{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:00:59Z","timestamp":1780477259439,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Paediatric Society\u2014Neonatal Resuscitation","award":["1R03HD104062-01"],"award-info":[{"award-number":["1R03HD104062-01"]}]},{"name":"Canadian Paediatric Society\u2014Neonatal Resuscitation","award":["R01 HD104909"],"award-info":[{"award-number":["R01 HD104909"]}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R03HD104062-01"],"award-info":[{"award-number":["1R03HD104062-01"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD104909"],"award-info":[{"award-number":["R01 HD104909"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Child Health and Human Development","award":["1R03HD104062-01"],"award-info":[{"award-number":["1R03HD104062-01"]}]},{"name":"National Institute of Child Health and Human Development","award":["R01 HD104909"],"award-info":[{"award-number":["R01 HD104909"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Current neonatal resuscitation guidelines recommend the use of epinephrine for bradycardia\/arrest not responding to ventilation and chest compressions. Vasopressin is a systemic vasoconstrictor and is more effective than epinephrine in postnatal piglets with cardiac arrest. There are no studies comparing vasopressin with epinephrine in newly born animal models with cardiac arrest induced by umbilical cord occlusion. Objective: To compare the effect of epinephrine and vasopressin on the incidence and time to return of spontaneous circulation (ROSC), hemodynamics, plasma drug levels, and vasoreactivity in perinatal cardiac arrest. Design\/Methods: Twenty-seven term fetal lambs in cardiac arrest induced by cord occlusion were instrumented and resuscitated following randomization to epinephrine or vasopressin through a low umbilical venous catheter. Results: Eight lambs achieved ROSC prior to medication. Epinephrine achieved ROSC in 7\/10 lambs by 8 \u00b1 2 min. Vasopressin achieved ROSC in 3\/9 lambs by 13 \u00b1 6 min. Plasma vasopressin levels in nonresponders were much lower than responders after the first dose. Vasopressin caused in vivo increased pulmonary blood flow and in vitro coronary vasoconstriction. Conclusions: Vasopressin resulted in lower incidence and longer time to ROSC compared to epinephrine in a perinatal model of cardiac arrest supporting the current recommendations for exclusive use of epinephrine in neonatal resuscitation.<\/jats:p>","DOI":"10.3390\/children10020349","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T02:56:13Z","timestamp":1675997773000},"page":"349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Masked Randomized Trial of Epinephrine versus Vasopressin in an Ovine Model of Perinatal Cardiac Arrest"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9703-9857","authenticated-orcid":false,"given":"Munmun","family":"Rawat","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Gugino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmon","family":"Koenigsknecht","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Helman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-6949","authenticated-orcid":false,"given":"Deepika","family":"Sankaran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UC Davis Medical Center, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayasree","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-3017","authenticated-orcid":false,"given":"Praveen","family":"Chandrasekharan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University at Buffalo, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2155","authenticated-orcid":false,"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UC Davis Medical Center, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/S2214-109X(21)00515-5","article-title":"Global, regional, and national trends in under-5 mortality between 1990 and 2019 with scenario-based projections until 2030: A systematic analysis by the UN Inter-agency Group for Child Mortality Estimation","volume":"10","author":"Sharrow","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_2","unstructured":"GBD 2016 Causes of Death Collaborators (2017). Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390, 1151\u20131210."},{"key":"ref_3","unstructured":"WHO (2023, January 10). Newborn Mortality, Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/levels-and-trends-in-child-mortality-report-2021."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"463.e1","DOI":"10.1016\/j.ajog.2006.10.877","article-title":"The long-term outcome in surviving infants with Apgar zero at 10 min: A systematic review of the literature and hospital-based cohort","volume":"196","author":"Harrington","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jpeds.2011.07.041","article-title":"Outcome of extremely low birth weight infants who received delivery room cardiopulmonary resuscitation","volume":"160","author":"Wyckoff","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1161\/CIR.0000000000000895","article-title":"Neonatal Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations","volume":"142","author":"Wyckoff","year":"2020","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/pr.2015.117","article-title":"Effects of chest compressions on cardiovascular and cerebral hemodynamics in asphyxiated near-term lambs","volume":"78","author":"Sobotka","year":"2015","journal-title":"Pediatr. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1161\/01.CIR.92.10.3089","article-title":"Epinephrine increases the severity of postresuscitation myocardial dysfunction","volume":"92","author":"Tang","year":"1995","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1097\/00003246-200005000-00028","article-title":"Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation","volume":"28","author":"Gedeborg","year":"2000","journal-title":"Crit. Care. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1161\/01.CIR.91.1.215","article-title":"Vasopressin improves vital organ blood flow during closed-chest cardiopulmonary resuscitation in pigs","volume":"91","author":"Lindner","year":"1995","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(97)80087-6","article-title":"Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation","volume":"349","author":"Lindner","year":"1997","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/00003246-199903000-00022","article-title":"Vasopressin improves vital organ blood flow after prolonged cardiac arrest with post countershock pulseless electrical activity in pigs","volume":"27","author":"Wenzel","year":"1999","journal-title":"Crit. Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1213\/00000539-200009000-00024","article-title":"Vasopressin improves survival after cardiac arrest in hypovolemic shock","volume":"91","author":"Voelckel","year":"2000","journal-title":"Anesth. Analg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2050313X221102289","DOI":"10.1177\/2050313X221102289","article-title":"Use of vasopressin in persistent pulmonary hypertension of the newborn: A case series","volume":"10","author":"Joshi","year":"2022","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/pr.2014.38","article-title":"Vasopressin improves survival compared with epinephrine in a neonatal piglet model of asphyxial cardiac arrest","volume":"75","author":"McNamara","year":"2014","journal-title":"Pediatr. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/01.ccm.0000810708.23191.69","article-title":"Effect of norepinephrine versus vasopressin on pulmonary artery pressure","volume":"50","author":"Korkames","year":"2022","journal-title":"Critical Care Medicine."},{"key":"ref_17","first-page":"R376","article-title":"Vasopressin and fetal cerebrovascular regulation","volume":"263","author":"Eisenach","year":"1992","journal-title":"Am. J. Physiol."},{"key":"ref_18","first-page":"57553","article-title":"The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation","volume":"138","author":"Vali","year":"2018","journal-title":"J. Vis. Exp."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0196-0644(84)80455-2","article-title":"The role of epinephrine in CPR: A reappraisal","volume":"13","author":"Otto","year":"1984","journal-title":"Ann. Emerg. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00003246-198105000-00005","article-title":"Mechanism of action of epinephrine in resuscitation from asphyxial arrest","volume":"9","author":"Otto","year":"1981","journal-title":"Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00000542-196303000-00008","article-title":"Evaluation of drugs for cardiac resuscitation","volume":"24","author":"Redding","year":"1963","journal-title":"Anesthesiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.clp.2005.11.016","article-title":"Use of high-dose epinephrine and sodium bicarbonate during neonatal resuscitation: Is there proven benefit?","volume":"33","author":"Wyckoff","year":"2006","journal-title":"Clin. Perinatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/01.CIR.78.2.382","article-title":"Failure of epinephrine to improve the balance between myocardial oxygen supply and demand during closed-chest resuscitation in dogs","volume":"78","author":"Ditchey","year":"1988","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1590\/S0066-782X2003000500002","article-title":"Effect of arginine vasopressin on the canine epicardial coronary artery: Experiments on V1-receptor-mediated production of nitric oxide","volume":"80","author":"Evora","year":"2003","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/00003246-200205000-00001","article-title":"Effects of epinephrine and vasopressin in a piglet model of prolonged ventricular fibrillation and cardiopulmonary resuscitation","volume":"30","author":"Voelckel","year":"2002","journal-title":"Crit. Care Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/bja\/65.4.548","article-title":"Acute pulmonary oedema following administration of ornithine-8-vasopressin","volume":"65","author":"Borgeat","year":"1990","journal-title":"Br. J. Anaesth."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00005344-199208000-00014","article-title":"Comparison of peptide and nonpeptide receptor-mediated responses in rat tail artery","volume":"20","author":"Fox","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1056\/NEJMe038195","article-title":"Vasopressin in asystolic cardiac arrest","volume":"350","author":"McIntyre","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1056\/NEJMoa025431","article-title":"A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation","volume":"350","author":"Wenzel","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sankaran, D., Molloy, E.J., and Lakshminrusimha, S. (2022). Is epinephrine effective during neonatal resuscitation?. Pediatr. Res., Epub ahead of print.","DOI":"10.1038\/s41390-022-02411-2"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Vali, P., Chandrasekharan, P., Rawat, M., Gugino, S., Koenigsknecht, C., Helman, J., Mathew, B., Berkelhamer, S., Nair, J., and Wyckoff, M. (2017). Hemodynamics and gas exchange during chest compressions in neonatal resuscitation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176478"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/pr.2013.221","article-title":"Age dependency of vasopressin pulmonary vasodilatory effect in rats","volume":"75","author":"Enomoto","year":"2014","journal-title":"Pediatr. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/cc4917","article-title":"Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury","volume":"10","author":"Meyer","year":"2006","journal-title":"Crit. Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/archdischild-2020-321034","article-title":"Randomised trial of epinephrine dose and flush volume in term newborn lambs","volume":"106","author":"Sankaran","year":"2021","journal-title":"Arch. Dis. Child. Fetal. Neonatal. Ed."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S444","DOI":"10.1161\/CIR.0000000000000261","article-title":"Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","volume":"132","author":"Link","year":"2015","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.resuscitation.2009.04.005","article-title":"Reduced effectiveness of vasopressin in repeated doses for patients undergoing prolonged cardiopulmonary resuscitation","volume":"80","author":"Mukoyama","year":"2009","journal-title":"Resuscitation"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/2\/349\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:29:52Z","timestamp":1760120992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/2\/349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["children10020349"],"URL":"https:\/\/doi.org\/10.3390\/children10020349","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}