{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:57:35Z","timestamp":1789934255620,"version":"4.0.1"},"reference-count":76,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Diet plays an important role in the etiopathology of dental caries. Milk and dairy products (DPs), especially in children and adolescents, are important sources of protein, calcium and phosphorus and could have an effect on dental and oral health. The aim of this scoping review was to analyze the scientific literature on the non-cariogenic effect of milk and DPs, with a focus on their potential to prevent dental caries in children and adolescents. PubMed, EMBASE, and Web of Science were searched for publications relevant to our topic from January 2013 to 30 September 2023. Thirty-eight studies were included in the qualitative analysis. The included studies highlight the properties of milk and DPs that contribute to enamel remineralization, exhibit antibacterial action, inhibit the growth of cariogenic bacteria, and promote a balanced oral microbiome. With regard to the addition of probiotics (PBs) and fluoride (F) to DPs, the mixed results of the studies analyzed did not allow a clear statement to be made about their non-cariogenic effects. However, several studies show that the addition of PBs can reduce cariogenic bacteria, create a protective barrier against pathogens and support the host\u2019s natural defense mechanisms. Further long-term and high-quality studies are needed to understand the impact of milk and its constituents on oral health in order to promote effective caries prevention strategies in children and adolescents.<\/jats:p>","DOI":"10.3390\/children11020149","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T07:42:16Z","timestamp":1706082136000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-Cariogenic Effect of Milk and Dairy Products on Oral Health in Children and Adolescents: A Scoping Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5152-7705","authenticated-orcid":false,"given":"Flavia","family":"Vitiello","sequence":"first","affiliation":[{"name":"Laboratory \u201cHealth, Systemic, Process\u201d (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France"},{"name":"Department of Clinical Sciences and Stomatology (DISCO), Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-2512","authenticated-orcid":false,"given":"Denis","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Laboratory \u201cHealth, Systemic, Process\u201d (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-9923","authenticated-orcid":false,"given":"Giulia","family":"Orilisi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Stomatology (DISCO), Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2641-0695","authenticated-orcid":false,"given":"Giovanna","family":"Orsini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Stomatology (DISCO), Universit\u00e0 Politecnica delle Marche, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-1636","authenticated-orcid":false,"given":"Florence","family":"Carrouel","sequence":"additional","affiliation":[{"name":"Laboratory \u201cHealth, Systemic, Process\u201d (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global Burden of Untreated Caries: A Systematic Review and Metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_2","unstructured":"(2023, July 10). The Global Status Report on Oral Health. Available online: https:\/\/www.who.int\/team\/noncommunicable-diseases\/global-status-report-on-oral-health-2022."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ribeiro, A.A., and Paster, B.J. (2023). Dental Caries and Their Microbiomes in Children: What Do We Do Now?. J. Oral Microbiol., 15.","DOI":"10.1080\/20002297.2023.2198433"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2012.11.006","article-title":"The Oral Microbiome in Health and Disease","volume":"69","author":"Wade","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chen, X., Daliri, E.B.-M., Kim, N., Kim, J.-R., Yoo, D., and Oh, D.-H. (2020). Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms. Pathogens, 9.","DOI":"10.3390\/pathogens9070569"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Fang, J., Yang, J., Gao, X., Dong, L., Zheng, X., Sun, L., Xia, B., Zhao, N., and Ma, Z. (2022). Streptococcus Mutans-Associated Bacteria in Dental Plaque of Severe Early Childhood Caries. J. Oral Microbiol., 14.","DOI":"10.1080\/20002297.2022.2046309"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0022034510379602","article-title":"The Role of Bacteria in the Caries Process: Ecological Perspectives","volume":"90","author":"Takahashi","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4034\/PBOCI.2015.151.17","article-title":"Buffer Capacity of Saliva as a Function of Time after Consumption of Sugary, Sugar-Free and Probiotic Chewing Gums","volume":"15","author":"Antunes","year":"2015","journal-title":"Pesqui. Bras. Em Odontopediatria E Cl\u00ednica Integr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhang, J.S., Chu, C.-H., and Yu, O.Y. (2022). Oral Microbiome and Dental Caries Development. Dent. J., 10.","DOI":"10.3390\/dj10100184"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mazurkiewicz, D., Pustu\u0142ka, M., Ambrozik-Haba, J., and Bienkiewicz, M. (2023). Dietary Habits and Oral Hygiene as Determinants of the Incidence and Intensity of Dental Caries\u2014A Pilot Study. Nutrients, 15.","DOI":"10.3390\/nu15224833"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tenelanda-L\u00f3pez, D., Valdivia-Moral, P., and Castro-S\u00e1nchez, M. (2020). Eating Habits and Their Relationship to Oral Health. Nutrients, 12.","DOI":"10.3390\/nu12092619"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105837","DOI":"10.1016\/j.jff.2023.105837","article-title":"Research Progress of Milk and Dairy Products to Prevent Caries","volume":"110","author":"Li","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9381","DOI":"10.1021\/jf5042454","article-title":"Dairy Products and Health: Recent Insights","volume":"63","author":"Tunick","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e1229","DOI":"10.1542\/peds.2014-2173","article-title":"Optimizing Bone Health in Children and Adolescents","volume":"134","author":"Golden","year":"2014","journal-title":"Pediatrics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"400S","DOI":"10.1080\/07315724.2011.10719983","article-title":"Milk and Dairy Products: A Unique Micronutrient Combination","volume":"30","author":"Gaucheron","year":"2011","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Castro, R.J., Maltz, M., Arthur, R.A., and Giacaman, R.A. (2020). Anti-Caries Effect of Fluoridated Milk-Based Drink Consumed by Older Adults on an in Vitro Root Caries Experimental Model. Arch. Oral Biol., 118.","DOI":"10.1016\/j.archoralbio.2020.104878"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41405-023-00170-8","article-title":"Effect of Various Types of Milk on Salivary pH among Children: A Pilot Randomized Controlled Crossover Trial","volume":"9","author":"Zamzam","year":"2023","journal-title":"BDJ Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000455374","article-title":"Chapter 8: Milk, Yoghurts and Dental Caries","volume":"28","author":"Woodward","year":"2020","journal-title":"Impact Nutr. Diet Oral Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.idairyj.2011.10.007","article-title":"Lactose Cariogenicity with an Emphasis on Childhood Dental Caries","volume":"22","author":"Aimutis","year":"2012","journal-title":"Int. Dairy J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s41110-018-0064-3","article-title":"Probiotic Supplementation in Dental Caries: Is It Possible to Replace Conventional Treatment?","volume":"43","author":"Coqueiro","year":"2018","journal-title":"Nutrire"},{"key":"ref_21","first-page":"69","article-title":"Fluoride and Oral Health","volume":"33","author":"Baez","year":"2016","journal-title":"Community Dent. Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4103\/jisppd.jisppd_236_21","article-title":"A Comparative Evaluation of Probiotic Formulations in Prevention of Dental Caries: A Clinical Study","volume":"39","author":"Sakhare","year":"2021","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103985","DOI":"10.1016\/j.jff.2020.103985","article-title":"A Critical Appraisal of the Effects of Probiotics on Oral Health","volume":"70","author":"Chugh","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4103\/jisppd.jisppd_519_20","article-title":"A Clinical Trial on Topical Effect of Probiotics on Oral Streptococcus Mutans Counts in Children","volume":"39","author":"Patil","year":"2021","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/nure.12078","article-title":"Dairy Product Intake in Children and Adolescents in Developed Countries: Trends, Nutritional Contribution, and a Review of Association with Health Outcomes","volume":"72","author":"Dror","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_27","unstructured":"(2023, November 23). Study Quality Assessment Tools|NHLBI, NIH, Available online: https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools."},{"key":"ref_28","first-page":"116","article-title":"A Review of Breastfeeding in Infants: Relation to the Occurrence of Early Childhood Caries (ECC)","volume":"11","author":"Sukmana","year":"2020","journal-title":"Syst. Rev. Pharm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000445910","article-title":"Breastfeeding, Dental Biofilm Acidogenicity, and Early Childhood Caries","volume":"50","author":"Neves","year":"2016","journal-title":"Caries Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.arcped.2019.10.004","article-title":"Breastfeeding and Early Childhood Caries. Review of the Literature, Recommendations, and Prevention","volume":"26","author":"Branger","year":"2019","journal-title":"Arch. Pediatr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1159\/000448145","article-title":"Breastfeeding Duration and Childhood Caries: A Cohort Study","volume":"50","author":"Nirunsittirat","year":"2016","journal-title":"Caries Res."},{"key":"ref_32","first-page":"283","article-title":"Association between Milk and Dairy Product Intake and the Risk of Dental Caries in Children and Adolescents: NHANES 2011\u20132016","volume":"30","author":"Wang","year":"2021","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/ipd.12150","article-title":"Assessment of the Healthy Eating Index-2005 as a Predictor of Early Childhood Caries","volume":"25","author":"Zaki","year":"2015","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"318","DOI":"10.17796\/jcpd.38.4.l172u301208153v2","article-title":"Comparison of Salivary Calcium, Phosphate and Alkaline Phosphatase Levels in Children with Early Childhood Caries after Administration of Milk, Cheese and GC Tooth Mousse: An in Vivo Study","volume":"38","author":"Hegde","year":"2014","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Johansson, I., Esberg, A., Eriksson, L., Haworth, S., and Lif Holgerson, P. (2018). Self-Reported Bovine Milk Intake Is Associated with Oral Microbiota Composition. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193504"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4028\/www.scientific.net\/JBBBE.48.105","article-title":"The Effect of Cheese and Milk on Buffering Capacity of Saliva in Children 10\u201312 Years","volume":"48","author":"Sungkar","year":"2020","journal-title":"JBBBE"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"057","DOI":"10.1055\/s-0040-1708642","article-title":"Remineralizing and Anticariogenic Benefits of Puremilk\u2014A Review","volume":"06","author":"Vakil","year":"2016","journal-title":"J. Health Allied Sci. NU"},{"key":"ref_38","first-page":"76","article-title":"Promoting Oral Health among 6-Year Old Children: The Impact of Social Environment and Feeding Behavior","volume":"38","year":"2021","journal-title":"Community Dent. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"215824402199741","DOI":"10.1177\/2158244021997413","article-title":"Is There an Impact of Social Factors and Food on Early Childhood Caries? A Cross-Sectional Study","volume":"11","author":"Yardimci","year":"2021","journal-title":"SAGE Open"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"583660","DOI":"10.3389\/fped.2021.583660","article-title":"Protective Factors for Early Childhood Caries in 3-Year-Old Children in Poland","volume":"9","author":"Gozdowski","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1159\/000509926","article-title":"Efficacy of Probiotic Milk for Caries Regression in Preschool Children: A Multicenter Randomized Controlled Trial","volume":"54","author":"Piwat","year":"2020","journal-title":"Caries Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1007\/s00784-020-03712-8","article-title":"The Consumption of Milk Supplemented with Probiotics Decreases the Occurrence of Caries and the Salivary Concentration of h\u03b2D-3 in Children","volume":"25","author":"Sandoval","year":"2021","journal-title":"Clin. Oral. Investig."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1007\/s00203-021-02292-9","article-title":"Salivary Microbial Community Alterations Due to Probiotic Yogurt in Preschool Children with Healthy Deciduous Teeth","volume":"203","author":"Xu","year":"2021","journal-title":"Arch. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e20170318","DOI":"10.1590\/1678-7757-2017-0318","article-title":"Effects of a Food Enriched with Probiotics on Streptococcus Mutans and Lactobacillus Spp. Salivary Counts in Preschool Children: A Cluster Randomized Trial","volume":"26","author":"Villavicencio","year":"2018","journal-title":"J. Appl. Oral Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5005\/jp-journals-10005-1883","article-title":"Comparative Evaluation of Efficacy of Kefir Milk Probiotic Curd and Probiotic Drink on Streptococcus Mutans in 8-12-Year-Old Children: An In Vivo Study","volume":"14","author":"Reddy","year":"2021","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_46","first-page":"ZC06","article-title":"Effect of Probiotic Containing Ice-Cream on Salivary Mutans Streptococci (SMS) Levels in Children of 6\u201312 Years of Age: A Randomized Controlled Double Blind Study with Six-Months Follow Up","volume":"9","author":"Ashwin","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4103\/JISPPD.JISPPD_45_19","article-title":"Comparative Evaluation of Antimicrobial Effectiveness of Probiotic Milk and Fluoride Mouthrinse on Salivary Streptococcus Mutans Counts and Plaque Scores in Children\u2014An in Vivo Experimental Study","volume":"37","author":"Patil","year":"2019","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_48","first-page":"47","article-title":"Comparative Study of Probiotic Ice Cream and Probiotic Drink on Salivary Streptococcus Mutans Levels in 6\u201312 Years Age Group Children","volume":"7","author":"Mahantesha","year":"2015","journal-title":"J. Int. Oral Health"},{"key":"ref_49","first-page":"81","article-title":"The Effect of Iranian Customary Used Probiotic Yogurt on the Children\u2019s Salivary Cariogenic Microflora","volume":"16","author":"Nozari","year":"2015","journal-title":"J. Dent."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.17796\/jcpd.38.4.p608312353256684","article-title":"Effect of Bifidobacterium Bifidum Containing Yoghurt on Dental Plaque Bacteria in Children","volume":"38","author":"Caglar","year":"2014","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000353467","article-title":"Effect of Yogurt Containing Bifidobacterium Animalis Subsp. Lactis DN-173010 Probiotic on Dental Plaque and Saliva in Orthodontic Patients","volume":"48","author":"Pinto","year":"2014","journal-title":"Caries Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00784-014-1228-z","article-title":"Probiotics Reduce Mutans Streptococci Counts in Humans: A Systematic Review and Meta-Analysis","volume":"18","author":"Laleman","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S1806-83242015000100229","DOI":"10.1590\/1807-3107BOR-2015.vol29.0033","article-title":"Effects of Probiotic Fermented Milk on Biofilms, Oral Microbiota, and Enamel","volume":"29","author":"Lodi","year":"2015","journal-title":"Braz. Oral Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ajodo.2018.01.010","article-title":"Effects of Probiotics on Salivary Streptecoccus Mutans and Lactobacillus Levels in Orthodontic Patients","volume":"154","author":"Alp","year":"2018","journal-title":"Am J. Orthod. Dentofac. Orthop."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1007\/s12602-020-09652-9","article-title":"A Review of the Role of Probiotic Supplementation in Dental Caries","volume":"12","author":"Sivamaruthi","year":"2020","journal-title":"Probiotics. Antimicrob. Proteins"},{"key":"ref_56","first-page":"191","article-title":"Comparative Analysis of Dental Plaque pH and Streptococcus Mutans Count Changes Following Probiotic Curd Consumption: A Prospective Randomized Control Trial","volume":"30","author":"Gurunathan","year":"2023","journal-title":"J. Popl. Ther. Clin. Pharmacol."},{"key":"ref_57","first-page":"85","article-title":"Effects of Probiotics on Preventing Caries in Preschool Children: A Systematic Review and Meta-Analysis","volume":"47","author":"Meng","year":"2023","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.51847\/0BB2ttxzlA","article-title":"Effectiveness of Fluoridated Milk in Children\u2019s Daily Diet for the Prevention of Caries","volume":"14","author":"Kallagova","year":"2023","journal-title":"Arch. Pharm. Pract."},{"key":"ref_59","first-page":"199","article-title":"Long-Term Evaluation of the Clinical Effectiveness of Community Milk Fluoridation in Bulgaria","volume":"32","author":"Petersen","year":"2015","journal-title":"Community Dent. Health"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3109\/00016357.2012.696687","article-title":"Effect of Fluoridated Milk on Enamel Demineralization Adjacent to Fixed Orthodontic Appliances","volume":"71","author":"Sollenius","year":"2013","journal-title":"Acta Odontol. Scand."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/00016357.2012.690447","article-title":"A Systematic Review on Fluoridated Food in Caries Prevention","volume":"71","author":"Cagetti","year":"2013","journal-title":"Acta Odontol. Scand."},{"key":"ref_62","first-page":"CD003876","article-title":"Fluoridated Milk for Preventing Dental Caries","volume":"2015","author":"Yeung","year":"2015","journal-title":"Acta Medica Acad."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.5005\/jp-journals-10005-1867","article-title":"Little Color, Little Flavor of Different Kinds of Commercially Available Flavored Milk and Their Consumption Effect on Salivary pH Value in Children: An In Vivo Study","volume":"13","author":"Navit","year":"2020","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_64","first-page":"152","article-title":"Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial","volume":"83","author":"Chi","year":"2016","journal-title":"J. Dent. Child."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/ipd.12484","article-title":"Early Childhood Caries Epidemiology, Aetiology, Risk Assessment, Societal Burden, Management, Education, and Policy: Global Perspective","volume":"29","author":"Tinanoff","year":"2019","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Orilisi, G., Monterubbianesi, R., Notarstefano, V., Tosco, V., Vitiello, F., Giuliani, G., Putignano, A., and Orsini, G. (2021). New Insights from Raman MicroSpectroscopy and Scanning Electron Microscopy on the Microstructure and Chemical Composition of Vestibular and Lingual Surfaces in Permanent and Deciduous Human Teeth. Spectrochim. Acta A Mol. Biomol. Spectrosc., 260.","DOI":"10.1016\/j.saa.2021.119966"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1542\/hpeds.2023-007116","article-title":"Essential Concepts for Reducing Bias in Observational Studies","volume":"13","author":"Markham","year":"2023","journal-title":"Hosp. Pediatr."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Pang, L., Zhi, Q., Jian, W., Liu, Z., and Lin, H. (2022). The Oral Microbiome Impacts the Link between Sugar Consumption and Caries: A Preliminary Study. Nutrients, 14.","DOI":"10.3390\/nu14183693"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Inchingolo, F., Inchingolo, A.M., Malcangi, G., De Leonardis, N., Sardano, R., Pezzolla, C., de Ruvo, E., Di Venere, D., Palermo, A., and Inchingolo, A.D. (2023). The Benefits of Probiotics on Oral Health: Systematic Review of the Literature. Pharmaceuticals, 16.","DOI":"10.3390\/ph16091313"},{"key":"ref_70","unstructured":"Nassar, Y., and Brizuela, M. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"87","DOI":"10.12775\/JEHS.2023.24.01.009","article-title":"Fluoride Prophylaxis\u2014Poison or Simple Way to Get Rid of Early Childhood Caries (ECC)\u2014Review","volume":"24","author":"Kurek","year":"2023","journal-title":"J. Educ. Health Sport"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4103\/2231-0762.165927","article-title":"Recent Advancements in Fluoride: A Systematic Review","volume":"5","author":"Bansal","year":"2015","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Tricco, A.C., Lillie, E., Zarin, W., O\u2019Brien, K., Colquhoun, H., Kastner, M., Levac, D., Ng, C., Sharpe, J.P., and Wilson, K. (2016). A Scoping Review on the Conduct and Reporting of Scoping Reviews. BMC Med. Res. Methodol., 16.","DOI":"10.1186\/s12874-016-0116-4"},{"key":"ref_74","first-page":"141","article-title":"Guidance for Conducting Systematic Scoping Reviews","volume":"13","author":"Peters","year":"2015","journal-title":"JBI Evid. Implement."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/jcpt.13558","article-title":"Practical Guide to Undertaking Scoping Reviews for Pharmacy Clinicians, Researchers and Policymakers","volume":"47","author":"Khalil","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Munn, Z., Peters, M.D.J., Stern, C., Tufanaru, C., McArthur, A., and Aromataris, E. (2018). Systematic Review or Scoping Review? Guidance for Authors When Choosing between a Systematic or Scoping Review Approach. BMC Med. Res. 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