{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:27:03Z","timestamp":1773980823438,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chang Gung Memorial Hospital","award":["CFRPG8K0071"],"award-info":[{"award-number":["CFRPG8K0071"]}]},{"name":"Chang Gung Memorial Hospital","award":["MOST 110-2635-B-182A-004"],"award-info":[{"award-number":["MOST 110-2635-B-182A-004"]}]},{"name":"Ministry of Science and Technology, Taiwan","award":["CFRPG8K0071"],"award-info":[{"award-number":["CFRPG8K0071"]}]},{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 110-2635-B-182A-004"],"award-info":[{"award-number":["MOST 110-2635-B-182A-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Food sensitization in early life identifies children at risk of developing allergic diseases. We investigated the sensitization to cow milk (CM), egg whites, and wheat. Newborns and infants under 3 years of age with available specific immunoglobulin E (sIgE) data were identified. A retrospective survey was conducted using data from the Chang Gung Research Database. Perinatal characteristics, such as singleton or multiples in a single pregnancy, parity, meconium staining, maternal age, spontaneous delivery or cesarean section, meconium passage, weeks of gestation, birth length, body weight, head and chest circumferences, and season, were obtained. The data on sIgE were collected, and a logistic regression model was used to determine the odds of sensitization. Positive sIgE for CM and egg whites was more likely to occur in boys than in girls. Early-life egg white and wheat sensitization was associated with increased birth body length and weight. A multivariate analysis indicated an association between egg white sIgE positivity and logarithmic total IgE. Higher total IgE levels and younger age were associated with egg white sensitization, and elevated weight and length at birth were linked to food sensitization, particularly to egg whites and wheat.<\/jats:p>","DOI":"10.3390\/children10050860","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T02:36:59Z","timestamp":1683859019000},"page":"860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age"],"prefix":"10.3390","volume":"10","author":[{"given":"Hsin-Yu","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zon-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"Department of Pharmacy, Tajen University, Pingtung 907, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Sai","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ling","family":"Feng","sequence":"additional","affiliation":[{"name":"The Biostatistics Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-0504","authenticated-orcid":false,"given":"Yao-Hsu","family":"Yang","sequence":"additional","affiliation":[{"name":"Health Information and Epidemiology Laboratory, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan"},{"name":"Department of Traditional Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan"},{"name":"School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Chen","family":"Ou-Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/all.12784","article-title":"The march from early life food sensitization to allergic disease: A systematic review and meta-analyses of birth cohort studies","volume":"71","author":"Alduraywish","year":"2016","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1398-9995.2007.01570.x","article-title":"Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life","volume":"63","author":"Venter","year":"2008","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100663","DOI":"10.1016\/j.waojou.2022.100663","article-title":"Prenatal and perinatal risk factors of food allergy in Taiwanese young children","volume":"15","year":"2022","journal-title":"World Allergy Organ. 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