{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:34:29Z","timestamp":1782974069205,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Current mortality is low in cases of childhood acute leukemia. Dilated cardiomyopathy induced by anthracyclines remains the main cause of morbidity and mortality during mid-term and long-term follow-up. The aim of our study was to analyze the profile of left ventricular alterations in children treated with anthracyclines and to analyze risks and protective factors, including physical activity. Children and young adults with acute leukemia treated with anthracyclines between 2000 and 2018 during childhood were included. The physical activity performed by the patients before and after treatment was quantified in metabolic equivalent tasks, MET.h, per week. An echocardiographic assessment was performed, including strain analysis. Thirty-eight patients with a median age of 5 [3\u20138] years were included. Dilated cardiomyopathy was diagnosed in 3 patients and longitudinal strain abnormalities were observed in 11 patients (28.9%). Radiotherapy, cumulative anthracycline doses &gt; 240 mg\/m2, and the practice of physical activity &gt; 14 MET.h per week (after leukemia treatment) were independently associated with strain abnormalities. In multivariate analysis, radiotherapy was significantly associated with an increased risk of LV GLS abnormalities (OR = 1.26 [1.01\u20131.57], p = 0.036), and physical activity &gt; 14 MET.h\/week after oncological treatment was significantly associated with a reduction in the risk of LV GLS abnormalities (OR of 0.03 [0.002\u20130.411], p = 0.009). The strain assessment of left ventricular function is an interesting tool for patient follow-up after leukemia treatment. Moderate and steady physical activity seems to be associated with fewer longitudinal strain abnormalities in patients treated with anthracyclines during childhood.<\/jats:p>","DOI":"10.3390\/children11030378","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:37:22Z","timestamp":1711021042000},"page":"378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Left Ventricular Longitudinal Strain Abnormalities in Childhood Exposure to Anthracycline Chemotherapy"],"prefix":"10.3390","volume":"11","author":[{"given":"Arnaud","family":"Rique","sequence":"first","affiliation":[{"name":"Cardio-Oncology Department, AP-HM Nord Hospital, 13915 Marseille, France"},{"name":"Pediatric and Congenital Cardiology Department, AP-HM Timone Enfants, 13385 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-8191","authenticated-orcid":false,"given":"Jennifer","family":"Cautela","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Department, AP-HM Nord Hospital, 13915 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8727-7154","authenticated-orcid":false,"given":"Franck","family":"Thuny","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Department, AP-HM Nord Hospital, 13915 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Michel","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Department, AP-HM Timone Enfants, 13385 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-2760","authenticated-orcid":false,"given":"Caroline","family":"Ovaert","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, AP-HM Timone Enfants, 13385 Marseille, France"},{"name":"Marseille Medical Genetics, Inserm UMR 1251, Aix Marseille University, 13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-4287","authenticated-orcid":false,"given":"Fedoua","family":"El Louali","sequence":"additional","affiliation":[{"name":"Pediatric and Congenital Cardiology Department, AP-HM Timone Enfants, 13385 Marseille, France"},{"name":"Laboratory of Biomechanics and Application, UMRT24, Aix Marseille University, 13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1161\/CIRCULATIONAHA.114.013777","article-title":"Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy","volume":"131","author":"Cardinale","year":"2015","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1200\/JCO.2002.12.102","article-title":"Long-Term Enalapril Therapy for Left Ventricular Dysfunction in Doxorubicin-Treated Survivors of Childhood Cancer","volume":"20","author":"Lipshultz","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/cvr\/cvz031","article-title":"Paediatric cardio-oncology: Epidemiology, screening, prevention, and treatment","volume":"115","author":"Chow","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1542\/peds.2007-0575","article-title":"Monitoring for cardiovascular disease in survivors of childhood cancer: Report from the Cardiovascular Disease Task Force of the Children\u2019s Oncology Group","volume":"121","author":"Shankar","year":"2008","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1249\/MSS.0000000000001430","article-title":"A Youth Compendium of Physical Activities: Activity Codes and Metabolic Intensities","volume":"50","author":"Butte","year":"2018","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.echo.2015.11.016","article-title":"Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis","volume":"29","author":"Levy","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.echo.2008.02.006","article-title":"Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: An echocardiographic study","volume":"21","author":"Pettersen","year":"2008","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.echo.2015.12.011","article-title":"New Reference Centiles for Left Ventricular Mass Relative to Lean Body Mass in Children","volume":"29","author":"Foster","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1161\/CIRCIMAGING.112.974428","article-title":"Normal values of left atrial volume in pediatric age group using a validated allometric model","volume":"5","author":"Bhatla","year":"2012","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.echo.2009.03.026","article-title":"Right ventricular function in infants, children and adolescents: Reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values","volume":"22","author":"Koestenberger","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.amjcard.2011.08.013","article-title":"Reference values of tricuspid annular peak systolic velocity in healthy pediatric patients, calculation of z score, and comparison to tricuspid annular plane systolic excursion","volume":"109","author":"Koestenberger","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.echo.2014.01.015","article-title":"Normal ranges of right ventricular systolic and diastolic strain measures in children: A systematic review and meta-analysis","volume":"27","author":"Levy","year":"2014","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1017\/S1047951113001182","article-title":"Left ventricular strain and strain rates are decreased in children with normal fractional shortening after exposure to anthracycline chemotherapy","volume":"24","author":"Moon","year":"2014","journal-title":"Cardiol. Young"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yu, A.F., Raikhelkar, J., Zabor, E.C., Tonorezos, E.S., Moskowitz, C.S., Adsuar, R., Mara, E., Huie, K., Oeffinger, K.C., and Steingart, R.M. (2016). Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer. Biomed. Res. Int., 2016.","DOI":"10.1155\/2016\/9363951"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2015.04.013","article-title":"Comprehensive Echocardiographic Detection of Treatment-Related Cardiac Dysfunction in Adult Survivors of Childhood Cancer: Results from the St. Jude Lifetime Cohort Study","volume":"65","author":"Armstrong","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/CIRCIMAGING.112.973321","article-title":"Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab","volume":"5","author":"Sawaya","year":"2012","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1007\/s00246-015-1203-8","article-title":"Abnormal Myocardial Strain Indices in Children Receiving Anthracycline Chemotherapy","volume":"36","author":"Pignatelli","year":"2015","journal-title":"Pediatr. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.4103\/0366-6999.233950","article-title":"Detection of Subclinical Anthracyclines\u2019 Cardiotoxicity in Children with Solid Tumor","volume":"131","author":"Hu","year":"2018","journal-title":"Chin. Med. J."},{"key":"ref_22","first-page":"4","article-title":"Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines","volume":"4","author":"Lee","year":"2018","journal-title":"Cardiooncology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1200\/JCO.2004.09.109","article-title":"Cardiovascular status in long-term survivors of Hodgkin\u2019s disease treated with chest radiotherapy","volume":"22","author":"Adams","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11556-012-0115-3","article-title":"The role of physical activity in primary cancer prevention","volume":"10","author":"Steindorf","year":"2013","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/0284186X.2012.742564","article-title":"Jones, Catherine M Alfano. Exercise-oncology research: Past, present, and future","volume":"52","author":"Lee","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1001\/jamaoncol.2018.2254","article-title":"Association of exercise with mortality in adult survivors of childhood cancer","volume":"4","author":"Scott","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1200\/JCO.2014.56.7511","article-title":"Exercise and risk of major cardiovascular events in adult survivors of childhood hodgkin lymphoma: A report from the childhood cancer survivor study","volume":"32","author":"Jones","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/HCO.0000000000000437","article-title":"Health benefits of physical activity: A systematic review of current systematic reviews","volume":"32","author":"Warburton","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/archdischild-2019-318017","article-title":"Moving more: Physical activity and its positive effects on long term conditions in children and young people","volume":"105","author":"Dimitri","year":"2020","journal-title":"Arch. Dis. Child."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7807856","DOI":"10.1155\/2020\/7807856","article-title":"Potential Benefits of Physical Activity in MCI and Dementia","volume":"2020","author":"Nuzum","year":"2020","journal-title":"Behav. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/BOR.0000000000000696","article-title":"Benefits and promotion of physical activity in rheumatoid arthritis","volume":"32","author":"Katz","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5114\/pedm.2018.83364","article-title":"Physical activity in children and adolescents with type 1 diabetes and contem-porary methods of its assessment","volume":"24","author":"Grzegorczyk","year":"2018","journal-title":"Pediatr. Endocrinol. Diabetes Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.2165\/00007256-200636120-00003","article-title":"Adolescent physical activity and health: A systematic review","volume":"36","author":"Hallal","year":"2006","journal-title":"Sports Med."},{"key":"ref_34","unstructured":"World Health Organization (2018). Global Action Plan on Physical Activity 2018\u20132030: More Active People for a Healthier World, World Health Organization."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11764-021-01028-4","article-title":"Asymptomatic systolic dysfunction on contemporary echocardiography in anthracycline-treated long-term childhood cancer survivors: A systematic review","volume":"16","author":"Merkx","year":"2022","journal-title":"J. Cancer Surviv."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/3\/378\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:38Z","timestamp":1760105858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/3\/378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["children11030378"],"URL":"https:\/\/doi.org\/10.3390\/children11030378","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]}}}