{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:55:58Z","timestamp":1776801358571,"version":"3.51.2"},"reference-count":28,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: One of the most prevalent illnesses in neonates that needs care and treatment is neonatal jaundice. Several drugs are used as pharmacological modalities for treating hyperbilirubinemia, like intravenous immunoglobulin, D-penicillamine, metalloporphyrin, phenobarbital, zinc sulfate and clofibrate. Previous studies suggest the usefulness of fenofibrate in the treatment of hyperbilirubinemia. Objectives: The study aims at assessing the effectiveness of oral fenofibrate in the treatment of indirect neonatal hyperbilirubinemia in full-term neonates. Method: This is a quasi-experimental study that was conducted at Heevi Pediatrics Teaching Hospital in Duhok, which is located in the Kurdistan Region of Iraq. It involved term infants who had jaundice. The neonates who were eligible for the study were randomly assigned to one of two groups: the intervention group or the control group. Both groups were treated with conventional phototherapy. Fenofibrate was administered in a single oral dose of 10 mg\/kg to the participants in the intervention group. Throughout the entirety of the treatment, levels of total serum bilirubin were compared and contrasted between the two groups. Results: After 12 h of treatment, a statistically significant difference (p-value = 0.001) was seen in the serum bilirubin levels between the two groups. The difference in serum bilirubin levels became significantly progressively pronounced after 24, 48, and 72 h. The average time of discharge was 63.6 h for the intervention group and 90.9 h for the control group, and this difference was statistically significant (p-value &lt; 0.001). Conclusions: The time it takes to lower high bilirubin levels in neonates may be shortened by combining conventional phototherapy with a single oral dosage of 10 mg\/kg fenofibrate. Consequently, these neonates will experience a shorter hospitalization and an accelerated discharge from the hospital.<\/jats:p>","DOI":"10.3390\/children10071192","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T01:40:02Z","timestamp":1689039602000},"page":"1192","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Indirect Neonatal Hyperbilirubinemia and the Role of Fenofibrate as an Adjuvant to Phototherapy"],"prefix":"10.3390","volume":"10","author":[{"given":"Salam K.","family":"Shabo","sequence":"first","affiliation":[{"name":"Heevi Paediatrics Teaching Hospital, Duhok 42001, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalaf H.","family":"Gargary","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Duhok, Duhok 42001, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Erdeve","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Ankara University, Ankara 06830, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"ref_1","first-page":"13","article-title":"Efficacy of Oral Fenofibrate in Management of Unconjugated Hyperbilirubinemia in the Neonate","volume":"6","author":"Pathak","year":"2020","journal-title":"Int. J. Health Res. Med. Leg. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"c2409","DOI":"10.1136\/bmj.c2409","article-title":"Neonatal Jaundice: Summary of NICE Guidance","volume":"340","author":"Rennie","year":"2010","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Diala, U.M., Usman, F., Appiah, D., Hassan, L., Ogundele, T., Abdullahi, F., Satrom, K.M., Bakker, C.J., Lee, B.W., and Slusher, T.M. (2023). Global Prevalence of Severe Neonatal Jaundice among Hospital Admissions: A Systematic Review and Meta-Analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12113738"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e000845","DOI":"10.1136\/bmjpo-2020-000845","article-title":"Management of Neonatal Jaundice in Low-Income and Middle-Income Countries","volume":"4","author":"Erdeve","year":"2020","journal-title":"BMJ Paediatr. Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3329\/bjch.v45i2.60084","article-title":"Effect of Single Dose Fenofibrate as an Adjunct to Phototherapy on Unconjugated Neonatal Hyperbilirubinemia: A RCT","volume":"45","author":"Islam","year":"2022","journal-title":"Bangladesh J. Child Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM200102223440807","article-title":"Neonatal Hyperbilirubinemia","volume":"344","author":"Dennery","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Erdeve, O., Okulu, E., Olukman, O., Ulubas, D., Buyukkale, G., Narter, F., Tunc, G., Atasay, B., Gultekin, N.D., and Arsan, S. (2018). The Turkish Neonatal Jaundice Online Registry: A National Root Cause Analysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193108"},{"key":"ref_8","first-page":"5","article-title":"Fenofibrate: A Novel Approach in Treating Uncomplicated Neonatal Hyperbilirubinemia?","volume":"5","author":"Kumar","year":"2012","journal-title":"People J. Sci. Res."},{"key":"ref_9","first-page":"873","article-title":"Evaluation and Treatment of Neonatal Hyperbilirubinemia","volume":"89","author":"Muchowski","year":"2014","journal-title":"Am. Fam. Physician"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1751-1097.2012.01237.x","article-title":"Effects of Light-Emitting Diode Radiations on Human Retinal Pigment Epithelial Cells In Vitro","volume":"89","author":"Chamorro","year":"2013","journal-title":"Photochem. Photobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/pr.2013.208","article-title":"Neonatal Hyperbilirubinemia and Rhesus Disease of the Newborn: Incidence and Impairment Estimates for 2010 at Regional and Global Levels","volume":"74","author":"Bhutani","year":"2013","journal-title":"Pediatr. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(14)60496-7","article-title":"Every Newborn: Progress, Priorities, and Potential beyond Survival","volume":"384","author":"Lawn","year":"2014","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.2174\/138161209789058219","article-title":"Pharmacological Therapies for Unconjugated Hyperbilirubinemia","volume":"15","author":"Cuperus","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_14","first-page":"5053","article-title":"The Effect of Oral Zinc Sulfate on Serum Bilirubine Level in Term Neonates with Jaundice","volume":"5","author":"Ranjbar","year":"2017","journal-title":"Int. J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cindoruk, M., Kerem, M., Karakan, T., Salman, B., Akin, O., Alper, M., Erdem, O., and \u00dcnal, S. (2007). Peroxisome Proliferators-Activated Alpha Agonist Treatment Ameliorates Hepatic Damage in Rats with Obstructive Jaundice: An Experimental Study. BMC Gastroenterol., 7.","DOI":"10.1186\/1471-230X-7-44"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.9734\/ajpr\/2020\/v4i230147","article-title":"Efficacy and Safety of Fenofibrate in Uncomplicated Hyperbilirubinemia in Newborn: A Randomized Trial, with a 6-Month Follow-Up","volume":"4","author":"Gohil","year":"2020","journal-title":"Asian J. Pediatr. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.32677\/IJCH.2016.v03.i01.012","article-title":"Oral Fenofibrate in Neonatal Hyperbilirubinemia: A Randomized Controlled Trial","volume":"3","author":"Chaudhary","year":"2016","journal-title":"Indian J. Child Health"},{"key":"ref_18","first-page":"8317","article-title":"Effect of Oral Fenofibrate on Serum Bilirubin Level in Term Neonates With Hyperbilirubinemia","volume":"6","author":"Moghadamnia","year":"2018","journal-title":"Int. J. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.21474\/IJAR01\/2676","article-title":"Role of Fenofibrate in Management of Unconjugated Hyperbilirubinemia in Neonates","volume":"4","author":"Dabour","year":"2016","journal-title":"Int. J. Adv. Res."},{"key":"ref_20","first-page":"76","article-title":"Effect of Fenofibrate on Neonatal Hyperbilirubinemia: A Systematic Review and Meta-Analysis","volume":"12","author":"Montazeri","year":"2021","journal-title":"Iran. J. Neonatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41372-020-00861-2","article-title":"Fenofibrate as an Adjuvant to Phototherapy in Pathological Unconjugated Hyperbilirubinemia in Neonates: A Randomized Control Trial","volume":"41","author":"Awad","year":"2021","journal-title":"J. Perinatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.4103\/2249-4847.154111","article-title":"Effect of Fenofibrate on Indirect Neonatal Hyperbilirubinemia","volume":"4","author":"Mabrouk","year":"2015","journal-title":"J. Clin. Neonatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.21608\/anj.2020.69366","article-title":"The Effect of Fenofibrate and Antioxidant Vitamins [D, E and C] in Treatment of Uncomplicated Neonatal Hyperbilirubinemia","volume":"2","author":"Riad","year":"2020","journal-title":"Ann. Neonatol. J."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Subcommittee on Hyperbilirubinemia (2004). Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation. Pediatrics, 114, 297\u2013316.","DOI":"10.1542\/peds.114.1.297"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1017\/cts.2023.35","article-title":"Oral Fenofibrate for Hyperbilirubinemia in Term Neonates: A Single-Blind Randomized Controlled Trial","volume":"7","author":"Saadat","year":"2023","journal-title":"J. Clin. Trans. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3329\/jafmc.v16i1.53843","article-title":"Effect of Oral Fenofibrate on Serum Bilirubin Level in Term Neonates with Unconjugated Hyperbilirubinaemia: A Randomized Control Trial","volume":"16","author":"Mosharref","year":"2021","journal-title":"J. Armed Med. Coll."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.33545\/26643685.2020.v3.i2b.97","article-title":"The Efficacy of Fenofibrate as an Adjunct to Phototherapy for Neonatal Hyperbilirubinemia","volume":"3","author":"Prabha","year":"2020","journal-title":"Int. J. Paediatr. Geriatr."},{"key":"ref_28","first-page":"235","article-title":"Efficacy of Oral Fenofibrate in the Management of Unconjugated Hyperbilirubinemia in Neonates\u2014A Prospective Study","volume":"13","author":"Gowda","year":"2014","journal-title":"Int. J. Recent Trends Sci."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/7\/1192\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:09:46Z","timestamp":1760126986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/7\/1192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,10]]},"references-count":28,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["children10071192"],"URL":"https:\/\/doi.org\/10.3390\/children10071192","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,10]]}}}