{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:53:26Z","timestamp":1793386406698,"version":"4.5.0"},"reference-count":95,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Opsoclonus-myoclonus ataxia syndrome (OMAS), also known as Kinsbourne syndrome, is a rare disorder that presents with myoclonus, ataxia, abnormal eye movements, irritability, and sleep disruptions, often in young children. We report a case of an infant barely 6 months old, with no significant past medical history, who presented to the emergency department with tremors, jerking motions of the head and arms, and rapid eye movements. After an extensive workup, she was found to have a neuroblastoma, which was subsequently surgically removed via thoracotomy. Despite an initial improvement in symptoms post-resection, the patient\u2019s symptoms recurred. She was subsequently treated with dexamethasone, intravenous immunoglobulin (IVIG), and rituximab. After treatment, the patient was noted to have mild global developmental delays but was otherwise well. This case report highlights the rare occurrence of OMAS in an infant barely 6 months old at diagnosis. Using the PubMed database, a systematic review was conducted to highlight the clinical presentation, diagnosis, and management of OMAS.<\/jats:p>","DOI":"10.3390\/children11030367","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:04:12Z","timestamp":1710911052000},"page":"367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Review of Opsoclonus-Myoclonus Ataxia Syndrome in Pediatric Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Mandy","family":"Hsu","sequence":"first","affiliation":[{"name":"University Park Program, Penn State College of Medicine, State College, PA 16803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-1357","authenticated-orcid":false,"given":"Isbaah","family":"Tejani","sequence":"additional","affiliation":[{"name":"Medical College, Aga Khan University, Karachi P.O. Box 8842, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasaq","family":"Olaosebikan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4949-1395","authenticated-orcid":false,"given":"Ashutosh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0482-4547","authenticated-orcid":false,"given":"Sunil","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3389\/fneur.2017.00468","article-title":"Demographic, Clinical, and Immunologic Features of 389 Children with Opsoclonus-Myoclonus Syndrome: A Cross-sectional Study","volume":"8","author":"Pranzatelli","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpn.2009.03.002","article-title":"A prospective study of the presentation and management of dancing eye syndrome\/opsoclonus-myoclonus syndrome in the United Kingdom","volume":"14","author":"Pang","year":"2010","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.braindev.2014.10.010","article-title":"A nationwide survey of opsoclonus-myoclonus syndrome in Japanese children","volume":"37","author":"Hasegawa","year":"2015","journal-title":"Brain Dev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.1542\/peds.2010-3114","article-title":"Outcome and prognostic features in opsoclonus-myoclonus syndrome from infancy to adult life","volume":"128","author":"Brunklaus","year":"2011","journal-title":"Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00247-009-1282-x","article-title":"The association between neuroblastoma and opsoclonus-myoclonus syndrome: A historical review","volume":"39","author":"Rothenberg","year":"2009","journal-title":"Pediatr. Radiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/01.mph.0000170532.76765.df","article-title":"Late presentation of opsoclonus-myoclonus-ataxia syndrome in a child with stage 4S neuroblastoma","volume":"27","author":"Mutch","year":"2005","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.radcr.2015.09.003","article-title":"Primary pancreatic neuroblastoma presenting with opsoclonus-myoclonus syndrome","volume":"11","author":"Galgano","year":"2016","journal-title":"Radiol. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1153","DOI":"10.1212\/NXI.0000000000001153","article-title":"Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective","volume":"9","author":"Rossor","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/practneurol-2011-000017","article-title":"The opsoclonus\u2013myoclonus syndrome","volume":"11","author":"Sahu","year":"2011","journal-title":"Pract. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1586\/1744666X.3.6.975","article-title":"Identification of autoantigens in pediatric opsoclonus-myoclonus syndrome","volume":"3","author":"Blaes","year":"2007","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0022-3476(97)70272-5","article-title":"Serum autoantibodies in childhood opsoclonus-myoclonus syndrome: An analysis of antigenic targets in neural tissues","volume":"130","author":"Connolly","year":"1997","journal-title":"J. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/pbc.20573","article-title":"Epstein-Barr virus related opsoclonus-myoclonus-ataxia does not rule out the presence of occult neuroblastic tumors","volume":"47","author":"Mora","year":"2006","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.pediatrneurol.2010.02.009","article-title":"Opsoclonus-myoclonus syndrome attributable to hepatitis C infection","volume":"42","author":"Ertekin","year":"2010","journal-title":"Pediatr. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1111\/ped.12433","article-title":"Opsoclonus-myoclonus syndrome following rotavirus gastroenteritis","volume":"56","author":"Gurkas","year":"2014","journal-title":"Pediatr. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1186\/s40064-015-1429-1","article-title":"Opsoclonus-myoclonus syndrome after adenovirus infection","volume":"4","author":"Syrbe","year":"2015","journal-title":"Springerplus"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2329048X17733215","DOI":"10.1177\/2329048X17733215","article-title":"Rapid Resolution of Enterovirus 71-Associated Opsoclonus Myoclonus Syndrome on Intravenous Immunoglobulin","volume":"4","author":"Sahly","year":"2017","journal-title":"Child Neurol. Open"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"744041","DOI":"10.3389\/fneur.2021.744041","article-title":"Clinical Analysis of Pediatric Opsoclonus-Myoclonus Syndrome in One of the National Children\u2019s Medical Center in China","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.ejpn.2018.05.002","article-title":"Acute transverse myelitis following an opsoclonus-myoclonus syndrome: An unusual presentation","volume":"22","author":"Simon","year":"2018","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.4103\/0301-4738.195611","article-title":"Opsoclonus myoclonus ataxia syndrome due to falciparum malaria in two Indian children","volume":"64","author":"Bose","year":"2016","journal-title":"Indian J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102855","DOI":"10.1016\/j.msard.2021.102855","article-title":"Immunotherapy responsive SARS-CoV-2 infection exacerbating opsoclonus myoclonus syndrome","volume":"50","author":"Wiegand","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ejpn.2005.06.007","article-title":"Opsoclonus-myoclonus in an HIV-infected child on antiretroviral therapy--possible immune reconstitution inflammatory syndrome","volume":"9","author":"Rabie","year":"2005","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_22","first-page":"e32578","article-title":"Opsoclonus Myoclonus Syndrome in a Case of Severe Acute Malnutrition in Children: A Case Report","volume":"14","author":"Sharma","year":"2022","journal-title":"Cureus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1469-8749.1999.tb00643.x","article-title":"Myoclonic encephalopathy and diabetes mellitus in a boy","volume":"41","author":"Lenti","year":"1999","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pediatrneurol.2015.09.021","article-title":"Opsoclonus-Myoclonus Syndrome, Neuroblastoma, and Insulin-Dependent Diabetes Mellitus in a Child: A Unique Patient","volume":"55","author":"Ghia","year":"2016","journal-title":"Pediatr. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/dmcn.14969","article-title":"Opsoclonus-myoclonus in Aicardi-Gouti\u00e8res syndrome","volume":"63","author":"Alburaiky","year":"2021","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/mds.23084","article-title":"Electrophysiological Evidence of Cerebral Dysfunction in Childhood Opsoclonus-Myoclonus Syndrome","volume":"25","author":"Sakuma","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/dmcn.13296","article-title":"Pediatric opsoclonus-myoclonus syndrome: The role of functional brain connectivity studies","volume":"59","author":"Gallerini","year":"2016","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/MPH.0000000000000976","article-title":"Genomic Profiles of Neuroblastoma Associated with Opsoclonus Myoclonus Syndrome","volume":"40","author":"Hero","year":"2018","journal-title":"J. Pediatr. Hematol.\/Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1176\/jnp.2006.18.2.239","article-title":"Mood and behavioral dysfunction with opsoclonus-myoclonus ataxia","volume":"18","author":"Turkel","year":"2006","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s00415-021-10536-3","article-title":"Opsoclonus-myoclonus-ataxia syndrome in children","volume":"269","author":"Bhatia","year":"2022","journal-title":"J. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejpn.2022.09.002","article-title":"Clinical features and outcomes of opsoclonus myoclonus ataxia syndrome","volume":"41","author":"Tanali","year":"2022","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0883073812471433","article-title":"Clinical profile and outcome of children with opsoclonus-myoclonus syndrome","volume":"29","author":"Singhi","year":"2014","journal-title":"J. Child Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pediatrneurol.2017.06.005","article-title":"Sleep-Related Laryngeal Stridor in Opsoclonus Myoclonus Syndrome","volume":"77","author":"Mizuno","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.braindev.2010.06.005","article-title":"Augmented startle response in opsoclonus-myoclonus syndrome","volume":"33","author":"Yonekawa","year":"2011","journal-title":"Brain Dev."},{"key":"ref_35","first-page":"93","article-title":"Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome","volume":"11","author":"Takenaka","year":"2023","journal-title":"Asia Ocean. J. Nucl. Med. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1469-8749.1995.tb11944.x","article-title":"Neurobehavioral and psychosocial functioning of children with opsoclonus-myoclonus syndrome","volume":"37","author":"Papero","year":"1995","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/pec.0b013e31815c9d66","article-title":"Dancing eyes, dancing feet: Opsoclonus-myoclonus in an 18-month-old child with neuroblastoma","volume":"23","author":"Badaki","year":"2007","journal-title":"Pediatr. Emerg. Care."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.4103\/0028-3886.241404","article-title":"Pediatric opsoclonus-myoclonus-ataxia syndrome: Experience from a tertiary care university hospital","volume":"66","author":"Huddar","year":"2018","journal-title":"Neurol. India"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/1043454204272560","article-title":"Neuroepidemiologic trends in 105 US cases of pediatric opsoclonus-myoclonus syndrome","volume":"22","author":"Tate","year":"2005","journal-title":"J. Pediatr. Oncol. Nurs."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4103\/aian.AIAN_101_18","article-title":"Clinical Profile, Prognostic Indicators, and Therapeutic Outcomes of Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome: A Single-Center Experience from South India","volume":"22","author":"Muthusamy","year":"2019","journal-title":"Ann. Indian Acad. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1177\/00099228221147407","article-title":"Pediatrician\u2019s Approach to Recognizing Neuroblastoma with Opsoclonus Myoclonus-Ataxia Syndrome","volume":"62","author":"Segal","year":"2022","journal-title":"Clin. Pediatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0887-8994(92)90060-C","article-title":"Opsoclonus-myoclonus with Beckwith-Wiedemann syndrome and hepatoblastoma","volume":"8","author":"Wilfong","year":"1992","journal-title":"Pediatr. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/adc.2009.160044","article-title":"Opsoclonus myoclonus: A non-epileptic movement disorder that may present as status epilepticus","volume":"94","author":"Haden","year":"2009","journal-title":"Arch. Dis. Child."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e28218","DOI":"10.1002\/pbc.28218","article-title":"Paraneoplastic opsoclonus myoclonus syndrome associated with inflammatory myofibroblastic tumor in a pediatric patient","volume":"67","author":"Gerstle","year":"2020","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.pediatrneurol.2015.07.010","article-title":"Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome Associated with Anti-N-methyl-D-aspartate Receptor Encephalitis","volume":"53","author":"Player","year":"2015","journal-title":"Pediatr. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2008.06.001","article-title":"Therapeutic down-regulation of central and peripheral B-cell-activating factor (BAFF) production in pediatric opsoclonus-myoclonus syndrome","volume":"44","author":"Pranzatelli","year":"2008","journal-title":"Cytokine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2009.03.006","article-title":"Elevated B-cell activating factor, BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome","volume":"210","author":"Bick","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/mds.20125","article-title":"CSF B-cell expansion in opsoclonus-myoclonus syndrome: A biomarker of disease activity","volume":"19","author":"Pranzatelli","year":"2004","journal-title":"Mov. Disord."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Storz, C., Bares, R., Ebinger, M., Handgretinger, R., Tsiflikas, I., and Sch\u00e4fer, J.F. (2019). Diagnostic value of whole-body MRI in Opsoclonus-myoclonus syndrome: A clinical case series (3 case reports). BMC Med. Imaging, 19.","DOI":"10.1186\/s12880-019-0372-y"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/adc.2010.204792","article-title":"Investigating neuroblastoma in childhood opsoclonus-myoclonus syndrome","volume":"97","author":"Brunklaus","year":"2012","journal-title":"Arch. Dis. Child."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00431-002-0934-8","article-title":"Metaiodobenzylguanidine total-body scintigraphy required for revealing occult neuroblastoma in opsoclonus-myoclonus syndrome","volume":"161","author":"Swart","year":"2002","journal-title":"Eur. J. Pediatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s00330-020-07587-x","article-title":"Diagnostic values of 68Ga-labelled DOTANOC PET\/CT imaging in pediatric patients presenting with paraneoplastic opsoclonus myoclonus ataxia syndrome","volume":"31","author":"Kumar","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.nrleng.2020.04.030","article-title":"Opsoclonus-myoclonus syndrome: Clinical characteristics, therapeutic considerations, and prognostic factors in a Spanish paediatric cohort","volume":"38","year":"2023","journal-title":"Neurolog\u00eda (Engl. Ed.)"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Auconi, M., Papetti, L., Ruscitto, C., Ferilli, M.A.N., Ursitti, F., Sforza, G., Vigevano, F., and Valeriani, M. (2021). Opsoclonus-Myoclonus Syndrome in Children and Adolescents: A Therapeutic Challenge. Children, 8.","DOI":"10.3390\/children8110965"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mizia-Malarz, A., Stolpa, W., and Sobol-Milejska, G. (2020). The Treatment of Opsoclonus-Myoclonus Syndrome Secondary to Neuroblastic Tumours-Single-Centre Experience and Literature Review. Medicina, 56.","DOI":"10.3390\/medicina56080412"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/pbc.21107","article-title":"Treatment of neuroblastoma-related opsoclonus-myoclonus-ataxia syndrome with high-dose dexamethasone pulses","volume":"50","author":"Ertle","year":"2008","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.braindev.2011.04.005","article-title":"Another promising treatment option for neuroblastoma-associated opsoclonus-myoclonus syndrome by oral high-dose dexamethasone pulse: Lymphocyte markers as disease activity","volume":"34","author":"Oguma","year":"2012","journal-title":"Brain Dev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S2352-4642(17)30130-X","article-title":"Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): A randomised, open-label, phase 3 trial","volume":"2","author":"Matthay","year":"2018","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1542\/peds.2004-0845","article-title":"Immunologic and clinical responses to rituximab in a child with opsoclonus-myoclonus syndrome","volume":"115","author":"Pranzatelli","year":"2005","journal-title":"Pediatrics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/pbc.20899","article-title":"Response to rituximab in a child with neuroblastoma and opsoclonus-myoclonus","volume":"50","author":"Bell","year":"2008","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejpn.2011.05.013","article-title":"Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments","volume":"16","author":"Battaglia","year":"2012","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_62","first-page":"164082","article-title":"Clinical responses to rituximab in a case of neuroblastoma with refractory opsoclonus myoclonus ataxia syndrome","volume":"2012","author":"Alavi","year":"2012","journal-title":"Case Rep. Oncol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e27776","DOI":"10.1002\/pbc.27776","article-title":"An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome","volume":"66","author":"Wilbur","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/01.mph.0000212991.64435.f0","article-title":"Rituximab (anti-CD20) adjunctive therapy for opsoclonus-myoclonus syndrome","volume":"28","author":"Pranzatelli","year":"2006","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/mds.22941","article-title":"B cell depletion therapy for new-onset opsoclonus-myoclonus","volume":"25","author":"Pranzatelli","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pediatrneurol.2018.05.003","article-title":"Evaluation of Responsiveness to Reduced-Dose Rituximab in Corticotropin\/Intravenous Immunoglobulin\/Rituximab Combination Immunotherapy for Opsoclonus-Myoclonus Syndrome","volume":"85","author":"Pranzatelli","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.braindev.2015.09.002","article-title":"Rituximab treatment for relapsed opsoclonus-myoclonus syndrome","volume":"38","author":"Toyoshima","year":"2016","journal-title":"Brain Dev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejpn.2007.05.005","article-title":"Chronic relapsing opsoclonus-myoclonus syndrome: Combination of cyclophosphamide and dexamethasone pulses","volume":"12","author":"Wilken","year":"2008","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ejpn.2018.02.009","article-title":"Effect of low-dose cyclophosphamide, ACTH, and IVIG combination immunotherapy on neuroinflammation in pediatric-onset OMS: A retrospective pilot study","volume":"22","author":"Pranzatelli","year":"2018","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/cei.13015","article-title":"6-Mercaptopurine modifies cerebrospinal fluid T cell abnormalities in paediatric opsoclonus-myoclonus as steroid sparer","volume":"190","author":"Pranzatelli","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0887-8994(00)00227-7","article-title":"Plasmapheresis as an effective treatment for opsoclonus-myoclonus syndrome","volume":"24","author":"Yiu","year":"2001","journal-title":"Pediatr. Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.pediatrneurol.2005.05.018","article-title":"Delayed, recurrent opsoclonus-myoclonus syndrome responding to plasmapheresis","volume":"33","author":"Armstrong","year":"2005","journal-title":"Pediatr. Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e26819","DOI":"10.1002\/pbc.26819","article-title":"Therapeutic plasma exchange for a case of refractory opsoclonus myoclonus ataxia syndrome","volume":"65","author":"Greensher","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e27110","DOI":"10.1002\/pbc.27110","article-title":"Autologous stem cell transplantation for refractory opsoclonus myoclonus ataxia syndrome","volume":"65","author":"Johnston","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00702-010-0366-y","article-title":"Clonazepam responsive opsoclonus myoclonus syndrome: Additional evidence in favour of fastigial nucleus disinhibition hypothesis?","volume":"117","author":"Paliwal","year":"2010","journal-title":"J. Neural Transm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/pbc.23187","article-title":"Ofatumumab for a rituximab-allergic child with chronic-relapsing paraneoplastic opsoclonus-myoclonus","volume":"58","author":"Pranzatelli","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"E163","DOI":"10.1002\/pbc.24646","article-title":"Ofatumumab for refractory opsoclonus-myoclonus syndrome following treatment of neuroblastoma","volume":"60","author":"Ketterl","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejpn.2009.04.011","article-title":"Dancing Eye Syndrome associated with spontaneous recovery and normal neurodevelopment","volume":"14","author":"Lynch","year":"2010","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pediatrneurol.2017.03.011","article-title":"Opsoclonus-Myoclonus Syndrome: A New Era of Improved Prognosis?","volume":"72","author":"Galstyan","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/0883073811428816","article-title":"Active comparator-controlled, rater-blinded study of corticotropin-based immunotherapies for opsoclonus-myoclonus syndrome","volume":"27","author":"Tate","year":"2012","journal-title":"J. Child Neurol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pediatrneurol.2017.04.027","article-title":"Dexamethasone, Intravenous Immunoglobulin, and Rituximab Combination Immunotherapy for Pediatric Opsoclonus-Myoclonus Syndrome","volume":"73","author":"Pranzatelli","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/ped.13180","article-title":"Transient symptomatic worsening by atropine in opsoclonus-myoclonus syndrome","volume":"59","author":"Miyoshi","year":"2017","journal-title":"Pediatr. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"373","DOI":"10.4103\/1817-1745.199462","article-title":"Neuroblastoma presenting as opsoclonus-myoclonus: A series of six cases and review of literature","volume":"11","author":"Meena","year":"2016","journal-title":"J. Pediatr. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e924","DOI":"10.1097\/MPH.0000000000002131","article-title":"Neuroblastoma with Opsoclonus-Myoclonus-Ataxia Syndrome: Role of Chemotherapy in the Management: Experience from a Tertiary Care Center in a Resource-limited Setting","volume":"43","author":"Anand","year":"2021","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.21037\/tcr-22-1120","article-title":"Comparison of mediastinal and non-mediastinal neuroblastoma and ganglioneuroblastoma associated with opsoclonus-myoclonus syndrome; a systematic review and meta analysis","volume":"11","author":"Xie","year":"2022","journal-title":"Transl. Cancer Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1067\/mpd.2001.118200","article-title":"Long-term neurobehavioral outcomes in children with neuroblastoma and opsoclonus-myoclonus-ataxia syndrome: Relationship to MRI findings and anti-neuronal antibodies","volume":"139","author":"Hayward","year":"2001","journal-title":"J. Pediatr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00431-006-0247-4","article-title":"Long-term outcome of ten children with opsoclonus-myoclonus syndrome","volume":"166","author":"Klein","year":"2007","journal-title":"Eur. J. Pediatr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/pbc.22226","article-title":"Improvement of neurological status and quality of life in children with opsoclonus myoclonus syndrome at long-term follow-up","volume":"53","author":"Aarsen","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1097\/MPH.0000000000002466","article-title":"Neuroblastoma-associated Opsoclonus Myoclonus Ataxia Syndrome: Profile and Outcome Report on 15 Egyptian Patients","volume":"45","author":"Elzomor","year":"2023","journal-title":"J. Pediatr. Hematol.\/Oncol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"368","DOI":"10.21037\/tp-21-519","article-title":"Long-term neurological outcomes of children with neuroblastoma with opsoclonus-myoclonus syndrome","volume":"11","author":"Sun","year":"2022","journal-title":"Transl. Pediatr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Goh, E.L., Scarff, K., Satariano, S., Lim, M., and Anand, G. (2020). Evolving Cognitive Dysfunction in Children with Neurologically Stable Opsoclonus-Myoclonus Syndrome. Children, 7.","DOI":"10.3390\/children7090103"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1177\/0883073816634856","article-title":"Sensory Processing Difficulties in Opsoclonus-Myoclonus Syndrome: A Pilot Project of Presentation and Possible Prevalence","volume":"31","author":"Green","year":"2016","journal-title":"J. Child. Neurol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ejpn.2009.12.005","article-title":"Opsoclonus-myoclonus in children associated or not with neuroblastoma","volume":"14","author":"Krug","year":"2010","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/pbc.23131","article-title":"Opsoclonus-myoclonus and anti-Hu positive limbic encephalitis in a patient with neuroblastoma","volume":"58","author":"Rubin","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.braindev.2015.11.007","article-title":"Trends and tenets in relapsing and progressive opsoclonus-myoclonus syndrome","volume":"38","author":"Pranzatelli","year":"2016","journal-title":"Brain Dev."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/3\/367\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:16:14Z","timestamp":1760105774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/3\/367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,19]]},"references-count":95,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["children11030367"],"URL":"https:\/\/doi.org\/10.3390\/children11030367","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,19]]}}}