{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:57:44Z","timestamp":1772751464355,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon Europe Coordination and Support Actions Programme","award":["101060201"],"award-info":[{"award-number":["101060201"]}]},{"name":"European Union\u2019s Horizon Europe Coordination and Support Actions Programme","award":["451-03-66\/2024-03\/200042"],"award-info":[{"award-number":["451-03-66\/2024-03\/200042"]}]},{"name":"European Union\u2019s Horizon Europe Coordination and Support Actions Programme","award":["F172"],"award-info":[{"award-number":["F172"]}]},{"name":"Ministry of Science, Technological Development, and Innovation of the Republic of Serbia","award":["101060201"],"award-info":[{"award-number":["101060201"]}]},{"name":"Ministry of Science, Technological Development, and Innovation of the Republic of Serbia","award":["451-03-66\/2024-03\/200042"],"award-info":[{"award-number":["451-03-66\/2024-03\/200042"]}]},{"name":"Ministry of Science, Technological Development, and Innovation of the Republic of Serbia","award":["F172"],"award-info":[{"award-number":["F172"]}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["101060201"],"award-info":[{"award-number":["101060201"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["451-03-66\/2024-03\/200042"],"award-info":[{"award-number":["451-03-66\/2024-03\/200042"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018992","name":"Serbian Academy of Sciences and Arts","doi-asserted-by":"publisher","award":["F172"],"award-info":[{"award-number":["F172"]}],"id":[{"id":"10.13039\/501100018992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>22q11.2 deletion syndrome (22q11.2DS), the most frequent microdeletion syndrome in humans, is related to a high risk of developing neurodevelopmental disorders. About 95% of patients with 22q11.2DS have speech and language impairments. Global articulation, story generation, and verbal memory tests were applied to compare articulatory characteristics of speech sounds, spontaneous language abilities, and immediate verbal memory between four groups of Serbian-speaking children: patients with 22q11.2DS, children with clinical presentation of 22q11.2DS that do not have the microdeletion, children with non-syndromic congenital heart defects, and their peers with typical speech\u2013sound development. The obtained results showed that children with this microdeletion have impaired articulation skills and expressive language abilities. However, we did not observe weaker receptive language skills and immediate verbal memory compared to healthy controls. Children with 22q11.2DS should be considered a risk category for the development of speech\u2013sound pathology and expressive language abilities. Since speech intelligibility is an instrument of cognition and adequate peer socialization, and language impairment in school-aged children with 22q11DS might be an indicator of increased risk for later psychotic symptoms, patients with 22q11.2 microdeletion should be included in a program of early stimulation of speech\u2013language development immediately after diagnosis is established.<\/jats:p>","DOI":"10.3390\/children11040489","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T04:10:15Z","timestamp":1713499815000},"page":"489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Speech Sounds Production, Narrative Skills, and Verbal Memory of Children with 22q11.2 Microdeletion"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-2021","authenticated-orcid":false,"given":"Marijana","family":"Rakonjac","sequence":"first","affiliation":[{"name":"Institute for Experimental Phonetics and Speech Pathology, Jovanova 35, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Cuturilo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia"},{"name":"University Children\u2019s Hospital, Tirsova 10, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-1283","authenticated-orcid":false,"given":"Natasa","family":"Kovacevic-Grujicic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Simeunovic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana","family":"Kostic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-7334","authenticated-orcid":false,"given":"Milena","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"},{"name":"Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia"},{"name":"Serbian Academy of Sciences and Arts, Kneza Mihaila 35, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-6673","authenticated-orcid":false,"given":"Danijela","family":"Drakulic","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.9778\/cmajo.20200294","article-title":"Estimate of the contemporary live-birth prevalence of recurrent 22q11.2 deletions: A cross-sectional analysis from population-based newborn screening","volume":"9","author":"Blagojevic","year":"2021","journal-title":"CMAJ Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/S0140-6736(07)61601-8","article-title":"Velocardiofacial syndrome, DiGeorge syndrome: The chromosome 22q11.2 deletion syndromes","volume":"370","author":"Kobrynski","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2147\/NDT.S52188","article-title":"22q11 deletion syndrome: A review of the neuropsychiatric features and their neurobiological basis","volume":"9","author":"Squarcione","year":"2013","journal-title":"Neuropsychiatr. 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