{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:49:28Z","timestamp":1793573368789,"version":"4.5.0"},"reference-count":25,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background. Foreign Body Aspiration (FBA) represents a leading cause of death among unintentional injuries in children less than one year of age. This study reviewed case reports and case series reporting non-food FBA in children to characterize aspirated foreign bodies, describing the clinical presentations and the outcomes. Methods: A systematic review was conducted according to the PRISMA checklist. Case reports and case series presenting non-food FBA in children (up to 18 years) were eligible to be included. Information regarding study characteristics, child demographics, foreign body characteristics, clinical presentation, and outcome were extracted. Results: The review included 248 articles published between 1965 and 2023, corresponding to 294 cases. The male gender was the most prevalent (194 cases, 66%), and the median age was 3.5 years (Interquartile Range: 1\u20138 years). Button batteries were the objects most frequently reported (21 cases, 7.1%). Objects were located most often in the bronchus (102 cases, 35%). The most common symptom was cough (181 cases, 62%), followed by respiratory distress (160 cases, 54%) and wheezing\/stridor (127 cases, 43%). Conclusions: The present systematic review may have relevant public health implications, since characterizing objects that cause foreign body injuries is essential to reduce the burden of this phenomenon.<\/jats:p>","DOI":"10.3390\/children10101709","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T11:53:56Z","timestamp":1697802836000},"page":"1709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of Non-Food Foreign Bodies Aspirated by Children: A Systematic Review of the Literature"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-4686","authenticated-orcid":false,"given":"Giulia","family":"Lorenzoni","sequence":"first","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vertuani","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Basso","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rescigno","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5823-1659","authenticated-orcid":false,"given":"Honoria","family":"Ocagli","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-0580","authenticated-orcid":false,"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5455\/medarh.2018.72.220-223","article-title":"Death as a Consequence of Foreign Body Aspiration in Children","volume":"72","author":"Brkic","year":"2018","journal-title":"Med. Arch."},{"key":"ref_2","unstructured":"World Health Organization (2007). Preventing Injuries and Violence: A Guide for Ministries of Health, WHO."},{"key":"ref_3","unstructured":"Peden, M., McGee, K., and Sharma, G. (2002). The Injury Chart Book: A Graphical Overview of the Global Burden of Injuries, WHO."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"830876","DOI":"10.3389\/fpubh.2022.830876","article-title":"Regulatory and Educational Initiatives to Prevent Food Choking Injuries in Children: An Overview of the Current Approaches","volume":"10","author":"Lorenzoni","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.ijporl.2012.02.006","article-title":"Non Food Foreign Body Injuries","volume":"76","author":"Slapak","year":"2012","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.3390\/ijerph9114056","article-title":"Scale-up Approach in CATI Surveys for Estimating the Number of Foreign Body Injuries in the Aero-Digestive Tract in Children","volume":"9","author":"Snidero","year":"2012","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1542\/peds.2009-2862","article-title":"Policy Statement\u2014Prevention of Choking among Children","volume":"125","author":"Gardner","year":"2010","journal-title":"Pediatrics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1542\/peds.111.3.687","article-title":"Aspiration of Fruit Gel Snacks","volume":"111","author":"Qureshi","year":"2003","journal-title":"Pediatrics"},{"key":"ref_9","first-page":"e21519","article-title":"Challenges in Diagnosing Foreign Body Aspiration in Children","volume":"14","author":"Goh","year":"2022","journal-title":"Cureus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.arcped.2022.05.006","article-title":"Delayed Diagnosis of Foreign Body Aspiration in Children","volume":"29","author":"Rance","year":"2022","journal-title":"Arch. P\u00e9diatrie"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"694211","DOI":"10.3389\/fped.2021.694211","article-title":"Diagnostic Errors in Initial Misdiagnosis of Foreign Body Aspiration in Children: A Retrospective Observational Study in a Tertiary Care Hospital in China","volume":"9","author":"Zhu","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_13","first-page":"217","article-title":"Chapter 7: Systematic Reviews of Etiology and Risk","volume":"Volume 5","author":"Moola","year":"2017","journal-title":"Joanna Briggs Institute Reviewer\u2019s Manual"},{"key":"ref_14","first-page":"2127","article-title":"Methodological Quality of Case Series Studies: An Introduction to the JBI Critical Appraisal Tool","volume":"18","author":"Munn","year":"2020","journal-title":"JBI Evid. Synth."},{"key":"ref_15","unstructured":"Canadian Pediatric Society (2020). Preventing Choking and Suffocation in Children, Canadian Pediatric Society."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110685","DOI":"10.1016\/j.ijporl.2021.110685","article-title":"Persistence of Choking Injuries in Children","volume":"144","author":"Chang","year":"2021","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jsr.2021.07.001","article-title":"Unintentional Injury Deaths in Children and Youth, 2010\u20132019","volume":"78","author":"West","year":"2021","journal-title":"J. Saf. Res."},{"key":"ref_18","unstructured":"Rose, D., and Dubensky, L. (2019). Airway Foreign Bodies, StatPearls."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1542\/peds.2009-3038","article-title":"Preventing Battery Ingestions: An Analysis of 8648 Cases","volume":"125","author":"Litovitz","year":"2010","journal-title":"Pediatrics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijporl.2017.06.030","article-title":"Pathophysiology of Esophageal Impairment Due to Button Battery Ingestion","volume":"100","author":"Schendzielorz","year":"2017","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/lio2.535","article-title":"Current Management of Button Battery Injuries","volume":"6","author":"Sethia","year":"2021","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"471","DOI":"10.31128\/AJGP-03-21-5873","article-title":"Button Battery Injury","volume":"51","author":"Park","year":"2022","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110431","DOI":"10.1016\/j.ijporl.2020.110431","article-title":"Severe Tracheobronchial Harm Due to Lithium Button Battery Aspiration: An in Vitro Study of the Pathomechanism and Injury Pattern","volume":"139","author":"Voelker","year":"2020","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1007\/s10900-019-00662-5","article-title":"Perception of Choking Injury Risk among Healthcare Students","volume":"44","author":"Fano","year":"2019","journal-title":"J. Community Health"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Nissen, T., and Wynn, R. (2014). The Clinical Case Report: A Review of Its Merits and Limitations. BMC Res. Notes, 7.","DOI":"10.1186\/1756-0500-7-264"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/10\/1709\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:09:19Z","timestamp":1760130559000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/10\/1709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["children10101709"],"URL":"https:\/\/doi.org\/10.3390\/children10101709","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,20]]}}}