{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:52:31Z","timestamp":1760147551855,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>External cephalic version (ECV) is a cost-effective and safe treatment option for breech presentation at term. Following ECV, fetal well-being is assessed via a non-stress test (NST). An alternative option to identify signs of fetal compromise is via the Doppler indices of the umbilical artery (UA), middle cerebral artery (MCA) and ductus venosus (DV). Inclusion criteria were an uncomplicated pregnancy with breech presentation at term. Doppler velocimetry of the UA, MCA and DV were performed up to 1 h before and up to 2 h after ECV. The study included 56 patients who underwent elective ECV with a success rate of 75%. After ECV, the UA S\/D ratio, UA pulsatility index (PI) and UA resistance index (RI) were increased compared to before the ECV (p = 0.021, p = 0.042, and p = 0.022, respectively). There were no differences in the Doppler MCA and DV before or after ECV. All patients were discharged after the procedure. ECV is associated with changes in the UA Doppler indices that might reflect interference in placental perfusion. These changes are probably short-term and have no detrimental effects on the outcomes of uncomplicated pregnancies. ECV is safe; yet it is a stimulus or stress that can affect placental circulation. Therefore, careful case selection for ECV is important.<\/jats:p>","DOI":"10.3390\/children10020354","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T03:28:46Z","timestamp":1676258926000},"page":"354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of External Cephalic Version on Fetal Circulation: A Prospective Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Offra","family":"Engel","sequence":"first","affiliation":[{"name":"Obstetrical & Gynecological Ultrasound Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Arnon","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Neonatology, Meir Medical Center, 4428163 Kfar Saba, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8526-2143","authenticated-orcid":false,"given":"Gil","family":"Shechter Maor","sequence":"additional","affiliation":[{"name":"Obstetrical & Gynecological Ultrasound Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Department of Neonatology, Meir Medical Center, 4428163 Kfar Saba, Israel"},{"name":"High Risk Pregnancy Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-0813","authenticated-orcid":false,"given":"Hanoch","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Obstetrical & Gynecological Ultrasound Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettie","family":"Piura","sequence":"additional","affiliation":[{"name":"Obstetrical & Gynecological Ultrasound Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Markovitch","sequence":"additional","affiliation":[{"name":"Obstetrical & Gynecological Ultrasound Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba 4428164, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"ref_1","first-page":"CD000083","article-title":"External cephalic version for breech presentation at term","volume":"2015","author":"Hofmeyr","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.5468\/ogs.2019.62.6.371","article-title":"Reviving external cephalic version: A review of its efficacy, safety, and technical aspects","volume":"62","author":"Kim","year":"2019","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"(2020). External cephalic version: ACOG practice bulletin, number 221. Obstet. Gynecol., 135, e203\u2013e212.","DOI":"10.1097\/AOG.0000000000003837"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kuppens, S.M., Smailbegovic, I., Houterman, S., de Leeuw, I., and Hasaart, T.H. (2017). Fetal heart rate abnormalities during and after external cephalic version: Which fetuses are at risk and how are they delivered?. BMC Pregnancy Childbirth, 17.","DOI":"10.1186\/s12884-017-1547-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.0001-6349.2004.00347.x","article-title":"External cephalic version: A safe procedure? A systematic review of version-related risks","volume":"83","author":"Collaris","year":"2004","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1471-0528.1983.tb06763.x","article-title":"Cardiotocographic changes after external cephalic version","volume":"90","author":"Hofmeyr","year":"1983","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/AOG.0b013e318179978c","article-title":"Fetomaternal hemorrhage during external cephalic version","volume":"112","author":"Boucher","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00404-015-3902-z","article-title":"Predictors for a successful external cephalic version: A single centre experience","volume":"293","author":"Ebner","year":"2016","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/uog.6277","article-title":"Ultrasound factors to predict the outcome of external cephalic version: A meta-analysis","volume":"33","author":"Kok","year":"2009","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1080\/14767050802244938","article-title":"Prognostic parameters for successful external cephalic version","volume":"21","author":"Erez","year":"2008","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejogrb.2015.10.007","article-title":"Prediction models for successful external cephalic version: A systematic review","volume":"195","author":"Velzel","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1067\/mob.2000.106582","article-title":"Cell-free fetal deoxyribonucleic acid in maternal circulation as a marker of fetal-maternal hemorrhage in patients undergoing external cephalic version near term","volume":"183","author":"Lau","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1067\/mob.2000.104769","article-title":"Effect of external cephalic version at term on fetal circulation","volume":"182","author":"Lau","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/uog.19067","article-title":"Maternal hemodynamics, fetal biometry and Doppler indices in pregnancies followed up for suspected fetal growth restriction","volume":"52","author":"Roberts","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/j.semperi.2008.04.007","article-title":"Fetal Doppler: Umbilical artery, middle cerebral artery, and venous system","volume":"32","author":"Mari","year":"2008","journal-title":"Semin. Perinatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1471-0528.2004.00273.x","article-title":"Fetal responses to placental insufficiency: An update","volume":"111","author":"Baschat","year":"2004","journal-title":"BJOG"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/uog.5386","article-title":"Progression of Doppler abnormalities in intrauterine growth restriction","volume":"32","author":"Turan","year":"2008","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/01.CIR.91.1.129","article-title":"Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation. Arterial, intracardiac, and venous blood flow velocity studies","volume":"91","author":"Hecher","year":"1995","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/a-1072-5161","article-title":"Diagnostic accuracy of doppler ultrasound in predicting perinatal outcome in appropriate for gestational age fetuses: A prospective study","volume":"42","author":"Buca","year":"2021","journal-title":"Ultraschall Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1471-0528.2004.00127.x","article-title":"External cephalic version induced fetal cerebral and umbilical blood flow changes are related to the amount of pressure exerted","volume":"111","author":"Leung","year":"2004","journal-title":"BJOG"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1471-0528.1985.tb01044.x","article-title":"Fetal umbilical artery flow velocity waveforms and placental resistance: Clinical significance","volume":"92","author":"Trudinger","year":"1985","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0301-2115(01)00375-X","article-title":"In vitro placental pressure-flow behaviour is non-linear and depends on the external pressure","volume":"99","author":"Boer","year":"2001","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_23","first-page":"e60636","article-title":"External cephalic version: Is it an effective and safe procedure?","volume":"160","year":"2020","journal-title":"J. Vis. Exp."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/0140-6736(91)92720-M","article-title":"Ultrasonographic velocimetry of the fetal ductus venosus","volume":"338","author":"Kiserud","year":"1991","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/uog.23663","article-title":"Diagnosis and management of fetal growth restriction: The SMFM guideline and comparison with the ISUOG guideline","volume":"57","author":"Abuhamad","year":"2021","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/uog.22134","article-title":"ISUOG Practice Guidelines: Diagnosis and management of small-for-gestational-age fetus and fetal growth restriction","volume":"56","author":"Lees","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/aogs.13572","article-title":"The controversial role of the ductus venosus in hypoxic human fetuses","volume":"98","author":"Ferrazzi","year":"2019","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.AOG.0000253215.79121.75","article-title":"Predictors of neonatal outcome in early-onset placental dysfunction","volume":"109","author":"Baschat","year":"2007","journal-title":"Obstet. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(14)62049-3","article-title":"2 year neurodevelopmental and intermediate perinatal outcomes in infants with very preterm fetal growth restriction (TRUFFLE): A randomised trial","volume":"385","author":"Lees","year":"2015","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ijgo.13522","article-title":"FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction","volume":"152","author":"Melamed","year":"2021","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_31","first-page":"CD001450","article-title":"Fetal and umbilical Doppler ultrasound in normal pregnancy","volume":"2015","author":"Alfirevic","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s13224-020-01357-x","article-title":"Study of Association of Fetal Cerebroplacental Ratio with Adverse Perinatal Outcome in Uncomplicated Term AGA Pregnancies","volume":"70","author":"Anand","year":"2020","journal-title":"J. Obstet. Gynaecol. India"},{"key":"ref_33","first-page":"663","article-title":"Relationship between fetal middle cerebral artery pulsatility index and cerebroplacental ratio with adverse neonatal outcomes in low-risk pregnancy candidates for elective cesarean section: A cross-sectional study","volume":"20","author":"Golshahi","year":"2022","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/uog.20150","article-title":"Cerebral-placental-uterine ratio as novel predictor of late fetal growth restriction: Prospective cohort study","volume":"54","author":"MacDonald","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00006250-199203000-00018","article-title":"Cerebral-umbilical Doppler ratio as a predictor of adverse perinatal outcome","volume":"79","author":"Gramellini","year":"1992","journal-title":"Obstet. Gynecol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.earlhumdev.2004.05.004","article-title":"Influence of maternal tobacco smoking during pregnancy on uterine, umbilical and fetal cerebral artery blood flows","volume":"80","author":"Albuquerque","year":"2004","journal-title":"Early Hum. Dev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s11604-011-0622-6","article-title":"Impact of passive smoking on uterine, umbilical, and fetal middle cerebral artery blood flows","volume":"29","author":"Yildiz","year":"2011","journal-title":"Jpn. J. Radiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/0002-9378(94)90095-7","article-title":"Short-term effects of inhaled albuterol on maternal and fetal circulations","volume":"171","author":"Rayburn","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1515\/jpme.1991.19.3.167","article-title":"Single dose of labetalol in hypertensive pregnancy: Effects on maternal hemodynamics and uterine and fetal flow velocity waveforms","volume":"19","author":"Pirhonen","year":"1991","journal-title":"J. Perinat. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"M\u0103lu\u021ban, A.M., Clinciu, D., Mirescu, \u0218.C., Ciortea, R., Dudea-Simon, M., and Mihu, D. (2019). Ultrasound probe pressure on the maternal abdominal wall and the effect on fetal middle cerebral artery doppler indices. Medicina, 55.","DOI":"10.3390\/medicina55080410"},{"key":"ref_41","first-page":"44","article-title":"The effect of the pressure exerted on the maternal abdominal wall by the US probe on fetal MCA peak systolic velocity","volume":"38","author":"Alpert","year":"2017","journal-title":"Ultraschall Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1471-0528.1990.tb16250.x","article-title":"Maternal abdominal pressure alters fetal cerebral blood flow","volume":"97","author":"Vyas","year":"1990","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1113\/JP271099","article-title":"The fetal brain sparing response to hypoxia: Physiological mechanisms","volume":"594","author":"Giussani","year":"2016","journal-title":"J. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1177\/0271678X17750324","article-title":"Fetal brain sparing in a mouse model of chronic maternal hypoxia","volume":"39","author":"Cahill","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/0-387-29540-2_14","article-title":"Chronic hypoxia modulates endothelium-dependent vasorelaxation through multiple independent mechanisms in ovine cranial arteries","volume":"578","author":"Pearce","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/GCO.0b013e32835e0e9c","article-title":"Cerebral blood flow studies in the diagnosis and management of intrauterine growth restriction","volume":"25","author":"Stampalija","year":"2013","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.earlhumdev.2006.03.011","article-title":"Acute centralization of blood flow in compromised human fetuses evoked by uterine contractions","volume":"82","author":"Li","year":"2006","journal-title":"Early Hum. Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1113\/jphysiol.2011.224576","article-title":"A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep","volume":"590","author":"Herrera","year":"2012","journal-title":"J. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"R678","DOI":"10.1152\/ajpregu.2001.280.3.R678","article-title":"Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep","volume":"280","author":"Giussani","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1203\/01.pdr.0000242268.99726.53","article-title":"Role of prostanoids in the regulation of cerebral blood flow during normoxia and hypoxia in the fetal sheep","volume":"60","author":"Nishida","year":"2006","journal-title":"Pediatr. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1113\/jphysiol.2002.038034","article-title":"Role of nitric oxide in hypoxic cerebral vasodilatation in the ovine fetus","volume":"549","author":"Hunter","year":"2003","journal-title":"J. Physiol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/2\/354\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:30:51Z","timestamp":1760121051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/2\/354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,10]]},"references-count":51,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["children10020354"],"URL":"https:\/\/doi.org\/10.3390\/children10020354","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2023,2,10]]}}}