{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:26Z","timestamp":1787027846333,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["5U54GM104942-05"],"award-info":[{"award-number":["5U54GM104942-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>(1) Background: Migraine is associated with comorbidities that are common in the general rural pediatric population. The purpose of this study is to evaluate the differences in the occurrence of comorbidities between rural children and adolescents with and without migraine. (2) Methods: A cross-sectional, secondary data analysis using electronic medical records of 1296 patients (53.8% females, aged 12.4 \u00b1 3.2) was completed. Mann\u2013Whitney U test was used to detect the difference in the number of comorbidities between the two groups. Chi-square test was used to identify the differences in the number of comorbidities, which were classified as low (0\u20131 comorbidities), medium (2\u20133 comorbidities), and high (4 or plus comorbidities) degree of comorbidities. (3) Results: Significant differences were found between those children and adolescents with migraine vs. those without for depression (p &lt; 0.0001), anxiety (p &lt; 0.0001), and Ehlers\u2013Danlos Syndrome (EDS; p = 0.0309). A marginally significant difference was found between those children and adolescents with migraine (47.2%; n = 306) vs. those without (42.1%; n = 273) for unhealthy weight (p = 0.0652). Approximately 40% of the migraineurs had 2\u20133 comorbidities, whereas 32% of the non-migraineurs had 2\u20133 comorbidities (p = 0.0003). (4) Conclusions: Findings demonstrate the importance of identifying comorbidities associated with rural pediatric migraine in order to develop effective treatment strategies that optimize patient outcomes.<\/jats:p>","DOI":"10.3390\/children10071133","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:43:30Z","timestamp":1688085810000},"page":"1133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comorbidities of Rural Children and Adolescents with Migraine and without Migraine"],"prefix":"10.3390","volume":"10","author":[{"given":"Suzy Mascaro","family":"Walter","sequence":"first","affiliation":[{"name":"Department of Family and Community Health, School of Nursing, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-0748","authenticated-orcid":false,"given":"Zheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Health Affairs Institute, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-3877","authenticated-orcid":false,"given":"Kesheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Family and Community Health, School of Nursing, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1055\/s-0041-1727574","article-title":"Obesity, Migraine, and Overlapping Comorbidities in a Rural Pediatric Population","volume":"12","author":"Walter","year":"2021","journal-title":"J. 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