{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:05:48Z","timestamp":1790683548008,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background and objectives: Very low birth weight (VLBW) infants are at high risk of developing acute kidney injury (AKI), presumably secondary to low kidney reserves, stressful postnatal events, and drug exposures. Our study aimed to identify the prevalence, risk factors, and outcomes associated with AKI in VLBW infants. Study design: Records of all VLBW infants admitted to two medical campuses between January 2019 and June 2020 were retrospectively reviewed. AKI was classified using the modified KDIGO definition to include only serum creatinine. Risk factors and composite outcomes were compared between infants with and without AKI. We evaluated the main predictors of AKI and death with forward stepwise regression analysis. Results: 152 VLBW infants were enrolled. 21% of them developed AKI. Based on the multivariable analysis, the most significant predictors of AKI were the use of vasopressors, patent ductus arteriosus, and bloodstream infection. AKI had a strong and independent association with neonatal mortality. Conclusions: AKI is common in VLBW infants and is a significant risk factor for mortality. Efforts to prevent AKI are necessary to prevent its harmful effects.<\/jats:p>","DOI":"10.3390\/children10020242","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T04:31:27Z","timestamp":1675053087000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor"],"prefix":"10.3390","volume":"10","author":[{"given":"Gilad","family":"Lazarovits","sequence":"first","affiliation":[{"name":"Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"},{"name":"School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5004-2397","authenticated-orcid":false,"given":"Noa","family":"Ofek Shlomai","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"},{"name":"School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Kheir","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Bdolah Abram","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smadar","family":"Eventov Friedman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"},{"name":"School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-1045","authenticated-orcid":false,"given":"Oded","family":"Volovelsky","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"},{"name":"Pediatric Nephrology Unit, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1001\/jama.2015.10244","article-title":"Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993\u20132012","volume":"314","author":"Stoll","year":"2015","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.2215\/CJN.18841220","article-title":"Severe acute kidney injury and mortality in extremely low gestational age neonates","volume":"16","author":"Hingorani","year":"2021","journal-title":"CJASN"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2021051220","DOI":"10.1542\/peds.2021-051220","article-title":"Advances in neonatal acute kidney injury","volume":"148","author":"Starr","year":"2021","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fped.2016.00068","article-title":"Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study","volume":"4","author":"Jetton","year":"2016","journal-title":"Front. 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