{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:09:54Z","timestamp":1787836194891,"version":"build-2784847793"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: infectious mononucleosis is very common during childhood and neurological manifestations are extremely rare. However, when they occur, an appropriate treatment must be undertaken to reduce morbidity and mortality as well as to ensure appropriate management. Methods: we describe the clinical and neurological records of a female patient with post-EBV acute cerebellar ataxia, whose symptoms rapidly resolved with intravenous immunoglobulin therapy. Afterwards, we compared our results with published data. Results: we reported the case of an adolescent female with a 5-day history of sudden asthenia, vomiting, dizziness, and dehydration, with a positive monospot test and hypertransaminasemia. In the following days, she developed acute ataxia, drowsiness, vertigo, and nystagmus with a positive EBV IgM titer, confirming acute infectious mononucleosis. The patient was clinically diagnosed with EBV-associated acute cerebellitis. A brain MRI showed no acute changes and a CT scan showed hepatosplenomegaly. She started therapy with acyclovir and dexamethasone. After a few days, because of her condition\u2019s deterioration, she received intravenous immunoglobulin and demonstrated a good clinical response. Conclusions: although there are no consensus guidelines for the treatment of post-infectious acute cerebellar ataxia, early intervention with intravenous immunoglobulin might prevent adverse outcomes, especially in cases that do not respond to high-dose steroid therapy.<\/jats:p>","DOI":"10.3390\/children10040668","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T03:31:38Z","timestamp":1680233498000},"page":"668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Post-Infectious Acute Cerebellar Ataxia Treatment, a Case Report and Review of Literature"],"prefix":"10.3390","volume":"10","author":[{"given":"Emanuela","family":"Del Giudice","sequence":"first","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Mond\u00ec","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"},{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Bazzanella","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"},{"name":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-9231","authenticated-orcid":false,"given":"Alessia","family":"Marcellino","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-4574","authenticated-orcid":false,"given":"Vanessa","family":"Martucci","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Pontrelli","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-6648","authenticated-orcid":false,"given":"Mariateresa","family":"Sanseviero","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-9560","authenticated-orcid":false,"given":"Piero","family":"Pavone","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University Hospital \u201cPoliclinico-San Marco\u201d, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-8318","authenticated-orcid":false,"given":"Silvia","family":"Bloise","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-2478","authenticated-orcid":false,"given":"Salvatore","family":"Martellucci","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Santa Maria Goretti Hospital, ASL Latina, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Carraro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Ventriglia","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Lichtner","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-955X","authenticated-orcid":false,"given":"Riccardo","family":"Lubrano","sequence":"additional","affiliation":[{"name":"Department of Maternal Infantile and Urological Sciences, Santa Maria Goretti Hospital, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1177\/0883073812450318","article-title":"Acute cerebellar ataxia, acute cerebellitis, and opsoclonus-myoclonus syndrome","volume":"27","author":"Desai","year":"2012","journal-title":"J. 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