{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:29:06Z","timestamp":1766399346709,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Pollen-food allergy syndrome (PFAS) is a common IgE-mediated allergic condition resulting from cross-reactions between pollen and plant food allergens, primarily those in the PR-10 subfamily. Mostly symptoms are limited to the mouth and throat causing oral allergy syndrome (OAS). Systemic reactions are extremely rare. We report an 11-year-old boy who experienced a unique anaphylactic reaction after consuming raw carrot juice. The patient exhibited symptoms within one minute, including abdominal pain, facial and eyelid swelling, dyspnea, a macular rash, choking sensation and drowsiness. Desloratadine alleviated these symptoms, and as his overall condition improved rapidly, there was no need for adrenaline administration. Carrot-specific IgE levels in the patient\u2019s serum were as follows: Dau c: 40.63 kUA\/L and Dau c1: 31.5 kUA\/L. He had previously been diagnosed with seasonal allergic rhinoconjunctivitis. The high degree of similarity among allergen components within the PR-10 subfamily contributed to cross-reactivity between birch pollen and carrots. It is important to remember that PFAS can manifest systemically, with symptoms ranging from mild skin itching to potentially fatal consequences. This highlights the need for healthcare professionals to be extra cautious and aware of this possibility, especially since carrots are commonly found in a wide range of dishes and snacks.<\/jats:p>","DOI":"10.3390\/children10111817","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:51:37Z","timestamp":1700045497000},"page":"1817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carrot-Induced Systemic Reaction: A Unique Presentation of Pollen-Food Allergy Syndrome in a Young Boy"],"prefix":"10.3390","volume":"10","author":[{"given":"Weronika M.","family":"Balas","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Allergology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Strzelecka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Allergology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Gody\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Allergology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Sybilski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Allergology, The National Institute of Medicine of the Ministry of the Interior and Administration, 02-507 Warsaw, Poland"},{"name":"2nd Department of Paediatrics, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/all.12666","article-title":"Position paper of the EAACI: Food allergy due to immunological cross-reactions with common inhalant allergens","volume":"70","author":"Werfel","year":"2015","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.anai.2009.11.007","article-title":"Oral allergy syndrome: A clinical, diagnostic, and therapeutic challenge","volume":"104","author":"Webber","year":"2010","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mastrorilli, C., Cardinale, F., Giannetti, A., and Caffarelli, C. (2019). Pollen-Food Allergy Syndrome: A not so Rare Disease in Childhood. Medicina, 55.","DOI":"10.3390\/medicina55100641"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13223-018-0284-3","article-title":"IgE-mediated food allergy","volume":"14","author":"Waserman","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_5","first-page":"470","article-title":"IgE-mediated allergy from vegetable allergens","volume":"71","author":"Ortolani","year":"1993","journal-title":"Ann. Allergy"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00431-006-0410-y","article-title":"Characterization of irritable bowel syndrome and constipation in children with allergic diseases","volume":"166","author":"Caffarelli","year":"2007","journal-title":"Eur. J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-1119(97)00246-1","article-title":"Genomic characterization of members of the Bet v 1 family: Genes coding for allergens and pathogenesis-related proteins share intron positions","volume":"197","author":"Radauer","year":"1997","journal-title":"Gene"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaci.2006.03.011","article-title":"Cooking birch pollen-related food: Divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo","volume":"118","author":"Bohle","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1398-9995.2006.01258.x","article-title":"The impact of pollen-related food allergens on pollen allergy","volume":"62","author":"Bohle","year":"2007","journal-title":"Allergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3345\/cep.2019.00780","article-title":"Pollen-food allergy syndrome in children","volume":"63","author":"Jeon","year":"2020","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_11","unstructured":"Sybilski, A.J. (2021). Algorytmy Post\u0119powania w Alergologii Dzieci\u0119cej, Medical Tribune."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2133.1941.tb10498.x","article-title":"The carot as a cause of dermatitis","volume":"53","author":"Vickers","year":"1941","journal-title":"Br. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1398-9995.1996.tb04642.x","article-title":"Hypersensitivity to carrot associated with specific IgE to grass and tree pollens","volume":"51","author":"Curiel","year":"1996","journal-title":"Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/ped.2022.0122","article-title":"Food-Dependent Exercise-Induced Anaphylaxis Caused by Carrots: A Case Report","volume":"35","author":"Hirai","year":"2022","journal-title":"Pediatr. Allergy Immunol. Pulmonol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0301-0546(02)79128-3","article-title":"Anaphylaxis due to carrot as hidden food allergen","volume":"30","author":"Schiappoli","year":"2002","journal-title":"Allergol. Immunopathol."},{"key":"ref_16","first-page":"189","article-title":"Food-borne nitrates and nitrites as a cause of methemoglobinemia","volume":"27","author":"Chan","year":"1996","journal-title":"Southeast Asian J. Trop. Med. Public. Health"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yasudo, H., Yamamoto-Hanada, K., Yang, L., Saito-Abe, M., Sato, M., Miyaji, Y., Shimada, M., Hirai, S., Toyokuni, K., and Ishikawa, F. (2022). Pollen Food Allergy Syndrome in Allergic March. Nutrients, 14.","DOI":"10.3390\/nu14132658"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/11\/1817\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:23:40Z","timestamp":1760131420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/10\/11\/1817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":17,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["children10111817"],"URL":"https:\/\/doi.org\/10.3390\/children10111817","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2023,11,15]]}}}