{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:46:06Z","timestamp":1791665166144,"version":"4.3.4"},"reference-count":55,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Previous studies have demonstrated that children who experience maltreatment show a more elevated risk of psychopathological disorders than children from the general population. The HPA (hypothalamic\u2013pituitary\u2013adrenal) axis is not mature at birth and undergoes strong social regulation during the first years of life. Consequently, early exposure to stress could modify the usual adaptative response to stress. In stressful situations, perturbations in both cortisol response and cortisol circadian rhythm have been observed. Nevertheless, studies that have evaluated the links between child abuse, dysregulation of the HPA axis, and mental disorders have shown diverse results. Because of the variety of methods employed in the different studies, no formal comparisons have been made. In this systematic review, we have brought together these results. Methods: We conducted a systematic review of studies analyzing the correlation between child abuse, mental disorders, and HPA axis activity in patients aged between 6 and 16 years. PubMed, Scopus, Cochrane, and Google Scholar were searched using relevant keywords and inclusion\/exclusion criteria (from 2000 to 2020). Results: Fifteen studies from the 351 identified were included. Most patients were children in the child welfare system. Children who had experienced child abuse presented with more severe mental disorders (particularly in the dimensional measure) than children who had not been abused. HPA axis activity was assessed by measuring basal cortisol for some studies and cortisol reactivity for other studies. For children experiencing child abuse, there was a possible association between abuse and a decrease in the reactivity of the HPA axis. In addition, early life stress could be associated with lower matinal cortisol. However, the association between mental disorders and cortisol secretion in maltreated children did not seem obvious. Conclusions: This systematic review demonstrates that mental disorders are more frequent and severe in cases where child abuse has occurred. Moreover, children who experienced child abuse seem to present changes in the reactivity of the HPA axis. Nevertheless, the potential correlation between these changes in the reactivity of the HPA axis and mental disorders in this population needs to be evaluated in further studies.<\/jats:p>","DOI":"10.3390\/children10081344","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T11:08:43Z","timestamp":1691060923000},"page":"1344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between Hpa Axis Functioning and Mental Health in Maltreated Children and Adolescents: A Systematic Literature Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Pierre-Antoine","family":"Leroux","sequence":"first","affiliation":[{"name":"Service de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, CHRU, 29200 Brest, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bretagne Occidentale, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-6181","authenticated-orcid":false,"given":"Nolwenn","family":"Dissaux","sequence":"additional","affiliation":[{"name":"Service de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, CHRU, 29200 Brest, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bretagne Occidentale, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Yves","family":"Le Reste","sequence":"additional","affiliation":[{"name":"EA 7479, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bronsard","sequence":"additional","affiliation":[{"name":"Service de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, CHRU, 29200 Brest, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bretagne Occidentale, 29200 Brest, France"},{"name":"EA 7479, 29200 Brest, France"},{"name":"D\u00e9partement de Sciences Humaines et Sociales, EA 3279 (CEReSS, AMU), 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-1970","authenticated-orcid":false,"given":"Nathalie","family":"Lavenne-Collot","sequence":"additional","affiliation":[{"name":"Service de Psychiatrie de l\u2019Enfant et de l\u2019Adolescent, CHRU, 29200 Brest, France"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Bretagne Occidentale, 29200 Brest, France"},{"name":"Laboratoire du Traitement de l\u2019Information M\u00e9dicale, Inserm U1101, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.yhbeh.2006.06.012","article-title":"The impact of early adverse care on HPA axis development: Nonhuman primate models","volume":"50","author":"Sanchez","year":"2006","journal-title":"Horm. 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