{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:43:04Z","timestamp":1777351384686,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy","award":["PII-C4-TC-2016-08"],"award-info":[{"award-number":["PII-C4-TC-2016-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Primary lactose intolerance (PLI) is characterized by the inability to digest lactose. Homozygotes for the lactase gene polymorphisms (CC or GG) are considered to be genetically predisposed to PLI. Still, symptoms may only be present later in life. The evidence supporting a link between PLI, dairy intake, and quality of life (QoL) is limited in children. Aim: This study investigates the link between LCT polymorphisms and suggestive symptoms and the influence of the genetic predisposition to PLI on dairy intake and QoL in Romanian children. Materials and methods: We recruited consecutive children evaluated in our ambulatory clinic. We asked all participants to complete a visual-analog symptoms scale, a dairy intake, and a QoL questionnaire. We used strip genotyping to identify genetic predisposition to PLI. Results: 51.7% of children had a CC genotype, and 34.5% also had a GG genotype. Most children reported no or mild symptoms. Dairy intake and QoL were similar across study groups. Conclusions: Our study shows that genetic predisposition does not necessarily assume the presence of specific symptoms. Genetic predisposition to PLI did not lead to dairy avoidance, nor did it negatively influence our children\u2019s QoL.<\/jats:p>","DOI":"10.3390\/children10061075","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:31:14Z","timestamp":1687138274000},"page":"1075","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic Predisposition to Primary Lactose Intolerance Does Not Influence Dairy Intake and Health-Related Quality of Life in Romanian Children: A Hospital-Based Cross-Sectional Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Corina","family":"Pienar","sequence":"first","affiliation":[{"name":"Department of Pediatrics, 2nd Pediatrics Clinic, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 2nd Pediatrics Clinic, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9754-4324","authenticated-orcid":false,"given":"Marilena","family":"L\u0103z\u0103rescu","sequence":"additional","affiliation":[{"name":"The Necker-Enfants Malades Hospital, University of Paris Descartes, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmila","family":"Cost\u0103chescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 2nd Pediatrics Clinic, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3923-3501","authenticated-orcid":false,"given":"Mirela","family":"Mogoi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, 2nd Pediatrics Clinic, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-5949","authenticated-orcid":false,"given":"Ruxandra","family":"Mare","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"\u0218ecl\u0103man","sequence":"additional","affiliation":[{"name":"Biochemistry Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1542\/peds.2006-1721","article-title":"Lactose Intolerance in Infants, Children, and Adolescents","volume":"118","author":"Heyman","year":"2006","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2147\/CEG.S32368","article-title":"Lactose intolerance: Diagnosis, genetic, and clinical factors","volume":"5","author":"Mattar","year":"2012","journal-title":"Clin. 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