{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:37:50Z","timestamp":1790422670589,"version":"4.1.0"},"reference-count":257,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>B lymphocytes are crucial mediators of systemic immune responses and are known to be substantial in the pathogenesis of autoimmune diseases with cutaneous manifestations. Amongst them are lupus erythematosus, dermatomyositis, systemic sclerosis and psoriasis, and particularly those driven by autoantibodies such as pemphigus and pemphigoid. However, the concept of autoreactive skin-associated B cells, which may reside in the skin and locally contribute to chronic inflammation, is gradually evolving. These cells are believed to differ from B cells of primary and secondary lymphoid organs and may provide additional features besides autoantibody production, including cytokine expression and crosstalk to autoreactive T cells in an antigen-presenting manner. In chronically inflamed skin, B cells may appear in tertiary lymphoid structures. Those abnormal lymph node-like structures comprise a network of immune and stromal cells possibly enriched by vascular structures and thus constitute an ideal niche for local autoimmune responses. In this review, we describe current considerations of different B cell subsets and their assumed role in skin autoimmunity. Moreover, we discuss traditional and B cell-associated approaches for the treatment of autoimmune skin diseases, including drugs targeting B cells (e.g., CD19- and CD20-antibodies), plasma cells (e.g., proteasome inhibitors, CXCR4 antagonists), activated pathways (such as BTK- and PI3K-inhibitors) and associated activator molecules (BLyS, APRIL).<\/jats:p>","DOI":"10.3390\/cells9122627","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T21:37:42Z","timestamp":1607377062000},"page":"2627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Skin-Associated B Cells in the Pathogenesis of Cutaneous Autoimmune Diseases\u2014Implications for Therapeutic Approaches"],"prefix":"10.3390","volume":"9","author":[{"given":"Tanja","family":"Fetter","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-0486","authenticated-orcid":false,"given":"Dennis","family":"Niebel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Braegelmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9727","DOI":"10.1073\/pnas.0803644105","article-title":"Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors","volume":"105","author":"Mietzner","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.coi.2014.03.001","article-title":"The imperfect control of self-reactive germinal center B cells","volume":"28","author":"Brink","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20042251","article-title":"Defective B cell tolerance checkpoints in systemic lupus erythematosus","volume":"201","author":"Yurasov","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1172\/JCI64413","article-title":"Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface","volume":"122","author":"Corti","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/icb.2016.78","article-title":"Germinal centers and autoimmune disease in humans and mice","volume":"94","author":"DeFranco","year":"2016","journal-title":"Immunol. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.4049\/jimmunol.1202317","article-title":"Pathogenic Long-Lived Plasma Cells and Their Survival Niches in Autoimmunity, Malignancy, and Allergy","volume":"189","author":"Winter","year":"2012","journal-title":"J. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2230.2011.04092.x","article-title":"The pathogenic role of autoantibodies in pemphigus vulgaris","volume":"36","author":"Pan","year":"2011","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clindermatol.2011.03.005","article-title":"Bullous pemphigoid: From the clinic to the bench","volume":"30","author":"Zambruno","year":"2012","journal-title":"Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.4049\/jimmunol.1801211","article-title":"Skin-Associated B Cells in Health and Inflammation","volume":"202","author":"Debes","year":"2019","journal-title":"J. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.it.2014.12.006","article-title":"Revisiting the role of B cells in skin immune surveillance","volume":"36","author":"Egbuniwe","year":"2015","journal-title":"Trends Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The immunological anatomy of the skin","volume":"19","author":"Kabashima","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.coi.2019.01.004","article-title":"B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis","volume":"57","author":"Corsiero","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/sqb.1999.64.1","article-title":"Lymphoid Development from Stem Cells and the Common Lymphocyte Progenitors","volume":"64","author":"Akashi","year":"1999","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: How they develop and function","volume":"112","author":"LeBien","year":"2008","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1172\/JCI78083","article-title":"Checkpoints that control B cell development","volume":"125","author":"Melchers","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nri.2017.19","article-title":"Mechanisms of central tolerance for B cells","volume":"17","author":"Nemazee","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ni829","article-title":"DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL","volume":"3","author":"Litinskiy","year":"2002","journal-title":"Nat. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1074-7613(03)00208-5","article-title":"Plasmacytoid Dendritic Cells Induce Plasma Cell Differentiation through Type I Interferon and Interleukin","volume":"19","author":"Jego","year":"2003","journal-title":"Immunity"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.immuni.2012.07.017","article-title":"Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen","volume":"37","author":"Chan","year":"2012","journal-title":"Immunity"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","article-title":"Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages","volume":"29","author":"Nurieva","year":"2008","journal-title":"Immunity"},{"key":"ref_21","first-page":"214","article-title":"T\u2013B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction","volume":"517","author":"Liu","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.immuni.2008.06.001","article-title":"A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells","volume":"29","author":"Vogelzang","year":"2008","journal-title":"Immunity"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1084\/jem.20091777","article-title":"IL-21 regulates germinal center B cell differentiation and proliferation through a B cell\u2013intrinsic mechanism","volume":"207","author":"Zotos","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/1074-7613(94)90095-7","article-title":"The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation","volume":"1","author":"Kawabe","year":"1994","journal-title":"Immunity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature13300","article-title":"Clonal selection in the germinal centre by regulated proliferation and hypermutation","volume":"509","author":"Gitlin","year":"2014","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1084\/jem.20092712","article-title":"Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity","volume":"207","author":"Guo","year":"2010","journal-title":"J. Exp. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.171.1.265","article-title":"Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation","volume":"171","author":"Shlomchik","year":"1990","journal-title":"J. Exp. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.20161533","article-title":"Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells","volume":"214","author":"Suan","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4614-6217-0_7","article-title":"Innate-Like B Cells and Their Rules of Engagement","volume":"785","author":"Baumgarth","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41577-019-0244-2","article-title":"B cell memory: Building two walls of protection against pathogens","volume":"20","author":"Akkaya","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/imr.12640","article-title":"Generation of memory B cells and their reactivation","volume":"283","author":"Inoue","year":"2018","journal-title":"Immunol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2009.05137.x","article-title":"B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer","volume":"1183","author":"DiLillo","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.smim.2007.12.002","article-title":"Plasma cell development: From B-cell subsets to long-term survival niches","volume":"20","author":"Fairfax","year":"2008","journal-title":"Semin. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1080\/00313020802320739","article-title":"Evaluation of the profile of the immune cell infiltrate in lichen planus, discoid lupus erythematosus, and chronic dermatitis","volume":"40","author":"Hussein","year":"2008","journal-title":"Pathology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jdermsci.2016.12.004","article-title":"Changes in T cell and B cell composition in discoid lupus erythematosus skin at different stages","volume":"85","author":"Hosler","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.jid.2017.05.032","article-title":"Pivotal Role of Lesional and Perilesional T\/B Lymphocytes in Pemphigus Pathogenesis","volume":"137","author":"Yuan","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-018-1569-0","article-title":"Characterization of inflammatory cell infiltrate of scleroderma skin: B cells and skin score progression","volume":"20","author":"Bosello","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e5374","DOI":"10.1590\/1414-431x20165374","article-title":"CD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis patients and their correlations with disease severity","volume":"49","author":"Lu","year":"2016","journal-title":"Braz. J. Med Biol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1346-8138.1999.tb02021.x","article-title":"Elevated B-Lymphocyte Levels in Lesional Tissue of Non-Arthritic Psoriasis","volume":"26","author":"Mahmoud","year":"1999","journal-title":"J. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.yexcr.2013.03.005","article-title":"B cells and their mediators as targets for therapy in solid tumors","volume":"319","author":"Gunderson","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-065X.2010.00938.x","article-title":"Memory B and memory plasma cells","volume":"237","author":"Yoshida","year":"2010","journal-title":"Immunol. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"13263","DOI":"10.1073\/pnas.230417497","article-title":"Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs","volume":"97","author":"Ochsenbein","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1126\/science.1201730","article-title":"Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response","volume":"331","author":"Pape","year":"2011","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.4049\/jimmunol.178.10.6092","article-title":"Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis","volume":"178","author":"Duddy","year":"2007","journal-title":"J. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1002\/eji.201040516","article-title":"Memory B cells from a subset of treatment-na\u00efve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-\u03b3 production in response to myelin basic protein and myelin oligodendrocyte glycoprotein","volume":"40","author":"Harp","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.4049\/jimmunol.180.6.3655","article-title":"Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL","volume":"180","author":"Benson","year":"2008","journal-title":"J. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/art.34400","article-title":"Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus","volume":"64","author":"Stohl","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3389\/fimmu.2019.01375","article-title":"Identification of Autoreactive B Cell Subpopulations in Peripheral Blood of Autoimmune Patients With Pemphigus Vulgaris","volume":"10","author":"Pollmann","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1046\/j.1523-1747.2000.00840.x","article-title":"Detection of Antigen-Specific B Cells in Patients with Pemphigus Vulgaris by Enzyme-Linked Immunospot Assay: Requirement of T Cell Collaboration for Autoantibody Production","volume":"114","author":"Nishifuji","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hennerici, T., Pollmann, R., Schmidt, T., Seipelt, M., Tackenberg, B., M\u00f6bs, C., Ghoreschi, K., Hertl, M., and Eming, R. (2016). Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148919"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1084\/jem.20060087","article-title":"Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation","volume":"203","author":"Paus","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_53","first-page":"133","article-title":"Lifetime of plasma cells in the bone marrow","volume":"388","author":"Manz","year":"1997","journal-title":"Nat. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/intimm\/10.11.1703","article-title":"Survival of long-lived plasma cells is independent of antigen [In Process Citation]","volume":"10","author":"Manz","year":"1998","journal-title":"Int. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1073\/pnas.0800555105","article-title":"Maintenance of the plasma cell pool is independent of memory B cells","volume":"105","author":"Ahuja","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral Immunity Due to Long-Lived Plasma Cells","volume":"8","author":"Slifka","year":"1998","journal-title":"Immunity"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.4049\/jimmunol.171.4.1684","article-title":"Plasma Cell Survival Is Mediated by Synergistic Effects of Cytokines and Adhesion-Dependent Signals","volume":"171","author":"Cassese","year":"2003","journal-title":"J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1182\/blood-2011-01-332940","article-title":"Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow","volume":"118","author":"Matthes","year":"2011","journal-title":"Blood"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1182\/blood-2017-06-789578","article-title":"BAFF and CD4+ T cells are major survival factors for long-lived splenic plasma cells in a B-cell\u2013depletion context","volume":"131","author":"Thai","year":"2018","journal-title":"Blood"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00296-008-0773-7","article-title":"Infiltrations of plasma cells in synovium are highly associated with synovial fluid levels of APRIL in inflamed peripheral joints of rheumatoid arthritis","volume":"29","author":"Dong","year":"2009","journal-title":"Rheumatol. Int."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Tiburzy, B., Szyska, M., Iwata, H., Chrobok, N., Kulkarni, U., Hirose, M., Ludwig, R.J., Kalies, K., Westermann, J., and Wong, D. (2013). Persistent Autoantibody-Production by Intermediates between Short-and Long-Lived Plasma Cells in Inflamed Lymph Nodes of Experimental Epidermolysis Bullosa Acquisita. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083631"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.4049\/jimmunol.1102639","article-title":"The Skin, a Novel Niche for Recirculating B Cells","volume":"188","author":"Geherin","year":"2012","journal-title":"J. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/1523-1747.ep12560807","article-title":"Identification of Secretory Immunoglobulin A in Human Sweat and Sweat Glands","volume":"90","author":"Okada","year":"1988","journal-title":"J. Investig. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0560.1989.tb00026.x","article-title":"Secretory immunoglobulin A in sweat gland tumors","volume":"16","author":"Metze","year":"1989","journal-title":"J. Cutan. Pathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.jid.2019.06.133","article-title":"A Niche for Plasma Cells: The Skin","volume":"139","author":"Karaaslan","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.jid.2019.05.009","article-title":"IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation","volume":"139","author":"Wilson","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/exd.13419","article-title":"High expression of B lymphocyte stimulator in lesional keratinocytes of patients with cutaneous lupus erythematosus","volume":"27","author":"Wenzel","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1080\/08916934.2020.1736049","article-title":"Abnormal expression of BAFF and its receptors in peripheral blood and skin lesions from systemic lupus erythematosus patients","volume":"53","author":"Chen","year":"2020","journal-title":"Autoimmun"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12026-015-8708-3","article-title":"The role of B-1 cells in inflammation","volume":"63","author":"Aziz","year":"2015","journal-title":"Immunol. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/nyas.12790","article-title":"The human counterpart of mouse B-1 cells","volume":"1362","author":"Rothstein","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/ni1301","article-title":"Identification of a B-1 B cell\u2013specified progenitor","volume":"7","author":"Leathers","year":"2006","journal-title":"Nat. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3389\/fimmu.2018.01064","article-title":"The Interplay between Innate-Like B Cells and Other Cell Types in Autoimmunity","volume":"9","author":"Tsay","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4049\/jimmunol.1102107","article-title":"Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential","volume":"188","author":"Kaveri","year":"2012","journal-title":"J. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1073\/pnas.97.3.1184","article-title":"Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM","volume":"97","author":"Boes","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/labinvest.3700497","article-title":"Lupus resistance is associated with marginal zone abnormalities in an NZM murine model","volume":"87","author":"Duan","year":"2007","journal-title":"Lab. Investig."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.autrev.2005.10.007","article-title":"Role of B-1a cells in autoimmunity","volume":"5","author":"Duan","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1084\/jem.20110978","article-title":"A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus","volume":"208","author":"Griffin","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","author":"Kessel","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"ref_79","first-page":"366","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"Shen","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nri2315","article-title":"Not always the bad guys: B cells as regulators of autoimmune pathology","volume":"8","author":"Fillatreau","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_81","first-page":"69","article-title":"Interleukin-10-Producing B Cells and the Regulation of Immunity","volume":"380","author":"Hilgenberg","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2010.00991.x","article-title":"Novel regulatory functions for Toll-like receptor-activated B cells during intracellular bacterial infection","volume":"240","author":"Fillatreau","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2015.04.006","article-title":"Regulatory plasma cells","volume":"23","author":"Fillatreau","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2012.63","article-title":"Regulatory functions of innate-like B cells","volume":"10","author":"Zhang","year":"2013","journal-title":"Cell. Mol. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/intimm\/dxv038","article-title":"The expanding family of regulatory B cells","volume":"27","author":"Mauri","year":"2015","journal-title":"Int. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.immuni.2014.10.016","article-title":"Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation","volume":"41","author":"Matsumoto","year":"2014","journal-title":"Immunity"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/251550a0","article-title":"B-cell suppression of delayed hypersensitivity reactions","volume":"251","author":"Katz","year":"1974","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.4049\/jimmunol.113.6.1716","article-title":"Specific suppression of delayed hypersensitivity: The possible presence of a suppressor B cell in the regulation of delayed hypersensitivity","volume":"113","author":"Neta","year":"1974","journal-title":"J. Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.4049\/jimmunol.1403246","article-title":"IL-10+Innate-like B Cells Are Part of the Skin Immune System and Require \u03b14\u03b21 Integrin To Migrate between the Peritoneum and Inflamed Skin","volume":"196","author":"Geherin","year":"2016","journal-title":"J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1002\/art.22811","article-title":"Development of psoriasis after B cell depletion with rituximab","volume":"56","author":"Dass","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1111\/pde.12437","article-title":"Rituximab Induced Psoriasis in an Infant","volume":"31","author":"Fiorillo","year":"2014","journal-title":"Pediatr. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3899\/jrheum.111347","article-title":"Incidence of New-onset and Flare of Preexisting Psoriasis During Rituximab Therapy for Rheumatoid Arthritis: Data from the French AIR Registry","volume":"39","author":"Thomas","year":"2012","journal-title":"J. Rheumatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1007\/s00296-012-2581-3","article-title":"Induced psoriasis after rituximab therapy for rheumatoid arthritis: A case report and review of the literature","volume":"33","author":"Guidelli","year":"2012","journal-title":"Rheumatol. Int."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Alahmari, H.S., Alhowaish, N.Y., and Omair, M.A. (2019). Rituximab-Induced Psoriasis in a Patient with Granulomatosis with Polyangitis Treated with Adalimumab. Case Rep. Rheumatol., 2019.","DOI":"10.1155\/2019\/5450863"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1684\/ejd.2015.2705","article-title":"New-onset psoriasis induced by rituximab therapy for non-Hodgkin lymphoma in a child","volume":"26","author":"Kim","year":"2016","journal-title":"Eur. J. Dermatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"27479","DOI":"10.1038\/srep27479","article-title":"Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/bjd.13192","article-title":"Impaired function of CD19+CD24hiCD38hiregulatory B cells in patients with pemphigus","volume":"172","author":"Zhu","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.4049\/jimmunol.176.6.3498","article-title":"Primary T Cell Expansion and Differentiation In Vivo Requires Antigen Presentation by B Cells","volume":"176","author":"Crawford","year":"2006","journal-title":"J. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.4049\/jimmunol.165.10.5558","article-title":"A Critical Role for B Cells in the Development of Memory CD4 Cells","volume":"165","author":"Linton","year":"2000","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.4049\/jimmunol.171.12.6478","article-title":"CD40-Induced Aggregation of MHC Class II and CD80 on the Cell Surface Leads to an Early Enhancement in Antigen Presentation","volume":"171","author":"Clatza","year":"2003","journal-title":"J. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/314537a0","article-title":"Antigen-specific interaction between T and B cells","volume":"314","author":"Lanzavecchia","year":"1985","journal-title":"Nature"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.4049\/jimmunol.179.6.3821","article-title":"The Role of B Cells in the Development of CD4 Effector T Cells during a Polarized Th2 Immune Response","volume":"179","author":"Liu","year":"2007","journal-title":"J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.4049\/jimmunol.179.8.5109","article-title":"Expression of CD80\/86 on B cells is essential for autoreactive T cell activation and the development of arthritis","volume":"179","author":"Cao","year":"2007","journal-title":"J. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17\u2013producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-immunol-030409-101212","article-title":"Differentiation of Effector CD4 T Cell Populations","volume":"28","author":"Zhu","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1084\/jem.189.10.1639","article-title":"A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus","volume":"189","author":"Chan","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.4049\/jimmunol.1500792","article-title":"B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus","volume":"195","author":"Giles","year":"2015","journal-title":"J. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1038\/jid.2008.172","article-title":"Rituximab Exerts a Dual Effect in Pemphigus Vulgaris","volume":"128","author":"Eming","year":"2008","journal-title":"J. Investig. Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.autrev.2017.05.009","article-title":"Pathogenesis of cutaneous lupus erythema associated with and without systemic lupus erythema","volume":"16","author":"Zhang","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41584-019-0272-0","article-title":"Cutaneous lupus erythematosus: New insights into pathogenesis and therapeutic strategies","volume":"15","author":"Wenzel","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/1346-8138.14498","article-title":"Analysis of possible structures of inducible skin-associated lymphoid tissue in lupus erythematosus profundus","volume":"45","author":"Kogame","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jid.2019.07.717","article-title":"Autoreactive B Cell Differentiation in Diffuse Ectopic Lymphoid-Like Structures of Inflamed Pemphigus Lesions","volume":"140","author":"Zhou","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"12s","DOI":"10.1111\/1523-1747.ep12536743","article-title":"Skin-Associated Lymphoid Tissues (SALT): Origins and Functions","volume":"80","author":"Streilein","year":"1983","journal-title":"J. Investig. Dermatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1111\/1523-1747.ep12275413","article-title":"Circuits and Signals of the Skin-Associated Lymphoid Tissues (SALT)","volume":"85","author":"Streilein","year":"1985","journal-title":"J. Investig. Dermatol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/ni.2992","article-title":"Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin","volume":"15","author":"Natsuaki","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fimmu.2016.00477","article-title":"Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation","volume":"7","author":"Barone","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2016.00491","article-title":"High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation","volume":"7","author":"Ruddle","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1172\/JCI71611","article-title":"Lymphatic vessels and tertiary lymphoid organs","volume":"124","author":"Ruddle","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fimmu.2012.00350","article-title":"Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma","volume":"3","author":"Stranford","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.ajpath.2010.12.039","article-title":"Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans","volume":"178","author":"Link","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20021761","article-title":"Ectopic LT\u03b1\u03b2 Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase","volume":"197","author":"Drayton","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1084\/jem.183.4.1461","article-title":"Chronic inflammation caused by lymphotoxin is lymphoid neogenesis","volume":"183","author":"Kratz","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"986","DOI":"10.4049\/jimmunol.168.3.986","article-title":"Cutting Edge: Organogenesis of Nasal-Associated Lymphoid Tissue (NALT) Occurs Independently of Lymphotoxin-\u03b1 (LT\u03b1) and Retinoic Acid Receptor-Related Orphan Receptor-\u03b3, but the Organization of NALT Is LT\u03b1 Dependent","volume":"168","author":"Harmsen","year":"2002","journal-title":"J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3389\/fimmu.2018.01952","article-title":"Tertiary Lymphoid Structures: Autoimmunity Goes Local","volume":"9","author":"Pipi","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"R2","DOI":"10.1186\/ar3220","article-title":"Salivary glands of primary Sjogren\u2019s syndrome patients express factors vital for plasma cell survival","volume":"13","author":"Szyszko","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.1073\/pnas.1503315112","article-title":"IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs","volume":"112","author":"Barone","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni.2053","article-title":"The development of inducible bronchus-associated lymphoid tissue depends on IL-17","volume":"12","author":"Carragher","year":"2011","journal-title":"Nat. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nri3700","article-title":"Ectopic lymphoid-like structures in infection, cancer and autoimmunity","volume":"14","author":"Pitzalis","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-immunol-032713-120252","article-title":"Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation","volume":"33","author":"Buckley","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/art.22400","article-title":"Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis","volume":"56","author":"Vos","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1874312900802010038","article-title":"Resistance to Rituximab Therapy and Local BAFF Overexpression in Sj\u00f6gren\u2019s Syndrome-Related Myoepithelial Sialadenitis and Low-Grade Parotid B-Cell Lymphoma","volume":"2","author":"Quartuccio","year":"2008","journal-title":"Open Rheumatol. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3389\/fimmu.2018.00835","article-title":"Targeting B Cells and Plasma Cells in Autoimmune Diseases","volume":"9","author":"Hofmann","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.0303-6987.2005.00351.x","article-title":"Lupus erythematosus panniculitis (lupus profundus): Clinical, histopathological, and molecular analysis of nine cases","volume":"32","author":"Massone","year":"2005","journal-title":"J. Cutan. Pathol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaci.2020.02.013","article-title":"Autoimmune bullous skin diseases, pemphigus and pemphigoid","volume":"145","author":"Egami","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1172\/JCI116856","article-title":"A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180","volume":"92","author":"Liu","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1172\/JCI115968","article-title":"Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic","volume":"90","author":"Amagai","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.4049\/jimmunol.176.3.2015","article-title":"Autoreactive T and B Cells from Bullous Pemphigoid (BP) Patients Recognize Epitopes Clustered in Distinct Regions of BP180 and BP180 and BP230","volume":"176","author":"Uter","year":"2006","journal-title":"J. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1590\/abd1806-4841.20153372","article-title":"Quality of life index in autoimmune bullous dermatosis patients","volume":"90","author":"Penha","year":"2015","journal-title":"An. Bras. Dermatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijwd.2017.11.004","article-title":"Psychosocial impact of inherited and autoimmune blistering diseases","volume":"4","author":"Jain","year":"2018","journal-title":"Int. J. Women\u2019s Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/jdv.15062","article-title":"The effect of autoimmune blistering diseases on work productivity","volume":"32","author":"Wang","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/art.21658","article-title":"Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation","volume":"54","author":"Kuhn","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.jid.2017.03.018","article-title":"Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus","volume":"137","author":"Scholtissek","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/imr.12815","article-title":"Autoreactive B cells in SLE, villains or innocent bystanders?","volume":"292","author":"Hamilton","year":"2019","journal-title":"Immunol. Rev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0733-8635(05)70230-8","article-title":"UPDATE ON SYSTEMIC GLUCOCORTICOSTEROIDS IN DERMATOLOGY","volume":"19","author":"Williams","year":"2001","journal-title":"Dermatol. Clin."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2036.1996.22164025.x","article-title":"Cytokine modulation by glucocorticoids: Mechanisms and actions in cellular studies","volume":"10","author":"Brattsand","year":"1996","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"23002","DOI":"10.1038\/srep23002","article-title":"Effects of Systemically Administered Hydrocortisone on the Human Immunome","volume":"6","author":"Olnes","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3389\/fimmu.2019.01418","article-title":"Pemphigus: Current and Future Therapeutic Strategies","volume":"10","author":"Didona","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1468-3083.2012.04717.x","article-title":"Randomized double blind trial of prednisolone and azathioprine, vs. prednisolone and placebo, in the treatment of pemphigus vulgaris","volume":"27","author":"Mortazavizadeh","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-4362.1990.tb04765.x","article-title":"Pemphigus Therapy with Oral Prednisolone Regimens A 5-Year Study","volume":"29","author":"Ratnam","year":"1990","journal-title":"Int. J. Dermatol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00004836-200110000-00006","article-title":"Side Effects of Corticosteroid Therapy","volume":"33","author":"Buchman","year":"2001","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.20040168","article-title":"Short-lived Plasmablasts and Long-lived Plasma Cells Contribute to Chronic Humoral Autoimmunity in NZB\/W Mice","volume":"199","author":"Hoyer","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-0960.2011.00839.x","article-title":"The use of methotrexate in dermatology: A review","volume":"53","author":"Shen","year":"2011","journal-title":"Australas. J. Dermatol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/ajd.12406","article-title":"Cyclophosphamide in dermatology","volume":"58","author":"Kim","year":"2017","journal-title":"Australas. J. Dermatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1993.tb00652.x","article-title":"Immunosuppressive and other Effects of Mycophenolic Acid and an Ester Prodrug, Mycophenolate Mofetil","volume":"136","author":"Allison","year":"1993","journal-title":"Immunol. Rev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-015-0603-8","article-title":"Differential effects of cyclophosphamide and mycophenolate mofetil on cellular and serological parameters in patients with systemic lupus erythematosus","volume":"17","author":"Fassbinder","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/ar3835","article-title":"Mycophenolic acid counteracts B cell proliferation and plasmablast formation in patients with systemic lupus erythematosus","volume":"14","author":"Eickenberg","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/archderm.142.11.1447","article-title":"A Comparison of Oral Methylprednisolone Plus Azathioprine or Mycophenolate Mofetil for the Treatment of Pemphigus","volume":"142","author":"Beissert","year":"2006","journal-title":"Arch. Dermatol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"s2","DOI":"10.1191\/0961203305LU2109OA","article-title":"Mechanisms of action of mycophenolate mofetil","volume":"14","author":"Allison","year":"2005","journal-title":"Lupus"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"27S","DOI":"10.1177\/1203475419857668","article-title":"Off-Label Use of Topical Calcineurin Inhibitors in Dermatologic Disorders","volume":"23","author":"Guenther","year":"2019","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"571","DOI":"10.4161\/mabs.21338","article-title":"CD19 as an attractive target for antibody-based therapy","volume":"4","author":"Hammer","year":"2012","journal-title":"mAbs"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s13317-017-0100-y","article-title":"Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment","volume":"8","author":"Du","year":"2017","journal-title":"Autoimmun. Highlights"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nbt.2076","article-title":"The discovery and development of belimumab: The anti-BLyS\u2013lupus connection","volume":"30","author":"Stohl","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13075-020-02153-8","article-title":"Inhibition of effector B cells by ibrutinib in systemic sclerosis","volume":"22","author":"Einhaus","year":"2020","journal-title":"Arthritis Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fimmu.2012.00256","article-title":"Selective inhibitors of phosphoinositide 3-kinase delta: Modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies","volume":"3","author":"Puri","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/eji.201646795","article-title":"Regulation of immune cell signaling by SHIP1: A phosphatase, scaffold protein, and potential therapeutic target","volume":"47","author":"Pauls","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.12688\/f1000research.7522.1","article-title":"The RhoA-ROCK pathway in the regulation of T and B cell responses","volume":"5","author":"Ricker","year":"2016","journal-title":"F1000Research"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"111646","DOI":"10.1016\/j.ejmech.2019.111646","article-title":"Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases","volume":"182","author":"Xi","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fendo.2019.00585","article-title":"The Role of the CXCL12\/CXCR4\/ACKR3 Axis in Autoimmune Diseases","volume":"10","author":"Santiago","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1172\/JCI97911","article-title":"Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans","volume":"128","author":"Ulrichts","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0167-5699(94)90276-3","article-title":"CD20: A regulator of cell-cycle progression of B lymphocytes","volume":"15","author":"Tedder","year":"1994","journal-title":"Immunol. Today"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1182\/blood-2019-129600","article-title":"Comparative Assessment of Surface CD19 and CD20 Expression on B-Cell Lymphomas from Clinical Biopsies: Implications for Targeted Therapies","volume":"134","author":"Horna","year":"2019","journal-title":"Blood"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2217\/imt-2017-0062","article-title":"Anti-CD 19 and anti-CD 20 CAR-modified T cells for B-cell malignancies: A systematic review and meta-analysis","volume":"9","author":"Zahid","year":"2017","journal-title":"Immunother."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Zhou, H., Luo, Y., Zhu, S., Wang, X., Zhao, Y., Ou, X., Zhang, T., and Ma, X. (2018). The efficacy and safety of anti-CD19\/CD20 chimeric antigen receptor- T cells immunotherapy in relapsed or refractory B-cell malignancies:a meta-analysis. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4817-4"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1007\/s12325-017-0612-x","article-title":"Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience","volume":"34","author":"Salles","year":"2017","journal-title":"Adv. Ther."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1056\/NEJMoa062930","article-title":"Treatment of Pemphigus Vulgaris with Rituximab and Intravenous Immune Globulin","volume":"355","author":"Ahmed","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1056\/NEJMoa067752","article-title":"A Single Cycle of Rituximab for the Treatment of Severe Pemphigus","volume":"357","author":"Joly","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41591-019-0421-7","article-title":"A safe and potent anti-CD19 CAR T cell therapy","volume":"25","author":"Ying","year":"2019","journal-title":"Nat. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1182\/blood-2011-04-348540","article-title":"Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias","volume":"118","author":"Brentjens","year":"2011","journal-title":"Blood"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.ymthe.2018.05.018","article-title":"Autologous CD19-Targeted CAR T Cells in Patients with Residual CLL following Initial Purine Analog-Based Therapy","volume":"26","author":"Geyer","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1126\/science.aaf6756","article-title":"Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease","volume":"353","author":"Ellebrecht","year":"2016","journal-title":"Science"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jaip.2016.06.022","article-title":"Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review","volume":"5","author":"Levin","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pr."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/S0140-6736(17)30070-3","article-title":"First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): A prospective, multicentre, parallel-group, open-label randomised trial","volume":"389","author":"Joly","year":"2017","journal-title":"Lancet"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Joly, P., Horwath, B., Patsatsi, \u0391., Uzun, S., Bech, R., Beissert, S., Bergman, R., Bernard, P., Borradori, L., and Caproni, M. (2020). Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV). J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.16752"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1200\/JCO.2002.11.017","article-title":"Treatment With Ibritumomab Tiuxetan Radioimmunotherapy in Patients With Rituximab-Refractory Follicular Non-Hodgkin\u2019s Lymphoma","volume":"20","author":"Witzig","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1517\/13543780902832679","article-title":"Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders","volume":"18","author":"Castillo","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jdcr.2020.05.034","article-title":"Refractory pemphigus vulgaris successfully treated with ofatumumab","volume":"6","author":"Klufas","year":"2020","journal-title":"JAAD Case Rep."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1182\/blood-2017-08-798322","article-title":"Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia","volume":"131","author":"Dombret","year":"2018","journal-title":"Blood"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/jamaoncol.2017.2380","article-title":"Salvage Chemoimmunotherapy With Inotuzumab Ozogamicin Combined With Mini-Hyper-CVD for Patients With Relapsed or Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Phase 2 Clinical Trial","volume":"4","author":"Jabbour","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrrheum.2009.184","article-title":"CD19: A promising B cell target for rheumatoid arthritis","volume":"5","author":"Tedder","year":"2009","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/BOR.0b013e328344c15e","article-title":"Targeting BLyS in rheumatic disease: The sometimes-bumpy road from bench to bedside","volume":"23","author":"Stohl","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(10)61354-2","article-title":"Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial","volume":"377","author":"Navarra","year":"2011","journal-title":"Lancet"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/art.30613","article-title":"A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus","volume":"63","author":"Furie","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/art.24699","article-title":"A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus","volume":"61","author":"Wallace","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/annrheumdis-2014-207090","article-title":"Efficacy and safety of tabalumab, an anti-B-cell-activating factor monoclonal antibody, in patients with rheumatoid arthritis who had an inadequate response to methotrexate therapy: Results from a phase III multicentre, randomised, double-blind study","volume":"74","author":"Smolen","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1517\/14712590903033919","article-title":"Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis","volume":"9","author":"Bracewell","year":"2009","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/art.40360","article-title":"Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus: Results of a Twenty-Four-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm, Phase IIb Study","volume":"70","author":"Merrill","year":"2018","journal-title":"Arthritis Rheumatol. (Hoboken NJ)"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrneurol.2014.48","article-title":"Multiple sclerosis: Atacicept increases relapse rates in multiple sclerosis","volume":"10","author":"Bible","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"eaas9944","DOI":"10.1126\/sciadv.aas9944","article-title":"BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance","volume":"4","author":"Matsushita","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJMc1309710","article-title":"Ibrutinib in Relapsed Chronic Lymphocytic Leukemia","volume":"369","author":"Rushworth","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1385\/IR:23:2-3:147","article-title":"Regulation of B Lymphocyte Development and Activation by Bruton\u2019s Tyrosine Kinase","volume":"23","author":"Khan","year":"2001","journal-title":"Immunol. Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1084\/jem.20040920","article-title":"Bruton\u2019s tyrosine kinase is essential for human B cell tolerance","volume":"200","author":"Ng","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1586\/1744666X.2016.1152888","article-title":"The role of Bruton\u2019s tyrosine kinase in autoimmunity and implications for therapy","volume":"12","author":"Crofford","year":"2016","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"R243","DOI":"10.1186\/ar4086","article-title":"Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus","volume":"14","author":"Hutcheson","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nri1056","article-title":"PI3K in lymphocyte development, differentiation and activation","volume":"3","author":"Okkenhaug","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.1073560","article-title":"Impaired B and T Cell Antigen Receptor Signaling in p110delta PI 3-Kinase Mutant Mice","volume":"297","author":"Okkenhaug","year":"2002","journal-title":"Science"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.7684160","article-title":"CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase","volume":"260","author":"Tuveson","year":"1993","journal-title":"Science"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4049\/jimmunol.173.4.2236","article-title":"Cutting Edge: Differential Roles for Phosphoinositide 3-Kinases, p110\u03b3 and p110\u03b4, in Lymphocyte Chemotaxis and Homing","volume":"173","author":"Reif","year":"2004","journal-title":"J. Immunol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1002\/eji.200838618","article-title":"B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta","volume":"38","author":"Henley","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_209","first-page":"8226","article-title":"The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival","volume":"63","author":"Camacho","year":"2003","journal-title":"Cancer Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/eji.200838266","article-title":"Role of PI3Kdelta and PI3Kgamma in inflammatory arthritis and tissue localization of neutrophils","volume":"38","author":"Randis","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cell.2009.08.041","article-title":"PI3 Kinase Signals BCR-Dependent Mature B Cell Survival","volume":"139","author":"Srinivasan","year":"2009","journal-title":"Cell"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1096\/fasebj.14.7.895","article-title":"Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo","volume":"14","author":"Borlado","year":"2000","journal-title":"FASEB J."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1084\/jem.20020805","article-title":"A Crucial Role for the p110\u03b4 Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation","volume":"196","author":"Clayton","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nm1291","article-title":"PI3K\u03b3 inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus","volume":"11","author":"Barber","year":"2005","journal-title":"Nat. Med."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm1284","article-title":"Blockade of PI3K\u03b3 suppresses joint inflammation and damage in mouse models of rheumatoid arthritis","volume":"11","author":"Camps","year":"2005","journal-title":"Nat. Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00228-017-2205-7","article-title":"First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3K\u03b4 inhibitor for the treatment of immune and inflammatory diseases","volume":"73","author":"Helmer","year":"2017","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.4049\/jimmunol.1103173","article-title":"Blockade of Phosphatidylinositol 3-Kinase (PI3K)\u03b4 or PI3K\u03b3 Reduces IL-17 and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis","volume":"189","author":"Roller","year":"2012","journal-title":"J. Immunol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.4049\/jimmunol.157.6.2234","article-title":"Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP","volume":"157","author":"Chacko","year":"1996","journal-title":"J. Immunol."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4049\/jimmunol.153.2.623","article-title":"B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein","volume":"153","author":"Saxton","year":"1994","journal-title":"J. Immunol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1074-7613(00)80555-5","article-title":"SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk","volume":"8","author":"Bolland","year":"1998","journal-title":"Immunity"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.191.9.1545","article-title":"Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain\u2013Containing 5\u2032 Inositol Phosphatase (Ship)","volume":"191","author":"Brauweiler","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2015.06.007","article-title":"B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens","volume":"62","author":"Akerlund","year":"2015","journal-title":"J. Autoimmun."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.immuni.2011.10.011","article-title":"Monophosphorylation of CD79a and CD79b ITAM Motifs Initiates a SHIP-1 Phosphatase-Mediated Inhibitory Signaling Cascade Required for B Cell Anergy","volume":"35","author":"Getahun","year":"2011","journal-title":"Immunity"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/art.27505","article-title":"Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus","volume":"62","author":"Taher","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Zhang, S., Zhou, X., Lang, R.A., and Guo, F. (2012). RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033773"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molcel.2004.12.012","article-title":"RhoA GTPase Regulates B Cell Receptor Signaling","volume":"17","author":"Saci","year":"2005","journal-title":"Mol. Cell"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1172\/JCI132414","article-title":"Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis","volume":"130","author":"Ricker","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.4049\/jimmunol.1602142","article-title":"Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10","volume":"198","author":"Weiss","year":"2017","journal-title":"J. Immunol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.1001074107","article-title":"Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis","volume":"107","author":"Huang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrrheum.2011.1","article-title":"Long-lived autoreactive plasma cells drive persistent autoimmune inflammation","volume":"7","author":"Hiepe","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"11826","DOI":"10.1038\/ncomms11826","article-title":"Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection","volume":"7","author":"Bohannon","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_232","first-page":"494","article-title":"Long-Lived Plasma Cells in Autoimmunity: Lessons from B-Cell Depleting Therapy","volume":"4","author":"Michel","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_233","first-page":"CD010816","article-title":"Bortezomib for the treatment of multiple myeloma","volume":"4","author":"Scott","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1182\/blood-2006-08-036947","article-title":"Extended follow-up of a phase 3 trial in relapsed multiple myeloma: Final time-to-event results of the APEX trial","volume":"110","author":"Richardson","year":"2007","journal-title":"Blood"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1763","article-title":"The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis","volume":"14","author":"Neubert","year":"2008","journal-title":"Nat. Med."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.4049\/jimmunol.1002539","article-title":"Proteasome Inhibition with Bortezomib Depletes Plasma Cells and Autoantibodies in Experimental Autoimmune Myasthenia Gravis","volume":"186","author":"Gomez","year":"2011","journal-title":"J. Immunol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/eji.201847492","article-title":"Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors","volume":"48","author":"Alexander","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_238","first-page":"31","article-title":"Refractory Primary Sj\u00f6gren Syndrome Successfully Treated With Bortezomib","volume":"21","author":"Llorente","year":"2015","journal-title":"JCR: J. Clin. Rheumatol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jdcr.2017.08.005","article-title":"Successful treatment of mucous membrane pemphigoid with bortezomib","volume":"4","author":"Saeed","year":"2018","journal-title":"JAAD Case Rep."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.imlet.2019.11.007","article-title":"CXCL12\/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy","volume":"217","author":"Mousavi","year":"2020","journal-title":"Immunol. Lett."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/eji.201747023","article-title":"CXCR4\u2013CXCL12 interaction is important for plasma cell homing and survival in NZB\/W mice","volume":"48","author":"Cheng","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2019.00721","article-title":"The Maintenance of Memory Plasma Cells","volume":"10","author":"Khodadadi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrneph.2016.20","article-title":"Plasma cells as an innovative target in autoimmune disease with renal manifestations","volume":"12","author":"Hiepe","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00277-018-3229-5","article-title":"A phase I\u2013II study of plerixafor in combination with fludarabine, idarubicin, cytarabine, and G-CSF (PLERIFLAG regimen) for the treatment of patients with the first early-relapsed or refractory acute myeloid leukemia","volume":"97","author":"Boluda","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"e26414","DOI":"10.1002\/pbc.26414","article-title":"A phase 1 study of the CXCR4 antagonist plerixafor in combination with high-dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators\u2019 Consortium study (POE 10-03)","volume":"64","author":"Cooper","year":"2017","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/wrr.12552","article-title":"CXCR4 antagonist delivery on decellularized skin scaffold facilitates impaired wound healing in diabetic mice by increasing expression of SDF-1 and enhancing migration of CXCR4-positive cells","volume":"25","author":"Liu","year":"2017","journal-title":"Wound Repair Regen."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1200\/JCO.2008.20.7209","article-title":"Phase III Prospective Randomized Double-Blind Placebo-Controlled Trial of Plerixafor Plus Granulocyte Colony-Stimulating Factor Compared With Placebo Plus Granulocyte Colony-Stimulating Factor for Autologous Stem-Cell Mobilization and Transplantation for Patients With Non-Hodgkin\u2019s Lymphoma","volume":"27","author":"DiPersio","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00262-012-1223-7","article-title":"Inhibition of stromal CXCR4 impairs development of lung metastases","volume":"61","author":"Barbieri","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.4049\/jimmunol.1403014","article-title":"FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin","volume":"194","author":"Pyzik","year":"2015","journal-title":"J. Immunol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1007\/s10875-012-9768-y","article-title":"The Immunologic Functions of the Neonatal Fc Receptor for IgG","volume":"33","author":"Rath","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1055\/s-0037-1613331","article-title":"Intravenous Immunoglobulin Mediates an Increase in Anti-Platelet Antibody Clearance via the FcRn Receptor","volume":"88","author":"Hansen","year":"2002","journal-title":"Thromb. Haemost."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF01706318","article-title":"Plasmapheresis: Technique and complications","volume":"16","author":"Reimann","year":"1990","journal-title":"Intensiv. Care Med."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1744-9987.1997.tb00037.x","article-title":"Plasmapheresis for the Treatment of Pemphigus Vulgaris and Bullous Pemphigoid","volume":"1","author":"Yamada","year":"1997","journal-title":"Ther. Apher."},{"key":"ref_254","first-page":"243","article-title":"Evaluating the Efficacy of Double-Filtration Plasmapheresis in Treating Five Patients With Drug-Resistant Pemphigus","volume":"21","author":"Higashihara","year":"2017","journal-title":"Ther. Apher. Dial. Off. Peer Rev. J. Int. Soc. Apher. Jpn. Soc. Apher. Jpn. Soc. Dial. Ther."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1346-8138.2000.tb02187.x","article-title":"A Case of Pemphigus Vulgaris Successfully Treated with Single Filtration Plasmapheresis: A Correlation of Clinical Disease Activity with Serum Antibody Levels","volume":"27","author":"Yano","year":"2000","journal-title":"J. Dermatol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1080\/08916930600972040","article-title":"Immunoadsorption in pemphigus","volume":"39","author":"Eming","year":"2006","journal-title":"Autoimmun."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1046\/j.1365-2133.2003.05302.x","article-title":"Protein A immunoadsorption: A novel and effective adjuvant treatment of severe pemphigus","volume":"148","author":"Schmidt","year":"2003","journal-title":"Br. J. 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