{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:26:35Z","timestamp":1785151595530,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002649","name":"2021 Yeungnam University Research Grant","doi-asserted-by":"publisher","award":["221A480001"],"award-info":[{"award-number":["221A480001"]}],"id":[{"id":"10.13039\/501100002649","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Febrile convulsion (FC) is the most common seizure disease in children, which occurs with a fever. We investigated the Korean Health Insurance Review and Assessment Service data of patients aged between 6 months and 5 years at the time of FC diagnosis. Diseases that can cause seizures with fever, such as neoplasms, metabolic disorders, nervous system disorders, cerebrovascular diseases, perinatal problems, and congenital abnormalities, were excluded. Weekly virus-positive detection rate (PDR) data were obtained from the Korea Disease Control and Prevention Agency for adenovirus, parainfluenza virus, respiratory syncytial virus (HRSV), influenza virus, coronavirus (HCoV), rhinovirus (HRV), bocavirus, metapneumovirus (HMPV), rotavirus, norovirus, and astrovirus. Using the Granger test, we then analyzed the monthly PDR and investigated the association between FC incidence and monthly PDR. We additionally identified monthly and seasonal FC incidence trends using the autoregressive integrated moving average. Between 2015 and 2019, 64,291 patients were diagnosed with FC. Annually, the incidence was the highest in May and the lowest in October. Most patients were diagnosed during the spring (26.7%). The PDRs for HRSV, HCoV, HRV, HMPV, and norovirus were associated with FC incidence after 1 month.<\/jats:p>","DOI":"10.3390\/children10030529","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T02:33:16Z","timestamp":1678329196000},"page":"529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Seasonal Trend of Viral Prevalence and Incidence of Febrile Convulsion: A Korea Public Health Data Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-7536","authenticated-orcid":false,"given":"Ha Rim","family":"Keum","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2648-0340","authenticated-orcid":false,"given":"Sang Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Medical Research Center, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Sun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-6282","authenticated-orcid":false,"given":"Jun Chul","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6822-1051","authenticated-orcid":false,"given":"Jae Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1542\/peds.2010-3318","article-title":"Febrile Seizures: Guideline for the Neurodiagnostic Evaluation of the Child with a Simple Febrile Seizure","volume":"127","author":"Seizures","year":"2011","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"212536","DOI":"10.7573\/dic.212536","article-title":"Febrile seizures: An overview","volume":"7","author":"Leung","year":"2018","journal-title":"Drugs Context"},{"key":"ref_3","first-page":"149","article-title":"Febrile seizures: Risks, evaluation, and prognosis","volume":"85","author":"Graves","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0140-6736(08)61198-8","article-title":"Death in children with febrile seizures: A population-based cohort study","volume":"372","author":"Vestergaard","year":"2008","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJM199806113382403","article-title":"Long-Term Intellectual and Behavioral Outcomes of Children with Febrile Convulsions","volume":"338","author":"Verity","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/adc.2006.110221","article-title":"Relationship between five common viruses and febrile seizure in children","volume":"92","author":"Chung","year":"2007","journal-title":"Arch. Dis. Child."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/2230-8229.98192","article-title":"Pattern of Febrile Illnesses in Children Seen at A Pediatric Ambulatory Care Setting","volume":"7","author":"Ghazal","year":"2000","journal-title":"J. Fam. Community Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/19371910903070333","article-title":"Introduction: Health of the Health Care System in Korea","volume":"25","author":"Kim","year":"2010","journal-title":"Soc. Work. Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/19371911003648275","article-title":"Special issue on the national health care system of South Korea Soc","volume":"25","author":"Kim","year":"2010","journal-title":"Work. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2014008","DOI":"10.4178\/epih\/e2014008","article-title":"A guide for the utilization of Health Insurance Review and Assessment Service National Patient Samples","volume":"36","author":"Kim","year":"2014","journal-title":"Epidemiol. Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2307\/1912791","article-title":"Investigating Causal Relations by Econometric Models and Cross-spectral Methods","volume":"37","author":"Granger","year":"1969","journal-title":"Econometrica"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"801321","DOI":"10.3389\/fped.2021.801321","article-title":"A Review of Febrile Seizures: Recent Advances in Understanding of Febrile Seizure Pathophysiology and Commonly Implicated Viral Triggers","volume":"9","author":"Sawires","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.seizure.2018.01.007","article-title":"Investigating the prevalence of febrile convulsion in Kayseri, Turkey: An assessment of the risk factors for recurrence of febrile convulsion and for development of epilepsy","volume":"55","author":"Canpolat","year":"2018","journal-title":"Seizure"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jped.2015.01.005","article-title":"Febrile seizures: A population-based study","volume":"91","author":"Dalbem","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1212\/WNL.34.2.175","article-title":"Epidemiology of febrile and afebrile convulsions in children in Japan","volume":"34","author":"Tsuboi","year":"1984","journal-title":"Neurology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e035977","DOI":"10.1136\/bmjopen-2019-035977","article-title":"Seizure prevalence in children aged up to 3 years: A longitudinal population-based cohort study in Japan","volume":"10","author":"Nishiyama","year":"2020","journal-title":"BMJ Open"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.seizure.2018.12.004","article-title":"Febrile seizures: Are they truly benign? Longitudinal analysis of risk factors and future risk of afebrile epileptic seizure based on the national sample cohort in South Korea, 2002\u20132013","volume":"64","author":"Choi","year":"2019","journal-title":"Seizure"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/j.1528-1157.1994.tb05932.x","article-title":"The Prevalence and Incidence of Convulsive Disorders in Children","volume":"35","author":"Hauser","year":"1994","journal-title":"Epilepsia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000522065","article-title":"Seasonal Variation and Risk of Febrile Seizures: A Danish Nationwide Cohort Study","volume":"56","author":"Christensen","year":"2022","journal-title":"Neuroepidemiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1469-8749.1997.tb07450.x","article-title":"Febrile seizures in a South Indian district: Incidence and associations","volume":"39","author":"Hackett","year":"1997","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pediatrneurol.2005.08.007","article-title":"Febrile Seizures in Southern Chinese Children: Incidence and Recurrence","volume":"34","author":"Chung","year":"2006","journal-title":"Pediatr. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.7861\/clinmedicine.18-2-155","article-title":"Acute encephalitis\u2014Diagnosis and management","volume":"18","author":"Ellul","year":"2018","journal-title":"Clin. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.seizure.2019.10.008","article-title":"Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data","volume":"73","author":"Han","year":"2019","journal-title":"Seizure"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.pediatrneurol.2015.01.001","article-title":"Diurnal and Seasonal Occurrence of Febrile Seizures","volume":"52","author":"Mikkonen","year":"2015","journal-title":"Pediatr. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1600-0404.1984.tb07814.x","article-title":"Seasonal variation of febrile convulsion in Japan","volume":"69","author":"Tsuboi","year":"1984","journal-title":"Acta Neurol. Scand."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Francis, J.R., Richmond, P., Robins, C., Lindsay, K., Levy, A., Effler, P.V., Borland, M., and Blyth, C.C. (2016). An observational study of febrile seizures: The importance of viral infection and immunization. BMC Pediatr., 16.","DOI":"10.1186\/s12887-016-0740-5"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107306","DOI":"10.1016\/j.yebeh.2020.107306","article-title":"The weather condition and epidemics as triggers for febrile seizure: A single-center retrospective observational study","volume":"111","author":"Kawakami","year":"2020","journal-title":"Epilepsy Behav."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/21645515.2018.1526588","article-title":"Viral etiological causes of febrile seizures for respiratory pathogens (EFES Study)","volume":"15","author":"Carman","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/0883073816670820","article-title":"Respiratory and Enteric Virus Detection in Children","volume":"32","author":"Pokorn","year":"2017","journal-title":"J. Child Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7196\/SAMJ.2021.v111i8.15431","article-title":"Incidence of febrile seizures and associated factors in children in Soweto, South Africa","volume":"111","author":"Tebeila","year":"2021","journal-title":"South Afr. Med. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3345\/kjp.2018.07066","article-title":"Respiratory syncytial virus-associated seizures in Korean children, 2011\u20132016","volume":"62","author":"Cha","year":"2019","journal-title":"Korean J. Pediatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.eplepsyres.2014.10.021","article-title":"Clinical characteristics of seizures associated with viral gastroenteritis in children","volume":"109","author":"Ueda","year":"2015","journal-title":"Epilepsy Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/0883073817707302","article-title":"Clinical Characteristics and Risk Factors for Seizures Associated With Norovirus Gastroenteritis in Childhood","volume":"32","author":"Hu","year":"2017","journal-title":"J. Child Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e17269","DOI":"10.1097\/MD.0000000000017269","article-title":"Molecular epidemiology and clinical characteristics of norovirus gastroenteritis with seizures in children in Taiwan, 2006\u20132015","volume":"98","author":"Chen","year":"2019","journal-title":"Medicine"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/3\/529\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:51:34Z","timestamp":1760122294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/3\/529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,9]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["children10030529"],"URL":"https:\/\/doi.org\/10.3390\/children10030529","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,9]]}}}