{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:09:46Z","timestamp":1791529786097,"version":"4.3.4"},"reference-count":134,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells"],"abstract":"<jats:p>During brain development, neurons need to form the correct connections with one another in order to give rise to a functional neuronal circuitry. Mistakes during this process, leading to the formation of improper neuronal connectivity, can result in a number of brain abnormalities and impairments collectively referred to as neurodevelopmental disorders. Cell adhesion molecules (CAMs), present on the cell surface, take part in the neurodevelopmental process regulating migration and recognition of specific cells to form functional neuronal assemblies. Among CAMs, the members of the protocadherin (PCDH) group stand out because they are involved in cell adhesion, neurite initiation and outgrowth, axon pathfinding and fasciculation, and synapse formation and stabilization. Given the critical role of these macromolecules in the major neurodevelopmental processes, it is not surprising that clinical and basic research in the past two decades has identified several PCDH genes as responsible for a large fraction of neurodevelopmental disorders. In the present article, we review these findings with a focus on the non-clustered PCDH sub-group, discussing the proteins implicated in the main neurodevelopmental disorders.<\/jats:p>","DOI":"10.3390\/cells9122711","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T04:12:01Z","timestamp":1608523921000},"page":"2711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Right Place at the Right Time: How Changes in Protocadherins Affect Synaptic Connections Contributing to the Etiology of Neurodevelopmental Disorders"],"prefix":"10.3390","volume":"9","author":[{"given":"Maria","family":"Mancini","sequence":"first","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR), Istituto di Neuroscienze, 20129 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bassani","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR), Istituto di Neuroscienze, 20129 Milan, Italy"},{"name":"NeuroMi, Milan Center for Neuroscience, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Passafaro","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche (CNR), Istituto di Neuroscienze, 20129 Milan, Italy"},{"name":"NeuroMi, Milan Center for Neuroscience, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0566-4","article-title":"Common genetic variants contribute to risk of rare severe neurodevelopmental disorders","volume":"562","author":"Niemi","year":"2018","journal-title":"Nature"},{"key":"ref_2","first-page":"100","article-title":"Genomics in neurodevelopmental disorders: An avenue to personalized medicine","volume":"50","author":"Novarino","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"i206","DOI":"10.1093\/bioinformatics\/btv240","article-title":"Identification of causal genes for complex traits","volume":"31","author":"Hormozdiari","year":"2015","journal-title":"Bioinformatics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2174\/138920207783591717","article-title":"Genetic and environmental factors in complex neurodevelopmental disorders","volume":"8","author":"Martens","year":"2007","journal-title":"Curr. Genom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1007\/s00018-017-2572-3","article-title":"Regulation of neural circuit formation by protocadherins","volume":"74","author":"Peek","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16011","DOI":"10.1073\/pnas.1418990111","article-title":"Giant cadherins and Dachsous self-bond to organize properly spaced intercellular junctions","volume":"111","author":"Tsukasaki","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrm1699","article-title":"Regulation of cadherin-mediated adhesion in morphogenesis","volume":"6","author":"Gumbiner","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrn2043","article-title":"The cadherin superfamily in neuronal connections and interactions","volume":"8","author":"Takeichi","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/BST0360149","article-title":"Regulation of cell-cell adhesion by the cadherin-catenin complex","volume":"36","author":"Nelson","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1006\/jmbi.2000.3777","article-title":"Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members","volume":"299","author":"Nollet","year":"2000","journal-title":"J. Mol. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1007\/s00018-005-5320-z","article-title":"Delta-protocadherins: Unique structures and functions","volume":"62","author":"Redies","year":"2005","journal-title":"Cell Mol. Life Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(00)80789-8","article-title":"A striking organization of a large family of human neural cadherin-like cell adhesion genes","volume":"97","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1101\/gad.1486806","article-title":"Cadherins in development: Cell adhesion, sorting, and tissue morphogenesis","volume":"20","author":"Halbleib","year":"2006","journal-title":"Genes Dev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.neuroscience.2007.03.052","article-title":"Spatiotemporal expression pattern of non-clustered protocadherin family members in the developing rat brain","volume":"147","author":"Kim","year":"2007","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4161\/cam.5.2.14374","article-title":"Non-clustered protocadherin","volume":"5","author":"Kim","year":"2011","journal-title":"Cell Adh. Migr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/cne.21696","article-title":"A cadherin-based code for the divisions of the mouse basal ganglia","volume":"508","author":"Hertel","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuroscience.2010.05.027","article-title":"The expression of non-clustered protocadherins in adult rat hippocampal formation and the connecting brain regions","volume":"170","author":"Kim","year":"2010","journal-title":"Neuroscience"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ceb.2007.09.006","article-title":"Protocadherin family: Diversity, structure, and function","volume":"19","author":"Morishita","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1002\/cne.22390","article-title":"Synaptic and nonsynaptic localization of protocadherin-gammaC5 in the rat brain","volume":"518","author":"Li","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e41050","DOI":"10.7554\/eLife.41050","article-title":"Tuning of delta-protocadherin adhesion through combinatorial diversity","volume":"7","author":"Bisogni","year":"2018","journal-title":"Elife"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuron.2016.04.004","article-title":"Structural basis of diverse homophilic recognition by clustered \u03b1- and \u03b2-protocadherins","volume":"90","author":"Goodman","year":"2016","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e20930","DOI":"10.7554\/eLife.20930","article-title":"\u03b3-Protocadherin structural diversity and functional implications","volume":"5","author":"Goodman","year":"2016","journal-title":"Elife"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E9829","DOI":"10.1073\/pnas.1713449114","article-title":"Protocadherin cis-dimer architecture and recognition unit diversity","volume":"114","author":"Goodman","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.celrep.2020.02.003","article-title":"Family-wide structural and biophysical analysis of binding interactions among non-clustered \u03b4-protocadherins","volume":"30","author":"Harrison","year":"2020","journal-title":"Cell Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14893","DOI":"10.1073\/pnas.1004526107","article-title":"Combinatorial hemophilic interaction between gamma-protocadherin multimers greatly expands the molecular diversity of cell adhesion","volume":"107","author":"Schreiner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1523\/JNEUROSCI.19-03-00995.1999","article-title":"Expression of novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain","volume":"19","author":"Hirano","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19437","DOI":"10.1074\/jbc.274.27.19473","article-title":"Arcadlin is a neural activity-regulated cadherin involved in long term potentiation","volume":"274","author":"Yamagata","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2010.04.065","article-title":"Adhesion properties and retinofugal expression of chicken protocadherin-19","volume":"1344","author":"Tai","year":"2010","journal-title":"Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ceb.2006.07.002","article-title":"Crosstalk between different adhesion molecules","volume":"18","author":"Chen","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuron.2007.08.020","article-title":"Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases","volume":"56","author":"Yasuda","year":"2007","journal-title":"Neuron"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1242\/dev.125.23.4681","article-title":"The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation","volume":"125","author":"Kim","year":"1998","journal-title":"Development"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature06091","article-title":"Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells","volume":"449","author":"Kazmierczak","year":"2007","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"11780","DOI":"10.1523\/JNEUROSCI.0969-12.2012","article-title":"Molecular and functional interaction between protocadherin-gammaC5 and GABAA receptors","volume":"32","author":"Li","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.yexcr.2003.11.019","article-title":"Cadherin-related neuronal receptor1 (CNR1) has cell adhesion activity with beta1 integrin mediated through the RGD site of CNR1","volume":"294","author":"Mutoh","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41586-019-1089-3","article-title":"Visualization of clustered protocadherin neuronal self-recognition complexes","volume":"569","author":"Brasch","year":"2019","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature11305","article-title":"Protocadherins mediate dendritic self-avoidance in the mammalian nervous system","volume":"488","author":"Lefevbre","year":"2012","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1523\/JNEUROSCI.3035-17.2018","article-title":"Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance","volume":"38","author":"Kostadinov","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.1523\/JNEUROSCI.2818-09.2009","article-title":"Control of CNS synapse development by {gamma}-protocadherin-mediated astrocyte-neuron contact","volume":"29","author":"Garrett","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.celrep.2016.03.093","article-title":"Homophilic protocadherin cell-cell interactions promote dendrite complexity","volume":"15","author":"Molumby","year":"2016","journal-title":"Cell Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mcn.2008.01.016","article-title":"The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse","volume":"38","author":"Hasegawa","year":"2008","journal-title":"Mol. Cell Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fnmol.2011.00054","article-title":"Direct and indirect regulation of spinal cord Ia afferent terminal formation by the \u03b3-protocadherins","volume":"4","author":"Prasad","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15908","DOI":"10.1038\/s41598-017-16120-y","article-title":"Protocadherin-\u03b1C2 is required for diffuse projections of serotoninergic axons","volume":"7","author":"Katori","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"427","DOI":"10.4103\/1673-5374.228724","article-title":"The protocadherin alpha cluster is required for axon extension and myelination in the developing central nervous system","volume":"13","author":"Lu","year":"2018","journal-title":"Neural. Regen Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neuron.2012.01.028","article-title":"\u03b3-protocadherins control cortical dendrite arborization by regulating the activity of a FAK\/PKC\/MARCKS signaling pathway","volume":"74","author":"Garrett","year":"2012","journal-title":"Neuron"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/jmcb\/mjs034","article-title":"Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase","volume":"4","author":"Suo","year":"2012","journal-title":"J. Mol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nn1960","article-title":"OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections","volume":"10","author":"Uemura","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.devcel.2014.07.015","article-title":"Protocadherin-17 mediates collective axon extension by recruiting actin regulator complexes to interaxonal contacts","volume":"30","author":"Hayashi","year":"2014","journal-title":"Dev. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/cam.1.4.5546","article-title":"Pioneers in the ventral telencephalon: The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation","volume":"1","author":"Hirano","year":"2007","journal-title":"Cell Adh. Migr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1523\/JNEUROSCI.4490-07.2008","article-title":"NF-protocadherin and TAF1 regulate retinal axon initiation and elongation in vivo","volume":"28","author":"Piper","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nn.3290","article-title":"Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation","volume":"16","author":"Leung","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1091\/mbc.e13-08-0475","article-title":"Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish","volume":"25","author":"Biswas","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1073\/pnas.0407931101","article-title":"Gamma protocadherins are required for synaptic development in the spinal cord","volume":"102","author":"Weiner","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuron.2012.06.039","article-title":"Functional significance of isoform diversification in the protocadherin gamma gene cluster","volume":"75","author":"Chen","year":"2012","journal-title":"Neuron"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tins.2006.02.002","article-title":"Selective stabilization and synaptic specificity: A new cell-biological model","volume":"29","author":"Jontes","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0896-6273(00)80495-X","article-title":"Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex","volume":"20","author":"Kohmura","year":"1998","journal-title":"Neuron"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0896-6273(01)00450-0","article-title":"The presynaptic particle web: Ultrastructure, composition, dissolution, and reconstitution","volume":"32","author":"Phillips","year":"2001","journal-title":"Neuron"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1523\/JNEUROSCI.23-12-05096.2003","article-title":"Gamma-protocadherins are target to subsets of synapses and intracellular organelles in neurons","volume":"23","author":"Phillips","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.celrep.2017.02.060","article-title":"\u03b3-protocadherins interact with neuroligin-1 and negatively regulate dendritic spine morphogenesis","volume":"18","author":"Molumby","year":"2017","journal-title":"Cell Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tcb.2005.02.002","article-title":"Synaptic contact dynamics controlled by cadherin and catenins","volume":"15","author":"Takeichi","year":"2005","journal-title":"Trends Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.biopsych.2016.06.008","article-title":"Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene","volume":"81","author":"Schoch","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuron.2013.03.031","article-title":"Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits","volume":"78","author":"Hoshina","year":"2013","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0306-4522(02)00944-2","article-title":"Distribution of OL-protocadherin protein in correlation with specific neural compartments and local circuits in the postnatal mouse brain","volume":"117","author":"Aoki","year":"2003","journal-title":"Neuroscience"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng.149","article-title":"X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment","volume":"40","author":"Dibbens","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0997-92","article-title":"Epilepsy and mental retardation limited to females: An X-linked dominant disorder with male sparing","volume":"17","author":"Ryan","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0022-3476(71)80382-7","article-title":"A new familial form of convulsive disorder and mental retardation limited to females","volume":"79","author":"Juberg","year":"1971","journal-title":"J. Pediatr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/epi.14678","article-title":"Schizophrenia is a later-onset feature of pcdh19 girls clustering epilepsy","volume":"60","author":"Vlaskamp","year":"2019","journal-title":"Epilepsia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41380-018-0066-9","article-title":"A systematic review and meta-analysis of 271 pcdh19-variant individuals identifies psychiatric comorbidities, and association of seizure onset and disease severity","volume":"24","author":"Kolc","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41398-020-0803-0","article-title":"A standardized patient-centered characterization of the phenotypic spectrum of pcdh19 girls clustering epilepsy","volume":"10","author":"Kolc","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/humu.23701","article-title":"A mutation update for the pcdh19 gene causing early-onset epilepsy in females with an unusual expression pattern","volume":"40","author":"Niazi","year":"2019","journal-title":"Hum. Mutat."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/humu.22029","article-title":"Pcdh19-related infantile epileptic encephalopathy: An unusual x-linked inheritance disorder","volume":"33","author":"Depienne","year":"2012","journal-title":"Hum. Mutat."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Depienne, C., Bouteiller, D., Keren, B., Cheuret, E., Poirier, K., Trouillard, O., Benyahia, B., Quelin, C., Carpentier, W., and Julia, S. (2009). Sporadic infantile epileptic encephalopathy caused by mutations in pcdh19 resembles Dravet syndrome but mainly affects females. PLoS Genet., 5.","DOI":"10.1371\/annotation\/314060d5-06da-46e0-b9e4-57194e8ece3a"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10048-013-0353-1","article-title":"Clinical and genetic aspects of pcdh19-related epilepsy syndromes and the possible role of pcdh19 mutations in males with autism spectrum disorders","volume":"14","author":"Weckhuysen","year":"2013","journal-title":"Neurogenetics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1111\/epi.13295","article-title":"Pcdh19-related epilepsy in two mosaic male patients","volume":"57","author":"Terracciano","year":"2016","journal-title":"Epilepsia"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/ajmg.a.37617","article-title":"Pcdh19-related epileptic encephalopathy in a male mosaic for a truncating variant","volume":"170","author":"Thiffault","year":"2016","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10048-017-0517-5","article-title":"Male patients affected by mosaic pcdh19 mutations: Five new cases","volume":"18","author":"Rump","year":"2017","journal-title":"Neurogenetics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/ajmg.a.38233","article-title":"Somatic mosaicism of pcdh19 in a male with early infantile epileptic encephalopathy and review of the literature","volume":"173","author":"Perez","year":"2017","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Tan, Y., Hou, M., Ma, S., Liu, P., Xia, S., Wang, Y., Chen, L., and Chen, Z. (2018). Chinese cases of early infantile epileptic encephalopathy: A novel mutation in the pcdh19 gene was proved in a mosaic male- case report. BMC Med. Genet., 19.","DOI":"10.1186\/s12881-018-0621-x"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.eplepsyres.2018.06.008","article-title":"Pcdh19-related epilepsy in a male with klinefelter syndrome: Additional evidence supporting pcdh19 cellular interference disease mechanism","volume":"145","author":"Romasko","year":"2018","journal-title":"Epilepsy Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.modgep.2006.03.001","article-title":"Expression of the delta-protocadherin gene pcdh19 in the developing mouse embryo","volume":"6","author":"Gaitan","year":"2006","journal-title":"Gene. Expr. Patterns"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/cne.24359","article-title":"Expression profile of N-cadherin and protocadherin-19 in postnatal mouse limbic structures","volume":"526","author":"Schaarschuch","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/hmg\/ddy019","article-title":"The female epilepsy protein pcdh19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of hippocampal neurons","volume":"27","author":"Bassani","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/mp.2016.106","article-title":"A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of mir-484\/protocadherin-19 signaling","volume":"22","author":"Fujitani","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1002\/cne.23140","article-title":"Cadherin expression delineates the divisions of the postnatal and adult mouse amygdala","volume":"520","author":"Hertel","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1111\/j.1528-1167.2012.03649.x","article-title":"Focal seizures with affective symptoms are a major feature of pcdh19 gene-related epilepsy","volume":"53","author":"Marini","year":"2012","journal-title":"Epilepsia"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.seizure.2015.02.006","article-title":"Immediate suppression of seizure clusters by corticosteroids in pcdh19 female epilepsy","volume":"27","author":"Higurashi","year":"2015","journal-title":"Seizure"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"26804","DOI":"10.18632\/oncotarget.5757","article-title":"Characterizing pcdh19 in human induced pluripotent stem cells (ipscs) and ipsc-derived developing neurons: Emerging role of a protein involved in controlling polarity during neurogenesis","volume":"6","author":"Compagnucci","year":"2015","journal-title":"Oncotarget"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nbd.2018.05.004","article-title":"Pcdh19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to pcdh19 girls clustering epilepsy","volume":"116","author":"Homan","year":"2018","journal-title":"Neurobiol. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1038\/s41467-019-11854-x","article-title":"Tbr2 coordinates neurogenesis expansion and precise microcircuit organization via protocadherin 19 in the mammalian cortex","volume":"10","author":"Lv","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.1038\/s41598-017-06374-x","article-title":"Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice","volume":"7","author":"Hayashi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuron.2017.12.005","article-title":"Abnormal cell sorting underlies the unique x-linked inheritance of pcdh19 epilepsy","volume":"97","author":"Pederick","year":"2018","journal-title":"Neuron"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.201507108","article-title":"Protocadherins control the modular assembly of neuronal columns in the zebrafish optic tectum","volume":"211","author":"Cooper","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Light, S.E.W., and Jontes, J.D. (2019). Multiplane calcium imaging reveals disrupted development of network topology in zebrafish. eNeuro, 6.","DOI":"10.1523\/ENEURO.0420-18.2019"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.201007008","article-title":"Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation","volume":"191","author":"Biswas","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1083\/jcb.201108115","article-title":"A complex of protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion","volume":"195","author":"Emond","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e18529","DOI":"10.7554\/eLife.18529","article-title":"Structural determinants of adhesion by protocadherin-19 and implications for its role in epilepsy","volume":"5","author":"Cooper","year":"2016","journal-title":"Elife"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2013.11.048","article-title":"The wave regulatory complex links diverse receptors to the actin cytoskeleton","volume":"156","author":"Chen","year":"2014","journal-title":"Cell"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuroscience.2020.09.033","article-title":"Proximity-dependent proteomics reveals extensive interactions of protocadherin-19 with regulators of rho GTPases and the microtubule cytoskeleton","volume":"452","author":"Emon","year":"2020","journal-title":"Neuroscience"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/dmcn.13595","article-title":"Focal cortical malformations in children with early infantile epilepsy and pcdh19 mutations: Case report","volume":"60","author":"Kurian","year":"2018","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.1093\/cercor\/bhaa177","article-title":"Quantitative MRI-based analysis identifies developmental limbic abnormalities in pcdh19 encephalopathy","volume":"30","author":"Lenge","year":"2020","journal-title":"Cereb. Cortex"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13041-019-0519-3","article-title":"Autism-like behaviors in male mice with a pcdh19 deletion","volume":"12","author":"Lim","year":"2019","journal-title":"Mol. Brain"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1111\/epi.16675","article-title":"Characterization of seizure susceptibility in pcdh19 mice","volume":"61","author":"Rakotomamonjy","year":"2020","journal-title":"Epilepsia"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.1093\/hmg\/ddv245","article-title":"Mutations of protocadherin 19 in female epilepsy (pcdh19-fe) lead to allopregnanolone deficiency","volume":"24","author":"Tan","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrn1703","article-title":"Neurosteroids: Endogenous regulators of the GABA(A) receptor","volume":"6","author":"Belelli","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1007\/s12035-020-02099-7","article-title":"The epilepsy-related protein pcdh19 regulates tonic inhibition, GABA","volume":"57","author":"Serratto","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_105","unstructured":"Sullivan, J., Specchio, N., Chez, M., Pinna, G., Locci, A., Jarrar, R., Poduri, A., Ridel, K., Masuoka, L., and Gasior, M. (December, January 30). Preliminary evidence of a predictive clinical biomarker in PCDH19-related epilepsy: Significant treatment effect of ganaxolone in biomarker-positive patients. Proceedings of the American Epilepsy Society Annual Meeting, New Orleans Ernest, N. Morial Convention Center, New Orleans, LA, USA."},{"key":"ref_106","unstructured":"(2019, December 16). ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). Study of Adjunctive Ganaxolone Treatment in Female Children with Protocadherin 19 (PCDH19)-Related Epilepsy (Violet Study), Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03865732."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molbrainres.2004.11.017","article-title":"Distribution of OL-protocadherin in axon fibers in the developing chick nervous system","volume":"134","author":"Nakao","year":"2005","journal-title":"Mol. Brain Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1038\/npp.2016.64","article-title":"Morphological alterations in the thalamus, striatum, and pallidum in Autism Spectrum Disorder","volume":"41","author":"Schuetze","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1152\/physrev.00014.2011","article-title":"Cadherins in brain morphogenesis and wiring","volume":"92","author":"Hirano","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.200802069","article-title":"Contact-dependent promotion of cell migration by the OL-protocadherin-Nap1 interaction","volume":"182","author":"Nakao","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.nbd.2017.08.013","article-title":"Protocadherin 10 alters \u03b4-oscillations, amino acid levels, and their coupling; baclofen partially restores these oscillatory deficits","volume":"108","author":"Port","year":"2017","journal-title":"Nerobiol. Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2217\/bmm.14.15","article-title":"\u03b3-band abnormalities as markers of autism spectrum disorders","volume":"8","author":"Rojas","year":"2014","journal-title":"Biomark Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1157657","article-title":"Identifying autism loci and genes by tracing recent shared ancestry","volume":"321","author":"Morrow","year":"2008","journal-title":"Science"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Bucan, M., Abrahams, B.S., Wang, K., Glessner, J.T., Herman, E.I., Sonnenblick, L.I., Alvarez Retuerto, A.I., Imielinski, M., Hadley, D., and Bradfield, J.P. (2009). Genome-wide analysis of exonic copy number variants in a family\u2014Based study point to novel autism susceptibility genes. PLoS Genet., 5.","DOI":"10.1371\/journal.pgen.1000536"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrn1667","article-title":"From mRNP trafficking to spine dysmorphogenesis: The roots of Fragile X syndrome","volume":"6","author":"Bagni","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuron.2010.03.017","article-title":"Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2","volume":"66","author":"Pfeiffer","year":"2010","journal-title":"Neuron"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.cell.2012.11.040","article-title":"Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95","volume":"151","author":"Tsai","year":"2012","journal-title":"Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2012.09.006","article-title":"Distribution of protocadherin 9 protein in the developing mouse nervous system","volume":"225","author":"Asahina","year":"2012","journal-title":"Neuroscience"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.biopsych.2015.01.017","article-title":"Genetic mapping in mice reveals the involvement of Pcdh9 in long-term social and object recognition and sensorimotor development","volume":"78","author":"Bruining","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/npp.2017.241","article-title":"The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder","volume":"43","author":"Xiao","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1177\/1073858408324024","article-title":"Transducing neuronal activity into dendritic spine morphology: New roles for p38 MAP kinase and N-cadherin","volume":"15","author":"Sugiura","year":"2009","journal-title":"Neuroscientist"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/ijms16011312","article-title":"Whole exome sequencing in females with autism implicates novel and candidate genes","volume":"16","author":"Butler","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"17849","DOI":"10.1073\/pnas.0706128104","article-title":"Genome-wide analyses of human perisylvian cerebral cortical patterning","volume":"104","author":"Abrahams","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/mp.2016.231","article-title":"The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders","volume":"23","author":"Chang","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0925-4773(01)00388-4","article-title":"Expression of Pcdh15 in the inner ear, nervous system and various epithelia of the developing embryo","volume":"105","author":"Murcia","year":"2001","journal-title":"Mech. Dev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/321277","article-title":"Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F","volume":"69","author":"Ahmed","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psychres.2007.08.011","article-title":"Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: Preliminary evidence","volume":"165","author":"Sallet","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/YPG.0b013e32835d718b","article-title":"Copy number variation findings among 50 children and adolescents with autism spectrum disorder","volume":"23","author":"Sorte","year":"2013","journal-title":"Psychiatr. Genet."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature12929","article-title":"De novo mutations mutations in schizophrenia implicate synaptic networks","volume":"506","author":"Fromer","year":"2014","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1093\/hmg\/ddu379","article-title":"De novo CNVs bipolar affective disorder and schizophrenia","volume":"23","author":"Georgieva","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/ajmg.b.32232","article-title":"Copy number variant study of bipolar disorder in Canadian and UK populations implicates synaptic genes","volume":"165B","author":"Noor","year":"2014","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.celrep.2018.08.022","article-title":"Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights","volume":"24","author":"Kushima","year":"2018","journal-title":"Cell Rep."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., and Nio, S. (2019). In Vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN. eNeuro, 6.","DOI":"10.1523\/ENEURO.0403-18.2019"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/jamapsychiatry.2014.1582","article-title":"Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder","volume":"71","author":"Konopaske","year":"2014","journal-title":"JAMA Psychiatry"}],"container-title":["Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/12\/2711\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:46:42Z","timestamp":1760179602000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4409\/9\/12\/2711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":134,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["cells9122711"],"URL":"https:\/\/doi.org\/10.3390\/cells9122711","relation":{},"ISSN":["2073-4409"],"issn-type":[{"value":"2073-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,18]]}}}