{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:07:02Z","timestamp":1788336422747,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00013"],"award-info":[{"award-number":["PI19\/00013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells. Objective: We studied here whether deregulation of miR-124 contributes to STAT3 pathway activation in CTCL. Methods: We measured the effect of ectopic mir-124 expression in active phosphorylated STAT3 (p-STAT3) levels and evaluated the transcriptional impact of miR-124-dependent STAT3 pathway regulation by expression microarray analysis. Results: We found that ectopic expression of miR-124 results in massive downregulation of activated STAT3 in different CTCL lines, which resulted in a significant alteration of genetic signatures related with gene transcription and proliferation such as MYC and E2F. Conclusions: Our study highlights the importance of the miR-124\/STAT3 axis in CTCL and demonstrates that the STAT3 pathway is regulated through epigenetic mechanisms in these cells. Since deregulated STAT3 signaling has a major impact on CTCL initiation and progression, a better understanding of the molecular basis of the miR-124\/STAT3 axis may provide useful information for future personalized therapies.<\/jats:p>","DOI":"10.3390\/cells9122692","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T09:12:57Z","timestamp":1608023577000},"page":"2692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma"],"prefix":"10.3390","volume":"9","author":[{"given":"Lidia","family":"Garc\u00eda-Colmenero","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma Barcelona, Carrer del Dr. Aiguader, 88, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Cancer Research Program Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain"},{"name":"Stem Cells and Cancer Research Laboratory-IMIM, CIBERONC, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Epigenomics Unit, IIS, La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Stem Cells and Cancer Research Laboratory-IMIM, CIBERONC, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Diaz-Lagares","sequence":"additional","affiliation":[{"name":"Cancer Epigenomics, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago (CHUS\/SERGAS), CIBERONC, 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Andrades","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma Barcelona, Carrer del Dr. Aiguader, 88, 08003 Barcelona, Spain"},{"name":"Cancer Research Program Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-7868","authenticated-orcid":false,"given":"Arnau","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Cancer Research Program Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain"},{"name":"Stem Cells and Cancer Research Laboratory-IMIM, CIBERONC, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Nonell","sequence":"additional","affiliation":[{"name":"Microarray Department-IMIM, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon Maria","family":"Pujol","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma Barcelona, Carrer del Dr. Aiguader, 88, 08003 Barcelona, Spain"},{"name":"Cancer Research Program Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bigas","sequence":"additional","affiliation":[{"name":"Stem Cells and Cancer Research Laboratory-IMIM, CIBERONC, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Stem Cells and Cancer Research Laboratory-IMIM, CIBERONC, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma Barcelona, Carrer del Dr. Aiguader, 88, 08003 Barcelona, Spain"},{"name":"Cancer Research Program Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ng.3356","article-title":"Genomic landscape of cutaneous T cell lymphoma","volume":"47","author":"Choi","year":"2015","journal-title":"Nat. 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