{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:13:28Z","timestamp":1760148808296,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Acute kidney injury is a frequent complication for critical newborns. Its management is a significant challenge, especially in extremely low-birth-weight (ELBW) infants. Currently, peritoneal dialysis (PD) is the most manageable treatment. However, data are lacking regarding when diuresis can be declared irreversible relative to the start of PD. A female infant born at 28 + 0 weeks with a birth weight of 800 g by monochorionic diamniotic pregnancy, complicated by twin-to-twin transfusion syndrome, developed acute renal failure on the second day of life because of long-term intrauterine hypoperfusion. PD was started on day 7. The patient remained anuric until the 52nd day of dialysis, when she presented adequate urine output of 2.5 mL\/kg\/h and PD was suspended for 11 days. After an episode of sepsis, PD was re-started, and after 50 days of treatment, given a urine output of 1.5 mL\/kg\/h, it was discontinued. The patient died on day 132 after a disseminate infection, which led to multiorgan failure. In ELBW infants, PD is a valid therapeutic instrument to treat patients with renal failure. Despite the evidence of low renal functional reserve in these patients, the duration of recovery from diuresis after a period of anuria can be very long.<\/jats:p>","DOI":"10.3390\/children10061032","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T01:32:34Z","timestamp":1686274354000},"page":"1032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Interesting Case of Neonatal AKI: What Is the Time to Consider Anuria Irreversible?"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-9328","authenticated-orcid":false,"given":"Antonio","family":"Gatto","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloisa","family":"Tiberi","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6479-1540","authenticated-orcid":false,"given":"Serena","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"},{"name":"Department of Pediatrics, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Piersanti","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena Valentina","family":"Paradiso","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-8583","authenticated-orcid":false,"given":"Lorenzo","family":"Nanni","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-481X","authenticated-orcid":false,"given":"Roberto","family":"Iezzi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-3413","authenticated-orcid":false,"given":"Alessandro","family":"Posa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Costa","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Vento","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, 00168 Rome, Italy"},{"name":"Neonatology Unit, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1053\/j.semperi.2003.11.003","article-title":"Acute renal failure in the newborn","volume":"28","author":"Andreoli","year":"2004","journal-title":"Semin. Perinatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1081\/JDI-200026749","article-title":"Acute renal failure in the neonatal period","volume":"26","author":"Agras","year":"2004","journal-title":"Ren. 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Padiatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.2215\/CJN.05190514","article-title":"Recognition and reporting of AKI in very low birth weight infants","volume":"9","author":"Carmody","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.24953\/turkjped.2020.06.020","article-title":"Peritoneal dialysis as a life-saving procedure in an extremely low birth weight infant: Case report and review of the literature","volume":"62","author":"Ercan","year":"2020","journal-title":"Turk. J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Noh, J., Kim, C.Y., Jung, E., Lee, J.H., Park, Y.S., Lee, B.S., Kim, E.A., and Kim, K.S. (2020). Challenges of acute peritoneal dialysis in extremely-low-birth-weight infants: A retrospective cohort study. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-02092-1"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"867715","DOI":"10.3389\/fped.2022.867715","article-title":"Management of Acute Kidney Injury in Extremely Low Birth Weight Infants","volume":"10","author":"Branagan","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/ckj\/sfu095","article-title":"Peritoneal dialysis in an extremely low-birth-weight infant with acute kidney injury","volume":"7","author":"Harshman","year":"2014","journal-title":"Clin. Kidney J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/0896860819887292","article-title":"Peritoneal dialysis in extremely and very low-birth-weight infants","volume":"40","author":"Burgmaier","year":"2020","journal-title":"Perit. Dial. Int."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/6\/1032\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:50:59Z","timestamp":1760125859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/6\/1032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["children10061032"],"URL":"https:\/\/doi.org\/10.3390\/children10061032","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2023,6,8]]}}}