{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T04:46:55Z","timestamp":1794545215365,"version":"4.9.1"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Adolescent idiopathic scoliosis (AIS) is the most frequent pediatric spinal deformity. Its treatment still shows limited results due to the existent lack of knowledge regarding etiopathogenesis. Thus, the purpose of the study is to check the existence of vestibular morphological alterations among idiopathic scoliosis patients. To meet the objective, we performed this systematic review searching studies in PubMed Medline, SCOPUS, Web of Science, CINAHL Complete and SciELO until 15 September 2022. Articles that analyzed the morphology of the vestibular apparatus were selected, comparing subjects with AIS versus healthy subjects. Variables were selected that measured the orientation of the channels as well as the general conformation of the vestibular apparatus. One hundred and eighty-five records were retrieved in the preliminary searches, of which five studies were finally included, providing data from 154 participants (83 cases and 71 healthy controls) with a mean age 16.07 \u00b1 2.48 years old. Two studies conclude that the superior and lateral semicircular canals are longer and thinner in patients with AIS. One study concluded that the measure between centers of superior and lateral canals and the angle whose vertex is placed the center of posterior canal were significantly shorter in subjects with AIS than in healthy controls in the left-side of vestibular apparatus. Two studies found an asymmetry in the verticality of the lateral canals on both sides in subjects with AIS, although it is not clear whether the left canal is in a more horizontal or vertical position. Patients with AIS seem to present morphological asymmetries of the vestibular apparatus, fundamentally on the left side. These anomalies seem to correlate with the location of the curve but not with its laterality or severity.<\/jats:p>","DOI":"10.3390\/children10010035","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:42:47Z","timestamp":1672116167000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Vestibular Morphological Alterations in Adolescent Idiopathic Scoliosis: A Systematic Review of Observational Studies"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-1399","authenticated-orcid":false,"given":"Irene","family":"Cort\u00e9s-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine, University of Almeria, Road Sacramento s\/n, 04120 Almeria, Spain"},{"name":"Department of Health Sciences, University of Jaen, Campus las Lagunillas, 23071 Jaen, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Salamanca-Montilla","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Jaen, Campus las Lagunillas, 23071 Jaen, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"G\u00e1miz-Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n Cl\u00ednica Adra, Distrito Sanitario Poniente de Almer\u00eda, Avenida Picasso, 1, 04770 Adra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-5500","authenticated-orcid":false,"given":"Esteban","family":"Obrero-Gait\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Jaen, Campus las Lagunillas, 23071 Jaen, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-9696","authenticated-orcid":false,"given":"Alfonso Javier","family":"Ib\u00e1\u00f1ez-Vera","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Jaen, Campus las Lagunillas, 23071 Jaen, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-6301","authenticated-orcid":false,"given":"Rafael","family":"Lomas-Vega","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Jaen, Campus las Lagunillas, 23071 Jaen, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"key":"ref_1","first-page":"CD007837","article-title":"Exercises for adolescent idiopathic scoliosis (Review) Summary of Findings for the Main Comparison","volume":"8","author":"Romano","year":"2012","journal-title":"Cochrain Libr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/0019-5413.108875","article-title":"Current concepts and controversies on adolescent idiopathic scoliosis: Part I","volume":"47","author":"Sud","year":"2013","journal-title":"Indian J. Orthop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1136\/bmj.f2508","article-title":"Adolescent idiopathic scoliosis","volume":"346","author":"Altaf","year":"2013","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sung, S., Chae, H.W., Lee, H.S., Kim, S., Kwon, J.W., Lee, S.B., Moon, S.H., Lee, H.M., and Lee, B.H. (2021). Incidence and Surgery Rate of Idiopathic Scoliosis: A Nationwide Database Study. Int. J. Environ. Res. Public Heal., 18.","DOI":"10.3390\/ijerph18158152"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1001\/jama.289.5.559","article-title":"Health and Function of Patients With Untreated Idiopathic Scoliosis: A 50-Year Natural History Study","volume":"289","author":"Weinstein","year":"2003","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1007\/s00586-022-07204-z","article-title":"Pulmonary symptoms in adolescent idiopathic scoliosis: A systematic review to identify patient-reported and clinical measurement instruments","volume":"31","author":"Faraj","year":"2022","journal-title":"Eur. Spine J."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Le\u00f3n-Morillas, F., de Oliveira-Sousa, S.L., Andrade-Ortega, J.A., Ib\u00e1\u00f1ez-Vera, A.J., Lomas-Vega, R., and Zagalaz-Anula, N. (2021). The type of conservative management could be related to the strength of the inspiratory muscles of adolescents with idiopathic scoliosis\u2014A case series. Children, 8.","DOI":"10.3390\/children8111002"},{"key":"ref_8","first-page":"219256822211264","article-title":"Predicting Health-Related Quality of Life Outcomes Following Major Scoliosis Surgery in Adolescents: A Latent Class Growth Analysis","volume":"2022","author":"Kerr","year":"2022","journal-title":"Glob. Spine J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.aott.2019.08.012","article-title":"Association between calcium-phosphorus balance and adolescent idiopathic scoliosis: A meta-analysis","volume":"53","author":"Zhu","year":"2019","journal-title":"Acta Orthop. Traumatol. Turc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/s41467-019-11596-w","article-title":"Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese","volume":"10","author":"Kou","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Obrero-Gait\u00e1n, E., Molina, F., Del-Pino-Casado, R., Ib\u00e1\u00f1ez-Vera, A.J., Rodr\u00edguez-Almagro, D., and Lomas-Vega, R. (2020). Visual verticality perception in spinal diseases: A systematic review and meta-analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061725"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jspd.2018.05.004","article-title":"Do Adolescents With Idiopathic Scoliosis Have an Erroneous Perception of the Gravitational Vertical?","volume":"7","author":"Pradeau","year":"2019","journal-title":"Spine Deform."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1523\/JNEUROSCI.4842-12.2013","article-title":"Restricted neural plasticity in vestibulospinal pathways after unilateral labyrinthectomy as the origin for scoliotic deformations","volume":"33","author":"Lambert","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/BF00250579","article-title":"A radiological analysis of the postural syndromes following hemilabyrinthectomy and selective canal and otolith lesions in the guinea pig","volume":"77","author":"Graf","year":"1989","journal-title":"Exp. brain Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"609555","DOI":"10.3389\/fped.2020.609555","article-title":"Case Report: Conservative Treatment of Adolescent Idiopathic Scoliosis Can Alter the Perception of Verticality. A Preliminary Study","volume":"8","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) Group","volume":"283","author":"Stroup","year":"2000","journal-title":"J. Am. Med. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Guidelines and Guidance Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_18","unstructured":"Higgins, J., and Green, S. (2011). Cochrane Handbook for Systematic Reviews of Interventions, John Wiley & Sons."},{"key":"ref_19","unstructured":"Wells, G., Shea, B., and O\u2019Connel, D. (2022, September 24). The Newcastle-Ottawa scale (NOS) for assessing the quality of non-randomised studies in meta-analysis. Available online: https:\/\/web.archive.org\/web\/20210716121605id_\/http:\/\/www3.med.unipmn.it\/dispense_ebm\/2009-2010\/Corso%20Perfezionamento%20EBM_Faggiano\/NOS_oxford.pdf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lo, C.K.-L., Mertz, D., and Loeb, M. (2014). Newcastle-Ottawa Scale: Comparing reviewers\u2019 to authors\u2019 assessments. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-45"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Carry, P.M., Duke, V.R., Brazell, C.J., Stence, N., Scholes, M., Rousie, D.L., and Miller, N.H. (2020). Lateral semi-circular canal asymmetry in females with idiopathic scoliosis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232417"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Xin, S.Q., He, Y., Fu, C.W., Wang, D., Lin, S., Chu, W.C.W., Cheng, J.C.Y., Gu, X., and Lui, L.M. (2011, January 18\u201322). Euclidean geodesic loops on high-genus surfaces applied to the morphometry of vestibular systems. Proceedings of the Medical Image Computing and Computer-Assisted Intervention\u2014MICCAI, Toronto, Canada.","DOI":"10.1007\/978-3-642-23629-7_47"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zeng, W., Lui, L.M., Shi, L., Wang, D., Chu, W.C.W., Cheng, J.C.Y., Hua, J., Yau, S.T., and Gu, X. (2010, January 20\u201324). Shape analysis of vestibular systems in adolescent idiopathic scoliosis using geodesic spectra. Proceedings of the Medical Image Computing and Computer-Assisted Intervention\u2014MICCAI, Beijing, China.","DOI":"10.1007\/978-3-642-15711-0_67"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hitier, M., Hamon, M., Denise, P., Lacoudre, J., Thenint, M.A., Mallet, J.F., Moreau, S., and Quarck, G. (2015). Lateral semicircular canal asymmetry in idiopathic scoliosis: An early link between biomechanical, hormonal and neurosensory theories?. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131120"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1016\/j.neuroimage.2010.04.002","article-title":"Automatic MRI segmentation and morphoanatomy analysis of the vestibular system in adolescent idiopathic scoliosis","volume":"54","author":"Shi","year":"2011","journal-title":"Neuroimage"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1111\/ejn.14525","article-title":"Postural and muscle responses to galvanic vestibular stimulation reveal a vestibular deficit in adolescents with idiopathic scoliosis","volume":"50","author":"Hatzilazaridis","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.3389\/fneur.2019.01270","article-title":"Asymmetric Unilateral Vestibular Perception in Adolescents With Idiopathic Scoliosis","volume":"10","author":"Woo","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wilczy\u0144ski, J. (2021). Relationship between muscle tone of the erector spinae and the concave and convex sides of spinal curvature in low-grade scoliosis among children. Children, 8.","DOI":"10.3390\/children8121168"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12477","DOI":"10.1523\/JNEUROSCI.2583-09.2009","article-title":"Vestibular Asymmetry as the Cause of Idiopathic Scoliosis: A Possible Answer from Xenopus","volume":"29","author":"Lambert","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/lary.29124","article-title":"Misperception of Visual Vertical in Peripheral Vestibular Disorders. A Systematic Review With Meta-Analysis","volume":"131","author":"Molina","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"701","DOI":"10.31616\/asj.2020.0308","article-title":"Impact of the Vestibular System on the Formation and Progression to Idiopathic Scoliosis: A Review of Literature","volume":"15","author":"Scheyerer","year":"2021","journal-title":"Asian Spine J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/cxo.12932","article-title":"Evaluation of choroidal changes in adolescent idiopathic scoliosis using enhanced depth imaging optical coherence tomography","volume":"103","author":"Ulusoy","year":"2021","journal-title":"Clin. Exp. Optom."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/08820538.2015.1068343","article-title":"Choroidal Thickness in Turkish Children with Anisometric Amblyopia","volume":"32","author":"Karaca","year":"2015","journal-title":"Semin. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4041\/kjod21.259","article-title":"Occlusal deviations in adolescents with idiopathic and congenital scoliosis","volume":"52","author":"Zhang","year":"2022","journal-title":"Korean J. Orthod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00210536","article-title":"Hereditary orthodontic anomalies and idiopathic scoliosis","volume":"15","year":"1991","journal-title":"Int. Orthop."},{"key":"ref_37","first-page":"119","article-title":"The influence of an experimentally-induced malocclusion on vertebral alignment in rats: A controlled pilot study","volume":"23","author":"Filippi","year":"2014","journal-title":"Cranio J. Craniomandib. Sleep Pract."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/1\/35\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:50:15Z","timestamp":1760147415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/1\/35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,24]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["children10010035"],"URL":"https:\/\/doi.org\/10.3390\/children10010035","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,24]]}}}