{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:18:52Z","timestamp":1782793132593,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Lipofibromatous hamartoma, first reported in 1953, is a rare, slowly progressive soft tissue tumor, the characteristics of which include the enlargement of the affected nerve via the epineurial and perineurial proliferation of adipose and fibrous tissues. Out of 200 previously reported cases of lipofibromatous hamartoma of the median nerve, there have been approximately 25 pediatric cases under the age of 18. Herein, we report a case of lipofibromatous hamatoma of the median nerve in a 3-year-old female patient who was surgically decompressed via carpal tunnel release and epineurolysis. The patient was followed-up on an outpatient clinic basis annually with sonographic evaluations, and the postoperative 10th-year follow-up did not show recurrence or any deficits in motor and sensory functions.<\/jats:p>","DOI":"10.3390\/children10091581","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T21:08:36Z","timestamp":1695330516000},"page":"1581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["10-Year Clinical Follow-Up after Decompression of Lipofibromatous Hamartoma of the Median Nerve in a 3-Year-Old Patient: Case Report and Review of the Literature"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-9412","authenticated-orcid":false,"given":"Seung Jin","family":"Yoo","sequence":"first","affiliation":[{"name":"Division of Hand and Microsurgery, Department of Orthopedic Surgery, Jeju National University Hospital, Jeju 63241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hand and Microsurgery, Department of Orthopedic Surgery, Jeju National University Hospital, Jeju 63241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Hand and Microsurgery, Department of Orthopedic Surgery, Jeju National University Hospital, Jeju 63241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ryeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jeju National University Hospital, Jeju 63241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-1606","authenticated-orcid":false,"given":"Kyu Bum","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Hand and Microsurgery, Department of Orthopedic Surgery, Jeju National University Hospital, Jeju 63241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref_1","first-page":"257","article-title":"AMERICAN Society for Surgery of the hand","volume":"35-a","author":"Mason","year":"1953","journal-title":"J. Bone Jt. Surgery. Am. Vol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/j.jhsa.2013.03.022","article-title":"Lipofibromatous hamartoma of the median nerve: A comprehensive review and systematic approach to evaluation, diagnosis, and treatment","volume":"38","author":"Tahiri","year":"2013","journal-title":"J. Hand Surg."},{"key":"ref_3","first-page":"394","article-title":"Lipofibromatous hamartoma: Review of early diagnosis and treatment","volume":"48","author":"Razzaghi","year":"2005","journal-title":"Can. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/0883073813504458","article-title":"Carpal tunnel syndrome in children","volume":"29","author":"Lipowska","year":"2014","journal-title":"J. Child Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jhsa.2012.10.042","article-title":"Lipofibromatous hamartoma of the median nerve","volume":"38","author":"Agarwal","year":"2013","journal-title":"J. Hand Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3941\/jrcr.v10i11.2787","article-title":"Lipofibromatous Hamartoma of the Median Nerve: A Case Report","volume":"10","author":"Shekhani","year":"2016","journal-title":"J. Radiol. Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0363-5023(88)90203-1","article-title":"Lipofibromatous hamartoma of nerve","volume":"13","author":"Amadio","year":"1988","journal-title":"J. Hand Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0363-5023(85)80044-7","article-title":"Lipofibromas of the median nerve: Long-term follow-up of four cases","volume":"10","author":"Louis","year":"1985","journal-title":"J. Hand Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00431-018-3100-7","article-title":"Fibrolipomatous hamartomas of the median nerve in infancy and early childhood-imaging hallmarks, symptomatology, and treatment","volume":"177","author":"Okechi","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2214\/AJR.04.1717","article-title":"Lipofibromatous hamartoma of the upper extremity: A review of the radiologic findings for 15 patients","volume":"186","author":"Toms","year":"2006","journal-title":"Am. J. Roentgenol."},{"key":"ref_11","first-page":"E146","article-title":"Lipofibromatous hamartoma of a digital nerve","volume":"37","author":"Cui","year":"2008","journal-title":"Am. J. Orthop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.bjps.2006.01.016","article-title":"Recurrent carpal tunnel syndrome in a child due to fibrolipomatous hamartoma of the median nerve successfully treated by limited excision and decompression","volume":"59","author":"Bains","year":"2006","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_13","first-page":"e33516","article-title":"Lipofibromatous Hamartoma of the Median Nerve: A Case Report","volume":"15","author":"Elbayer","year":"2023","journal-title":"Cureus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11552-010-9290-8","article-title":"Carpal tunnel syndrome due to fibrolipomatous hamartoma of the median nerve","volume":"6","author":"Louaste","year":"2011","journal-title":"Hand"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00006534-197010000-00009","article-title":"Radical excision of a fibro-fatty proliferation of the median nerve, with no neurological loss symptoms","volume":"46","author":"Bergman","year":"1970","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0266-7681_87_90018-0","article-title":"Fibrolipomatous hamartoma of the median nerve","volume":"12","author":"Sondergaard","year":"1987","journal-title":"J. Hand Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0266-7681_87_90017-9","article-title":"Lipofibroma of the median nerve: A report of two cases","volume":"12","author":"Langa","year":"1987","journal-title":"J. Hand Surg."},{"key":"ref_18","first-page":"237","article-title":"Case report 667. Fibrolipomatous hamartoma of the median nerve","volume":"20","author":"Walker","year":"1991","journal-title":"Skelet. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0266-7681(98)80242-8","article-title":"Intraneural lipofibroma of the median nerve","volume":"23","author":"Camilleri","year":"1998","journal-title":"J. Hand Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s003830050728","article-title":"Macrodystrophia lipomatosa with associated fibrolipomatous hamartoma of the median nerve","volume":"16","author":"Brodwater","year":"2000","journal-title":"Pediatr. Surg. Int."},{"key":"ref_21","first-page":"111","article-title":"Lipofibromatous hamartoma of the median nerve with long-term follow-up","volume":"28","author":"Hsu","year":"2005","journal-title":"Chang Gung Med. J."},{"key":"ref_22","first-page":"341","article-title":"Lipofibromatous hamartoma of the median nerve and macrodactyly","volume":"19","year":"2008","journal-title":"Genet. Couns."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s00247-008-0884-z","article-title":"Lipofibromatous hamartoma","volume":"38","author":"Liaw","year":"2008","journal-title":"Pediatr. Radiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00402-008-0695-6","article-title":"Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: Diagnosis and treatment of a rare disease causing carpal tunnel syndrome","volume":"129","author":"Ulrich","year":"2009","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"B98","DOI":"10.1111\/j.1440-1673.2007.01790.x","article-title":"Fibrolipomatous hamartoma of median nerve","volume":"51","author":"Jain","year":"2007","journal-title":"Australas. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1016\/j.bjps.2007.11.061","article-title":"Lipofibromatous hamartoma of the median nerve. Three case reports","volume":"62","author":"Nardella","year":"2009","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijscr.2012.05.007","article-title":"Intraneural lipomatous tumor of the median nerve: Three case reports with a review of literature","volume":"3","author":"Okubo","year":"2012","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/229255031402200307","article-title":"Fibrolipomatous hamartoma of the median nerve: A cause of acute bilateral carpal tunnel syndrome in a three-year-old child: A case report and comprehensive literature review","volume":"22","author":"Senger","year":"2014","journal-title":"Plast. Surg."},{"key":"ref_29","first-page":"87","article-title":"Lipofibromatous Hamartoma of the Median Nerve in Association with or without Macrodactyly","volume":"34","author":"Kini","year":"2018","journal-title":"Turk. J. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-0038-1626682","article-title":"Lipofibromatous Hamartoma of the Palmar Cutaneous Branch of the Median Nerve","volume":"10","author":"Hoellwarth","year":"2018","journal-title":"J. Hand Microsurg."},{"key":"ref_31","first-page":"57","article-title":"Giant Median Nerve Due to Hamartoma Causing Severe Carpal Tunnel Syndrome","volume":"8","author":"Kitridis","year":"2018","journal-title":"J. Orthop. Case Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jcot.2019.05.023","article-title":"Lipofibromatous hamartoma of the median nerve with macrodactyly of middle finger","volume":"10","author":"Dawood","year":"2019","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"107818","DOI":"10.1016\/j.ijscr.2022.107818","article-title":"Microsurgical interfascicular dissection operation is a viable treatment of carpal tunnel syndrome caused by Lipofibromatous hamartoma: A case report","volume":"102","author":"Xiao","year":"2023","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_34","unstructured":"Ali, S., and Mulita, F. (2023, April 01). Hamartoma, Statspearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK562298\/."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"250.e1","DOI":"10.1016\/j.jhsa.2020.06.003","article-title":"Ultrasound-Guided Percutaneous Nerve Stimulation for the Treatment of Chronic Intractable Pain Originating from a Lipofibromatous Hamartoma of the Median Nerve","volume":"46","author":"Hurdle","year":"2021","journal-title":"J. Hand Surg."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/9\/1581\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:55:17Z","timestamp":1760129717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/9\/1581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["children10091581"],"URL":"https:\/\/doi.org\/10.3390\/children10091581","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]}}}