{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:58:34Z","timestamp":1775059114352,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>(1) Background: Retinopathy of prematurity (ROP) can cause severe visual impairment or even blindness. We aimed to assess the hematological risk factors that are associated with different stages of ROP in a cohort of preterm newborns, and to compare the clinical characteristics and therapeutic interventions between groups. (2) Methods: This retrospective study included 149 preterm newborns from a tertiary maternity hospital in Romania between January 2018 and December 2018, who were segregated into: Group 1 (with ROP, n = 59 patients), and Group 2 (without ROP, n = 90 patients). The patients that were affected by ROP were subsequently divided into the following subgroups: Subgroup 1 (Stage 1, n = 21), Subgroup 2 (Stage 2, n = 35), and Subgroup 3 (Stage 3, n = 25). The associations were analyzed using multivariate logistic regression and sensitivity analysis. (3) Results: Platelet mass indexes (PMI) that were determined in the first, seventh, and tenth days of life were significantly associated with Stage 1 ROP. PMI determined in the first day of life was also significantly associated with Stage 2 ROP. The sensitivity and specificity of these parameters were modest, ranging from 44 to 57%, and 59 to 63%. (4) Conclusions: PMI has a modest ability to predict the development of ROP.<\/jats:p>","DOI":"10.3390\/children10030567","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T03:33:57Z","timestamp":1679024037000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hematologic Risk Factors for the Development of Retinopathy of Prematurity\u2014A Retrospective Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-4586","authenticated-orcid":false,"given":"Gabriela Ildiko","family":"Zonda","sequence":"first","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Mogos","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina-S\u00eenziana","family":"Melinte-Popescu","sequence":"additional","affiliation":[{"name":"Department of Mother and Newborn Care, Faculty of Medicine and Biological Sciences, \u2018\u0218tefan cel Mare\u2019 University, 720229 Suceava, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Maria","family":"Adam","sequence":"additional","affiliation":[{"name":"Clinical and Surgical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriu","family":"Harabor","sequence":"additional","affiliation":[{"name":"Clinical and Surgical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2345-1077","authenticated-orcid":false,"given":"Dragos","family":"Nemescu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-0200","authenticated-orcid":false,"given":"Demetra","family":"Socolov","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamaria","family":"Harabor","sequence":"additional","affiliation":[{"name":"Clinical and Surgical Department, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Melinte-Popescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine and Biological Sciences, \u2018\u0218tefan cel Mare\u2019 University, 720229 Suceava, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0694-9028","authenticated-orcid":false,"given":"Maura Adelina","family":"Hincu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4718-392X","authenticated-orcid":false,"given":"Ingrid-Andrada","family":"Vasilache","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-7039","authenticated-orcid":false,"given":"Alexandru","family":"Carauleanu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gigi","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u2018Dunarea de Jos\u2019 University, 800216 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-797X","authenticated-orcid":false,"given":"Luminita","family":"Paduraru","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/s41372-021-01015-8","article-title":"80 Years of vision: Preventing blindness from retinopathy of prematurity","volume":"41","author":"Wood","year":"2021","journal-title":"J. Perinatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.survophthal.2018.04.002","article-title":"Retinopathy of prematurity: A review of risk factors and their clinical significance","volume":"63","author":"Kim","year":"2018","journal-title":"Surv. 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