{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:02:51Z","timestamp":1788876171622,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Indizen Optical Technologies"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Children"],"abstract":"<jats:p>Background: Different designs of ophthalmic lenses have been studied to control the progression of myopia in children. This study aims to evaluate the short-term efficacy of a new design of ophthalmic lens with asymmetric myopic peripheral defocus (MPDL) on myopia progression in children compared to a control group wearing a single-vision lens (SVL). Methods: Children aged 5 to 12 with myopia up to \u22120.50 D, astigmatism and anisometropia under 1.50 D, and corrected visual acuity over 20\/20 were randomized to either the study group (MPDL) or control group (SVL). The myopia progression was evaluated by measuring axial length (AL) growth (IOL Master; Zeiss) over a period of one year. Results: Ninety-two subjects were recruited. Forty-six children were randomly assigned to the control group, and 46 to the study group. In total, 83 children completed the clinical trial, with a mean age of 10.81 [9.53\u201311.92] years, among which 59.04% were female. After one year of treatment, there was less AL elongation in the study group compared to the control group (0.14 \u00b1 0.14 mm vs. 0.23 \u00b1 0.15 mm, p = 0.014). Conclusions: The MPDL significantly reduced the absolute growth of AL by 39% (p = 0.014) and relative growth of AL by 37.3% (p = 0.012) after 12 months in comparison to the control group in a Spanish population.<\/jats:p>","DOI":"10.3390\/children11020177","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T08:44:08Z","timestamp":1706777048000},"page":"177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of a Spectacle Lens with a Specific Asymmetric Myopic Peripheral Defocus: 12-Month Results in a Spanish Population"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-1789","authenticated-orcid":false,"given":"Miguel","family":"S\u00e1nchez-Tena","sequence":"first","affiliation":[{"name":"Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain"},{"name":"ISEC LISBOA-Instituto Superior de Educa\u00e7\u00e3o e Ci\u00eancias, 1750-179 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-6616","authenticated-orcid":false,"given":"Jose","family":"Cleva","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Indizen Optical Technologies, 28002 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-8264","authenticated-orcid":false,"given":"Cesar","family":"Villa-Collar","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Science, Universidad Europea de Madrid, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7453-5633","authenticated-orcid":false,"given":"Marta","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Indizen Optical Technologies, 28002 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-5914","authenticated-orcid":false,"given":"Alicia","family":"Ruiz-Pomeda","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-5007","authenticated-orcid":false,"given":"Clara","family":"Martinez-Perez","sequence":"additional","affiliation":[{"name":"ISEC LISBOA-Instituto Superior de Educa\u00e7\u00e3o e Ci\u00eancias, 1750-179 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-4325","authenticated-orcid":false,"given":"Cristina","family":"Andreu-Vazquez","sequence":"additional","affiliation":[{"name":"Faculty of Biomedical and Health Science, Universidad Europea de Madrid, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Chamorro","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Indizen Optical Technologies, 28002 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-4581","authenticated-orcid":false,"given":"Cristina","family":"Alvarez-Peregrina","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2017.09.004","article-title":"The epidemics of myopia: Aetiology and prevention","volume":"62","author":"Morgan","year":"2018","journal-title":"Prog. 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