{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:12:12Z","timestamp":1780668732200,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: The appropriate alignment of the lower teeth is indicated by the Curve of Spee (COS), which can be observed in the sagittal profile view of human skulls. Graf Von Spee made the initial observation on this occlusal curvature. Through this systematic review and meta-analysis, we evaluated studies that looked at how COS affected masticatory activities. Methods: The databases PubMed-MEDLINE, Web of Science, Cochrane, and Scopus were all searched. A total of 12 documents were ultimately picked because they met the necessary inclusion and exclusion requirements. The data was then loaded into the RevMan 5 programme for meta-analysis after being chosen for information on the sample size, variables analyzed, and various aspects of the research. Results: The Curve of Spee was found to have a noticeable impact on both the masticatory efficiency as well as dentofacial alignment in the 12 studies that we selected for the review and meta-analysis. In addition, other occlusal curvatures such as the Curve of Monson and the Curve of Wilson were found to be of vital importance on a similar level to the COS. The meta-analysis further revealed that seven of the included clinical trials had mentioned the noticeable impact on masticatory efficiency. Conclusions: This study focused on the significance of the COS on force distribution in the oral cavity as well as the necessity of COS corrections after receiving full orthodontic care. Following orthodontic treatment, the COS, along with other occlusal curves such as the Curve of Wilson and the Curve of Monson, is essential in removing strains from the condyle, as well as the maxilla and mandible, which enhances masticatory effectiveness and lessens the overall strain on a patient\u2019s oral cavity.<\/jats:p>","DOI":"10.3390\/children10030511","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T04:29:58Z","timestamp":1678076998000},"page":"511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Accentuation of Curve of Spee on Masticatory Efficiency\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"10","author":[{"given":"Zainab A.","family":"Alkhalaf","sequence":"first","affiliation":[{"name":"Department of Prosthetic Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ghazi","family":"Sghaireen","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0046-3529","authenticated-orcid":false,"given":"Rakhi","family":"Issrani","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3178-9513","authenticated-orcid":false,"given":"Kiran Kumar","family":"Ganji","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"},{"name":"Department of Periodontics & Implantology, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education & Research, Sawangi (Meghe), Wardha 442107, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah Nasser","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Dental Intern, College of Dentistry, Jouf University Sakaka, Sakaka 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghad Mohammed","family":"Alsaleh","sequence":"additional","affiliation":[{"name":"Dental Intern, College of Dentistry, Jouf University Sakaka, Sakaka 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musab Redha S.","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Dental Intern, College of Dentistry, Jouf University Sakaka, Sakaka 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshari Farhan","family":"Alabdali","sequence":"additional","affiliation":[{"name":"Dental Intern, College of Dentistry, Jouf University Sakaka, Sakaka 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munahi Abdullah Rushdallah","family":"Alsirhani","sequence":"additional","affiliation":[{"name":"Dental Intern, College of Dentistry, Jouf University Sakaka, Sakaka 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-1752","authenticated-orcid":false,"given":"Mohammad Khursheed","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"},{"name":"Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai 600077, India"},{"name":"Department of Public Health, Faculty of Allied Health Sciences, Daffodil lnternational University, Dhaka 1216, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ajpa.23020","article-title":"Spatial determinants of the mandibular curve of Spee in modern and archaic Homo","volume":"161","author":"Laird","year":"2016","journal-title":"Am. J. Phys. Anthr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ajodo.2003.09.027","article-title":"Changes in the curve of Spee with treatment and at 2 years posttreatment","volume":"125","author":"Shannon","year":"2004","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.14219\/jada.archive.1980.0239","article-title":"The gliding path of the mandible along the skull","volume":"100","author":"Spee","year":"1890","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S323","DOI":"10.4103\/0975-7406.100287","article-title":"Significance of curve of Spee: An orthodontic review","volume":"4","author":"Tamizharasi","year":"2012","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_5","first-page":"7obac01","article-title":"Conserved and Taxon-Specific Patterns of Phenotypic Modularity in the Mammalian Dentition","volume":"4","author":"Takenaka","year":"2022","journal-title":"Integr. Org. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/joor.12501","article-title":"Realistic kinetic loading of the jaw system during single chewing cycles: A finite element study","volume":"44","author":"Choy","year":"2017","journal-title":"J. Oral Rehabil."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ajodo.2006.10.037","article-title":"Development of the curve of Spee","volume":"134","author":"Marshall","year":"2008","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dawson, E. (2006). Functional Occlusion: From TMJ to Smile Design, Elsevier. [1st ed.].","DOI":"10.4103\/0972-4052.32520"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.prosdent.2004.08.023","article-title":"An evaluation of the curve of Spee in the maxilla and mandible of human permanent healthy dentitions","volume":"92","author":"Xu","year":"2004","journal-title":"J. Prosthet. Dent."},{"key":"ref_10","first-page":"349","article-title":"Investigation of the changes in the positions of upper and lower incisors, overjet, overbite, and irregularity index in subjects with different depths of curve of Spee","volume":"74","author":"Yavuz","year":"2004","journal-title":"Angle Orthod."},{"key":"ref_11","first-page":"1","article-title":"Quantification of dental occlusal variation: A review of methods","volume":"21","author":"Harris","year":"2008","journal-title":"Dent. Anthr."},{"key":"ref_12","first-page":"766","article-title":"Exploration of variations in positions of upper and Lower incisors, overjet, overbite, and irreg-ularity Index in orthodontic patients with dissimilar depths of Curve of spee","volume":"28","author":"Kumari","year":"2016","journal-title":"J. Ayub. Med. Coll Abbottabad."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ajodo.2012.06.004","article-title":"Question about relapse of corrected deepbites","volume":"142","author":"Yu","year":"2012","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_14","unstructured":"Cordon, N.E. (1996). Post Treatment Stability of Deep Bite Malocclusions. [Ph.D. Thesis, The University of Oklahoma]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0002-9416(72)90268-0","article-title":"The six keys to normal occlusion","volume":"62","author":"Andrews","year":"1972","journal-title":"Am. J. Orthod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2319\/111312-870.1","article-title":"The role of occlusal curvatures and maxillary arch dimensions in patients with signs and symptoms of temporomandibular disorders","volume":"84","author":"Kanavakis","year":"2014","journal-title":"Angle Orthod."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., G\u00f8tzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., and Moher, D. (2009). The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000100"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.21608\/eos.2020.44824.1003","article-title":"The relationship between the depth of the curve of Spee and different types of malocclusion","volume":"58","author":"Aboulfotouh","year":"2020","journal-title":"Egypt. Orthod. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/0974909820130303","article-title":"Curve of Spee and Its Relationship with Dentoskeletal Morphology","volume":"47","author":"Batham","year":"2013","journal-title":"J. Indian Orthod. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.archoralbio.2012.06.006","article-title":"Association between occlusal curvature and food comminution and mixing in human young adults with permanent dentitions","volume":"58","author":"Fueki","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/ejo\/cji111","article-title":"Post-treatment development of the curve of Spee","volume":"28","author":"Lie","year":"2006","journal-title":"Eur. J. Orthod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/0970-9290.79985","article-title":"Comparative evaluation of the curve of Spee in two age groups and its relation to posterior teeth disclusion","volume":"22","author":"Mohan","year":"2011","journal-title":"Indian J. Dent. Res."},{"key":"ref_23","first-page":"21","article-title":"Investigation of variation in curve of Spee, over jet and overbite among class-I and class-II malocclusion subjects and to find sexual dimorphism, if any","volume":"4","author":"Negi","year":"2016","journal-title":"J. Adv. Med. Dent. Sci. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.18231\/2455-6785.2016.0010","article-title":"Evaluation of skeletal and dental parameters in individuals with variations in depth of Curve of Spee","volume":"2","author":"Yadav","year":"2016","journal-title":"Indian J. Orthod. Dentofac. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.ajodo.2016.09.023","article-title":"Leveling the curve of Spee with continuous archwire appliances in different vertical skeletal patterns: A retrospective study","volume":"151","author":"Rozzi","year":"2017","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jos.JOS_39_20","article-title":"Does the flatting of the curve of spee affect the chewing force distribution in the mandible? (3D finite element study)","volume":"10","author":"Hasan","year":"2021","journal-title":"J. Orthod. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Marshall, S.D., Kruger, K., Franciscus, R.G., and Southard, T.E. (2019). Development of the mandibular curve of spee and maxillary compensating curve: A finite element model. PLoS ONE, 14.","DOI":"10.1101\/723429"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.archoralbio.2013.10.001","article-title":"Changes in mandibular dimensions during the mediaeval to post-mediaeval transition in London: A possible response to decreased masticatory load","volume":"59","author":"Rando","year":"2014","journal-title":"Arch. Oral Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ajpa.10329","article-title":"Tooth wear and the \u201cdesign\u201d of the human dentition: A perspective from evolutionary medicine","volume":"122","author":"Kaifu","year":"2003","journal-title":"Am. J. Phys. Anthr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0003-9969(99)00095-3","article-title":"The effects of dental wear on third molar eruption and on the curve of Spee in human archaeological dentitions","volume":"44","author":"Sengupta","year":"1999","journal-title":"Arch. Oral Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jhevol.2003.11.007","article-title":"Does space in the jaw influence the timing of molar crown initiation? A model using baboons (Papio anubis) and great apes (Pan troglodytes, Pan paniscus)","volume":"46","author":"Boughner","year":"2004","journal-title":"J. Hum. Evol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1073\/pnas.1113050108","article-title":"Global human mandibular variation reflects differences in agricultural and hunter-gatherer subsistence strategies","volume":"108","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ejo\/9.1.15","article-title":"A pilot study of the effect of masticatory muscle training on facial growth in long-face children","volume":"9","author":"Ingervall","year":"1987","journal-title":"Eur. J. Orthod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2242","DOI":"10.7717\/peerj.2242","article-title":"Human feeding biomechanics: Performance, variation, and functional constraints","volume":"4","author":"Ledogar","year":"2016","journal-title":"PeerJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1038\/s41598-018-24293-3","article-title":"Human mandibular shape is associated with masticatory muscle force","volume":"8","author":"Pokhojaev","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/3\/511\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:07Z","timestamp":1760122087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/3\/511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,4]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["children10030511"],"URL":"https:\/\/doi.org\/10.3390\/children10030511","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,4]]}}}