{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:17:06Z","timestamp":1787897826395,"version":"build-2784847793"},"reference-count":126,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy Cluj-Napoca","award":["35.161\/17.12.2021"],"award-info":[{"award-number":["35.161\/17.12.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>(1) Background: Vascular endothelial growth factor (VEGF) is essential in vasculo- and angiogenesis due to its role in endothelial cell proliferation and migration. As a vascular proliferative factor, VEGF is one of the hallmarks of cancer and, in adult populations, the relationship between genetic polymorphism and neoplasm was widely investigated. For the neonatal population, only a few studies attempted to uncover the link between the genetic polymorphism of VEGF and neonatal pathology, especially related to late-onset complications. Our objective is to evaluate the literature surrounding VEGF genetic polymorphisms and the morbidity of the neonatal period. (2) Methods: A systematic search was initially conducted in December 2022. The PubMed platform was used to explore MEDLINE (1946 to 2022) and PubMed Central (2000 to 2022) by applying the search string ((VEGF polymorphism*) and newborn*). (3) Results: The PubMed search yielded 62 documents. A narrative synthesis of the findings was undertaken considering our predetermined subheadings (infants with low birth weight or preterm birth, heart pathologies, lung diseases, eye conditions, cerebral pathologies, and digestive pathologies). (4) Conclusion: The VEGF polymorphisms seem to be associated with neonatal pathology. The involvement of VEGF and VEGF polymorphism has been demonstrated for retinopathy of prematurity.<\/jats:p>","DOI":"10.3390\/children10040744","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T04:22:51Z","timestamp":1681878171000},"page":"744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic Polymorphisms of Vascular Endothelial Growth Factor in Neonatal Pathologies: A Systematic Search and Narrative Synthesis of the Literature"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9143-5664","authenticated-orcid":false,"given":"Monica G.","family":"H\u0103\u015fm\u0103\u015fanu","sequence":"first","affiliation":[{"name":"Department of Neonatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia M.","family":"Procopciuc","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-5846","authenticated-orcid":false,"given":"Melinda","family":"Matyas","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-4586","authenticated-orcid":false,"given":"Gabriela I.","family":"Zonda","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Care, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela C.","family":"Zaharie","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/annonc\/mdp533","article-title":"Bevacizumab combined with chemotherapy for patients with advanced colorectal cancer: A systematic review","volume":"21","author":"Welch","year":"2009","journal-title":"Ann. Oncol."},{"key":"ref_2","first-page":"30","article-title":"A Survey on the Role of Interleukin-10 in Breast Cancer: A Narrative","volume":"7","author":"Sheikhpour","year":"2018","journal-title":"Rep. Biochem. Mol. 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