{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:32:36Z","timestamp":1760149956732,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Nasal nitric oxide (nNO) is a gas synthesized by the inducible and constitutive NO synthase (NOS) enzyme in the airway cells of the nasal mucosa. Like lung nitric oxide, it is thought to be associated with airway inflammation in various respiratory diseases in children. The aim of our review was to investigate the current state of use of nNO measurement in children. A comprehensive search was conducted using the Web of Science and PubMed databases specifically targeting publications in the English language, with the following keywords: nasal NO, children, allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, primary ciliary dyskinesia (PCD), and cystic fibrosis (CF). We describe the use of nNO in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF based on the latest literature. nNO is a noninvasive, clinically applicable test for use in pediatric allergic rhinitis, chronic rhinosinusitis, acute rhinosinusitis, PCD, and CF. It can be used as a complementary method in the diagnosis of these respiratory diseases and as a monitoring method for the treatment of allergic rhinitis and acute and chronic rhinosinusitis.<\/jats:p>","DOI":"10.3390\/children10101671","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T10:48:33Z","timestamp":1696848513000},"page":"1671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nasal Nitric Oxide in Children: A Review of Current Outreach in Pediatric Respiratory Medicine"],"prefix":"10.3390","volume":"10","author":[{"given":"Iva","family":"Mrki\u0107 Kobal","sequence":"first","affiliation":[{"name":"Outpatient Clinic for Sick Children Dr. Sabol, 10000 Zagreb, Croatia"},{"name":"Faculty of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-861X","authenticated-orcid":false,"given":"Mirjana","family":"Turkalj","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Children\u2019s Hospital Srebrnjak, 10000 Zagreb, Croatia"},{"name":"Faculty of Medicine, Catholic University of Croatia, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davor","family":"Plavec","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, JJ Strossmayer University of Osijek, 31000 Osijek, Croatia"},{"name":"Prima Nova, Healthcare Institution, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/thorax.58.2.175","article-title":"Multiple roles of nitric oxide in the airways","volume":"58","author":"Ricciardolo","year":"2003","journal-title":"Thorax"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1034\/j.1398-9995.2001.00145.x","article-title":"Nasal nitric oxide","volume":"56","author":"Jorissen","year":"2001","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kawasumi, T., Takeno, S., Ishikawa, C., Takahara, D., Taruya, T., Takemoto, K., Hamamoto, T., Ishino, T., and Ueda, T. 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