{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:17:10Z","timestamp":1785269830377,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Introduction: Vulvar lichen sclerosus (VLS), a chronic inflammatory skin disorder, often coexists with autoimmune thyroid disease (AITD). VLS presents with subtle symptoms including vulvar itching and discomfort. Clinically, a \u201cFigure 8\u201d pattern involving the labia minora, clitoral hood, and perianal region is often observed. It is prevalent both in pre-pubertal girls and women aged 40\u201360, and the link between VLS and AITD remains unclear, with proposed causes including autoimmune, hormonal or genetic factors, and environmental triggers. This study addresses the lack of research on the association in children, aiming to investigate the largest group of underage girls to date. Aim: This study aimed to investigate the coexistence of thyroid autoimmune diseases in girls diagnosed with vulvar lichen sclerosus (VLS) and to assess the presence of antibodies for specific thyroid autoimmune diseases. Materials and Methods: Our study was conducted from July 2020 to February 2021, involving a sample of 55 girls aged 2\u201318 years old, all free from systemic diseases. The study group comprised 20 girls previously diagnosed with vulvar lichen sclerosus (VLS), while the control group included 35 girls without VLS. Legal guardians completed questionnaires detailing the medical history of their children. Blood samples were collected from all participants and subjected to biochemical analysis. The presence of human IgG antibodies against thyroid peroxidase and IgG antibodies against thyroglobulin was assessed using the immunoenzymatic method with commercially available ELISA kits. Results: In the study group, common symptoms included itching, soreness, burning sensation, excoriation, and erythema or pallor of the skin and perineal mucosa. An evaluation of anti-thyroglobulin and anti-thyroid peroxidase antibodies revealed no statistical significance between the study and control groups (anti-TG p = 0.379, anti-TPO p = 0.96). Family history of autoimmune diseases showed no significant correlation with anti-thyroid antibodies in girls. Although no significant relation between VLS occurrence and antibody levels was found, it emphasizes the need for multidisciplinary medical care. Further research with larger patient groups is necessary.<\/jats:p>","DOI":"10.3390\/children11020255","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T06:00:25Z","timestamp":1708063225000},"page":"255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Potential Coexistence of Autoimmune Thyroid Diseases and Pediatric Vulvar Lichen sclerosus"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-9280","authenticated-orcid":false,"given":"Agnieszka","family":"Dulska","sequence":"first","affiliation":[{"name":"Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Markiefki 87, 40-211 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Bodziony","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences in Katowice, Medyk\u00f3w 18, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Janik","sequence":"additional","affiliation":[{"name":"Euroimmun Polska Sp. z o.o., 50-543 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Drosdzol-Cop","sequence":"additional","affiliation":[{"name":"Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Markiefki 87, 40-211 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"ref_1","first-page":"A4424","article-title":"Childhood lichen sclerosus is a rare but important diagnosis","volume":"59","author":"Jensen","year":"2012","journal-title":"Dan. Med. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5152\/tpa.2014.1365","article-title":"An uncommon cause of vulval pruritus in childhood: Lichen sclerosus","volume":"49","author":"Topal","year":"2017","journal-title":"Turk. Arch. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e230","DOI":"10.1542\/peds.2004-1544","article-title":"Constipation as a Feature of Anogenital Lichen sclerosus in Children","volume":"115","author":"Maronn","year":"2005","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jaad.2020.08.011","article-title":"Autoimmune and dermatologic conditions associated with lichen sclerosus","volume":"85","author":"Bieber","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1530\/EC-17-0262","article-title":"Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: A hint for endocrinologists","volume":"6","author":"Arduino","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_6","first-page":"1","article-title":"Granuloma Annulare, Autoimmune Thyroiditis, and Lichen Sclerosus in a Woman: Randomness or Significant Association?","volume":"2013","author":"Batsikosta","year":"2013","journal-title":"Case Rep. Dermatol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fendo.2017.00146","article-title":"Thyroid Autoimmunity and Lichen","volume":"8","author":"Guarneri","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijgo.13480","article-title":"The prevalence of self-reported medical comorbidities in patients with vulvar lichen sclerosus: A single-center retrospective study","volume":"153","author":"Hu","year":"2020","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1020709","DOI":"10.3389\/fpubh.2022.1020709","article-title":"Global prevalence and epidemiological trends of Hashimoto\u2019s thyroiditis in adults: A systematic review and meta-analysis","volume":"10","author":"Hu","year":"2022","journal-title":"Front. Public Heal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101387","DOI":"10.1016\/j.beem.2020.101387","article-title":"Graves\u2019 disease: Epidemiology, genetic and environmental risk factors and viruses","volume":"34","author":"Antonelli","year":"2020","journal-title":"Best Pr. Res. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Corazza, M., Schettini, N., Zedde, P., and Borghi, A. (2021). Vulvar Lichen Sclerosus from Pathophysiology to Therapeutic Approaches: Evidence and Prospects. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080950"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1067\/mjd.2001.113474","article-title":"Childhood vulvar lichen sclerosus: An increasingly common problem","volume":"44","author":"Powell","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.urology.2019.12.029","article-title":"Lichen Sclerosus in Prepubertal Girls: An Uncommon but Treatable Cause of Lower Urinary Tract Symptoms","volume":"137","author":"Arlen","year":"2020","journal-title":"Urology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/039463201302600326","article-title":"Lichen Sclerosus et Atrophicus Induced by Carbamazepine: A Case Report","volume":"26","author":"Pranteda","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/pde.12109","article-title":"Childhood Lichen Sclerosus\u2014A Challenge for Clinicians","volume":"30","author":"Lagerstedt","year":"2013","journal-title":"Pediatr. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/ijc.30621","article-title":"Lichen sclerosus and risk of cancer","volume":"140","author":"Halonen","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107767","DOI":"10.1016\/j.maturitas.2023.04.010","article-title":"Genital and extragenital oncological risk in women with vulvar lichen sclerosus: A multi-center Italian study","volume":"175","author":"Preti","year":"2023","journal-title":"Maturitas"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1610-0387.2006.06087.x","article-title":"HLA markers in familial Lichen Sclerosus","volume":"4","author":"Aslanian","year":"2006","journal-title":"JDDG: J. der Dtsch. Dermatol. Ges."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2133.1995.tb05013.x","article-title":"The association between lichen sclerosus and antigens of the HLA system","volume":"132","author":"Marren","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2133.1981.tb08172.x","article-title":"An investigation into the incidence of auto-immune disorders in patients with lichen sclerosus and atrophicus","volume":"104","author":"Harrington","year":"1981","journal-title":"Br. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/bmj.4.5936.78","article-title":"Organ-specific Antibodies in Patients with Lichen Sclerosus","volume":"4","author":"Goolamali","year":"1974","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2133.1988.tb01748.x","article-title":"Lichen sclerosus et atrophicus and autoimmunity\u2014a study of 350 women","volume":"118","author":"Thomas","year":"1988","journal-title":"Br. J. Dermatol."},{"key":"ref_23","first-page":"33","article-title":"Familial lichen sclerosus","volume":"147","author":"Salim","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000075049","article-title":"Coexistence of HLA-B*08 and HLA-B*18 in Four Siblings with Lichen sclerosus","volume":"208","author":"Birinci","year":"2004","journal-title":"Dermatology"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Medici, M., Porcu, E., Pistis, G., Teumer, A., Brown, S.J., Jensen, R.A., Rawal, R., Roef, G.L., Plantinga, T.S., and Vermeulen, S.H. (2014). Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004123"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/105072503322021151","article-title":"High Prevalence of Autoimmune Thyroiditis in Schoolchildren After Elimination of Iodine Deficiency in Northwestern Greece","volume":"13","author":"Zois","year":"2003","journal-title":"Thyroid"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jaut.2009.02.007","article-title":"The etiology of autoimmune thyroid disease: A story of genes and environment","volume":"32","author":"Tomer","year":"2009","journal-title":"J. Autoimmun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/7480754","article-title":"Etiology, Clinical Features, and Diagnosis of Vulvar Lichen Sclerosus: A Scoping Review","volume":"2020","author":"Singh","year":"2020","journal-title":"Obstet. Gynecol. Int."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/2\/255\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:00:39Z","timestamp":1760104839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/2\/255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["children11020255"],"URL":"https:\/\/doi.org\/10.3390\/children11020255","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]}}}