{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:34Z","timestamp":1760143114149,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oral Special Care Academic Resources (OSCAR)","award":["2019-1-RO01-KA202-063820"],"award-info":[{"award-number":["2019-1-RO01-KA202-063820"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Primary failure of eruption (PFE) is a rare non-syndromic condition involving total or partial non-eruption of posterior teeth in the absence of mechanical obstruction. This paper presents the case of a healthy girl referred at age 4 for asymmetry of the upper arch. Clinical examination confirmed a slight shift of the upper midline to the left, with no erupted teeth distal to the upper left canine and a left posterior open bite. Panoramic X-rays showed delayed intraosseous development of the lateral left upper teeth compared to the right side. Clinic and radiographic follow-up during the next 9 years showed that 26 had not erupted by almost 13 years of age, 27 had delayed development and an unusual shape, and there was an agenesis in 24 and 25. Genetic analysis using the PTH1R single-gene sequencing method did not detect any known disease-causing or rare pathogenic variants that could explain the patient\u2019s phenotype. Even when detected early, PFE raises difficult problems with regard to diagnosis and ortho-surgical treatment planning due to the impossibility of accurately predicting its evolution. Tooth agenesis on the same arch worsens the prognosis and adds challenges to planning the treatment. Close long-term follow-up and timely adjustment of the treatment plan in accordance with the evolution of the case are needed.<\/jats:p>","DOI":"10.3390\/children11020152","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T03:59:42Z","timestamp":1706155182000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare Case of First Permanent Molar Primary Failure of Eruption with Agenesis of Premolars"],"prefix":"10.3390","volume":"11","author":[{"given":"Arina","family":"Vinereanu","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-9898","authenticated-orcid":false,"given":"Aneta","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Clauss","sequence":"additional","affiliation":[{"name":"Faculty of Dental Surgery, University of Strasbourg, 67081 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eusebiu Vlad","family":"Gorduza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Grigore. T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e05632","DOI":"10.1002\/ccr3.5632","article-title":"Review and case report of the treatment in a young girl with primary failure of eruption","volume":"10","author":"Awad","year":"2022","journal-title":"Clin. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2319\/062717-430.1","article-title":"Primary failure of eruption: Clinical and genetic findings in the mixed dentition","volume":"88","author":"Grippaudo","year":"2018","journal-title":"Angle Orthod."},{"key":"ref_3","first-page":"180","article-title":"Alterations of the permanent molars eruption","volume":"45","author":"Castaneda","year":"2016","journal-title":"Rev. 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Oral Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16469","DOI":"10.1038\/s41598-019-52935-7","article-title":"KMT2C, a histone methyltransferase, is mutated in a family segregating non-syndromic primary failure of tooth eruption","volume":"9","author":"Assiry","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034519882692","article-title":"Mesenchymal progenitor regulation of tooth eruption: A view from PTHrP","volume":"99","author":"Nagata","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jdsr.2022.08.002","article-title":"Primary failure of tooth eruption: Etiology and management","volume":"58","author":"Yamaguchi","year":"2022","journal-title":"Jpn. Dent. Sci. 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Dent."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/2\/152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:48:52Z","timestamp":1760104132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/2\/152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["children11020152"],"URL":"https:\/\/doi.org\/10.3390\/children11020152","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2024,1,25]]}}}