schlumberger","year":"2010","journal-title":"Toxicon"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/toxsci\/kfi097","article-title":"Inhibition of voltage-gated potassium currents by gambierol in mouse taste cells","volume":"85","author":"Ghiaroni","year":"2005","journal-title":"Toxicol. Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.toxicon.2008.01.004","article-title":"Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels","volume":"51","author":"Cuypers","year":"2008","journal-title":"Toxicon"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/chemse\/bjl008","article-title":"Effect of ciguatoxin 3C on voltage-gated Na+ and K+ currents in mouse taste cells","volume":"31","author":"Ghiaroni","year":"2006","journal-title":"Chem. Senses"},{"key":"ref_179","unstructured":"M\u00e9ndez-Vilas, A. (2017). Confocal microscopy and passive staining with the styryl dye FM1-43: A convenient method to evaluate morphometric changes in nodes of Ranvier of single living myelinated axons. Microscopy and Imaging Science Practical Approaches to Applied Research and Education, Formatex Research Center."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0041-0101(83)90092-2","article-title":"The mouse ciguatoxin bioassay: A dose-response curve and symptomatology analysis","volume":"21","author":"Hoffman","year":"1983","journal-title":"Toxicon"},{"key":"ref_181","unstructured":"Hallegraeff, G., Anderson, D., and Cembella, A. (1995). Detection of Ciguatoxins and related Benthic Dinoflagellate Toxins: In vivo and in vitro Methods. Manual on Harmful Marine Microalgae, UNESCO. IOC Manuals and Guides No. 33."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1001\/archinte.1992.00400220135023","article-title":"Orthostatic hypotension in ciguatera fish poisoning","volume":"152","author":"Geller","year":"1992","journal-title":"Arch. Intern. Med."},{"key":"ref_183","first-page":"113","article-title":"Ciguatera fish poisoning","volume":"129","author":"Armstrong","year":"2016","journal-title":"NZMJ"},{"key":"ref_184","unstructured":"Gopalakrishnakone, P., and Tan, C.K. (1987). Pathological changes in the mammalian gut following administration of ciguatoxin. Progress in Venom and Toxin Research, Proceedings of the First Asia-Pacific Congress on Animal, Plant and Microbial Toxins, Singapore, 24\u201327 June 1987, Faculty of Medicine, National University of Singapore."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0041-0101(95)00112-3","article-title":"Morphological observations of diarrhea in mice caused by experimental ciguatoxicosis","volume":"34","author":"Ito","year":"1996","journal-title":"Toxicon"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3389\/fneur.2019.00970","article-title":"Architecture of the Cutaneous Autonomic Nervous System","volume":"10","author":"Glatte","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_187","first-page":"748","article-title":"Mode of the ciguatoxin-induced supersensitivity in the guinea-pig vas deferens","volume":"221","author":"Ohizumi","year":"1982","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_188","first-page":"13","article-title":"Clinical and experimental aspects of cutaneous neurogenic inflammation","volume":"58","author":"Zegarska","year":"2006","journal-title":"Pharmacol. Rep."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuron.2013.01.030","article-title":"Peptidergic CGRP\u03b1 primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold","volume":"78","author":"McCoy","year":"2013","journal-title":"Neuron"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"14055","DOI":"10.1523\/JNEUROSCI.1722-14.2014","article-title":"Multimodal use of calcitonin gene-related peptide and substance P in itch and acute pain uncovered by the elimination of vesicular glutamate transporter 2 from transient receptor potential cation channel subfamily V member 1 neurons","volume":"34","author":"Rogoz","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_191","unstructured":"Stinn, J.F., De Sylva, D.P., Fleming, L.E., and Hack, E. (2000, January 18\u201320). Geographical information systems and ciguatera fish poisoning in the tropical Western Atlantic region. Proceedings of the 1998 Geographic Information Systems in Public Health Conference, Third National Conference, San Diego, CA, USA."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/89945","article-title":"Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway","volume":"7","author":"Vergnolle","year":"2001","journal-title":"Nat. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003","article-title":"Proteinase-activated receptor-2 mediates itch: A novel pathway for pruritus in human skin","volume":"23","author":"Steinhoff","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.pain.2008.03.016","article-title":"Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: Evidence for a role in pain","volume":"139","author":"Zhao","year":"2008","journal-title":"Pain"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/j.pain.0000000000000092","article-title":"Selective keratinocyte stimulation is sufficient to evoke nociception in mice","volume":"156","author":"Pang","year":"2015","journal-title":"Pain"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"e09674","DOI":"10.7554\/eLife.09674","article-title":"Keratinocytes can modulate and directly initiate nociceptive responses","volume":"4","author":"Baumbauer","year":"2015","journal-title":"Elife Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"e31684","DOI":"10.7554\/eLife.31684","article-title":"Keratinocytes mediate innocuous and noxious touch via ATP-P2 \u00d7 4 signaling","volume":"7","author":"Moehring","year":"2018","journal-title":"Elife"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/exd.13411","article-title":"What about physical contacts between epidermal keratinocytes and sensory neurons?","volume":"27","author":"Talagas","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.1007\/s12035-016-0093-y","article-title":"Acute Exposure to Pacific Ciguatoxin Reduces Electroencephalogram Activity and Disrupts Neurotransmitter Metabolic Pathways in Motor Cortex","volume":"54","author":"Kumar","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrd2757","article-title":"Transient receptor potential channels: Targeting pain at the source","volume":"8","author":"Patapoutian","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.envres.2017.12.022","article-title":"Ciguatoxins activate the Calcineurin signalling pathway in yeasts: Potential for development of an alternative detection tool?","volume":"162","author":"Gironde","year":"2018","journal-title":"Environ. Res."},{"key":"ref_204","first-page":"75","article-title":"Ciguatera and acute polyradiculoneuritis. Description of two cases in French Polynesia: Immunoallergic hypothesis?","volume":"69","author":"Oehler","year":"2009","journal-title":"Med. Trop."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0022-510X(91)90021-X","article-title":"Effects of ciguatoxin on nerve excitability in rats (Part I)","volume":"101","author":"Cameron","year":"1991","journal-title":"J. Neurol. Sci."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0022-510X(91)90022-Y","article-title":"Electrophysiological studies on ciguatera poisoning in man (Part II)","volume":"101","author":"Cameron","year":"1991","journal-title":"J. Neurol. Sci."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/1097-4598(200010)23:10<1598::AID-MUS20>3.0.CO;2-P","article-title":"Mild ciguatera poisoning: Case reports with neurophysiological evaluations","volume":"23","author":"Butera","year":"2000","journal-title":"Muscle Nerve"},{"key":"ref_208","first-page":"10","article-title":"Vascularization of the dorsal root ganglia and peripheral nerve of the mouse: Implications for chemical-induced peripheral sensory neuropathies","volume":"4","author":"Herrera","year":"2008","journal-title":"Mol. Pain"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"26809","DOI":"10.1038\/srep26809","article-title":"Ciguatoxin reduces regenerative capacity of axotomized peripheral neurons and delays functional recovery in pre-exposed mice after peripheral nerve injury","volume":"6","author":"Au","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12017-013-8220-7","article-title":"Neurotoxicity and Reactive Astrogliosis in the Anterior Cingulate Cortex in Acute Ciguatera Poisoning","volume":"15","author":"Zhang","year":"2013","journal-title":"Neuromol. Med."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"6769","DOI":"10.1007\/s12035-018-0875-5","article-title":"Pacific Ciguatoxin Induces Excitotoxicity and Neurodegeneration in the Motor Cortex Via Caspase 3 Activation: Implication for Irreversible Motor Deficit","volume":"55","author":"Asthana","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0378-8741(92)90017-L","article-title":"Traditional remedies used in the Western Pacific for the treatment of ciguatera poisoning","volume":"36","author":"Bourdy","year":"1992","journal-title":"J. Ethnopharmacol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/ptr.3396","article-title":"A review of traditional remedies of ciguatera fish poisoning in the Pacific","volume":"25","author":"Darius","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_214","unstructured":"Gopalakrishnakone, P., and Tan, C.K. (1992). Screening of Traditional Remedies Used in Ciguatera Fish Poisoning Treatment. Recent Advances in Toxinology Research, Venom & Toxin Research Group, National University of Singapore."},{"key":"ref_215","unstructured":"Laurent, D., and Amade, P. (1992). Rem\u00e8des Traditionnels Contre la Ciguatera en Nouvelle Cal\u00e9donie, ORSTOM."},{"key":"ref_216","first-page":"33","article-title":"Reversal of Pacific ciguatoxin-1B effects on myelinated axons by agents used in ciguatera treatment","volume":"24","author":"Benoit","year":"2000","journal-title":"Cybium"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.toxicon.2005.07.002","article-title":"Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators","volume":"46","author":"Benoit","year":"2005","journal-title":"Toxicon"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jep.2009.03.039","article-title":"Ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in RAW 264.7 macrophages","volume":"123","author":"Matsui","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jep.2009.09.020","article-title":"Characterisation of the anti-inflammatory potential of Vitex trifolia L. (Labiatae), a multipurpose plant of the Pacific traditionnal medicine","volume":"126","author":"Matsui","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_220","unstructured":"Tadahide, N., Ryuta, T., and Yoropiy, A. (2003). Ciguatera fish poisoning in Ulithi Atoll, Yap State, Micronesia. Occasional Papers No. 39, Kagoshima University Research Center for the Pacific Islands."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jep.2012.05.045","article-title":"Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin","volume":"143","author":"Rossi","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s12640-013-9429-9","article-title":"Neuroprotective Effects of Rosmarinic Acid on Ciguatoxin in Primary Human Neurons","volume":"25","author":"Braidy","year":"2014","journal-title":"Neurotox. Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM198607033150115","article-title":"Symptomatic improvement with amitriptyline in ciguatera fish poisoning","volume":"315","author":"Davis","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/15563658708992645","article-title":"Treatment of ciguatera fish poisoning with amitriptyline and nifedipine","volume":"25","author":"Calvert","year":"1987","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0002-9343(88)90320-8","article-title":"Potential benefit of tocainide in the treatment of ciguatera: Report of three cases","volume":"84","author":"Lange","year":"1988","journal-title":"Am. J. Med."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1136\/pgmj.75.889.678","article-title":"Ciguatera fish poisoning","volume":"75","author":"Crump","year":"1999","journal-title":"Postgrad. Med. J."},{"key":"ref_227","first-page":"514","article-title":"Ciguatera and peripheral neuropathy: A case report","volume":"156","author":"Derouiche","year":"2000","journal-title":"Rev. Neurol."},{"key":"ref_228","unstructured":"Gabrie, C., and Salvat, B. (June, January 27). Respiratory and cardio-vascular effects of ciguatoxin in cats; antagonistic action of Hexamethonium, Atropine, Propranolol, Phentolamine, Yohimbine, Prazosin, Verapamil, Calcium and Lidocaine. Proceedings of the Fifth International Coral Reef Conference, Tahiti, France."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/mus.880160714","article-title":"Modification of the peripheral nerve disturbance in ciguatera poisoning in rats with lidocaine","volume":"16","author":"Cameron","year":"1993","journal-title":"Muscle Nerve"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM200103013440919","article-title":"Treatment of ciguatera poisoning with gabapentin","volume":"344","author":"Perez","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3109\/15563650.2015.1052499","article-title":"Pregabalin to treat ciguatera fish poisoning","volume":"53","author":"Brett","year":"2015","journal-title":"Clin Toxicol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1023\/B:CEMN.0000023629.81595.09","article-title":"Brevenal Is a Natural Inhibitor of Brevetoxin Action in Sodium Channel Receptor Binding Assays","volume":"24","author":"Bourdelais","year":"2004","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.hal.2013.03.001","article-title":"Brevenal, a brevetoxin antagonist from Karenia brevis, binds to a previously unreported site on mammalian sodium channels","volume":"26","author":"Gold","year":"2013","journal-title":"Harmful Algae"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.toxicon.2009.02.017","article-title":"Use of monoclonal antibodies as an effective strategy for treatment of ciguatera poisoning","volume":"53","author":"Inoue","year":"2009","journal-title":"Toxicon"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1001\/jama.1988.03720180066035","article-title":"Successful treatment of ciguatera fish poisoning with intravenous mannitol","volume":"259","author":"Palafox","year":"1988","journal-title":"JAMA"},{"key":"ref_236","first-page":"425","article-title":"Clinical experience with i.v. Mannitol in the treatment of ciguatera","volume":"85","author":"Blythe","year":"1992","journal-title":"Bull. Soc. Pathol. Exot."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/15563650.2017.1327664","article-title":"Is mannitol the treatment of choice for patients with ciguatera fish poisoning?","volume":"55","author":"Mullins","year":"2017","journal-title":"Clin. Toxicol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1212\/WNL.58.6.873","article-title":"Ciguatera fish poisoning: A double-blind randomized trial of mannitol therapy","volume":"58","author":"Schnorf","year":"2002","journal-title":"Neurology"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1580\/0953-9859-4.3.304","article-title":"An outbreak of ciguatera poisoning in a group of scuba divers","volume":"4","author":"Adams","year":"1993","journal-title":"J. Wilderness Med."}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/10\/2291\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:20:58Z","timestamp":1760178058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/10\/2291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"references-count":239,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["cells9102291"],"URL":"https:\/\/doi.org\/10.3390\/cells9102291","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,14]]}}}