{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:54:57Z","timestamp":1760144097664,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>There are few data on yellow fever (YF) and hepatitis A (HA) off-label vaccination. Given the rising trend of travel to endemic countries, there is a growing necessity to broaden vaccination coverage among the pediatric population. For this reason, we aim to assess the adverse effects associated with off-label vaccination, with the ultimate purpose of expanding the vaccine spectrum. We analyzed ambispectively ninety-four children under 12 months of age who received YF or HA off-label vaccines. The YF vaccine was administered to children aged 6\u20139 months and those allergic to eggs (with a prior negative prick test and no history of anaphylaxis), while the HA vaccine was given to children aged 6\u201312 months. Overall, 71 (75%) were vaccinated against YF, and 57 (60%) against HA; 34 against both. All of them fulfilled off-label vaccination criteria. No immediate adverse effects (AEs) were reported. Mild common AEs (diarrhea, fever, or malaise) were experienced by 10.8% of patients within 10 days after vaccination. The rate of AEs associated with off-label vaccination for HA and YF is low, suggesting that the vaccines could be considered safe.<\/jats:p>","DOI":"10.3390\/children11030374","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T06:35:30Z","timestamp":1711002930000},"page":"374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Off-Label Yellow Fever and Hepatitis A Vaccination in Traveling Children"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4301-096X","authenticated-orcid":false,"given":"Cecilia","family":"Muruz\u00e1bal","sequence":"first","affiliation":[{"name":"Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-4885","authenticated-orcid":false,"given":"Lorea","family":"Vicente","sequence":"additional","affiliation":[{"name":"Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6317-0336","authenticated-orcid":false,"given":"Luc\u00eda","family":"Escolano Taravillo","sequence":"additional","affiliation":[{"name":"Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-0703","authenticated-orcid":false,"given":"Blanca","family":"Bravo Queipo de Llano","sequence":"additional","affiliation":[{"name":"Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"La Paz Institute for Health Research (IdiPAZ), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-3423","authenticated-orcid":false,"given":"Cristina","family":"Calvo","sequence":"additional","affiliation":[{"name":"Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"La Paz Institute for Health Research (IdiPAZ), 28029 Madrid, Spain"},{"name":"Biomedical Research Network Centre for Infectious Diseases (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Translational Research Network in Pediatric Infectious Diseases (RITIP), 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-1029","authenticated-orcid":false,"given":"Milagros","family":"Garc\u00eda L\u00f3pez Hortelano","sequence":"additional","affiliation":[{"name":"Pediatric and Infectious Diseases Department, La Paz University Hospital, 28046 Madrid, Spain"},{"name":"Biomedical Research Network Centre for Infectious Diseases (CIBERINFEC), Carlos III Health Institute, 28029 Madrid, Spain"},{"name":"Pediatric Tropical Diseases Unit, International Adoption and Consultation of Traveling Children, La Paz University Hospital, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","unstructured":"Mark Gershman, J.E.S. (2023, November 03). Yellow Fever. Travel-Associated Infections & Diseases, CDC Yellow Book, Available online: https:\/\/wwwnc.cdc.gov\/travel\/yellowbook\/2024\/infections-diseases\/yellow-fever."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S1473-3099(19)30323-8","article-title":"Long-term immunity against yellow fever in children vaccinated during infancy: A longitudinal cohort study","volume":"19","author":"Domingo","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_3","first-page":"481130","article-title":"Short-lived immunity after 17DD yellow fever single dose indicates that booster vaccination may be required to guarantee protective immunity in children","volume":"10","author":"Reis","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S1695-4033(07)70654-9","article-title":"Vacuna triple v\u00edrica y alergia al huevo. Experiencia en una unidad de vacunaci\u00f3n hospitalaria","volume":"67","author":"Lushchenkova","year":"2007","journal-title":"An. Pediatr."},{"key":"ref_5","unstructured":"Itasca, I. (2021). Red Book: 2021\u20132024 Report of the Committee on Infectious Diseases, American Academy of Pediatrics Committee on Infectious Diseases. [32nd ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.12688\/f1000research.74576.3","article-title":"Transmission of yellow fever vaccine virus from breast feeding mothers to their infants: Reporting of yellow fever virus (YFV) RNA detection in milk specimens","volume":"11","author":"Hassan","year":"2022","journal-title":"F1000Research"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.1097\/INF.0000000000002625","article-title":"Yellow Fever Vaccination In EGG-Allergic Children","volume":"39","author":"Sharma","year":"2020","journal-title":"Pediatr. Infect. Dis. J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.jaip.2019.01.025","article-title":"Vaccine Allergy? Skin Testing and Challenge at a Tertiary Pediatric Hospital in Melbourne, Australia","volume":"7","author":"Cheung","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_9","unstructured":"WHO (2023, November 15). Hepatitis A. Fact Sheets, Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-a."},{"key":"ref_10","first-page":"105","article-title":"Clinical trial to evaluate immunogenicity and safety of inactivated hepatitis A vaccination starting at 2-month-old children","volume":"42","author":"Kanra","year":"2000","journal-title":"Turk. J. Pediatr."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/3\/374\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:16Z","timestamp":1760105836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/3\/374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["children11030374"],"URL":"https:\/\/doi.org\/10.3390\/children11030374","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2024,3,21]]}}}