{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:29:58Z","timestamp":1767713398596,"version":"build-2065373602"},"reference-count":75,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Sepsis represents one of the leading causes of death in newborns and infants, and prompt diagnosis is essential for achieving favorable outcomes. Regarding malnourished children with concurrent infection, most studies have focused, besides blood culture, on C-reactive protein and procalcitonin. Because malnutrition has a deleterious effect on cellular immune competence, the present study characterized the acute-phase response, including hematological indices, in response to sepsis. Among the examined laboratory biomarkers, procalcitonin and neutrophil-to-lymphocyte ratio were the most accurate discriminators between sepsis patients and those with bacterial infection. Moreover, these two parameters showed a gradual increase between sepsis, severe sepsis, and septic shock patients (p &lt; 0.001). Subgroup analysis of the sepsis group revealed positive correlations of NLR with prolonged ICU stay (&lt;0.001), acute organ dysfunction (0.038), mechanical ventilation (&lt;0.001), and fatality (&lt;0.001). In summary, our results suggest that the neutrophil-to-lymphocyte ratio can be used as an auxiliary diagnostic index in discriminating the presence and severity of bacterial sepsis in malnourished infants.<\/jats:p>","DOI":"10.3390\/children10101616","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T01:42:12Z","timestamp":1695865332000},"page":"1616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Neutrophil-to-Lymphocyte Ratio (NLR) Can Predict Sepsis\u2019s Presence and Severity in Malnourished Infants\u2014A Single Center Experience"],"prefix":"10.3390","volume":"10","author":[{"given":"Alina Emilia","family":"Domnicu","sequence":"first","affiliation":[{"name":"Ph.D. School Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Clinical Section I Pediatrics\u2014Nutritional Recovery, Children\u2019s Emergency Hospital \u2018Louis Turcanu\u2019, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen Radu","family":"Boia","sequence":"additional","affiliation":[{"name":"Department IX Surgery I, Discipline ENT, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"ENT Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3923-3501","authenticated-orcid":false,"given":"Mirela","family":"Mogoi","sequence":"additional","affiliation":[{"name":"Pediatric Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniko-Maria","family":"Manea","sequence":"additional","affiliation":[{"name":"Neonatology and Puericulture Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Neonatology and Preterm Department, Children\u2019s Emergency Hospital \u2018Louis Turcanu\u2019, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara Marcela","family":"Marcovici","sequence":"additional","affiliation":[{"name":"Clinical Section I Pediatrics\u2014Nutritional Recovery, Children\u2019s Emergency Hospital \u2018Louis Turcanu\u2019, 300011 Timisoara, Romania"},{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otilia","family":"M\u0103rginean","sequence":"additional","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u2018Louis Turcanu\u2019, 300011 Timisoara, Romania"},{"name":"Department XI Pediatrics, Discipline I Pediatrics, Disturbances of Growth and Development in Children\u2014BELIVE, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marioara","family":"Boia","sequence":"additional","affiliation":[{"name":"Neonatology and Puericulture Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Neonatology and Preterm Department, Children\u2019s Emergency Hospital \u2018Louis Turcanu\u2019, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/PCC.0000000000000225","article-title":"Pediatric severe sepsis in U.S. children\u2019s hospitals","volume":"15","author":"Balamuth","year":"2014","journal-title":"Pediatr. 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