{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:11:44Z","timestamp":1771639904714,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brazil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: The health and developmental issues of people with Down syndrome (DS) are complex and are associated with many medical, psychological, and social problems from childhood through into adulthood. DS children have an increased risk of multiorgan comorbidities, including congenital heart disease. Atrioventricular septal defect (AVSD) is a congenital heart malformation that often occurs in DS people. Aim: Physical activity and exercise are recommended for patients with cardiovascular disease and are considered to be the gold standard of cardiac rehabilitation. Whole-body vibration exercise (WBVE) is considered a form of exercises. The aim of this case report is to show the effects of WBVE on sleep disturbances, body temperature, body composition, tone, and clinical parameters in a child with DS with corrected total AVSD. The subject is a 10-year-old girl, with free-type DS, who underwent surgery to correct a total AVSD at 6 months. She underwent periodic cardiological monitoring and was released to perform any type of physical exercise, including WBVE. WBVE improved sleep quality and body composition. Conclusion: WBVE leads to physiological effects that benefit the DS child.<\/jats:p>","DOI":"10.3390\/children10020213","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T01:30:30Z","timestamp":1674696630000},"page":"213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of the Whole-Body Vibration Exercise on Sleep Disorders, Body Temperature, Body Composition, Tone, and Clinical Parameters in a Child with Down Syndrome Who Underwent Total Atrioventricular Septal Defect Surgery: A Case-Report"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6038-4419","authenticated-orcid":false,"given":"Luiza","family":"Torres-Nunes","sequence":"first","affiliation":[{"name":"Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Roberto Alc\u00e2ntara Gomes Institute of Biology and Piquet Carneiro University Polyclinic, State University of Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Program of Postgraduate Degree in Clinical and Experimental Pathophysiology, State University of Rio de Janeiro, Rio de Janeiro 20550-170, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Prado","family":"da Costa-Borges","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Roberto Alc\u00e2ntara Gomes Institute of Biology and Piquet Carneiro University Polyclinic, State University of Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-5056","authenticated-orcid":false,"given":"Laisa Liane","family":"Paineiras-Domingos","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Roberto Alc\u00e2ntara Gomes Institute of Biology and Piquet Carneiro University Polyclinic, State University of Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Department of Physiotherapy, Multidisciplinary Institute of Rehabilitation and Health, Federal University of Bahia, Salvador 40110-909, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5836-9618","authenticated-orcid":false,"given":"Jos\u00e9 Alexandre","family":"Bachur","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, University of Franca, Franca 14404-600, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-6060","authenticated-orcid":false,"given":"Ana Carolina","family":"Coelho-Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Roberto Alc\u00e2ntara Gomes Institute of Biology and Piquet Carneiro University Polyclinic, State University of Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Program of Postgraduate Degree in Clinical and Experimental Pathophysiology, State University of Rio de Janeiro, Rio de Janeiro 20550-170, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-1576","authenticated-orcid":false,"given":"Dan\u00fabia","family":"da Cunha de S\u00e1-Caputo","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Roberto Alc\u00e2ntara Gomes Institute of Biology and Piquet Carneiro University Polyclinic, State University of Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"},{"name":"Program of Postgraduate Degree in Clinical and Experimental Pathophysiology, State University of Rio de Janeiro, Rio de Janeiro 20550-170, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-448X","authenticated-orcid":false,"given":"Mario","family":"Bernardo-Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Mechanical Vibrations and Integrative Practices, Department of Biophysics and Biometrics, Roberto Alc\u00e2ntara Gomes Institute of Biology and Piquet Carneiro University Polyclinic, State University of Rio de Janeiro, Rio de Janeiro 20950-003, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.stem.2021.12.002","article-title":"Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors","volume":"29","author":"Meharena","year":"2022","journal-title":"Cell Stem Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lanfranchi, S., Meneghetti, C., Toffalini, E., and Carretti, B. 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