{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:29:53Z","timestamp":1775183393391,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Fetal lung interstitial tumor (FLIT) is an extremely rare pediatric lung tumor that shares radiological features with congenital pulmonary malformations (cPAM) and other lung neoplasms. A review of the literature, together with the first European case, are herein reported. A systematic and manual search of the literature using the keyword \u201cfetal lung interstitial tumor\u201d was conducted on PUBMED, Scopus, and SCIE (Web of Science). Following the PRISMA guidelines, 12 articles were retrieved which describe a total of 21 cases of FLIT, and a new European case is presented. A prenatal diagnosis was reported in only 3 out of 22 (13%) cases. The mean age at surgery was 31 days of life (1\u2013150); a lobectomy was performed in most of the cases. No complications or recurrence of disease were reported at a mean follow-up of 49 months. FLIT is rarely diagnosed during pregnancy, may present at birth with different levels of respiratory distress, and requires prompt surgical resection. Histology and immunohistochemistry allow for the differentiation of FLIT from cPAM and other lung tumors with poor prognosis, such as pleuropulmonary blastoma, congenital peri-bronchial myofibroblastic tumor, inflammatory myofibroblastic tumor, and congenital or infantile fibrosarcoma.<\/jats:p>","DOI":"10.3390\/children10050828","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T01:36:38Z","timestamp":1683077798000},"page":"828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fetal Lung Interstitial Tumor (FLIT): Review of The Literature"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-6795","authenticated-orcid":false,"given":"Silvia","family":"Perin","sequence":"first","affiliation":[{"name":"Pediatric Surgery Unit, C\u00e0 Foncello Hospital, 31100 Treviso, Italy"},{"name":"Pediatric Surgery Unit, Department of Women and Child Health, University of Padua, 35141 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Cataldo","sequence":"additional","affiliation":[{"name":"Pathology Unit, C\u00e0 Foncello Hospital, 31100 Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Baciorri","sequence":"additional","affiliation":[{"name":"Pathology Unit, C\u00e0 Foncello Hospital, 31100 Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Azienda Ospedaliera Universit\u00e0 Padova, 35141 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Dei Tos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Azienda Ospedaliera Universit\u00e0 Padova, 35141 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Guido","sequence":"additional","affiliation":[{"name":"Pathology Unit, C\u00e0 Foncello Hospital, 31100 Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4543-9298","authenticated-orcid":false,"given":"Paola","family":"Midrio","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, C\u00e0 Foncello Hospital, 31100 Treviso, Italy"},{"name":"Pediatric Surgery Unit, Department of Women and Child Health, University of Padua, 35141 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jpedsurg.2010.11.004","article-title":"Prenatal diagnosis and outcome of fetal lung masses","volume":"46","author":"Cass","year":"2011","journal-title":"J. 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