{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:40:11Z","timestamp":1771054811671,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PhysioAssist Aix-en-Provence-France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Cystic fibrosis (CF) patients require regular airway clearance therapy (ACT). The aim of this study was to evaluate homecare therapeutic effects of a new ACT (Simeox\u00ae) added to the optimal standard of care, including home chest physiotherapy, in the treatment of clinically stable children. Methods: Forty pediatric CF patients (8\u201317 years old) with stable disease were randomized 1:1 in a single-center, prospective, open-label, cross-over trial into two groups: with or without Simeox\u00ae. Lung function (impulse oscillometry, spirometry, body plethysmography, multi-breath nitrogen washout) results, health-related quality of life, and safety were assessed during the study after 1 month of therapy at home. Results: A significant decrease in proximal airway obstruction (as supported by improvement in airway resistance at 20 Hz (R20Hz) and maximum expiratory flow at 75% of FVC (MEF75)) compared to the control group was observed after 1 month of therapy with the device. Lung-clearance index was stable in the study group, while it worsened in the control group. In addition, the device group demonstrated a significant increase in the Cystic Fibrosis Questionnaire\u2014Revised (CFQ-R) physical score. No side effects were identified during the study. Conclusions: Simeox\u00ae may improve drainage of the airways in children with clinically stable CF and could be an option in chronic treatment of the disease.<\/jats:p>","DOI":"10.3390\/children10020204","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T01:29:45Z","timestamp":1674523785000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of the Simeox\u00ae Airway Clearance Technology in the Homecare Treatment of Children with Clinically Stable Cystic Fibrosis: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"10","author":[{"given":"Dorota","family":"Sands","sequence":"first","affiliation":[{"name":"Cystic Fibrosis Department, Institute of Mother and Child, 01-211 Warsaw, Poland"},{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-8737","authenticated-orcid":false,"given":"Katarzyna","family":"Walicka-Serzysko","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department, Institute of Mother and Child, 01-211 Warsaw, Poland"},{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-9963","authenticated-orcid":false,"given":"Justyna","family":"Milczewska","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department, Institute of Mother and Child, 01-211 Warsaw, Poland"},{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Postek","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department, Institute of Mother and Child, 01-211 Warsaw, Poland"},{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Jeneralska","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Cichocka","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Siedlecka","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Borawska-Kowalczyk","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Department, Institute of Mother and Child, 01-211 Warsaw, Poland"},{"name":"Cystic Fibrosis Centre, Pediatric Hospital, 05-092 Dziekanow Lesny, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7406-4838","authenticated-orcid":false,"given":"Laurent","family":"Morin","sequence":"additional","affiliation":[{"name":"PhysioAssist, 34090 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.4187\/respcare.02590","article-title":"Airway clearance therapy: Finding the evidence","volume":"58","author":"Volsko","year":"2013","journal-title":"Respir. 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